Research Programs Unit

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Publications 1966 2020

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1982

A BLOOD GROUP-M SPECIFIC HEMAGGLUTININ IN PYELONEPHRITOGENIC ESCHERICHIA-COLI

JOKINEN, M., VAISANEN, J., KORHONEN, TK., KALKKINEN, N., GAHMBERG, CG. & EHNHOLM, C., 1982, In : Hoppe-Seylers zeitschrift fur physiologische chemie. 363, 9, p. 1031-1031 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

2008

Prognostic Impact of Microvessel Density in Follicular Lymphoma Patients Treated with Immunochemotherapy.

Taskinen, M., Bono, P. & Leppa, S., 16 Nov 2008, In : Blood. 112, 11, p. 980-980 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

2009

Activated Protein C in Severe Acute Pancreatitis: A Double-Blind Randomized Human Pilot Study

Kemppainen, E., Pettila, V., Kyhala, L., Kylanpaa, L., Tallgren, M., Repo, H. & Puolakkainen, P., Nov 2009, In : Pancreas. 38, 8, p. 1015-1015 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

2010

Exon-Based Transcriptome Profiling Reveals Genes That Have Prognostic Impact on the Survival of Young High Risk Diffuse Large B-Cell/Follicular Grade 3 Lymphoma Patients Treated with Dose-Dense Chemoimmuno-therapy and CNS Prophylaxis. Results From a Nordic Lymphoma Group Phase II Study.

Koivula, S., Taskinen, M., Chen, P., Holte, H., Delabie, J., Karjalainen-Lindsberg, M-L., Bjorkholm, M., Fluge, O., Pedersen, L. M., Jerkeman, M., Eriksson, M., Hautaniemi, S. & Leppa, S., 19 Nov 2010, In : Blood. 116, 21, p. 1281-1281 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Systematic functional analysis of microRNAs by transfection of 1129 miRNAs into prostate cancer cells

Ostling, P., Leivonen, S-K., Aakula, A., Kohonen, P., Makela, R., Perala, M. & Kallioniemi, O., Apr 2010, In : Cancer Research. 70, 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

The Genetics of a Novel Form of Lafora Disease

Turnbull, J., Girard, J-M., Lohi, H., Chan, E., Wang, P., Tiberia, E., Omer, S., Ahmed, M., Bennett, C., Chakrabarty, A., Pencea, N., Zhao, X., Scherer, S., Ackerley, C. & Minassian, B., 27 Jul 2010, In : Neurology. 75, 4, p. 380-381 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

TRAC gene expression analysis in in vitro drug metabolism screening

Rautio, J., Kotimaa, J. & Sirkia, M., 17 Jul 2010, In : Toxicology Letters. 196, p. S145-S146 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

2011

Addition of Rituximab to Chemotherapy Alters the Prognostic Impact of Tumor-Associated Macrophages in Diffuse Large B-Cell Lymphoma

Riihijarvi, S., Poyhonen, M., Taskinen, M., Karjalainen-Lindsberg, M-L. & Leppa, S., 18 Nov 2011, In : Blood. 118, 21, p. 1139-1139 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Hyperglycaemic E1-DN mice develop albuminuria and glomerular injury

Hyvonen, M. E., Ustinov, J., Otonkoski, T., Miettinen, P. J. & Lehtonen, S., Sep 2011, In : Diabetologia. 54, p. S432-S432 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Inhibition of HER2 Positive Breast Cancer Cells by Drug Screening

Nyberg, S., Hongisto, V., Tadele, D. S., Leivonen, S. K., Edgren, H., Kallioniemi, O., Borresen-Dale, A. L., Perala, M. & Sahlberg, K. K., Sep 2011, In : European Journal of Cancer. 47, p. S330-S331 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

INTEGRATIVE GENOMIC PROFILING OF HIGH-RISK DIFFUSE LARGE B-CELL LYMPHOMA PATIENTS LESS THAN 65 YEARS OLD TREATED WITH DOSE-DENSE CHEMOIMMUNOTHERAPY AND CNS PROPHYLAXIS

Koivula, S., Taskinen, M., Louhimo, R., Chen, P., Delabie, J., Holte, H., Karjalainen-Lindsberg, M., Bjorkholm, M., Fluge, O., Pedersen, L. M., Jerkeman, M., Eriksson, M., Hautaniemi, S. & Leppa, S., Jun 2011, In : Annals of Oncology. 22, p. 207-207 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Reticulon 4b modulates mammalian Endoplasmic Reticulum

Ramo, O., Gucciardo, E., Belevich, I., Vihinen, H. & Jokitalo, E., 2011, In : Molecular Biology of the Cell. 22, 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Systematic analysis of microRNAs targeting the androgen receptor in prostate cancer cells

Ostling, P., Leivonen, S-K., Aakula, A., Kohonen, P., Makela, R., Hagman, Z., Edsjo, A., Kangaspeska, S., Edgren, H., Nicorici, D., Bjartell, A., Ceder, Y., Perala, M. & Kallioniemi, O., 15 Apr 2011, In : Cancer Research. 71, 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

2012

Alternative Splicing and Expression of Class II Tubulin Beta (TUBB2B) Are Associated with Outcome in Diffuse Large B-Cell Lymphoma

Taskinen, M., Koivula, S., Chen, P., Karjalainen-Lindsberg, M-L., Cervera, A., Delabie, J., Holte, H., Hautaniemi, S. & Leppa, S., 16 Nov 2012, In : Blood. 120, 21, 2 p., Meeting Abstract: 1557.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Discovery of STAT5b Mutations and Small Subclones of STAT3 Mutations in Large Granular Lymphocytic (LGL) Leukemia

Rajala, H. L. M., Eldfors, S., Kuusanmaki, H., Andersson, E. I., van Adrichem, A. J., Lagstrom, S., Olson, T., Jerez, A., Clemente, M. J., Zhang, D., Awwad, A., Pihlman, M., Ellonen, P., Kallioniemi, O., Wennerberg, K., Porkka, K., Maciejewski, J. P., Loughran, T. P., Heckman, C. A. & Mustjoki, S., 16 Nov 2012, In : Blood. 120, 21, 2 p., Meeting Abstract: 871.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

MED12 exon 2 mutations in common and histopathological variants of uterine leiomyoma and leiomyosarcoma

Makinen, N., Arola, J., Vahteristo, P., Lehtonen, H. J., Heinonen, H., Butzow, R. & Aaltonen, L. A., Oct 2012, In : Histopathology. 61, p. 101-101 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Small Molecular Weight ARTN Mimetic for the Treatment of Neuropathic Pain

Sidorova, Y. A., Bespalov, M. M., Karelson, M. & Saarma, M., 2012, In : Cell Transplantation. 21, 4, p. 792-792 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Somatic PTPRT and ANGPT2 Mutations in Large Granulocyte Leukemia

Andersson, E. I., Eldfors, S., Koskela, H. L. M., Ellonen, P., Olson, T., Jerez, A., Clemente, M. J., Kallioniemi, O., Porkka, K., Loughran, T. P., Maciejewski, J. P., Heckman, C. & Mustjoki, S., 16 Nov 2012, In : Blood. 120, 21, 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Use of exon-based transcriptome profiling to identify novel signaling pathways and survival-associated genes in diffuse large B-cell lymphoma

Leppa, S., Taskinen, M., Koivula, S., Chen, P., Louhimo, R., Delabie, J., Karjalainen-Lindsberg, M-L., Bjorkholm, M., Fluge, O., Pedersen, L. M., Rydstrom, K., Jerkeman, M., Eriksson, M., Hautaniemi, S., Holte, H. & Nordic Lymphoma Grp, 20 May 2012, In : Journal of Clinical Oncology. 30, 15, 1 p., Meeting Abstract: 8074.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

2013

Conditional expression of a constitutively active EGF-R in beta cells protects against diabetes

Hakonen, E., Ustinov, J., Eizirik, D. L., Miettinen, P. J. & Otonkoski, T., Sep 2013, In : Diabetologia. 56, p. S73-S73 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Cross-talk of circadian and immune system in neuropeptide S receptor 1 deficient mice

Pulkkinen, V., Savinko, T., Karisola, P., Hyytia, P., Greco, D., Hovatta, I., Kere, J., Mandelin, J. & Alenius, H., 1 Sep 2013, In : European Respiratory Journal. 42, Suppl. 57, p. 1264 1 p., P531.

Research output: Contribution to journalMeeting AbstractResearch

Electron and confocal microscopy of diabetic E1-DN mouse glomeruli revealed thickening of basement membrane and decreased nephrin expression

Dumont, V., Hyvonen, M. E., Lehtonen, E., Ustinov, J., Tienari, J., Otonkoski, T., Miettinen, P. J. & Lehtonen, S., Sep 2013, In : Diabetologia. 56, p. S478-S479 2 p.

Research output: Contribution to journalMeeting AbstractResearch

Genetic Prediction of Type 2 Diabetes: A Meta-Analysis of Prospective Studies of 62,264 Individuals

Engage European Network Genetic, Jul 2013, In : Diabetes. 62, p. A32-A32 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Genome-Wide Association Analysis of Canine Retinal Dysplasia and Vitreous Degeneration

Ahonen, S. & Lohi, H., Jun 2013, In : Investigative Ophthalmology & Visual Science. 54, 15, 2 p.

Research output: Contribution to journalMeeting AbstractResearch

Global Profiling Of Outcome Associated Alternative Splicing Events and Gene Expression In Diffuse Large B-Cell Lymphoma

Taskinen, M., Chen, P., Karjalainen-Lindsberg, M-L., Cervera, A., Delabie, J., Holte, H., Hautaniemi, S. & Leppae, S., 15 Nov 2013, In : Blood. 122, 21, 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

High-throughput drug screening and molecular profiling for therapeutic targeting of NUP98-NSD1-positive AML

Kontro, M. P., Pemovska, T., Heckman, C. A., Kallioniemi, O-P., Wennerberg, J. K. & Porkka, K. V. K., Feb 2013, In : Annals of Hematology. 92, Supplement 1, p. S18

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Stromal cell supported high-throughput screening of primary acute myeloid leukemia cells for assessing sensitivity to cytotoxic drugs

Karjalainen, R. J., Pemovska, T., Yadav, B., Wennerberg, J. K. & Heckman, C. A., Feb 2013, In : Annals of Hematology. 92, Supplement 1, p. S17

Research output: Contribution to journalMeeting AbstractResearchpeer-review

2014

Acinetobacter in the skin microbiota protects from atopic sensitisation

Fyhrquist, N. T., Ruokolainen, L., Suomalainen, A., Lehtimaki, S., Veckman, V., Vendelin, J., Karisola, P., Savinko, T., Lehto, M., Jarva, H., Kosunen, T., Corander, J., Petri, A., von Hertzen, L., Laatikainen, T., Mäkelä, M., Haahtela, T., Greco, D., Hanski & Alenius, H., Sep 2014, In : Allergy : European journal of allergy and clinical immunology. 69, p. 4-5 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Characterization of the Microrna Expression Profiles of Paired Primary and Relapsed Diffuse Large B-Cell Lymphoma (DLBCL) By Next-Generation Sequencing

Leivonen, S-K., Icay, K., Liu, C., Taskinen, M., Lehtonen, R., Karjalainen-Lindsberg, M-L., Delabie, J., Holte, H., Hautaniemi, S. & Leppa, S., 6 Dec 2014, In : Blood. 124, 21, 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Hereditary cataract in Bichon Frise dogs: Genome-wide association study suggests a new preliminary locus finding

Kaukonen, M. K., Ahonen, S. J. & Lohi, H., Apr 2014, In : Investigative Ophthalmology & Visual Science. 55, 13, 2 p.

Research output: Contribution to journalMeeting AbstractResearch

Hunting new anxiety genes with the help of man's best friend, the dog

Hakosalo, O., Tiira, K., James, F., Jokinen, T., Sarviaho, R., Sillanpaa, M., Kere, J. & Lohi, H., 2014, In : International Journal of Molecular Medicine. 34, p. S88-S88 1 p.

Research output: Contribution to journalMeeting AbstractResearch

Identification of Novel Germline Variants in Early-Onset Familial Classical Hodgkin Lymphoma with Exome Sequencing

Kilpivaara, O., Ristolainen, H., Kamper, P., Taskinen, M., Saarinen, S., Leppa, S., d'Amore, F. & Lauri, A. A., 6 Dec 2014, In : Blood. 124, 21, p. 4402 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Progressive Retinal Atrophy in the Karelian Beardog; A Large Animal Model for Retinitis Pigmentosa

Ahonen, S. J. & Lohi, H., Apr 2014, In : Investigative Ophthalmology & Visual Science. 55, 13, 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Somatic Mutations in E3 Ubiquitin Ligase Deltex 1 Are Associated with Survival in Diffuse Large B-Cell Lymphoma

Taskinen, M., Meriranta, L., Pasanen, A., Louhimo, R., Cervera, A., Karjalainen-Lindsberg, M-L., Holte, H., Delabie, J., Lehtonen, R., Hautaniemi, S. & Leppa, S., 6 Dec 2014, In : Blood. 124, 21, 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

The gonadal hypoplasia of Northern Finncattle and PIRM syndrome in Ayrshire breed

Venhoranta, H., Pausch, H., Flisikowski, K., Taponen, J., Fries, R., Lohi, H. & Andersson, M., Sep 2014, In : Reproduction in Domestic Animals. 49, p. 42 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

2015

A Higher Neutrophil Count Before Thrombolysis Is Associated With Worse Outcome

Maestrini, I., Strbian, D., Gautier, S., Haapaniemi, E., Moulin, S., Sairanen, T., Dequatre-Ponchelle, N., Sibolt, G., Cordonnier, C., Melkas, S., Leys, D., Tatlisumak, T. & Bordet, R., Feb 2015, In : Stroke. 46, 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Association between post-thrombolytic blood pressure and symptomatic intracerebral hemorrhage

Melkas, S., Waltimo, T., Haapaniemi, E., Sairanen, T., Sibolt, G., Tatlisumak, T. & Strbian, D., Apr 2015, In : International Journal of Stroke. 10, p. 118-118 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Comparison of CT rating scales for cerebral white matter lesions in a large cohort of acute ischemic stroke patients

Curtze, S., Sibolt, G., Melkas, S., Haapaniemi, E., Mustanoja, S., Putaala, J., Sairanen, T., Tiainen, M., Tatlisumak, T. & Strbian, D., Apr 2015, In : International Journal of Stroke. 10, p. 328-328 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Identification of Novel Candidate Genes in Canine Noise Phobia - A Model for Human Phobias

Hakosalo, O., Tiira, K., Sarviaho, R., Sillanpaa, M., Kere, J. & Lohi, H., 1 May 2015, In : Biological Psychiatry. 77, 9, p. 80S-81S 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Learning From Dogs? Environmental Factors that Associate with Fearfulness in Family Dogs

Tiira, K. & Lohi, H., 1 May 2015, In : Biological Psychiatry. 77, 9, p. 376S-377S 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

New oncolytic vaccine platform enhance anti-tumor immunity in humanized mice with human melanomas

Capasso, C., Hirvinen, M., Garofalo, M., Romaniuk, D., Kuryk, L., Sarvela, T., Vitale, A., Antopolsky, M., Magarkar, A., Viitala, T., Suutari, T., Bunker, A., Yliperttula, M., Urtti, A. & Cerullo, V., 1 Oct 2015, In : Human Gene Therapy. 26, 10, p. A53-A53 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

White matter lesions are associated with worse outcome after thrombolysis in stroke patients

Curtze, S., Melkas, S., Haapaniemi, E., Mustanoja, S., Putaala, J., Sairanen, T., Sibolt, G., Tiainen, M., Tatlisumak, T. & Strbian, D., Apr 2015, In : International Journal of Stroke. 10, p. 25-25 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

2016

Cause of Stroke is not Associated With the Risk of Symptomatic Post-thrombolytic Intracerebral Hemorrhage

Curtze, S., Sibolt, G., Melkas, S., Mustanoja, S., Haapaniemi, E., Putaala, J., Sairanen, T., Tiainen, M., Tatlisumak, T. & Strbian, D., Feb 2016, In : Stroke. 47, 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

CML Patients with Primary Resistance or Suboptimal Response to TKI Therapy Have Variants in Genes Affecting Drug Absorption and Metabolism

Pietarinen, P., Koskenvesa, P., Klievink, J., Porkka, K., Niemi, M. & Mustjoki, S., 2 Dec 2016, In : Blood. 128, 22, 4 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Dasatinib Exerts Differential Effects on Normal and BCR-ABL Positive Hematopoietic Cells in a Transgenic Mouse Model of Chronic Phase-CML

Schubert, C., Chatain, N., Braunschweig, T., Schemionek, M., Feldberg, K., Hoffmann, M., Brummendorf, T. H., Mustjoki, S., Dufva, O. & Koschmieder, S., 2 Dec 2016, In : Blood. 128, 22, 6 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Dose-Dense Chemoimmunotherapy Including Early CNS Prophylaxis for High-Risk DLBCL. -Final Analysis from a Nordic Phase II Study (the CHIC trial)

Leppa, S., Joergensen, J., Tierens, A., Ostlie, I., Fagerli, U. M., Brown, P. D. N., Larsen, T. S., Mannisto, S., Munksgaard, L., Maisenholder, M., Vasala, K., Meyer, P., Jerkeman, M., Bjorkholm, M., Fluge, O., Jyrkkio, S., Ralfkiaer, E., Spetalen, S., Karjalainen-Lindsberg, M-L. & Holte, H., 2 Dec 2016, In : Blood. 128, 22, 6 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Effects of a lifestyle intervention during pregnancy and 1-year postpartum - results from the RADIEL study

Huvinen, H., Koivusalo, S., Stach-Lempinen, B., Kautiainen, H. & Eriksson, J., 26 Feb 2016, In : Gynecological Endocrinology. 32, p. 161-161 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Haptoglobin Hp2 Variant Associates With an Increased Risk of Ischemic Cardiovascular Death After First-ever Stroke.

Ijas, P., Melkas, S., Saksi, J., Jula, A., Jauhiainen, M., Pohjasvaara, T., Kaste, M., Karhunen, P. J., Lindsberg, P. & Erkinjuntti, T., Feb 2016, In : Stroke. 47, 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review