Research Programs Unit

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Publications 1966 2020

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Meeting Abstract

Wnt pathway activation in 3D nephron progenitor culture facilitates self-organization, expansion, and differentiation

Dapkunas, A., Rantanen, V., Kuure, S., Sainio, K. & Sariola, H., Jul 2017, In : Mechanisms of Development. 145, p. S162-S163 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

White matter lesions are associated with worse outcome after thrombolysis in stroke patients

Curtze, S., Melkas, S., Haapaniemi, E., Mustanoja, S., Putaala, J., Sairanen, T., Sibolt, G., Tiainen, M., Tatlisumak, T. & Strbian, D., Apr 2015, In : International Journal of Stroke. 10, p. 25-25 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Use of exon-based transcriptome profiling to identify novel signaling pathways and survival-associated genes in diffuse large B-cell lymphoma

Leppa, S., Taskinen, M., Koivula, S., Chen, P., Louhimo, R., Delabie, J., Karjalainen-Lindsberg, M-L., Bjorkholm, M., Fluge, O., Pedersen, L. M., Rydstrom, K., Jerkeman, M., Eriksson, M., Hautaniemi, S., Holte, H. & Nordic Lymphoma Grp, 20 May 2012, In : Journal of Clinical Oncology. 30, 15, 1 p., Meeting Abstract: 8074.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Uptake and functionality of prostate cancer extracellular vesicles depends on the metastatic stage of the parent cells

Lazaro Ibanez, E., Neuvonen, K. M., Takatalo-Laine, S. M., Thanigai Arasu, U., Capasso, C., Rhim, J., Rilla, K., Yliperttula, M. L. & Siljander, P. R-M., May 2017, In : Journal of Extracellular Vesicles. 6, sup1

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Open Access

UNSTABLE LDL - NOVEL MECHANISM OF ATHEROGENESIS AND LINK TO CARDIOVASCULAR DEATHS

Ruuth, M., Nguyen, S. D., Vihervaara, T., Laajala, T. D., Uusitupa, M., Schwab, U., Savolainen, M., Sinisalo, J., Aittokallio, T., Kakela, R., Jauhiainen, M., Kovanen, P. & Oorni, K., Sep 2016, In : Atherosclerosis. 252, p. E208-E208 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

TRAC gene expression analysis in in vitro drug metabolism screening

Rautio, J., Kotimaa, J. & Sirkia, M., 17 Jul 2010, In : Toxicology Letters. 196, p. S145-S146 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

The gonadal hypoplasia of Northern Finncattle and PIRM syndrome in Ayrshire breed

Venhoranta, H., Pausch, H., Flisikowski, K., Taponen, J., Fries, R., Lohi, H. & Andersson, M., Sep 2014, In : Reproduction in Domestic Animals. 49, p. 42 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

The Genetics of a Novel Form of Lafora Disease

Turnbull, J., Girard, J-M., Lohi, H., Chan, E., Wang, P., Tiberia, E., Omer, S., Ahmed, M., Bennett, C., Chakrabarty, A., Pencea, N., Zhao, X., Scherer, S., Ackerley, C. & Minassian, B., 27 Jul 2010, In : Neurology. 75, 4, p. 380-381 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

THE ECONOMIC IMPACT OF SERIOUS FLUOROQUINOLONE-RELATED ADVERSE EVENTS

Saarukka, L., Backman, J. T. & Blom, M., Nov 2019, In : Value in Health. 22, p. S600-S600 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Th1/2 Immune Response Signature Predicts Outcome after Dose-Dense Immunochemotherapy in Patients with High Risk Diffuse Large B-Cell Lymphoma - Results from Nordic Lymphoma Group Trials

Autio, M., Leivonen, S-K., Jorgensen, J. M., Karjalainen-Lindsberg, M-L., Beiske, K., Holte, H. & Leppä, S., 7 Dec 2017, In : Blood. 130, 2 p., 4008.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Systematic functional analysis of microRNAs by transfection of 1129 miRNAs into prostate cancer cells

Ostling, P., Leivonen, S-K., Aakula, A., Kohonen, P., Makela, R., Perala, M. & Kallioniemi, O., Apr 2010, In : Cancer Research. 70, 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Systematic analysis of microRNAs targeting the androgen receptor in prostate cancer cells

Ostling, P., Leivonen, S-K., Aakula, A., Kohonen, P., Makela, R., Hagman, Z., Edsjo, A., Kangaspeska, S., Edgren, H., Nicorici, D., Bjartell, A., Ceder, Y., Perala, M. & Kallioniemi, O., 15 Apr 2011, In : Cancer Research. 71, 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Synergistic effect of combined administration of an oncolytic adenovirus and Bifidobacterium spp. supplements in a mouse model of melanoma

Tripodi, L., Leggiero, E., D'Argenio, V., Granata, I., Capasso, C., Passariello, M., D'Agostino, A., Guarracino, M. R., De Lorenzo, C., Cerullo, V. & Pastore, L., 1 Nov 2019, In : Human Gene Therapy. 30, 11, p. A30-A31 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Stromal cell supported high-throughput screening of primary acute myeloid leukemia cells for assessing sensitivity to cytotoxic drugs

Karjalainen, R. J., Pemovska, T., Yadav, B., Wennerberg, J. K. & Heckman, C. A., Feb 2013, In : Annals of Hematology. 92, Supplement 1, p. S17

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Somatic PTPRT and ANGPT2 Mutations in Large Granulocyte Leukemia

Andersson, E. I., Eldfors, S., Koskela, H. L. M., Ellonen, P., Olson, T., Jerez, A., Clemente, M. J., Kallioniemi, O., Porkka, K., Loughran, T. P., Maciejewski, J. P., Heckman, C. & Mustjoki, S., 16 Nov 2012, In : Blood. 120, 21, 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Somatic Mutations in E3 Ubiquitin Ligase Deltex 1 Are Associated with Survival in Diffuse Large B-Cell Lymphoma

Taskinen, M., Meriranta, L., Pasanen, A., Louhimo, R., Cervera, A., Karjalainen-Lindsberg, M-L., Holte, H., Delabie, J., Lehtonen, R., Hautaniemi, S. & Leppa, S., 6 Dec 2014, In : Blood. 124, 21, 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Somatic MED12 mutations in hematological malignancies

Heikkinen, T., Kampjarvi, K., Leppa, S., Hokland, P., Kuusanmaki, H., Mustjoki, S., Sinisalo, M., Heckman, C., Kontro, M. & Vahteristo, P., Jul 2016, In : Cancer Research. 76, 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Small Molecular Weight ARTN Mimetic for the Treatment of Neuropathic Pain

Sidorova, Y. A., Bespalov, M. M., Karelson, M. & Saarma, M., 2012, In : Cell Transplantation. 21, 4, p. 792-792 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

RISK GENE PROFILE IN FINNISH PANDEMRIX ASSOCIATED NARCOLEPSY

Saavalainen, P. M., Jaatinen, T., Vuorela, A., Kere, J., Partinen, M., Ilonen, J. & Vaarala, O., Jul 2014, In : Tissue Antigens. 84, 1, p. 19-19 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Reticulon 4b modulates mammalian Endoplasmic Reticulum

Ramo, O., Gucciardo, E., Belevich, I., Vihinen, H. & Jokitalo, E., 2011, In : Molecular Biology of the Cell. 22, 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Psychiatric Disorders and Return to Work after Mild Traumatic Brain Injury

Marinkovic, I., Isokuortti, H., Huovinen, A., Korvenoja, A., Vataja, R. & Melkas, S., 2 May 2019, In : Brain Injury. 33, p. 153-153 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Progressive Retinal Atrophy in the Karelian Beardog; A Large Animal Model for Retinitis Pigmentosa

Ahonen, S. J. & Lohi, H., Apr 2014, In : Investigative Ophthalmology & Visual Science. 55, 13, 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Prognostic Impact of Microvessel Density in Follicular Lymphoma Patients Treated with Immunochemotherapy.

Taskinen, M., Bono, P. & Leppa, S., 16 Nov 2008, In : Blood. 112, 11, p. 980-980 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

POLYGENIC HYPERLIPIDEMIA INCREASES CORONARY ARTERY DISEASE RISK IN THE UK BIOBANK

Ripatti, P., Ramo, J. T., Soderlund, S., Surakka, I., Havulinna, A. S., Widen, E., Palta, P., Freimer, N. B., Salomaa, V., Pirinen, M., Palotie, A., Taskinen, M. R. & Ripatti, S., Aug 2019, In : Atherosclerosis. 287, p. E92-E92 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Pharmacogenomic profiling to identify novel therapeutic strategies in colorectal cancer

Bruun, J., Eide, P. W., Kryeziu, K., Sveen, A., Murumagi, A., Kolberg, M., Arjama, M., Kallioniemi, O. & Lothe, R. A., Jul 2017, In : Cancer Research. 77, 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Pan-Hematopoietic Cancer Gene Expression Analysis Identifies Immunologically Active Acute Myeloid Leukemia Subtypes

Dufva, O., Polonen, P., Keranen, M. A., Liuksiala, T., Lin, J., Mehtonen, J., Hayrynen, S., Granberg, K., Nykter, M., Lohi, O., Heinaniemi, M. & Mustjoki, S., 2 Dec 2016, In : Blood. 128, 22, 6 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Oncolytic Adenoviruses Encapsulated into the Extracellular Vesicles as Carriers for Cancer Drug Delivery

Garofalo, M., Saari, H., Somersalo, P., Crescenti, D., Kuryk, L., Aksela, L., Capasso, C., Madetoja, M., Koskinen, K., Makitie, A., Jalasvuori, M., Cerullo, V., Ciana, P. & Yliperttula, M., May 2018, In : Molecular therapy. 26, 5, p. 203-203 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Novel therapeutic possibilities for chemorefractory ovarian cancer patients identified by functional ex vivo drug sensitivity testing of primary cells

Murumagi, A., Hirasawa, A., Khan, S., Arjama, M., Pellinen, T., Koivisto-Korander, R., Leminen, A., Magi, A., Aittokallio, T., Butzow, R. & Kallioniemi, O., Oct 2016, In : International Journal of Gynecological Cancer. 26, p. 653-653 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Novel Mutations in Patients with Blast Crisis or Accelerated Phase Chronic Myeloid Leukemia

Awad, S. A., Kankainen, M., Eldfors, S., Kytola, S., Ellonen, P., Kamel, M., Heckman, C. A., Porkka, K. & Mustjoki, S., 2 Dec 2016, In : Blood. 128, 22, 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Novel drug discovery by pharmacogenomic profiling of 36 colorectal cancer cell lines.

Eide, P., Bruun, J., Sveen, A., MurumAfagi, A., Mpindi, J., Arjama, M., Kallioniemi, O. & Lothe, R. A., 1 Feb 2016, In : Journal of Clinical Oncology. 34, 4, 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

New oncolytic vaccine platform enhance anti-tumor immunity in humanized mice with human melanomas

Capasso, C., Hirvinen, M., Garofalo, M., Romaniuk, D., Kuryk, L., Sarvela, T., Vitale, A., Antopolsky, M., Magarkar, A., Viitala, T., Suutari, T., Bunker, A., Yliperttula, M., Urtti, A. & Cerullo, V., 1 Oct 2015, In : Human Gene Therapy. 26, 10, p. A53-A53 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Mutational Landscape of Aggressive Natural Killer Cell Leukemia and Drug Sensitivity Profiling Reveal Therapeutic Options in Natural Killer Cell Malignancies

Dufva, O., Kankainen, M., Kelkka, T., Awad, S. A., Sekiguchi, N., Yadav, B., Eldfors, S., Kuusanmaki, H., Andersson, E. I., Malani, D., Pietarinen, P., Saikko, L., Kovanen, P. E., Suzumiya, J., Suzuki, R., Ko, Y. H., Kim, W. S., Chuang, S-S., Loughran, T. P., Chan, W. C. & 4 others, Ohshima, K., Aittokallio, T., Ishida, F. & Mustjoki, S., 2 Dec 2016, In : Blood. 128, 22, 4 p., 2921.

Research output: Contribution to journalMeeting AbstractResearch

Multi-Parametric Single Cell Profiling Defines Distinct Drug Responses in Healthy Hematological Cell Lineages That Are Retained in Corresponding Malignant Cell Types

Majumder, MM., Leppä, A-M., Hellesøy, M., Dowling, P., Malyutina, A., Bazou, D., Andersson, E. I., Parsons, A., Tang, J., Kallioniemi, O-P., Mustjoki, S. M., O'Gorman, P., Wennerberg, J. K., Porkka, K. V. K., Gjertsen, B-T. & Heckman, C. A., 2018, In : Blood. 132

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Open Access

Molecular Characterization of Cytotoxic T Cell Repertoire in Aplastic Anemia and Myelodysplastic Syndromes

Lundgren, S. A., Keränen, M. A., Savola, P., Park, G., Ebeling, F., Walldin, G., Hellstroem-Lindsberg, E. & Mustjoki, S., 2 Dec 2016, In : Blood. 128, 22, 4 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Modeling of monogenic primary hepatic steatosis with hiPSC derived hepatocyte like cells

Toivonen, S., Holtta-Vuori, M., Lipsanen-Nyman, M., Ikonen, E. & Otonkoski, T., May 2013, In : Human Gene Therapy. 24, 5, p. A33-A34 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Membrane-type-3 matrix metalloproteinase (MT3-MMP) functions as a matrix composition -dependent effector of MT1-MMP activity and tumor cell invasion

Tatti, O., Arjama, M., Keski-Oja, J. & Lehti, K., Sep 2010, In : Journal of Investigative Dermatology. 130, p. S52-S52 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Melatonin receptor type 1A gene linked to intolerance to shift work and Alzheimer's disease in old age

Sulkava, S., Muggalla, P., Sulkava, R., Ollila, H. M., Peuralinna, T., Myllykangas, L., Helisalmi, S., Soininen, H., Polvikoski, T., Hiltunen, M., Tienari, P. J., Huttunen, H. J. & Paunio, T., Sep 2018, In : Journal of Sleep Research. 27, Supplement 1, 1 p., P007.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

MED12 exon 2 mutations in common and histopathological variants of uterine leiomyoma and leiomyosarcoma

Makinen, N., Arola, J., Vahteristo, P., Lehtonen, H. J., Heinonen, H., Butzow, R. & Aaltonen, L. A., Oct 2012, In : Histopathology. 61, p. 101-101 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Lymphoid somatic mutations in multiple sclerosis

Valori, M., Jansson, L., Kiviharju, A., Porkka, K., Ellonen, P., Mustjoki, S. & Tienari, P., Sep 2016, In : Multiple Sclerosis Journal . 22, p. 170-171 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Low Expression of the CIITA Gene Predicts Poor Outcome in Diffuse Large B-Cell Lymphoma

Autio, M., Jantti, K., Cervera, A., Hautaniemi, S. & Leppa, S., 2 Dec 2016, In : Blood. 128, 22, 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Low Expression of T/NK-Cell Signature Predicts Poor Survival in Patients with Primary Testicular and Diffuse Large B-Cell Lymphoma

Leivonen, S-K., Pollari, M., Bruck, O., Pellinen, T., Karjalainen-Lindsberg, M-L., Mannisto, S., Kellokumpu-Lehtinen, P-L., Mustjoki, S. & Leppa, S., 7 Dec 2017, In : Blood. 130, 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Low Expression and Somatic Mutations of the KLHL6 Gene Predict Poor Survival in Patients with Activated B-Cell like Diffuse Large B-Cell Lymphoma

Meriranta, L., Pasanen, A., Cervera, A., Holte, H., Lehtonen, R., Hautaniemi, S. & Leppa, S., 2 Dec 2016, In : Blood. 128, 22, 4 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Learning From Dogs? Environmental Factors that Associate with Fearfulness in Family Dogs

Tiira, K. & Lohi, H., 1 May 2015, In : Biological Psychiatry. 77, 9, p. 376S-377S 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Intracranial Traumatic Lesions Delay Return to Work in Mild Traumatic Injury Patients

Huovinen, A., Marinkovic, I., Isokuortti, H., Korvenoja, A., Vanni, S. & Melkas, S., 2 May 2019, In : Brain Injury. 33, p. 130-131 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

INTEGRATIVE GENOMIC PROFILING OF HIGH-RISK DIFFUSE LARGE B-CELL LYMPHOMA PATIENTS LESS THAN 65 YEARS OLD TREATED WITH DOSE-DENSE CHEMOIMMUNOTHERAPY AND CNS PROPHYLAXIS

Koivula, S., Taskinen, M., Louhimo, R., Chen, P., Delabie, J., Holte, H., Karjalainen-Lindsberg, M., Bjorkholm, M., Fluge, O., Pedersen, L. M., Jerkeman, M., Eriksson, M., Hautaniemi, S. & Leppa, S., Jun 2011, In : Annals of Oncology. 22, p. 207-207 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Integrative Genetic and Clinical Analysis through Whole Exome Sequencing in 1001 Diffuse Large B Cell Lymphoma (DLBCL) Patients Reveals Novel Disease Drivers and Risk Groups

Zhang, J., Reddy, A., Love, C., Moffitt, A. B., Rajagopalan, D., Leppa, S., Pasanen, A., Meriranta, L., Karjalainen-Lindsberg, M-L., Norgaard, P. H., Pederson, M., Gang, A. O., Hogdall, E., Richards, K. L., Fedoriw, Y. D., Bernal-Mizrachi, L., Koff, J. L., Staton, A. D., Flowers, C., Paltiel-Clarfield, O. & 23 others, Goldschmidt, N., Calaminici, M., Clear, A. J., Gribben, J., Nguyen, E., Czader, M., Ondrejka, S. L., Collie, A., Hsi, E. D., Au-Yeung, R., Yok-Lam, K., Choi, W. L., Srivastava, G., Evens, A. M., Pilichowska, M., Sengar, M., Reddy, N., Li, S., Jaffe, E. S., Tzeng, T., Datta, J., Dunson, D. & Dave, S., 2 Dec 2016, In : Blood. 128, 22, 6 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Injury Severity and Extracranial Injuries Are Associated with Delayed Return to Work in Mild Traumatic Brain Injury Patients

Huovinen, A., Isokuortti, H., Marinkovic, I., Vanni, S. & Melkas, S., 2 May 2019, In : Brain Injury. 33, p. 128-129 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review