• Viikinkaari 9 , Biokeskus 1C, 6. kerros

    00014 Helsingin yliopisto

Publications

  • 39 Article
  • 2 Review Article
  • 2 Doctoral Thesis
  • 1 Conference contribution
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Article
2018

Glutamaattireseptorien vasteiden poikkeavuus särö-X-kantasoluissa

Achuta, V. S., Möykkynen, T., Peteri, U-K., Turconi, G., Rivera, C., Keinänen, K. & Castren, M. L., 2018, In : Duodecim. 134, 4, p. 364 1 p.

Research output: Contribution to journalArticleProfessional

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2017

Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors

von Ossowski, L., Li, L-L., Möykkynen, T., Coleman, S. K., Courtney, M. J. & Keinänen, K., 2 Feb 2017, In : PLoS One. 12, 2, 15 p., 0171489.

Research output: Contribution to journalArticleScientificpeer-review

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Molecular mechanisms controlling synaptic recruitment of GluA4 subunit-containing AMPA-receptors critical for functional maturation of CA1 glutamatergic synapses

Luchkina, N. V., Coleman, S. K., Huupponen, J., Cai, C., Kivistö, A., Taira, T., Keinänen, K. & Lauri, S. E., Jan 2017, In : Neuropharmacology. 112, p. 46-56 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Aggregation Limits Surface Expression of Homomeric GluA3 Receptors

Coleman, S. K., Hou, Y., Willibald, M., Semenov, A., Möykkynen, T. & Keinänen, K., 15 Apr 2016, In : Journal of Biological Chemistry. 291, 16, p. 8784-8794 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2015

MIM-Induced Membrane Bending Promotes Dendritic Spine Initiation

Saarikangas, J., Kourdougli, N., Senju, Y., Chazal, G., Segerstråle, M., Minkeviciene, R., Kuurne, J., Mattila, P. K., Garrett, L., Hölter, S. M., Becker, L., Racz, I., Hans, W., Klopstock, T., Wurst, W., Zimmer, A., Fuchs, H., Gailus-Durner, V., de Angelis, M. H., von Ossowski, L. & 4 others, Taira, T., Lappalainen, P., Rivera Baeza, C. & Hotulainen, P., 22 Jun 2015, In : Developmental Cell. 33, 6, p. 644-659 16 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Developmental switch in the kinase dependency of long-term potentiation depends on expression of GluA4 subunit-containing AMPA receptors

Luchkina, N. V., Huupponen, J., Clarke, V. R. J., Coleman, S. K., Keinanen, K., Taira, T. & Lauri, S. E., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 11, p. 4321-4326 6 p.

Research output: Contribution to journalArticleScientificpeer-review

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The N-terminal Domain Modulates alpha-Amino-3-hydroxy-5methyl-4-isoxazolepropionic acid ( AMPA) Receptor Desensitization

Moykkynen, T., Coleman, S. K., Semenov, A. & Keinanen, K., 9 May 2014, In : Journal of Biological Chemistry. 289, 19, p. 13197-13205 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Autoinactivation of the Stargazin–AMPA Receptor Complex: Subunit-Dependency and Independence from Physical Dissociation

Semenov, A., Möykkynen, T. P., Korpi, E. R., Coleman, S. K. & Keinänen, K., 2012, In : PLoS One. 7, 11, p. e49282 6 p.

Research output: Contribution to journalArticleScientificpeer-review

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Importance of GluA1 Subunit-Containing AMPA Glutamate Receptors for Morphine State-Dependency

Aitta-aho, T., Möykkynen, T. P., Panhelainen, A. E., Vekovischeva, O. Y., Bäckström, P. & Korpi, E. R., 2012, In : PLoS One. 7, Article Number: e38325, p. - 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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Post-Synapse Model Cell for Synaptic Glutamate Receptor (GluR)-Based Biosensing: Strategy and Engineering to Maximize Ligand-Gated Ion-Flux Achieving High Signal-to-Noise Ratio

Tateishi, A., Coleman, S. K., Migita, S., Keinänen, K. & Haruyama, T., 2012, In : Sensors. 12, 1, p. 1035-1041 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2011

Cold-adapted protease enables quantitation of surface proteins in the absence of membrane trafficking.

Ahmad, F., Coleman, S. K., Kaila, K. & Blaesse, P., 2011, In : BioTechniques. 50, 4, p. 255-257 3 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Analysis of the Potential Role of GluA4 Carboxyl-Terminus in PDZ Interactions

Coleman, S. K., Cai, C., Kalkkinen, N., Korpi, E. R. & Keinanen, K., 2010, In : PLoS One. 5, 1, p. art. e8715 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Ligand-Binding Domain Determines Endoplasmic Reticulum Exit of AMPA Receptors

Coleman, S. K., Möykkynen, T., Hinkkuri, S., Vaahtera, L., Pentikäinen, O. T., Korpi, E. R. & Keinänen, K., 2010, In : Journal of Biological Chemistry. 285, 46, p. 36032-36039 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors

Anliker, B., Abel, T., Kneissl, S., Hlavaty, J., Caputi, A., Brynza, J., Schneider, I. C., Muench, R. C., Petznek, H., Kontermann, R. E., Koehl, U., Johnston, I. C. D., Keinänen, K., Mueller, U. C., Hohenadl, C., Monyer, H., Cichutek, K. & Buchholz, C. J., Nov 2010, In : Nature methods. 7, 11, p. 929-935 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Agonist occupancy is essential for forward trafficking of AMPA receptors

Coleman, S. K., Möykkynen, T., Jouppila, A., Koskelainen, S., Rivera, C., Korpi, E. R. & Keinänen, K., 2009, In : Journal of Neuroscience. 29, 2, p. 303-312 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Dynamic visualization of membrane-inserted fraction of pHluorin-tagged channels using repetitive acidification technique

Khiroug, S., Pryazhnikov, E., Coleman, S. K., Jeromin, A., Keinänen, K. & Khirug, L., 2009, In : BMC Neuroscience. 10, p. 141-151 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Ethanol increases desensitization of recombinant GluR-D AMPA receptor and TARP combinations

Möykkynen, T., Coleman, S. K., Keinänen, K., Lovinger, D. & Korpi, E. R., 2009, In : Alcohol.. 43, 4, p. 277-284 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Interaction of the RhoA exchange factor Net1 with discs large homolog 1 protects it from proteasome-mediated degradation and potentiates Net1 activity

Carr, H. S., Cai, C., Keinänen, K. & Frost, J. A., 2009, In : Journal of Biological Chemistry. 284, 36, p. 24269-24280 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Somatostatin receptor subtype 1 is a PDZ ligand for synapse-associated protein 97 and a potential regulator of growth cone dynamics

Cai, C., Li, H., Kangasniemi, A., Pihlajamaa, T., Ossowski von, L., Kerkelä, K. M., Schulz, S., Rivera Baeza, C. & Keinänen, K., 2008, In : Neuroscience. 157, 4, p. 833-843 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

KCC2 interacts with the dendritic cytoskeleton to promote spine development

Li, H., Khirug, S., Cai, C., Ludwig, A., Blaesse, P., Kolikova, J., Afzalov, R., Coleman, S. K., Lauri, S., Airaksinen, M. S., Keinanen, K., Khiroug, L., Saarma, M., Kaila, K. & Rivera, C., 2007, In : Neuron. 56, 6, p. 1019-1033 15 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Crystal structure of the second PDZ domain of SAP97 in complex with a GluR-A C-terminal peptide

von Ossowski, I., Oksanen, E., von Ossowski, L., Cai, C., Sundberg, M., Goldman, A. & Keinänen, K., 2006, In : The FEBS Journal. 273, 22, p. 5219-5229 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Interaction between SAP97 and PSD-95, two Maguk proteins involved in synaptic trafficking of AMPA receptors

Cai, C., Li, H., Rivera Baeza, C. & Keinänen, K., 2006, In : Journal of Biological Chemistry. 281, 7, p. 4267-4273 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Isoform-specific early trafficking of AMPA receptor flip and flop variants

Coleman, S. K., Möykkynen, T., Cai, C., Ossowski von, L., Kuismanen, E., Korpi, E. R. & Keinänen, K., 2006, In : Journal of Neuroscience. 26, 43, p. 11220-11229 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Peptide binding and NMR analysis of the interaction between SAP97 PDZ2 and GluR-A: potential involvement of a disulfide bond

von Ossowski, L., Tossavainen, H., von Ossowski, I., Cai, C., Aitio, O., Fredriksson, K., Permi, P., Annila, A. & Keinänen, K., 2006, In : Biochemistry. 45, 17, p. 5567-5575 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2004

Stereochemistry of glutamate receptor agonist efficacy: Engineering a dual-specificity AMPA/kainate receptor

Madden, D. R., Cheng, Q., Thiran, S., Rajan, S., Rigo, F., Keinanen, K., Reinelt, S., Zimmermann, H. & Jayaraman, V., 2004, In : Biochemistry. 43, p. 15838-15844 7 p.

Research output: Contribution to journalArticleScientificpeer-review

The three-dimensional structure of an ionotropic glutamate receptor reveals a dimer-of-dimers assembly

Tichelaar, W., Safferling, M., Keinanen, K., Stark, H. & Madden, D. R., 2004, In : Journal of Molecular Biology. 344, p. 435-442 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2003

A biosensing system based on extracellular potential recording of ligand-gated ion channel function overexpressed in insect cells

Haruyama, T., Bongsebandhu-Phubhakdi, S., Nakamura, I., Mottershead, D., Keinänen, K., Kobatake, E. & Aizawa, M., 2003, In : Analytical Chemistry. 75, 4, p. 918-921 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Characterization of the functional role of the N-glycans in the AMPA receptor ligand-binding domain

Pasternack, A., Coleman, S. K., Fethiere, J., Madden, D. R., LeCaer, J. P., Rossier, J., Pasternack, M. & Keinanen, K., 2003, In : Journal of Neurochemistry. 84, p. 1184-1192 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Surface expression of GluR-D AMPA receptor is dependent on an interaction between its C-terminal domain and a 4.1 protein

Coleman, S. K., Cai, C., Mottershead, D. G., Haapalahti, J. P., Keinänen, K. & Keinanen, K., 2003, In : Journal of Neuroscience. 23, p. 798-806 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2002

alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor channels lacking the N-terminal domain

Pasternack, A., Coleman, S. K., Jouppila, A., Mottershead, D. G., Lindfors, M., Pasternack, M. & Keinänen, K., 2002, In : Journal of Biological Chemistry. 277, 51, p. 49662-49667 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Determinants of antagonist binding at the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit, GluR-D - Role of the conserved arginine 507 and glutamate 727 residues

Jouppila, A., Pentikäinen, O. T., Settimo, L., Nyrönen, T., Haapalahti, J-P., Lampinen, M., Mottershead, D. G., Johnson, M. S. & Keinänen, K., 2002, In : European Journal of Biochemistry. 269, 24, p. 6261-6270 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Discrimination between agonists and antagonists by the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-selective glutamate receptor

Lampinen, M., Settimo, L., Pentikäinen, O. T., Jouppila, A., Mottershead, D. G., Johnson, M. S. & Keinänen, K., 2002, In : Journal of Biological Chemistry. 277, 44, p. 41940-41947 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif

Cai, C., Coleman, S. K., Niemi, K. & Keinanen, K., 2002, In : Journal of Biological Chemistry. 277, p. 31484-31490 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2001

First images of a glutamate receptor ion channel: Oligomeric state and molecular dimensions of GluRB homomers

Safferling, M., Tichelaar, W., Kummerle, G., Jouppila, A., Kuusinen, A., Keinanen, K. & Madden, D. R., 2001, In : Biochemistry. 40, p. 13948-13953 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2000

Crystallization of an AMPA receptor binding domain without agonist: importance of carbohydrate content and flash-cooling conditions

Fethiere, J., Andersson, A., Keinanen, K. & Madden, D. R., 2000, In : Acta Crystallographica. Section D: Biological Crystallography. 56, p. 1625-1629 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Immunoassay systems based on immunoliposomes consisting of genetically engineered single-chain antibody

Kobatake, E., Yun, K., Yanagida, Y., Haruyama, T., Keinänen, K. & Aizawa, M., 2000, In : Sensors and Actuators B: Chemical. 65, 1-3, p. 42-45 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Large-scale expression and thermodynamic characterization of a glutamate receptor agonist-binding domain

Madden, D. R., Abele, R., Andersson, A. & Keinanen, K., 2000, In : European Journal of Biochemistry. 267, p. 4281-4289 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Use of proteoliposomes to generate phage antibodies against native AMPA receptor

Jespersen, L. K., Kuusinen, A., Orellana, A., Keinanen, K. & Engberg, J., 2000, In : European Journal of Biochemistry. 267, p. 1382-1389 8 p.

Research output: Contribution to journalArticleScientificpeer-review