Projects per year
Organisation profile
We are studying the role of prolyl oligopeptidase (PREP, formerly known as POP) on disease progression and neuronal toxicity in neurodegenerative disorders with protein aggregation. These disorders involve several serious diseases such as Alzheimer’s and Parkinson’s diseases, and several more rare neurodegenerative conditions. Based on PREP inhibitors, we are developing novel and disease-modifying drug therapies to stop the neuronal death in Alzheimer's and Parkinson's diseases.
Read more on our website
International and National Collaboration
Publications and projects within past five years.
Profiles
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Tony Eteläinen
- Divisions of Faculty of Pharmacy - Visiting scholar
- PREP in neurodegenerative disorders
Person: Visiting scholar, Teaching and research personnel
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Tommi Kilpeläinen
- Divisions of Faculty of Pharmacy - Visiting scholar
- PREP in neurodegenerative disorders
Person: Visiting scholar, Teaching and research personnel
Projects
- 6 Finished
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Prolyylioligopeptidaasi (PREP) - mahdollinen biomarkkeri ja yhteinen lääkekehityskohde useaan hermostoa rappeuttavaan sairauteen?
Myöhänen, T. & Kilpeläinen, T.
01/09/2018 → 31/08/2022
Project: Research project
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Prolyylioligopeptidaasin ligandit - yhteinen hoitomuoto useille hermostoa rappeuttaville sairauksille?
01/10/2016 → 30/09/2018
Project: Research project
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New Protein Kinase Modulators for Cancer and Alzheimer’s Disease
Tuominen, R. K., Boije af Gennäs, G., Yli-Kauhaluoma, J., Provenzani, R. & Jäntti, M.
Suomen Kulttuurirahasto, Magnus Ehrnroothin säätiö
01/01/2014 → 31/12/2017
Project: Research project
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The effects of Prolyl Oligopeptidase (POP) and its inhibition on alpha-synuclein aggregation and Parkinson's disease
Myöhänen, T., Savolainen, M. & Svarcbahs, R.
01/09/2013 → 31/08/2018
Project: Research project
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A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy
Eteläinen, T., Silva, M. C., Uhari-Väänänen, J., De Lorenzo, F., Jäntti, M., Cui, H., Chavero-Pieres, M., Kilpeläinen, T., Mechtler, C., Svarcbahs, R., Seppälä, E., Savinainen, J., Puris, E., Fricker, G., Gynther, M., Julku, U., Huttunen, H., Haggarty, S. & Myöhänen, T., 12 Apr 2023, In: Science translational medicine. 15, 691, 10.1126/scitranslmed.abq2915.Research output: Contribution to journal › Article › Scientific › peer-review
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Nigrostriatal 6-hydroxydopamine lesions increase alpha-synuclein levels and permeability in rat colon
Cui, H., Elford, J. D., Alitalo, O., Perez-Pardo, P., Tampio, J., Huttunen, K. M., Kraneveld, A., Forsberg, M. M., Myohanen, T. T. & Jalkanen, A. J., Sep 2023, In: Neurobiology of Aging. 129, p. 62-71 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access -
Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on alpha-Synuclein Mouse Models of Parkinson's Disease
Kilpelainen, T. P., Patsi, H. T., Svarcbahs, R., Julku, U. H., Eteläinen, T. S., Cui, H., Auno, S., Sipari, N., Norrbacka, S., Leino, T. O., Jäntti, M., Myöhänen, T. T. & Wallen, E. A. A., 29 May 2023, In: Journal of Medicinal Chemistry. 66, 11, p. 7475-7496 22 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Inhibition of prolyl oligopeptidase: A promising pathway to prevent the progression of age-related macular degeneration
Hellinen, L., Koskela, A., Vattulainen, E., Liukkonen, M., Wegler, C., Treyer, A., Handin, N., Svensson, R., Myöhänen, T., Poso, A., Kaarniranta, K., Artursson, P. & Urtti, A., Feb 2022, In: Biomedicine & Pharmacotherapy. 146, 15 p., 112501.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Prolyl oligopeptidase acts as a link between chaperone-mediated autophagy and macroautophagy
Cui, H., Norrbacka, S. M. & Myöhänen, T., Mar 2022, In: Biochemical Pharmacology. 197, 18 p., 114899.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile
Activities
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Career as an academic PI
Timo Myöhänen (Speaker)
7 Jun 2019Activity: Talk or presentation types › Invited talk
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FM Johanna Viiri vastaväittöjä
Timo Myöhänen (Supervisor)
9 Aug 2019Activity: Examination types › Opponent of doctoral dissertation
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Prolyl oligopeptidase on alpha-synuclein aggregation
Timo Myöhänen (Speaker)
26 Feb 2019Activity: Talk or presentation types › Invited talk
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Journal of Neuroinflammation (Journal)
Timo Myöhänen (Reviewer)
2018Activity: Publication peer-review and editorial work types › Peer review of manuscripts
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World Congress on Basic and Clinical Pharmacology 2018
Timo Myöhänen (Attendee)
5 Jul 2018Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
Press/Media
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Suomalaistutkijat haluavat pysäyttää dementian, hiirillä muistikokeiden tulokset olivat jo yllättävän hyviä – Yksi ongelma jarruttaa lääkkeeksi etenemistä
22/04/2023
1 Media contribution
Press/Media: Press / Media
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Suomalaistutkijat haluavat pysäyttää dementian, hiirillä muistikokeiden tulokset olivat jo yllättävän hyviä – Yksi ongelma jarruttaa lääkkeeksi etenemistä
22/04/2023
1 Media contribution
Press/Media: Press / Media
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Mullistava tutkimus muistisairauden hoidosta – haitallisen aineen kertymistä aivoihin onnistuttiin estämään
18/04/2023
1 item of Media coverage
Press/Media: Press / Media
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Tutkimus: Muistisairauksien estämiseen löytyi mahdollinen ratkaisu
14/04/2023
1 item of Media coverage
Press/Media: Press / Media
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