Receptor Biochemistry

Publications

Research output per year 2000 2000 2002 2003 2006 2009 2010 2012 2017 2022

• 41 Article
• 3 Review Article
• 2 Doctoral Thesis
• 1 Conference contribution
• 1 More
  • 1 Letter

Research output per year

Research output per year

Search results

• 2022

  Mitotic spindle disassembly in human cells relies on CRIPT having hierarchical redox signals

  Xu, K., Wang, C., Keinänen, K., Li, H. & Cai, C., 23 Sept 2022, In: Journal of Cell Science. 135, 18, 11 p., jcs259657.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Review of the scientific evidence on the individual sensitivity to electromagnetic fields (EHS)

  Leszczynski, D., 2022, In: Reviews on environmental health. 37, 3, p. 423–450 28 p.

  Research output: Contribution to journal › Review Article › peer-review

  Open Access

  File
• 2021

  Response to Letter by Benson et al. on 'Hangover and the Effects of L-Cysteine'

  Eriksson, C. J. P., Metsälä, M., Möykkynen, T., Mäkisalo, H., Kärkkäinen, O., Palmén, M., Salminen, J. E. & Kauhanen, J., Sept 2021, In: Alcohol & Alcoholism. 56, 5, p. 630-631 2 p.

  Research output: Contribution to journal › Letter › Scientific
• 2020

  L-Cysteine Containing Vitamin Supplement Which Prevents or Alleviates Alcohol-related Hangover Symptoms: Nausea, Headache, Stress and Anxiety

  Eriksson, C. J. P., Metsälä, M., Möykkynen, T., Mäkisalo, H., Kärkkäinen, O., Palmen, M., Salminen, J. E. & Kauhanen, J., Nov 2020, In: Alcohol & Alcoholism. 55, 6, p. 660-666 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2019

  Dysregulated Ca2+-Permeable AMPA Receptor Signaling in Neural Progenitors Modeling Fragile X Syndrome

  Danesi, C. E., Keinänen, K. P. & Castren, M. L., 8 Feb 2019, In: Frontiers in Synaptic Neuroscience. 11, 8 p., 2.

  Research output: Contribution to journal › Review Article › peer-review

  Open Access

  File
• 2018

  Glutamaattireseptorien vasteiden poikkeavuus särö-X-kantasoluissa

  Achuta, V. S., Möykkynen, T., Peteri, U.-K., Turconi, G., Rivera, C., Keinänen, K. & Castren, M. L., 2018, In: Duodecim. 134, 4, p. 364 1 p.

  Research output: Contribution to journal › Article › Professional

  Open Access

  File
• 2017

  Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors

  von Ossowski, L., Li, L.-L., Möykkynen, T., Coleman, S. K., Courtney, M. J. & Keinänen, K., 2 Feb 2017, In: PLoS One. 12, 2, 15 p., 0171489.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Interaction of GluA1 AMPA receptor with Synapse-Associated Protein 97

  von Ossowski, M.E.-L., 3 Feb 2017, Helsinki: University of Helsinki. 137 p.

  Research output: Thesis › Doctoral Thesis › Collection of Articles

  Open Access

• Molecular mechanisms controlling synaptic recruitment of GluA4 subunit-containing AMPA-receptors critical for functional maturation of CA1 glutamatergic synapses

  Luchkina, N. V., Coleman, S. K., Huupponen, J., Cai, C., Kivistö, A., Taira, T., Keinänen, K. & Lauri, S. E., Jan 2017, In: Neuropharmacology. 112, p. 46-56 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2016

  Aggregation Limits Surface Expression of Homomeric GluA3 Receptors

  Coleman, S. K., Hou, Y., Willibald, M., Semenov, A., Möykkynen, T. & Keinänen, K., 15 Apr 2016, In: Journal of Biological Chemistry. 291, 16, p. 8784-8794 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access
• 2015

  MIM-Induced Membrane Bending Promotes Dendritic Spine Initiation

  Saarikangas, J., Kourdougli, N., Senju, Y., Chazal, G., Segerstråle, M., Minkeviciene, R., Kuurne, J., Mattila, P. K., Garrett, L., Hölter, S. M., Becker, L., Racz, I., Hans, W., Klopstock, T., Wurst, W., Zimmer, A., Fuchs, H., Gailus-Durner, V., de Angelis, M. H. & von Ossowski, L. & 4 others, Taira, T., Lappalainen, P., Rivera Baeza, C. & Hotulainen, P., 22 Jun 2015, In: Developmental Cell. 33, 6, p. 644-659 16 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2014

  Developmental switch in the kinase dependency of long-term potentiation depends on expression of GluA4 subunit-containing AMPA receptors

  Luchkina, N. V., Huupponen, J., Clarke, V. R. J., Coleman, S. K., Keinanen, K., Taira, T. & Lauri, S. E., 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 11, p. 4321-4326 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• The N-terminal Domain Modulates alpha-Amino-3-hydroxy-5methyl-4-isoxazolepropionic acid ( AMPA) Receptor Desensitization

  Moykkynen, T., Coleman, S. K., Semenov, A. & Keinanen, K., 9 May 2014, In: Journal of Biological Chemistry. 289, 19, p. 13197-13205 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2012

  Acute Effects of Ethanol on Glutamate Receptors

  Möykkynen, T. P. & Korpi, E. R., 2012, In: Basic & Clinical Pharmacology & Toxicology. 111, 1, p. 4-13 10 p.

  Research output: Contribution to journal › Review Article › peer-review

• Autoinactivation of the Stargazin–AMPA Receptor Complex: Subunit-Dependency and Independence from Physical Dissociation

  Semenov, A., Möykkynen, T. P., Korpi, E. R., Coleman, S. K. & Keinänen, K., 2012, In: PLoS One. 7, 11, p. e49282 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Importance of GluA1 Subunit-Containing AMPA Glutamate Receptors for Morphine State-Dependency

  Aitta-aho, T., Möykkynen, T. P., Panhelainen, A. E., Vekovischeva, O. Y., Bäckström, P. & Korpi, E. R., 2012, In: PLoS One. 7, Article Number: e38325, p. - 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Interactions of AMPA receptors with intracellular proteins

  Cai, C., 11 Dec 2012, Helsinki: [C. Chunlin]. 79 p.

  Research output: Thesis › Doctoral Thesis › Collection of Articles

• Post-Synapse Model Cell for Synaptic Glutamate Receptor (GluR)-Based Biosensing: Strategy and Engineering to Maximize Ligand-Gated Ion-Flux Achieving High Signal-to-Noise Ratio

  Tateishi, A., Coleman, S. K., Migita, S., Keinänen, K. & Haruyama, T., 2012, In: Sensors. 12, 1, p. 1035-1041 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2011

  Cold-adapted protease enables quantitation of surface proteins in the absence of membrane trafficking.

  Ahmad, F., Coleman, S. K., Kaila, K. & Blaesse, P., 2011, In: BioTechniques. 50, 4, p. 255-257 3 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2010

  Analysis of the Potential Role of GluA4 Carboxyl-Terminus in PDZ Interactions

  Coleman, S. K., Cai, C., Kalkkinen, N., Korpi, E. R. & Keinanen, K., 2010, In: PLoS One. 5, 1, p. art. e8715 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Ligand-Binding Domain Determines Endoplasmic Reticulum Exit of AMPA Receptors

  Coleman, S. K., Möykkynen, T., Hinkkuri, S., Vaahtera, L., Pentikäinen, O. T., Korpi, E. R. & Keinänen, K., 2010, In: Journal of Biological Chemistry. 285, 46, p. 36032-36039 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors

  Anliker, B., Abel, T., Kneissl, S., Hlavaty, J., Caputi, A., Brynza, J., Schneider, I. C., Muench, R. C., Petznek, H., Kontermann, R. E., Koehl, U., Johnston, I. C. D., Keinänen, K., Mueller, U. C., Hohenadl, C., Monyer, H., Cichutek, K. & Buchholz, C. J., Nov 2010, In: Nature methods. 7, 11, p. 929-935 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2009

  Activity dependent plasma membrane insertion and internalization of Kv4.2 potassium channels in cultured hippocampal neurons

  Pryazhnikov, E., Khiroug, S., Coleman, S. K., Keinänen, K., Jeromin, A. & Khirug, L., Oct 2009, Abstract book of 39th SfN annual meeting.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific

• Agonist occupancy is essential for forward trafficking of AMPA receptors

  Coleman, S. K., Möykkynen, T., Jouppila, A., Koskelainen, S., Rivera, C., Korpi, E. R. & Keinänen, K., 2009, In: Journal of Neuroscience. 29, 2, p. 303-312 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Dynamic visualization of membrane-inserted fraction of pHluorin-tagged channels using repetitive acidification technique

  Khiroug, S., Pryazhnikov, E., Coleman, S. K., Jeromin, A., Keinänen, K. & Khirug, L., 2009, In: BMC Neuroscience. 10, p. 141-151 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Ethanol increases desensitization of recombinant GluR-D AMPA receptor and TARP combinations

  Möykkynen, T., Coleman, S. K., Keinänen, K., Lovinger, D. & Korpi, E. R., 2009, In: Alcohol.. 43, 4, p. 277-284 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Interaction of the RhoA exchange factor Net1 with discs large homolog 1 protects it from proteasome-mediated degradation and potentiates Net1 activity

  Carr, H. S., Cai, C., Keinänen, K. & Frost, J. A., 2009, In: Journal of Biological Chemistry. 284, 36, p. 24269-24280 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2008

  Somatostatin receptor subtype 1 is a PDZ ligand for synapse-associated protein 97 and a potential regulator of growth cone dynamics

  Cai, C., Li, H., Kangasniemi, A., Pihlajamaa, T., Ossowski von, L., Kerkelä, K. M., Schulz, S., Rivera Baeza, C. & Keinänen, K., 2008, In: Neuroscience. 157, 4, p. 833-843 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2007

  KCC2 interacts with the dendritic cytoskeleton to promote spine development

  Li, H., Khirug, S., Cai, C., Ludwig, A., Blaesse, P., Kolikova, J., Afzalov, R., Coleman, S. K., Lauri, S., Airaksinen, M. S., Keinanen, K., Khiroug, L., Saarma, M., Kaila, K. & Rivera, C., 2007, In: Neuron. 56, 6, p. 1019-1033 15 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2006

  Crystal structure of the second PDZ domain of SAP97 in complex with a GluR-A C-terminal peptide

  von Ossowski, I., Oksanen, E., von Ossowski, L., Cai, C., Sundberg, M., Goldman, A. & Keinänen, K., 2006, In: The FEBS Journal. 273, 22, p. 5219-5229 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Interaction between SAP97 and PSD-95, two Maguk proteins involved in synaptic trafficking of AMPA receptors

  Cai, C., Li, H., Rivera Baeza, C. & Keinänen, K., 2006, In: Journal of Biological Chemistry. 281, 7, p. 4267-4273 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Isoform-specific early trafficking of AMPA receptor flip and flop variants

  Coleman, S. K., Möykkynen, T., Cai, C., Ossowski von, L., Kuismanen, E., Korpi, E. R. & Keinänen, K., 2006, In: Journal of Neuroscience. 26, 43, p. 11220-11229 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Peptide binding and NMR analysis of the interaction between SAP97 PDZ2 and GluR-A: potential involvement of a disulfide bond

  von Ossowski, L., Tossavainen, H., von Ossowski, I., Cai, C., Aitio, O., Fredriksson, K., Permi, P., Annila, A. & Keinänen, K., 2006, In: Biochemistry. 45, 17, p. 5567-5575 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2004

  Stereochemistry of glutamate receptor agonist efficacy: Engineering a dual-specificity AMPA/kainate receptor

  Madden, D. R., Cheng, Q., Thiran, S., Rajan, S., Rigo, F., Keinanen, K., Reinelt, S., Zimmermann, H. & Jayaraman, V., 2004, In: Biochemistry. 43, p. 15838-15844 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• The three-dimensional structure of an ionotropic glutamate receptor reveals a dimer-of-dimers assembly

  Tichelaar, W., Safferling, M., Keinanen, K., Stark, H. & Madden, D. R., 2004, In: Journal of Molecular Biology. 344, p. 435-442 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2003

  A biosensing system based on extracellular potential recording of ligand-gated ion channel function overexpressed in insect cells

  Haruyama, T., Bongsebandhu-Phubhakdi, S., Nakamura, I., Mottershead, D., Keinänen, K., Kobatake, E. & Aizawa, M., 2003, In: Analytical Chemistry. 75, 4, p. 918-921 4 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Characterization of the functional role of the N-glycans in the AMPA receptor ligand-binding domain

  Pasternack, A., Coleman, S. K., Fethiere, J., Madden, D. R., LeCaer, J. P., Rossier, J., Pasternack, M. & Keinanen, K., 2003, In: Journal of Neurochemistry. 84, p. 1184-1192 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Selective agonist binding of (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) and 2S-(2 alpha,3 beta,4 beta)-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid (kainate) receptors: a molecular modeling study

  Pentikainen, O. T., Settimo, L., Keinanen, K. & Johnson, M. S., 2003, In: Biochemical Pharmacology. 66, p. 2413-2425 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Surface expression of GluR-D AMPA receptor is dependent on an interaction between its C-terminal domain and a 4.1 protein

  Coleman, S. K., Cai, C., Mottershead, D. G., Haapalahti, J. P., Keinänen, K. & Keinanen, K., 2003, In: Journal of Neuroscience. 23, p. 798-806 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• 2002

  alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor channels lacking the N-terminal domain

  Pasternack, A., Coleman, S. K., Jouppila, A., Mottershead, D. G., Lindfors, M., Pasternack, M. & Keinänen, K., 2002, In: Journal of Biological Chemistry. 277, 51, p. 49662-49667 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Determinants of antagonist binding at the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit, GluR-D - Role of the conserved arginine 507 and glutamate 727 residues

  Jouppila, A., Pentikäinen, O. T., Settimo, L., Nyrönen, T., Haapalahti, J.-P., Lampinen, M., Mottershead, D. G., Johnson, M. S. & Keinänen, K., 2002, In: European Journal of Biochemistry. 269, 24, p. 6261-6270 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Discrimination between agonists and antagonists by the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-selective glutamate receptor

  Lampinen, M., Settimo, L., Pentikäinen, O. T., Jouppila, A., Mottershead, D. G., Johnson, M. S. & Keinänen, K., 2002, In: Journal of Biological Chemistry. 277, 44, p. 41940-41947 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif

  Cai, C., Coleman, S. K., Niemi, K. & Keinanen, K., 2002, In: Journal of Biological Chemistry. 277, p. 31484-31490 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2001

  First images of a glutamate receptor ion channel: Oligomeric state and molecular dimensions of GluRB homomers

  Safferling, M., Tichelaar, W., Kummerle, G., Jouppila, A., Kuusinen, A., Keinanen, K. & Madden, D. R., 2001, In: Biochemistry. 40, p. 13948-13953 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2000

  Crystallization of an AMPA receptor binding domain without agonist: importance of carbohydrate content and flash-cooling conditions

  Fethiere, J., Andersson, A., Keinanen, K. & Madden, D. R., 2000, In: Acta Crystallographica. Section D: Biological Crystallography. 56, p. 1625-1629 5 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Immunoassay systems based on immunoliposomes consisting of genetically engineered single-chain antibody

  Kobatake, E., Yun, K., Yanagida, Y., Haruyama, T., Keinänen, K. & Aizawa, M., 2000, In: Sensors and Actuators B: Chemical. 65, 1-3, p. 42-45 4 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Large-scale expression and thermodynamic characterization of a glutamate receptor agonist-binding domain

  Madden, D. R., Abele, R., Andersson, A. & Keinanen, K., 2000, In: European Journal of Biochemistry. 267, p. 4281-4289 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Use of proteoliposomes to generate phage antibodies against native AMPA receptor

  Jespersen, L. K., Kuusinen, A., Orellana, A., Keinanen, K. & Engberg, J., 2000, In: European Journal of Biochemistry. 267, p. 1382-1389 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review