Reproductive Disease Modeling

Publications

2020

Ageing women with PCOS: Menstrual cycles, metabolic health and health related quality of life (HRQoL)

Ollila, M-M., Piltonen, T. T., Tapanainen, J. S. & Morin-Papunen, L., 28 Feb 2020, In : Current opinion in endocrine and metabolic research.

Research output: Contribution to journalArticleScientificpeer-review

2019

Age at adiposity rebound in childhood is associated with PCOS diagnosis and obesity in adulthood-longitudinal analysis of BMI data from birth to age 46 in cases of PCOS

Koivuaho, E., Laru, J., Ojaniemi, M., Puukka, K., Kettunen, J., Tapanainen, J. S., Franks, S., Järvelin, M. -R., Morin-Papunen, L., Sebert, S. & Piltonen, T. T., Jul 2019, In : International Journal of Obesity. 43, 7, p. 1370-1379 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Akuutti gynekologia

Tapanainen, J. & Savolainen-Peltonen, H., 2019, Naistentaudit ja synnytykset. Tapanainen, J., Heikinheimo, O. & Mäkikallio, K. (eds.). 6. uud. p. ed. Helsinki: Duodecim, p. 251-256 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Awareness of polycystic ovary syndrome among obstetrician-gynecologists and endocrinologists in Northern Europe

Piltonen, T. T., Ruokojärvi, M., Karro, H., Kujanpää, L., Morin-Papunen, L., Tapanainen, J. S., Stener-Victorin, E., Sundrström-Poromaa, I., Hirschberg, A. L., Ravn, P., Glintborg, D., Mellembakken, J. R., Steingrimsdottir, T., Gibson-Helm, M., Vanky, E., Andersen, M., Arffman, R. K., Teede, H. & Falah-Hassani, K., 2019, In : PLoS One. 14, 12, 12 p., e0226074.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Circulating antimullerian hormone and steroid hormone levels remain high in pregnant women with polycystic ovary syndrome at term

Piltonen, T. T., Giacobini, P., Edvinsson, A., Hustad, S., Lager, S., Morin-Papunen, L., Tapanainen, J. S., Sundström-Poromaa, I. & Arffman, R. K., Mar 2019, In : Fertility and Sterility : official journal of the American Fertility Society . 111, 3, p. 588-+ 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Complement in Human Pre-implantation Embryos: Attack and Defense

Reichhardt, M. P., Lundin, K., Lokki, A. I., Recher, G., Vuoristo, S., Katayama, S., Tapanainen, J. S., Kere, J., Meri, S. & Tuuri, T., 18 Sep 2019, In : Frontiers in Immunology. 10, 12 p., 2234.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Demographic and evolutionary trends in ovarian function and aging

Laisk, T., Tsuiko, O., Jatsenko, T., Horak, P., Otala, M., Lahdenperä, M., Lummaa, V., Tuuri, T., Salumets, A. & Tapanainen, J. S., 2019, In : Human Reproduction Update. 25, 1, p. 34-50 17 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Effect of polycystic ovary syndrome on cardiac autonomic function at a late fertile age: a prospective Northern Finland Birth Cohort 1966 study

Ollila, M-M., Kiviniemi, A., Stener-Victorin, E., Tulppo, M., Puukka, K., Tapanainen, J., Franks, S., Morin-Papunen, L. & Piltonen, T., 15 Dec 2019, In : BMJ Open. 9, 12, 10 p., e033780.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Hormone profiling, including anti-Mullerian hormone (AMH), for the diagnosis of polycystic ovary syndrome (PCOS) and characterization of PCOS phenotypes

Sova, H., Unkila-Kallio, L., Tiitinen, A., Hippeläinen, M., Perheentupa, A., Tinkanen, H., Puukka, K., Bloigu, R., Piltonen, T., Tapanainen, J. S. & Morin-Papunen, L., 3 Jul 2019, In : Gynecological Endocrinology. 35, 7, p. 595-600 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Hyperglycosylated hCG activates LH/hCG-receptor with lower activity than hCG

Koistinen, H., Koel, M., Peters, M., Rinken, A., Lundin, K., Tuuri, T., Tapanainen, J. S., Alfthan, H., Salumets, A., Stenman, U-H. & Lavogina, D., 5 Jan 2019, In : Molecular and Cellular Endocrinology. 479, p. 103-109 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Kuukautiskierron hormonaalinen säätely

Tapanainen, J. & Heikinheimo, O., 2019, Naistentaudit ja synnytykset. Tapanainen, J., Heikinheimo, O. & Mäkikallio, K. (eds.). 6. uud. p. ed. Helsinki: Duodecim, p. 23-43 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Long-term health of women with genetic POI due to FSH-resistant ovaries

Luiro, K., Aittomäki, K., Jousilahti, P. & Tapanainen, J. S., Oct 2019, In : Endocrine Connections. 8, 10, p. 1354-1362 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Metformin decreases bone turnover markers in polycystic ovary syndrome: a post hoc study

Lingaiah, S., Morin-Papunen, L., Risteli, J. & Tapanainen, J. S., Aug 2019, In : Fertility and Sterility : official journal of the American Fertility Society . 112, 2, p. 362-370 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Naistentaudit ja synnytykset

Tapanainen, J. (ed.), Heikinheimo, O. (ed.) & Mäkikallio, K. (ed.), 2019, 6. uud. p. ed. Helsinki: Duodecim. 624 p.

Research output: Book/ReportBook

Self-Reported Polycystic Ovary Syndrome Is Associated With Hypertension: A Northern Finland Birth Cohort 1966 Study

Ollila, M-M. E., Kaikkonen, K., Järvelin, M-R., Huikuri, H. V., Tapanainen, J. S., Franks, S., Piltonen, T. T. & Morin-Papunen, L., Apr 2019, In : Journal of Clinical Endocrinology and Metabolism. 104, 4, p. 1221-1231 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Serum retinol-binding protein 4 levels in polycystic ovary syndrome

Lingaiah, S., Morin-Papunen, L., Piltonen, T., Sundström-Poromaa, I., Stener-Victorin, E. & Tapanainen, J. S., 1 Jun 2019, In : Endocrine Connections. 8, 6, p. 709-717 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The effect of length of birth interval on the risk of breast cancer by subtype in grand multiparous women

Katuwal, S., Tapanainen, J. S., Pukkala, E. & Kauppila, A., 4 Mar 2019, In : BMC Cancer. 19, 7 p., 199.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Advances in the Molecular Pathophysiology, Genetics, and Treatment of Primary Ovarian Insufficiency

Huhtaniemi, I., Hovatta, O., La Marca, A., Livera, G., Monniaux, D., Persani, L., Heddar, A., Jarzabek, K., Laisk-Podar, T., Salumets, A., Tapanainen, J. S., Veitia, R. A., Visser, J. A., Wieacker, P., Wolczynski, S. & Misrahi, M., Jun 2018, In : Trends in Endocrinology and Metabolism. 29, 6, p. 400-419 20 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Protect us from poor-quality medical research

ESHRE Capri Workshop Grp, May 2018, In : Human Reproduction. 33, 5, p. 770-776 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome

Int PCOS Network, Teede, H. J., Misso, M. L., Costello, M. F., Dokras, A., Laven, J., Moran, L., Piltonen, T., Norman, R. J. & Tapanainen, J., Sep 2018, In : Clinical Endocrinology. 89, 3, p. 251-268 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome

Int PCOS Network, Teede, H. J., Misso, M. L., Costello, M. F., Dokras, A., Laven, J., Moran, L., Piltonen, T., Norman, R. J. & Tapanainen, J., Aug 2018, In : Fertility and Sterility : official journal of the American Fertility Society . 110, 3, p. 364-379 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome

Int PCOS Network, Teede, H. J., Misso, M. L., Costello, M. F., Dokras, A., Laven, J., Moran, L., Piltonen, T., Norman, R. J. & Tapanainen, J., Sep 2018, In : Human Reproduction. 33, 9, p. 1602-1618 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Testosterone is associated with insulin resistance index independently of adiposity in women with polycystic ovary syndrome

Luotola, K., Piltonen, T. T., Puurunen, J., Morin-Papunen, L. C. & Tapanainen, J. S., 2018, In : Gynecological Endocrinology. 34, 1, p. 40-44 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The Long-Term Footprint of Endometriosis: Population-Based Cohort Analysis Reveals Increased Pain Symptoms and Decreased Pain Tolerance at Age 46 Years

Vuontisjarvi, S., Rossi, H-R., Herrala, S., Morin-Papunen, L., Tapanainen, J. S., Karjula, S., Karppinen, J., Auvinen, J. & Piltonen, T. T., Jul 2018, In : Journal of Pain. 19, 7, p. 754-763 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

A missense mutation in SLC26A3 is associated with human male subfertility and impaired activation of CFTR

Wedenoja, S., Khamaysi, A., Shimshilashvili, L., Anbtawe-Jomaa, S., Elomaa, O., Toppari, J., Hoglund, P., Aittomaki, K., Holmberg, C., Hovatta, O., Tapanainen, J. S., Ohana, E. & Kere, J., 27 Oct 2017, In : Scientific Reports. 7, 11 p., 14208.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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A prognosis-based approach to infertility: understanding the role of time

Albertini, D. F., Anderson, R., Bhattacharya, S., Evers, J. L. H., Mclernon, D. J., Repping, S., Somigliana, E., Baird, D. T., Crosignani, P. G., Diedrich, K., Farquharson, R. G., Lundin, K., Tapanainen, J. S., Van Steirteghem, A. & ESHRE Capri Workshop Grp, Aug 2017, In : Human Reproduction. 32, 8, p. 1556-1559 4 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access

Bone markers in polycystic ovary syndrome: A multicentre study

Lingaiah, S., Morin-Papunen, L., Piltonen, T., Puurunen, J., Sundstrom-Poromaa, I., Stener-Victorin, E., Bloigu, R., Risteli, J. & Tapanainen, J. S., Dec 2017, In : Clinical Endocrinology. 87, 6, p. 673-679 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Determination of biological activity of gonadotropins hCG and FSH by Forster resonance energy transfer based biosensors

Mazina, O., Allikalt, A., Tapanainen, J. S., Salumets, A. & Rinken, A., 9 Feb 2017, In : Scientific Reports. 7, 7 p., 42219.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Niche matters: The comparison between bone marrow stem cells and endometrial stem cells and stromal fibroblasts reveal distinct migration and cytokine profiles in response to inflammatory stimulus

Khatun, M., Sorjamaa, A., Kangasniemi, M., Sutinen, M., Saio, T., Liakka, A., Lehenkari, P., Tapanainen, J. S., Vuolteenaho, O., Chen, J. C., Lehtonen, S. & Piltonen, T. T., 18 Apr 2017, In : PLoS One. 12, 4, 21 p., 0175986.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Normo- and hyperandrogenic women with polycystic ovary syndrome exhibit an adverse metabolic profile through life

Pinola, P., Puukka, K., Piltonen, T. T., Puurunen, J., Vanky, E., Sundström-Poromaa, I., Stener-Victorin, E., Hirschberg, A. L., Ravn, P., Andersen, M. S., Glintborg, D., Mellembakken, J. R., Ruokonen, A., Tapanainen, J. & Morin-Papunen, L. C., Mar 2017, In : Fertility and Sterility : official journal of the American Fertility Society . 107, 3, p. 788-795 10 p., ARTN 795.e2.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Overweight and obese but not normal weight women with PCOS are at increased risk of Type 2 diabetes mellitus-a prospective, population-based cohort study

Ollila, M. -M. E., West, S., Keinanen-Kiukaanniemi, S., Jokelainen, J., Auvinen, J., Puukka, K., Ruokonen, A., Jarvelin, M. -R., Tapanainen, J. S., Franks, S., Piltonen, T. T. & Morin-Papunen, L. C., 1 Feb 2017, In : Human Reproduction. 32, 2, p. 423-431 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Psychological Distress Is More Prevalent in Fertile Age and Premenopausal Women With PCOS Symptoms: 15-Year Follow-Up

Karjula, S., Morin-Papunen, L., Auvinen, J., Ruokonen, A., Puukka, K., Franks, S., Jarvelin, M-R., Tapanainen, J. S., Jokelainen, J., Miettunen, J. & Piltonen, T. T., Jun 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 6, p. 1861-1869 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Racial and ethnic differences in the prevalence of metabolic syndrome and its components of metabolic syndrome in women with polycystic ovary syndrome: a regional cross-sectional study

Chan, J. L., Kar, S., Vanky, E., Morin-Papunen, L., Piltonen, T., Puurunen, J., Tapanainen, J. S., Maciel, G. A. R., Hayashida, S. A. Y., Soares, J. M., Baracat, E. C., Mellembakken, J. R. & Dokras, A., Aug 2017, In : American Journal of Obstetrics and Gynecology. 217, 2, 8 p., ARTN 189.e1-8.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The prevalence of Type 2 diabetes is not increased in normal-weight women with PCOS

Pelanis, R., Mellembakken, J. R., Sundström-Poromaa, I., Ravn, P., Morin-Papunen, L., Tapanainen, J. S., Piltonen, T., Puurunen, J., Hirschberg, A. L., Fedorcsak, P., Andersen, M. & Glintborg, D., Nov 2017, In : Human Reproduction. 32, 11, p. 2279-2286 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

The Role of Sequential BMP Signaling in Directing Human Embryonic Stem Cells to Bipotential Gonadal Cells

Sepponen, K., Lundin, K., Knuus, K., Vayrynen, P., Raivio, T., Tapanainen, J. S. & Tuuri, T., 1 Nov 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 11, p. 4303-4314 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2016

Copy number variation analysis detects novel candidate genes involved in follicular growth and oocyte maturation in a cohort of premature ovarian failure cases

Tsuiko, O., Noukas, M., Zilina, O., Hensen, K., Tapanainen, J. S., Magi, R., Kals, M., Kivistik, P. A., Haller-Kikkatalo, K., Salumets, A. & Kurg, A., Aug 2016, In : Human Reproduction. 31, 8, p. 1913-1925 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Functional Expression of FSH Receptor in Endometriotic Lesions

Ponikwicka-Tyszko, D., Chrusciel, M., Stelmaszewska, J., Bernaczyk, P., Sztachelska, M., Sidorkiewicz, I., Doroszko, M., Tomaszewski, J., Tapanainen, J. S., Huhtaniemi, I., Wolczynski, S. & Rahman, N. A., Jul 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 7, p. 2905-2914 10 p.

Research output: Contribution to journalArticleScientificpeer-review

IL-1 receptor antagonist levels are associated with glucose tolerance in polycystic ovary syndrome

Luotola, K., Piltonen, T. T., Puurunen, J. & Tapanainen, J. S., Sep 2016, In : Clinical Endocrinology. 85, 3, p. 430-435 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Incidence of cancer among grand multiparous women in Finland with special focus on non-gynaecological cancers: A population-based cohort study

Högnäs, E., Kauppila, A., Hinkula, M., Tapanainen, J. S. & Pukkala, E., 3 Mar 2016, In : Acta Oncologica. 55, 3, p. 370-376 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Müllerin tiehyitä surkastuttava peptidi - merkkiaine munasarjatoiminnan tutkimiseen

Koskela, S. & Tapanainen, J., 2016, In : Duodecim. 132, 3, p. 226-232 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Ovarian Physiology and GWAS: Biobanks, Biology, and Beyond

Laisk-Podar, T., Lindgren, C. M., Peters, M., Tapanainen, J. S., Lambalk, C. B., Salumets, A. & Maegi, R., Jul 2016, In : Trends in Endocrinology and Metabolism. 27, 7, p. 516-528 13 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Should we individualize lipid profiling in women with polycystic ovary syndrome?

Poromaa, I. S., Mellembakken, J. R., Papunen, L. M., Piltonen, T., Puurunen, J., Tapanainen, J. S., Stener-Victorin, E., Hirschberg, A. L., Vanky, E., Ravn, P., Glintborg, D. & Andersen, M., Dec 2016, In : Human Reproduction. 31, 12, p. 2791-2795 5 p.

Research output: Contribution to journalArticleScientificpeer-review

The influence of social factors on gender(aEuro) health

Aboulghar, M., Albertini, D. F., Allen, J. F., Bhattacharya, S., Cottingham Terralis C, J., Evers, J. L. H., Geraedts, J. P. M., Glasier, A., Hunt, K., Hussein, J., La Vecchia, C., Luy, W., Michaud, P-A., Negri, E., Peters, S. A. E., Sethi, D., Baird, D. T., Crosignani, P. G., Devroey, P., Diedrich, K. & 11 others, Farquharson, R. G., Fraser, L., Gianaroli, L., Lundin, K., Sunde, A., Tapanainen, J. S., Tarlatzis, B., Van Steirteghem, A., Veiga, A., Volpe, A. & ESHRE Capri Workshop Grp, Aug 2016, In : Human Reproduction. 31, 8, p. 1631-1637 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Weight Gain and Dyslipidemia in Early Adulthood Associate With Polycystic Ovary Syndrome: Prospective Cohort Study

Ollila, M-M. E., Piltonen, T., Puukka, K., Ruokonen, A., Jarvelin, M-R., Tapanainen, J. S., Franks, S. & Morin-Papunen, L., Feb 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 2, p. 739-747 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Androgen Profile Through Life in Women With Polycystic Ovary Syndrome: A Nordic Multicenter Collaboration Study

Pinola, P., Piltonen, T. T., Puurunen, J., Vanky, E., Sundstrom-Poromaa, I., Stener-Victorin, E., Ruokonen, A., Puukka, K., Tapanainen, J. S. & Morin-Papunen, L. C., Sep 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 9, p. 3400-3407 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Economic aspects of infertility care: a challenge for researchers and clinicians

Crosignani, P. G., Baird, D. T., Barri, P. N., Bhattacharya, S., Devroey, P., Evers, J. L. H., Gianaroli, L., Somigliana, E., Tapanainen, J. S., van Wely, M., Diedrich, K., Fraser, L., Geraedts, J. P. M., Lundin, K., Sunde, A., Tarlatzis, B., Van Steirteghem, A. & Veiga, A., Oct 2015, In : Human Reproduction. 30, 10, p. 2243-2248 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Effect of controlled hypoglycaemia on sympathetic skin response in patients with Type 1 diabetes and control subjects

Koivikko, M. L., Airaksinen, K. E. J., Perkiomaki, J. S., Huikuri, H. V., Tapanainen, J. S. & Kallio, M. A., Apr 2015, In : Diabetic Medicine. 32, 4, p. 556-560 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Endometrial mesenchymal stem cells present with high regeneration and migration potential suggesting their involvement in endometrial monthly regeneration and development of endometrial disorders

Khatun, M., Lehtonen, S., Kangasniemi, M., Sutinen, M., Salo, T., Liakka, A., Lehenkari, P., Tapanainen, J. S. & Piltonen, T. T., Jun 2015, In : Human Reproduction. 30, p. 104-105 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

The clinical utility of serum anti-Mullerian hormone in the follow-up of ovarian adult-type granulosa cell tumorsA comparative study with inhibin B

Farkkila, A., Koskela, S., Bryk, S., Alfthan, H., Butzow, R., Leminen, A., Puistola, U., Tapanainen, J. S., Heikinheimo, M., Anttonen, M. & Unkila-Kallio, L., 1 Oct 2015, In : International Journal of Cancer. 137, 7, p. 1661-1671 11 p.

Research output: Contribution to journalArticleScientificpeer-review