Projects per year
Organisation profile
Organisation Profile
RESEARCH in my laboratory focuses on AMPA receptors, tetrameric ion channels that mediate glutamate signaling in the brain and other tissues. AMPA receptors are important regulators of the efficiency of synaptic transmission, a key property underlying learning and memory, and contribute - when malfunctioning - to numerous neuropathologies. We are using a combination of biochemical, molecular biological and electrophysiological methods to study the mechanisms which determine the subunit composition, cellular localization and protein interactions of AMPA receptors in order to understand their function in normal and diseased brain in molecular detail.
Current topics:
1. Cytosolic protein interactions of long-tailed AMPA receptor subunits GluA1 and GluA4
2. Modulation of AMPA receptor function by interacting proteins
3. Quality control of AMPA receptor trafficking
Fields of Science
- 1182 Biochemistry, cell and molecular biology
- 318 Medical biotechnology
International and National Collaboration
Profiles
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Kari Keinänen
- Molecular and Integrative Biosciences Research Programme - Professor
- Receptor Biochemistry
- Doctoral Programme in Integrative Life Science - Supervisor for doctoral programme
Person: UH , U4 Research and teaching staff
Projects
- 5 Finished
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To identify common themes in quality control of the ionotropic glutamate receptor family
Coleman, S.
01/05/2015 → 31/12/2016
Project: Research project
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Leukocyte integrin cross-talk - a novel concept in cell adhesion
Gahmberg, C. G. & Keinänen, K.
01/09/2013 → 31/08/2017
Project: Research project
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Membrec (Membranes and Receptors)
Keinänen, K., Finne, J., Siljander, P., Gahmberg, C. G., Käkelä, R., Eskelinen, E. & Kukkonen, J.
01/01/2013 → 31/12/2016
Project: Research project
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Ehrnrooth Coleman 2012: Domain - Domain Interaction Analyses of Ionotropic Glutamate Receptors
Coleman, S.
06/03/2012 → 31/05/2013
Project: Research project
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Ehrnrooth Coleman AMPA receptors and the 4.1. family: Defining the interaction
Coleman, S.
06/03/2011 → 31/05/2012
Project: Research project
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Mitotic spindle disassembly in human cells relies on CRIPT having hierarchical redox signals
Xu, K., Wang, C., Keinänen, K., Li, H. & Cai, C., 23 Sept 2022, In: Journal of Cell Science. 135, 18, 11 p., jcs259657.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Review of the scientific evidence on the individual sensitivity to electromagnetic fields (EHS)
Leszczynski, D., 2022, In: Reviews on environmental health. 37, 3, p. 423–450 28 p.Research output: Contribution to journal › Review Article › peer-review
Open AccessFile -
Response to Letter by Benson et al. on 'Hangover and the Effects of L-Cysteine'
Eriksson, C. J. P., Metsälä, M., Möykkynen, T., Mäkisalo, H., Kärkkäinen, O., Palmén, M., Salminen, J. E. & Kauhanen, J., Sept 2021, In: Alcohol & Alcoholism. 56, 5, p. 630-631 2 p.Research output: Contribution to journal › Letter › Scientific
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L-Cysteine Containing Vitamin Supplement Which Prevents or Alleviates Alcohol-related Hangover Symptoms: Nausea, Headache, Stress and Anxiety
Eriksson, C. J. P., Metsälä, M., Möykkynen, T., Mäkisalo, H., Kärkkäinen, O., Palmen, M., Salminen, J. E. & Kauhanen, J., Nov 2020, In: Alcohol & Alcoholism. 55, 6, p. 660-666 7 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Dysregulated Ca2+-Permeable AMPA Receptor Signaling in Neural Progenitors Modeling Fragile X Syndrome
Danesi, C. E., Keinänen, K. P. & Castren, M. L., 8 Feb 2019, In: Frontiers in Synaptic Neuroscience. 11, 8 p., 2.Research output: Contribution to journal › Review Article › peer-review
Open AccessFile
Activities
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Doctoral Thesis Committee Member (8 students)
Kari Keinänen (Member of thesis committee / follow-up group)
1 Jan 2017 → …Activity: Examination types › Member of doctoral thesis committee / follow-up group
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British Neuroscience Association Festival of Neuroscience 2015
Sarah Coleman (Poster Presentation)
12 Apr 2015 → 15 Apr 2015Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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Pre-examiner of doctoral thesis
Sarah Coleman (Pre-examiner)
Feb 2014 → Mar 2014Activity: Examination types › Pre-examiner of doctoral thesis
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Pre-examiner of Doctoral thesis
Sarah Coleman (Pre-examiner)
Aug 2014 → Dec 2014Activity: Examination types › Pre-examiner of doctoral thesis
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Molecular pharmacology : an international journal (Journal)
Sarah Coleman (Reviewer)
Mar 2013 → Jul 2013Activity: Publication peer-review and editorial work types › Peer review of manuscripts