Publications 2006 2019

2019
Open Access
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Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson's disease

Albert, K., Voutilainen, M. H., Domanskyi, A., Piepponen, T. P., Ahola, S., Tuominen, R. K., Richie, C., Harvey, B. K. & Airavaara, M., Mar 2019, In : Journal of Neuroscience Research. 97, 3, p. 346-361 16 p.

Research output: Contribution to journalArticleScientificpeer-review

2018

Combination of CDNF and Deep Brain Stimulation Decreases Neurological Deficits in Late-stage Model Parkinson's Disease

Huotarinen, A., Penttinen, A-M., Bäck, S., Voutilainen, M. H., Julku, U., Piepponen, T. P., Männistö, P. T., Saarma, M., Tuominen, R., Laakso, A. & Airavaara, M., 15 Mar 2018, In : Neuroscience. 374, p. 250-263 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Open Access
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Pre-α-pro-GDNF and Pre-β-pro-GDNF Isoforms Are Neuroprotective in the 6-hydroxydopamine Rat Model of Parkinson's Disease

Penttinen, A-M., Parkkinen, I., Voutilainen, M. H., Koskela, M., Bäck, S., Their, A., Richie, C. T., Domanskyi, A., Harvey, B. K., Tuominen, R. K., Nevalaita, L., Saarma, M. & Airavaara, M., 20 Jun 2018, In : Frontiers in neurology. 9, 14 p., 457.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Role of CDNF in SOD1-G93A Mouse Model of Amyotrophic Lateral Sclerosis

Voutilainen, M. H., De Lorenzo, F., Montonen, E., Tuominen, R. K., Lindholm, D., Sendtner, M. & Saarma, M., Apr 2018, In : Cell Transplantation. 27, 4, p. 717-718 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

2017

AAV Vector-Mediated Gene Delivery to Substantia Nigra Dopamine Neurons: Implications for Gene Therapy and Disease Models

Albert, K., Voutilainen, M. H., Domanskyi, A. & Airavaara, M., Feb 2017, In : Genes. 8, 2, 15 p., 63.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Depolarizing γ-aminobutyric acid contributes to glutamatergic network rewiring in epilepsy

Kourdougli, N., Pellegrino, C., Renko, J-M., Khirug, S., Chazal, G., Kukko-Lukjanov, T-K., Lauri, S. E., Gaiarsa, J-L., Zhou, L., Peret, A., Castrén, E., Tuominen, R. K., Crepel, V. & Rivera Baeza, C., Feb 2017, In : Annals of Neurology. 81, 2, p. 251-265 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Development and plasticity of meningeal lymphatic vessels

Antila, S., Karaman, S., Nurmi, H., Airavaara, M., Voutilainen, M. H., Mathivet, T., Chilov, D., Li, Z., Koppinen, T., Park, J-H., Fang, S., Aspelund, A., Saarma, M., Eichmann, A., Thomas, J-L. & Alitalo, K., Dec 2017, In : Journal of Experimental Medicine. 214, 12, p. 3645-3667 23 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra

Mätlik, K., Vihinen, A. H., Bienemann, A., Palgi, J., Voutilainen, M. H., Booms, S., Lindahl, M. S., Jokitalo, E. S., Saarma, M., Huttunen, H. J., Airavaara, M. T. & Arumäe, U., 20 Feb 2017, In : eNeuro. 4, 1, 15 p., e0128-16.2017.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Characterization of a new low-dose 6-hydroxydopamine model of Parkinson's disease in rat

Penttinen, A-M., Suleymanova, I., Albert, K., Anttila, J., Voutilainen, M. & Airavaara, M., Apr 2016, In : Journal of Neuroscience Research. 94, 4, p. 318-328 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Differentiation and molecular heterogeneity of inhibitory and excitatory neurons associated with midbrain dopaminergic nuclei

Lahti, L., Haugas, M., Tikker, L., Airavaara, M., Voutilainen, M., Anttila, J., Kumar, S., Inkinen, C., Salminen, M. & Partanen, J., 1 Feb 2016, In : Development. 143, 3, p. 516-529 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Lääkkeiden yhteis- ja haittavaikutukset

Renko, J-M. J., Kononoff, J. P., Salminen, O. S., Vihavainen, T. & Tuominen, R. K., 24 Oct 2016, (In preparation) Farmakoterapian tilanneharjoituksia. 8. ed. Helsinki: Farmasian opettajien ja tutkijoiden yhdistys ry, Vol. 2017. 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Mesenchymal stem cells in cardiac regeneration: a detailed progress report of the last 6 years (2010–2015)

Singh, A., Singh, A. & Sen, D., 4 Jun 2016, In : Stem Cell Research & Therapy.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Therapeutic Value of Adeno Associated Virus as a Gene Therapy Vector for Parkinson's Disease – A Focused Review

Singh, A. & Sen, D., 2016, In : Current Gene Therapy.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
2015

Therapeutic potential of the endoplasmic reticulum located and secreted CDNF/MANF family of neurotrophic factors in Parkinson's disease

Voutilainen, M. H., Arumäe, U., Airavaara, M. & Saarma, M., 21 Dec 2015, In : FEBS Letters. 589, 24, p. 3739-3748 10 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2014

Comparison of striatal and nigral administration of CDNF in 6-OHDA rat model of PD

Voutilainen, M. H., Panhelainen, A., Albert, K., Tuominen, R. K., Airavaara, M. & Saarma, M., May 2014, In : Movement Disorders. 29, p. S331-S331 1 p.

Research output: Contribution to journalConference articleScientific

Still a long way to go to achieve multidisciplinarity for the benefit of patients: commentary on the ESMO position paper (Annals of Oncology 25(1): 9-15, 2014)

Valentini, V., Abrahamsson, P. -A., Aranda, S. K., Astier, A., Audisio, R. A., Boniol, M., Bonomo, L., Brunelli, A., Bultz, B., Chiti, A., De Lorenzo, F., Eriksen, J. G., Goh, V., Gospodarowicz, M. K., Grassi, L., Kelly, J., Kortmann, R. D., Kutluk, T., Plate, A., Poston, G. & 7 othersSaarto, T., Soffietti, R., Torresin, A., van Harten, W. H., Verzijlbergen, J. F., von Kalle, C. & Poortmans, P., Sep 2014, In : Annals of Oncology. 25, 9, p. 1863-1865 4 p.

Research output: Contribution to journalArticleScientific

2013

Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease

Bäck, S., Peränen, J., Galli, E., Pulkkila, P., Lonka-Nevalaita, L., Tamminen, T., Voutilainen, M. H., Raasmaja, A., Saarma, M., Männistö, P. T. & Tuominen, R. K., Mar 2013, In : Brain and Behavior. 3, 2, p. 75-88 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2012

Neurorestoration

Airavaara, M., Voutilainen, M., Wang, Y. & Hoffer, B., 18 Jan 2012, In : Parkinsonism & Related Disorders. 18, Suppl. 1, p. S143-S146 4 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2011

CDNF Protects the Nigrostriatal Dopamine System and Promotes Recovery After MPTP Treatment n Mice

Airavaara, M., Harvey, B. K., Voutilainen, M. H., Chou, J., Lindholm, P., Lindahl, M., Tuominen, R. K., Saarma, M., Wang, Y. & Hoffer, B., 2011, In : Cell Transplantation. 20, Supplement 1, p. 544-545 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease

Voutilainen, M. H., Back, S., Peranen, J., Lindholm, P., Raasmaja, A., Mannisto, P. T., Saarma, M. & Tuominen, R. K., 2011, In : Experimental Neurology. 228, 1, p. 99-108 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's Disease

Voutilainen, M., Bäck, S., Pörsti, E., Toppinen, L., Lindgren, L., Lindholm, P., Peränen, J., Saarma, M. & Tuominen, R. K., 2009, In : Journal of Neuroscience. 29, 30, p. 9651-9659 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo

Lindholm, P., Voutilainen, M., Lauren, J., Peränen, J., Leppänen, V-M., Andressoo, J-O., Lindahl, M., Janhunen, S., Kalkkinen, N., Timmusk, T., Tuominen, R. K. & Saarma, M., 2007, In : Nature. 448, 7147, p. 73-78 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

C3-halogenation of cytisine generates potent and efficacious nicotinic receptor agonists

Abin -Carriquiry, J. A., Voutilainen, M., Barik, J., Cassels, B., Iturriaga-Vasquez, P., Bermudez, I., Durand, C., Dajas, F. & Wonnacott, S., 2006, In : European Journal of Pharmacology.

Research output: Contribution to journalArticleScientificpeer-review