• Viikinkaari 9 , Biokeskus 1C, 6. kerros

    00014 Helsingin yliopisto

Organization profile

Organisation Profile

RESEARCH in my laboratory focuses on AMPA receptors, tetrameric ion channels that mediate glutamate signaling in the brain and other tissues. AMPA receptors are important regulators of the efficiency of synaptic transmission, a key property underlying learning and memory, and contribute - when malfunctioning - to numerous neuropathologies. We are using a combination of biochemical, molecular biological and electrophysiological methods to study the mechanisms which determine the subunit composition, cellular localization and protein interactions of AMPA receptors in order to understand their function in normal and diseased brain in molecular detail.

Current topics:

1. Cytosolic protein interactions of long-tailed AMPA receptor subunits GluA1 and GluA4

2. Modulation of AMPA receptor function by interacting proteins

3. Quality control of AMPA receptor trafficking

Fields of Science

  • 1182 Biochemistry, cell and molecular biology
  • 318 Medical biotechnology

International and National Collaboration Publications and projects within past five years.

Projects

Publications

  • 39 Article
  • 2 Review Article
  • 2 Doctoral Thesis
  • 1 Conference contribution

Dysregulated Ca2+-Permeable AMPA Receptor Signaling in Neural Progenitors Modeling Fragile X Syndrome

Danesi, C. E., Keinänen, K. P. & Castren, M. L., 8 Feb 2019, In : Frontiers in Synaptic Neuroscience. 11, 8 p., 2.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File

Glutamaattireseptorien vasteiden poikkeavuus särö-X-kantasoluissa

Achuta, V. S., Möykkynen, T., Peteri, U-K., Turconi, G., Rivera, C., Keinänen, K. & Castren, M. L., 2018, In : Duodecim. 134, 4, p. 364 1 p.

Research output: Contribution to journalArticleProfessional

Open Access
File

Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors

von Ossowski, L., Li, L-L., Möykkynen, T., Coleman, S. K., Courtney, M. J. & Keinänen, K., 2 Feb 2017, In : PLoS One. 12, 2, 15 p., 0171489.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Interaction of GluA1 AMPA receptor with Synapse-Associated Protein 97

von Ossowski, M. E-L., 3 Feb 2017, Helsinki: University of Helsinki. 137 p.

Research output: ThesisDoctoral ThesisCollection of Articles

Open Access

Molecular mechanisms controlling synaptic recruitment of GluA4 subunit-containing AMPA-receptors critical for functional maturation of CA1 glutamatergic synapses

Luchkina, N. V., Coleman, S. K., Huupponen, J., Cai, C., Kivistö, A., Taira, T., Keinänen, K. & Lauri, S. E., Jan 2017, In : Neuropharmacology. 112, p. 46-56 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Activities

Doctoral Thesis Committee Member (8 students)

Kari Keinänen (Member of thesis committee / follow-up group)

1 Jan 2017 → …

Activity: Examination typesMember of doctoral thesis committee / follow-up group

British Neuroscience Association Festival of Neuroscience 2015

Sarah Coleman (Poster Presentation)

12 Apr 201515 Apr 2015

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Pre-examiner of doctoral thesis

Sarah Coleman (Pre-examiner)

Feb 2014Mar 2014

Activity: Examination typesPre-examiner of doctoral thesis

Pre-examiner of Doctoral thesis

Sarah Coleman (Pre-examiner)

Aug 2014Dec 2014

Activity: Examination typesPre-examiner of doctoral thesis

Molecular pharmacology : an international journal (Journal)

Sarah Coleman (Reviewer)

Mar 2013Jul 2013

Activity: Publication peer-review and editorial work typesPeer review of manuscripts