Organization profile

Organisation Profile

We are studying the role of prolyl oligopeptidase (PREP, formerly known as POP) on disease progression and neuronal toxicity in neurodegenerative disorders with protein aggregation. These disorders involve several serious diseases such as Alzheimer’s and Parkinson’s diseases, and several more rare neurodegenerative conditions. Based on PREP inhibitors, we are developing novel and disease-modifying drug therapies to stop the neuronal death in Alzheimer's and Parkinson's diseases.

Read more on our website

International and National Collaboration Publications and projects within past five years.

Projects 2011 2022

Publications 2011 2019

Entsyymien merkitys hermorappeumataudeissa

Kursula, P. & Myöhänen, T., 2019, In : Duodecim. 135, 8, p. 745-752

Research output: Contribution to journalArticleScientificpeer-review

New tricks of prolyl oligopeptidase inhibitors - A common drug therapy for several neurodegenerative diseases

Svarcbahs, R., Julku, U., Kilpelainen, T., Kyyrö, M., Jäntti, M. & Myohänen, T. T., Mar 2019, In : Biochemical Pharmacology. 161, p. 113-120 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Combination of CDNF and Deep Brain Stimulation Decreases Neurological Deficits in Late-stage Model Parkinson's Disease

Huotarinen, A., Penttinen, A-M., Bäck, S., Voutilainen, M. H., Julku, U., Piepponen, T. P., Männistö, P. T., Saarma, M., Tuominen, R., Laakso, A. & Airavaara, M., 15 Mar 2018, In : Neuroscience. 374, p. 250-263 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Constitutive Ret signaling leads to long-lasting expression of amphetamine-induced place conditioning via elevation of mesolimbic dopamine

Kopra, J., Villarta-Aguilera, M., Savolainen, M., Weingerl, S., Myohänen, T. T., Rannanpää, S., Salvatore, M. E., Andressoo, J-O. & Piepponen, T. P., Jan 2018, In : Neuropharmacology. 128, p. 221-230 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Activities 2010 2019

Prolyl oligopeptidase on alpha-synuclein aggregation

Timo Myöhänen (Speaker)
26 Feb 2019

Activity: Talk or presentation typesInvited talk

FM Johanna Viiri vastaväittöjä

Timo Myöhänen (Supervisor)
9 Aug 2019

Activity: Examination typesOpponent of doctoral dissertation

Career as an academic PI

Timo Myöhänen (Speaker)
7 Jun 2019

Activity: Talk or presentation typesInvited talk

World Congress on Basic and Clinical Pharmacology 2018

Timo Myöhänen (Attendee)
5 Jul 2018

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Epilepsia Open (Journal)

Timo Myöhänen (Reviewer)
2018

Activity: Publication peer-review and editorial work typesPeer review of manuscripts