Reproductive Disease Modeling

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2020

Ageing women with PCOS: Menstrual cycles, metabolic health and health related quality of life (HRQoL)

Ollila, M-M., Piltonen, T. T., Tapanainen, J. S. & Morin-Papunen, L., 28 Feb 2020, In : Current opinion in endocrine and metabolic research.

Research output: Contribution to journalArticleScientificpeer-review

2019

Age at adiposity rebound in childhood is associated with PCOS diagnosis and obesity in adulthood-longitudinal analysis of BMI data from birth to age 46 in cases of PCOS

Koivuaho, E., Laru, J., Ojaniemi, M., Puukka, K., Kettunen, J., Tapanainen, J. S., Franks, S., Järvelin, M. -R., Morin-Papunen, L., Sebert, S. & Piltonen, T. T., Jul 2019, In : International Journal of Obesity. 43, 7, p. 1370-1379 10 p.

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Awareness of polycystic ovary syndrome among obstetrician-gynecologists and endocrinologists in Northern Europe

Piltonen, T. T., Ruokojärvi, M., Karro, H., Kujanpää, L., Morin-Papunen, L., Tapanainen, J. S., Stener-Victorin, E., Sundrström-Poromaa, I., Hirschberg, A. L., Ravn, P., Glintborg, D., Mellembakken, J. R., Steingrimsdottir, T., Gibson-Helm, M., Vanky, E., Andersen, M., Arffman, R. K., Teede, H. & Falah-Hassani, K., 2019, In : PLoS One. 14, 12, 12 p., e0226074.

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Circulating antimullerian hormone and steroid hormone levels remain high in pregnant women with polycystic ovary syndrome at term

Piltonen, T. T., Giacobini, P., Edvinsson, A., Hustad, S., Lager, S., Morin-Papunen, L., Tapanainen, J. S., Sundström-Poromaa, I. & Arffman, R. K., Mar 2019, In : Fertility and Sterility : official journal of the American Fertility Society . 111, 3, p. 588-+ 10 p.

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Complement in Human Pre-implantation Embryos: Attack and Defense

Reichhardt, M. P., Lundin, K., Lokki, A. I., Recher, G., Vuoristo, S., Katayama, S., Tapanainen, J. S., Kere, J., Meri, S. & Tuuri, T., 18 Sep 2019, In : Frontiers in Immunology. 10, 12 p., 2234.

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Effect of polycystic ovary syndrome on cardiac autonomic function at a late fertile age: a prospective Northern Finland Birth Cohort 1966 study

Ollila, M-M., Kiviniemi, A., Stener-Victorin, E., Tulppo, M., Puukka, K., Tapanainen, J., Franks, S., Morin-Papunen, L. & Piltonen, T., 15 Dec 2019, In : BMJ Open. 9, 12, 10 p., e033780.

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Hormone profiling, including anti-Mullerian hormone (AMH), for the diagnosis of polycystic ovary syndrome (PCOS) and characterization of PCOS phenotypes

Sova, H., Unkila-Kallio, L., Tiitinen, A., Hippeläinen, M., Perheentupa, A., Tinkanen, H., Puukka, K., Bloigu, R., Piltonen, T., Tapanainen, J. S. & Morin-Papunen, L., 3 Jul 2019, In : Gynecological Endocrinology. 35, 7, p. 595-600 6 p.

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Hyperglycosylated hCG activates LH/hCG-receptor with lower activity than hCG

Koistinen, H., Koel, M., Peters, M., Rinken, A., Lundin, K., Tuuri, T., Tapanainen, J. S., Alfthan, H., Salumets, A., Stenman, U-H. & Lavogina, D., 5 Jan 2019, In : Molecular and Cellular Endocrinology. 479, p. 103-109 7 p.

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Long-term health of women with genetic POI due to FSH-resistant ovaries

Luiro, K., Aittomäki, K., Jousilahti, P. & Tapanainen, J. S., Oct 2019, In : Endocrine Connections. 8, 10, p. 1354-1362 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Metformin decreases bone turnover markers in polycystic ovary syndrome: a post hoc study

Lingaiah, S., Morin-Papunen, L., Risteli, J. & Tapanainen, J. S., Aug 2019, In : Fertility and Sterility : official journal of the American Fertility Society . 112, 2, p. 362-370 9 p.

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Self-Reported Polycystic Ovary Syndrome Is Associated With Hypertension: A Northern Finland Birth Cohort 1966 Study

Ollila, M-M. E., Kaikkonen, K., Järvelin, M-R., Huikuri, H. V., Tapanainen, J. S., Franks, S., Piltonen, T. T. & Morin-Papunen, L., Apr 2019, In : Journal of Clinical Endocrinology and Metabolism. 104, 4, p. 1221-1231 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Serum retinol-binding protein 4 levels in polycystic ovary syndrome

Lingaiah, S., Morin-Papunen, L., Piltonen, T., Sundström-Poromaa, I., Stener-Victorin, E. & Tapanainen, J. S., 1 Jun 2019, In : Endocrine Connections. 8, 6, p. 709-717 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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The effect of length of birth interval on the risk of breast cancer by subtype in grand multiparous women

Katuwal, S., Tapanainen, J. S., Pukkala, E. & Kauppila, A., 4 Mar 2019, In : BMC Cancer. 19, 7 p., 199.

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2018

Protect us from poor-quality medical research

ESHRE Capri Workshop Grp, May 2018, In : Human Reproduction. 33, 5, p. 770-776 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome

Int PCOS Network, Teede, H. J., Misso, M. L., Costello, M. F., Dokras, A., Laven, J., Moran, L., Piltonen, T., Norman, R. J. & Tapanainen, J., Sep 2018, In : Clinical Endocrinology. 89, 3, p. 251-268 18 p.

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Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome

Int PCOS Network, Teede, H. J., Misso, M. L., Costello, M. F., Dokras, A., Laven, J., Moran, L., Piltonen, T., Norman, R. J. & Tapanainen, J., Sep 2018, In : Human Reproduction. 33, 9, p. 1602-1618 17 p.

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Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome

Int PCOS Network, Teede, H. J., Misso, M. L., Costello, M. F., Dokras, A., Laven, J., Moran, L., Piltonen, T., Norman, R. J. & Tapanainen, J., Aug 2018, In : Fertility and Sterility : official journal of the American Fertility Society . 110, 3, p. 364-379 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Testosterone is associated with insulin resistance index independently of adiposity in women with polycystic ovary syndrome

Luotola, K., Piltonen, T. T., Puurunen, J., Morin-Papunen, L. C. & Tapanainen, J. S., 2018, In : Gynecological Endocrinology. 34, 1, p. 40-44 5 p.

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The Long-Term Footprint of Endometriosis: Population-Based Cohort Analysis Reveals Increased Pain Symptoms and Decreased Pain Tolerance at Age 46 Years

Vuontisjarvi, S., Rossi, H-R., Herrala, S., Morin-Papunen, L., Tapanainen, J. S., Karjula, S., Karppinen, J., Auvinen, J. & Piltonen, T. T., Jul 2018, In : Journal of Pain. 19, 7, p. 754-763 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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2017

A missense mutation in SLC26A3 is associated with human male subfertility and impaired activation of CFTR

Wedenoja, S., Khamaysi, A., Shimshilashvili, L., Anbtawe-Jomaa, S., Elomaa, O., Toppari, J., Hoglund, P., Aittomaki, K., Holmberg, C., Hovatta, O., Tapanainen, J. S., Ohana, E. & Kere, J., 27 Oct 2017, In : Scientific Reports. 7, 11 p., 14208.

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Bone markers in polycystic ovary syndrome: A multicentre study

Lingaiah, S., Morin-Papunen, L., Piltonen, T., Puurunen, J., Sundstrom-Poromaa, I., Stener-Victorin, E., Bloigu, R., Risteli, J. & Tapanainen, J. S., Dec 2017, In : Clinical Endocrinology. 87, 6, p. 673-679 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Determination of biological activity of gonadotropins hCG and FSH by Forster resonance energy transfer based biosensors

Mazina, O., Allikalt, A., Tapanainen, J. S., Salumets, A. & Rinken, A., 9 Feb 2017, In : Scientific Reports. 7, 7 p., 42219.

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Niche matters: The comparison between bone marrow stem cells and endometrial stem cells and stromal fibroblasts reveal distinct migration and cytokine profiles in response to inflammatory stimulus

Khatun, M., Sorjamaa, A., Kangasniemi, M., Sutinen, M., Saio, T., Liakka, A., Lehenkari, P., Tapanainen, J. S., Vuolteenaho, O., Chen, J. C., Lehtonen, S. & Piltonen, T. T., 18 Apr 2017, In : PLoS One. 12, 4, 21 p., 0175986.

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Normo- and hyperandrogenic women with polycystic ovary syndrome exhibit an adverse metabolic profile through life

Pinola, P., Puukka, K., Piltonen, T. T., Puurunen, J., Vanky, E., Sundström-Poromaa, I., Stener-Victorin, E., Hirschberg, A. L., Ravn, P., Andersen, M. S., Glintborg, D., Mellembakken, J. R., Ruokonen, A., Tapanainen, J. & Morin-Papunen, L. C., Mar 2017, In : Fertility and Sterility : official journal of the American Fertility Society . 107, 3, p. 788-795 10 p., ARTN 795.e2.

Research output: Contribution to journalArticleScientificpeer-review

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Overweight and obese but not normal weight women with PCOS are at increased risk of Type 2 diabetes mellitus-a prospective, population-based cohort study

Ollila, M. -M. E., West, S., Keinanen-Kiukaanniemi, S., Jokelainen, J., Auvinen, J., Puukka, K., Ruokonen, A., Jarvelin, M. -R., Tapanainen, J. S., Franks, S., Piltonen, T. T. & Morin-Papunen, L. C., 1 Feb 2017, In : Human Reproduction. 32, 2, p. 423-431 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Psychological Distress Is More Prevalent in Fertile Age and Premenopausal Women With PCOS Symptoms: 15-Year Follow-Up

Karjula, S., Morin-Papunen, L., Auvinen, J., Ruokonen, A., Puukka, K., Franks, S., Jarvelin, M-R., Tapanainen, J. S., Jokelainen, J., Miettunen, J. & Piltonen, T. T., Jun 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 6, p. 1861-1869 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Racial and ethnic differences in the prevalence of metabolic syndrome and its components of metabolic syndrome in women with polycystic ovary syndrome: a regional cross-sectional study

Chan, J. L., Kar, S., Vanky, E., Morin-Papunen, L., Piltonen, T., Puurunen, J., Tapanainen, J. S., Maciel, G. A. R., Hayashida, S. A. Y., Soares, J. M., Baracat, E. C., Mellembakken, J. R. & Dokras, A., Aug 2017, In : American Journal of Obstetrics and Gynecology. 217, 2, 8 p., ARTN 189.e1-8.

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The prevalence of Type 2 diabetes is not increased in normal-weight women with PCOS

Pelanis, R., Mellembakken, J. R., Sundström-Poromaa, I., Ravn, P., Morin-Papunen, L., Tapanainen, J. S., Piltonen, T., Puurunen, J., Hirschberg, A. L., Fedorcsak, P., Andersen, M. & Glintborg, D., Nov 2017, In : Human Reproduction. 32, 11, p. 2279-2286 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

The Role of Sequential BMP Signaling in Directing Human Embryonic Stem Cells to Bipotential Gonadal Cells

Sepponen, K., Lundin, K., Knuus, K., Vayrynen, P., Raivio, T., Tapanainen, J. S. & Tuuri, T., 1 Nov 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 11, p. 4303-4314 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2016

Copy number variation analysis detects novel candidate genes involved in follicular growth and oocyte maturation in a cohort of premature ovarian failure cases

Tsuiko, O., Noukas, M., Zilina, O., Hensen, K., Tapanainen, J. S., Magi, R., Kals, M., Kivistik, P. A., Haller-Kikkatalo, K., Salumets, A. & Kurg, A., Aug 2016, In : Human Reproduction. 31, 8, p. 1913-1925 13 p.

Research output: Contribution to journalArticleScientificpeer-review

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Functional Expression of FSH Receptor in Endometriotic Lesions

Ponikwicka-Tyszko, D., Chrusciel, M., Stelmaszewska, J., Bernaczyk, P., Sztachelska, M., Sidorkiewicz, I., Doroszko, M., Tomaszewski, J., Tapanainen, J. S., Huhtaniemi, I., Wolczynski, S. & Rahman, N. A., Jul 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 7, p. 2905-2914 10 p.

Research output: Contribution to journalArticleScientificpeer-review

IL-1 receptor antagonist levels are associated with glucose tolerance in polycystic ovary syndrome

Luotola, K., Piltonen, T. T., Puurunen, J. & Tapanainen, J. S., Sep 2016, In : Clinical Endocrinology. 85, 3, p. 430-435 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Incidence of cancer among grand multiparous women in Finland with special focus on non-gynaecological cancers: A population-based cohort study

Högnäs, E., Kauppila, A., Hinkula, M., Tapanainen, J. S. & Pukkala, E., 3 Mar 2016, In : Acta Oncologica. 55, 3, p. 370-376 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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Should we individualize lipid profiling in women with polycystic ovary syndrome?

Poromaa, I. S., Mellembakken, J. R., Papunen, L. M., Piltonen, T., Puurunen, J., Tapanainen, J. S., Stener-Victorin, E., Hirschberg, A. L., Vanky, E., Ravn, P., Glintborg, D. & Andersen, M., Dec 2016, In : Human Reproduction. 31, 12, p. 2791-2795 5 p.

Research output: Contribution to journalArticleScientificpeer-review

The influence of social factors on gender(aEuro) health

Aboulghar, M., Albertini, D. F., Allen, J. F., Bhattacharya, S., Cottingham Terralis C, J., Evers, J. L. H., Geraedts, J. P. M., Glasier, A., Hunt, K., Hussein, J., La Vecchia, C., Luy, W., Michaud, P-A., Negri, E., Peters, S. A. E., Sethi, D., Baird, D. T., Crosignani, P. G., Devroey, P., Diedrich, K. & 11 others, Farquharson, R. G., Fraser, L., Gianaroli, L., Lundin, K., Sunde, A., Tapanainen, J. S., Tarlatzis, B., Van Steirteghem, A., Veiga, A., Volpe, A. & ESHRE Capri Workshop Grp, Aug 2016, In : Human Reproduction. 31, 8, p. 1631-1637 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Weight Gain and Dyslipidemia in Early Adulthood Associate With Polycystic Ovary Syndrome: Prospective Cohort Study

Ollila, M-M. E., Piltonen, T., Puukka, K., Ruokonen, A., Jarvelin, M-R., Tapanainen, J. S., Franks, S. & Morin-Papunen, L., Feb 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 2, p. 739-747 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Androgen Profile Through Life in Women With Polycystic Ovary Syndrome: A Nordic Multicenter Collaboration Study

Pinola, P., Piltonen, T. T., Puurunen, J., Vanky, E., Sundstrom-Poromaa, I., Stener-Victorin, E., Ruokonen, A., Puukka, K., Tapanainen, J. S. & Morin-Papunen, L. C., Sep 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 9, p. 3400-3407 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Economic aspects of infertility care: a challenge for researchers and clinicians

Crosignani, P. G., Baird, D. T., Barri, P. N., Bhattacharya, S., Devroey, P., Evers, J. L. H., Gianaroli, L., Somigliana, E., Tapanainen, J. S., van Wely, M., Diedrich, K., Fraser, L., Geraedts, J. P. M., Lundin, K., Sunde, A., Tarlatzis, B., Van Steirteghem, A. & Veiga, A., Oct 2015, In : Human Reproduction. 30, 10, p. 2243-2248 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Effect of controlled hypoglycaemia on sympathetic skin response in patients with Type 1 diabetes and control subjects

Koivikko, M. L., Airaksinen, K. E. J., Perkiomaki, J. S., Huikuri, H. V., Tapanainen, J. S. & Kallio, M. A., Apr 2015, In : Diabetic Medicine. 32, 4, p. 556-560 5 p.

Research output: Contribution to journalArticleScientificpeer-review

The clinical utility of serum anti-Mullerian hormone in the follow-up of ovarian adult-type granulosa cell tumorsA comparative study with inhibin B

Farkkila, A., Koskela, S., Bryk, S., Alfthan, H., Butzow, R., Leminen, A., Puistola, U., Tapanainen, J. S., Heikinheimo, M., Anttonen, M. & Unkila-Kallio, L., 1 Oct 2015, In : International Journal of Cancer. 137, 7, p. 1661-1671 11 p.

Research output: Contribution to journalArticleScientificpeer-review

The effect of atorvastatin treatment on serum oxysterol concentrations and cytochrome P450 3A4 activity

Hukkanen, J., Puurunen, J., Hyötyläinen, T., Savolainen, M. J., Ruokonen, A., Morin-Papunen, L., Oresic, M., Piltonen, T. & Tapanainen, J. S., Sep 2015, In : British Journal of Clinical Pharmacology. 80, 3, p. 473-479 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Anti-Mullerian hormone: correlation with testosterone and oligo- or amenorrhoea in female adolescence in a population-based cohort study

Pinola, P., Morin-Papunen, L. C., Bloigu, A., Puukka, K., Ruokonen, A., Jarvelin, M. -R., Franks, S., Tapanainen, J. S. & Lashen, H., Oct 2014, In : Human Reproduction. 29, 10, p. 2317-2325 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Birth defects and congenital health risks in children conceived through assisted reproduction technology (ART): a meeting report

Albertini, D. F., Evers, J. L. H., Geraedts, J. P. M., Gianaroli, L., Sharpe, R., Sinclair, K. D., Sunde, A., Van Steirteghem, A., Baird, D. T., Crosignani, P. G., Devroey, P., Diedrich, K., Fauser, B. C. J. M., Fraser, L., Tapanainen, J. S., Tarlatzis, B., Veiga, A. & ESHRE Capri Workshop Grp, Aug 2014, In : Journal of Assisted Reproduction and Genetics. 31, 8, p. 947-958 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Cancer Risk in Women With 10 or More Deliveries

Hognas, E., Kauppila, A., Pukkala, E. & Tapanainen, J. S., Apr 2014, In : Obstetrics and Gynecology. 123, 4, p. 811-816 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Irregular menstruation and hyperandrogenaemia in adolescence are associated with polycystic ovary syndrome and infertility in later life: Northern Finland Birth Cohort 1986 study

West, S., Lashen, H., Bloigu, A., Franks, S., Puukka, K., Ruokonen, A., Jarvelin, M. -R., Tapanainen, J. S. & Morin-Papunen, L., Oct 2014, In : Human Reproduction. 29, 10, p. 2339-2351 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Serum sex hormone-binding globulin and testosterone in relation to cardiovascular disease risk factors in young men: a population-based study

Canoy, D., Barber, T. M., Pouta, A., Hartikainen, A. L., McCarthy, M. I., Franks, S., Jarvelin, M. R., Tapanainen, J. S., Ruokonen, A., Huhtaniemi, I. T. & Martikainen, H., Jun 2014, In : European Journal of Endocrinology. 170, 6, p. 863-872 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Antimullerian hormone levels decrease in women using combined contraception independently of administration route

Kallio, S., Puurunen, J., Ruokonen, A., Vaskivuo, T., Piltonen, T. & Tapanainen, J. S., Apr 2013, In : Fertility and Sterility : official journal of the American Fertility Society . 99, 5, p. 1305-1310 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Factors affecting the outcome of frozen-thawed embryo transfer

Veleva, Z., Orava, M., Nuojua-Huttunen, S., Tapanainen, J. S. & Martikainen, H., 2013, In : Human Reproduction. 28, 9, p. 2425-2431 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Research Resource: Small RNA-seq of Human Granulosa Cells Reveals miRNAs in FSHR and Aromatase Genes

Velthut-Meikas, A., Simm, J., Tuuri, T., Tapanainen, J. S., Metsis, M. & Salumets, A., Jul 2013, In : Molecular Endocrinology. 27, 7, p. 1128-1141 14 p.

Research output: Contribution to journalArticleScientificpeer-review