Research Programs Unit

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Publications 1966 2020

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Meeting Abstract

A BLOOD GROUP-M SPECIFIC HEMAGGLUTININ IN PYELONEPHRITOGENIC ESCHERICHIA-COLI

JOKINEN, M., VAISANEN, J., KORHONEN, TK., KALKKINEN, N., GAHMBERG, CG. & EHNHOLM, C., 1982, In : Hoppe-Seylers zeitschrift fur physiologische chemie. 363, 9, p. 1031-1031 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Acinetobacter in the skin microbiota protects from atopic sensitisation

Fyhrquist, N. T., Ruokolainen, L., Suomalainen, A., Lehtimaki, S., Veckman, V., Vendelin, J., Karisola, P., Savinko, T., Lehto, M., Jarva, H., Kosunen, T., Corander, J., Petri, A., von Hertzen, L., Laatikainen, T., Mäkelä, M., Haahtela, T., Greco, D., Hanski & Alenius, H., Sep 2014, In : Allergy : European journal of allergy and clinical immunology. 69, p. 4-5 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Activated Protein C in Severe Acute Pancreatitis: A Double-Blind Randomized Human Pilot Study

Kemppainen, E., Pettila, V., Kyhala, L., Kylanpaa, L., Tallgren, M., Repo, H. & Puolakkainen, P., Nov 2009, In : Pancreas. 38, 8, p. 1015-1015 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Addition of Rituximab to Chemotherapy Alters the Prognostic Impact of Tumor-Associated Macrophages in Diffuse Large B-Cell Lymphoma

Riihijarvi, S., Poyhonen, M., Taskinen, M., Karjalainen-Lindsberg, M-L. & Leppa, S., 18 Nov 2011, In : Blood. 118, 21, p. 1139-1139 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

A Higher Neutrophil Count Before Thrombolysis Is Associated With Worse Outcome

Maestrini, I., Strbian, D., Gautier, S., Haapaniemi, E., Moulin, S., Sairanen, T., Dequatre-Ponchelle, N., Sibolt, G., Cordonnier, C., Melkas, S., Leys, D., Tatlisumak, T. & Bordet, R., Feb 2015, In : Stroke. 46, 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Alternative Splicing and Expression of Class II Tubulin Beta (TUBB2B) Are Associated with Outcome in Diffuse Large B-Cell Lymphoma

Taskinen, M., Koivula, S., Chen, P., Karjalainen-Lindsberg, M-L., Cervera, A., Delabie, J., Holte, H., Hautaniemi, S. & Leppa, S., 16 Nov 2012, In : Blood. 120, 21, 2 p., Meeting Abstract: 1557.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Association between post-thrombolytic blood pressure and symptomatic intracerebral hemorrhage

Melkas, S., Waltimo, T., Haapaniemi, E., Sairanen, T., Sibolt, G., Tatlisumak, T. & Strbian, D., Apr 2015, In : International Journal of Stroke. 10, p. 118-118 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Brain metabolome during anesthesia - similarities and differences between post-ictal state

Kohtala, S., Kärkkäinen, O. & Rantamäki, T., 2019, In : European Neuropsychopharmacology. 29, p. S645-S646 2 p.

Research output: Contribution to journalMeeting AbstractResearch

Cardiovascular autonomic function after simultaneous pancreas-kidney and kidney-alone transplantation in patients with diabetes

Paajanen, H., Bordino, M., Sandelin, A., Ekstrand, A., Lempinen, M., Forsblom, C., Bernardi, L. & Groop, P-H., 2018, (Accepted/In press) In : Diabetes Care. 1 p.

Research output: Contribution to journalMeeting AbstractResearch

Cause of Stroke is not Associated With the Risk of Symptomatic Post-thrombolytic Intracerebral Hemorrhage

Curtze, S., Sibolt, G., Melkas, S., Mustanoja, S., Haapaniemi, E., Putaala, J., Sairanen, T., Tiainen, M., Tatlisumak, T. & Strbian, D., Feb 2016, In : Stroke. 47, 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Characterization Of Focal And Generalized Epilepsy Polygenic Burden In 630,603 Individuals

Epi-Twenty-Five Consortium, Nov 2019, In : Epilepsia. 60, p. 27-28 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Characterization of Immunological Profiles with Clinical Significance in Patients with Classical Hodgkin Lymphoma

Karihtala, K., Leivonen, S-K., Karjalainen-Lindsberg, M-L. & Leppa, S., 7 Dec 2017, In : Blood. 130, 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Characterization of the Microrna Expression Profiles of Paired Primary and Relapsed Diffuse Large B-Cell Lymphoma (DLBCL) By Next-Generation Sequencing

Leivonen, S-K., Icay, K., Liu, C., Taskinen, M., Lehtonen, R., Karjalainen-Lindsberg, M-L., Delabie, J., Holte, H., Hautaniemi, S. & Leppa, S., 6 Dec 2014, In : Blood. 124, 21, 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Clinical and Genetic Characterization of Canine Vitreous Degeneration

Kaukonen, M. & Lohi, H., Jul 2018, In : Investigative Ophthalmology & Visual Science. 59, 9, 2 p., 6042.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Open Access

CML Patients with Primary Resistance or Suboptimal Response to TKI Therapy Have Variants in Genes Affecting Drug Absorption and Metabolism

Pietarinen, P., Koskenvesa, P., Klievink, J., Porkka, K., Niemi, M. & Mustjoki, S., 2 Dec 2016, In : Blood. 128, 22, 4 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Combined Targeting of BET Family Proteins and BCL2 Is Synergistic in Acute Myeloid Leukemia Cells Overexpressing S100A8 and S100A9

Karjalainen, R., Liu, M., Kumar, A., Parsons, A., He, L., Malani, D. R., Kontro, M., Porkka, K. & Heckman, C. A., 2018, In : Blood. 132

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Open Access

Comparison of CT rating scales for cerebral white matter lesions in a large cohort of acute ischemic stroke patients

Curtze, S., Sibolt, G., Melkas, S., Haapaniemi, E., Mustanoja, S., Putaala, J., Sairanen, T., Tiainen, M., Tatlisumak, T. & Strbian, D., Apr 2015, In : International Journal of Stroke. 10, p. 328-328 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Conditional expression of a constitutively active EGF-R in beta cells protects against diabetes

Hakonen, E., Ustinov, J., Eizirik, D. L., Miettinen, P. J. & Otonkoski, T., Sep 2013, In : Diabetologia. 56, p. S73-S73 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

COSTS AND HEALTH SERVICE USE ASSOCIATED WITH FLUOROQUINOLONE-RELATED TENDON INJURIES

Saarukka, L., Backman, J. T. & Blom, M., Oct 2018, In : Value in Health. 21, p. S293-S293 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Cross-talk of circadian and immune system in neuropeptide S receptor 1 deficient mice

Pulkkinen, V., Savinko, T., Karisola, P., Hyytia, P., Greco, D., Hovatta, I., Kere, J., Mandelin, J. & Alenius, H., 1 Sep 2013, In : European Respiratory Journal. 42, Suppl. 57, p. 1264 1 p., P531.

Research output: Contribution to journalMeeting AbstractResearch

Dasatinib Exerts Differential Effects on Normal and BCR-ABL Positive Hematopoietic Cells in a Transgenic Mouse Model of Chronic Phase-CML

Schubert, C., Chatain, N., Braunschweig, T., Schemionek, M., Feldberg, K., Hoffmann, M., Brummendorf, T. H., Mustjoki, S., Dufva, O. & Koschmieder, S., 2 Dec 2016, In : Blood. 128, 22, 6 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

DISC1 GENE NETWORK MUTATIONS IN MAJOR MENTAL ILLNESS

Sinha, V., Ortega-Alonso, A., Ukkola-Vuoti, L., Hovatta, I., Haukka, J., Torniainen, M., Therman, S., Cannon, T., Kaprio, J., Lonnqvist, J., Partonen, T., Isometsa, E., Paunio, T., Suvisaari, J. & Hennah, W., Oct 2017, In : European Neuropsychopharmacology. 27, p. S406-S407 2 p., M57.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Discovery of STAT5b Mutations and Small Subclones of STAT3 Mutations in Large Granular Lymphocytic (LGL) Leukemia

Rajala, H. L. M., Eldfors, S., Kuusanmaki, H., Andersson, E. I., van Adrichem, A. J., Lagstrom, S., Olson, T., Jerez, A., Clemente, M. J., Zhang, D., Awwad, A., Pihlman, M., Ellonen, P., Kallioniemi, O., Wennerberg, K., Porkka, K., Maciejewski, J. P., Loughran, T. P., Heckman, C. A. & Mustjoki, S., 16 Nov 2012, In : Blood. 120, 21, 2 p., Meeting Abstract: 871.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Dose-Dense Chemoimmunotherapy Including Early CNS Prophylaxis for High-Risk DLBCL. -Final Analysis from a Nordic Phase II Study (the CHIC trial)

Leppa, S., Joergensen, J., Tierens, A., Ostlie, I., Fagerli, U. M., Brown, P. D. N., Larsen, T. S., Mannisto, S., Munksgaard, L., Maisenholder, M., Vasala, K., Meyer, P., Jerkeman, M., Bjorkholm, M., Fluge, O., Jyrkkio, S., Ralfkiaer, E., Spetalen, S., Karjalainen-Lindsberg, M-L. & Holte, H., 2 Dec 2016, In : Blood. 128, 22, 6 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Effects of a lifestyle intervention during pregnancy and 1-year postpartum - results from the RADIEL study

Huvinen, H., Koivusalo, S., Stach-Lempinen, B., Kautiainen, H. & Eriksson, J., 26 Feb 2016, In : Gynecological Endocrinology. 32, p. 161-161 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Electron and confocal microscopy of diabetic E1-DN mouse glomeruli revealed thickening of basement membrane and decreased nephrin expression

Dumont, V., Hyvonen, M. E., Lehtonen, E., Ustinov, J., Tienari, J., Otonkoski, T., Miettinen, P. J. & Lehtonen, S., Sep 2013, In : Diabetologia. 56, p. S478-S479 2 p.

Research output: Contribution to journalMeeting AbstractResearch

Eltrombopag Promotes Megakaryocyte Survival and Signaling in the Presence of Specific Cytotoxic Agents

Javarappa, K. K., Tsallos, D., Zagidullin, B., Saad, J., Tang, J., Ramos, P. M., Pallaud, C. & Heckman, C. A., 2018, In : Blood. 132

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Enantiospecific Pharmacogenomics of Fluvastatin

Hirvensalo, P., Tornio, A., Neuvonen, M., Kiander, W., Kidron, H., Paile-Hyvärinen, M., Tapaninen, T., Backman, J. & Niemi, M., May 2018, In : Basic & Clinical Pharmacology & Toxicology. 123, p. 7-7 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Exon-Based Transcriptome Profiling Reveals Genes That Have Prognostic Impact on the Survival of Young High Risk Diffuse Large B-Cell/Follicular Grade 3 Lymphoma Patients Treated with Dose-Dense Chemoimmuno-therapy and CNS Prophylaxis. Results From a Nordic Lymphoma Group Phase II Study.

Koivula, S., Taskinen, M., Chen, P., Holte, H., Delabie, J., Karjalainen-Lindsberg, M-L., Bjorkholm, M., Fluge, O., Pedersen, L. M., Jerkeman, M., Eriksson, M., Hautaniemi, S. & Leppa, S., 19 Nov 2010, In : Blood. 116, 21, p. 1281-1281 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Exploration of tissue morphologies in breast cancer samples using unsupervised machine learning

Turkki, R., Bychkov, D., Linder, N., Isola, J., Joensuu, H. T. & Lundin, J., 1 Jul 2017, In : Cancer Research. 77, 13 Supplement, p. 673 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Fluoroquinolone-Related Adverse Events Resulting In Health Care Use And Costs: A Systematic Review

Kuula, L. SM., Viljemaa, K. M., Backman, J. T. & Blom, M. L. J., Oct 2017, In : Value in Health. 20, p. A669-A670 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

GDNF CONTROLS URETER LENGTH BY REGULATING COLLECTING DUCT PROGENITOR EXPANSION

Li, H., Jakobson, M., Ola, R., Sariola, H., Andressoo, J. & Kuure, S., Sep 2017, In : Pediatric Nephrology. 32, 9, p. 1651-1651 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Genetic Prediction of Type 2 Diabetes: A Meta-Analysis of Prospective Studies of 62,264 Individuals

Engage European Network Genetic, Jul 2013, In : Diabetes. 62, p. A32-A32 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

GENETICS OF HUMAN PLASMA LIPIDOME AND ITS LINK TO DISEASES SUSCEPTIBILITY

SK Serv, T FinnGen Project, Tabassum, R., Rämö, J. T., Ripatti, P., Koskela, J. T., Kurki, M., Karjalainen, J., Palta, P., Hassan, S., Nunez-Fontarnau, J., Kiiskinen, T. T. J., Soderlund, S., Matikainen, N., Laivuori, H., Havulinna, A. S., Salomaa, V., Pirinen, M., Jauhiainen, M., Daly, M. J. & 3 others, Palotie, A., Taskinen, M. R. & Ripatti, S., Aug 2019, In : Atherosclerosis. 287, p. E14-E15 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Genome-Wide Association Analysis of Canine Retinal Dysplasia and Vitreous Degeneration

Ahonen, S. & Lohi, H., Jun 2013, In : Investigative Ophthalmology & Visual Science. 54, 15, 2 p.

Research output: Contribution to journalMeeting AbstractResearch

Global Profiling Of Outcome Associated Alternative Splicing Events and Gene Expression In Diffuse Large B-Cell Lymphoma

Taskinen, M., Chen, P., Karjalainen-Lindsberg, M-L., Cervera, A., Delabie, J., Holte, H., Hautaniemi, S. & Leppae, S., 15 Nov 2013, In : Blood. 122, 21, 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Haptoglobin Hp2 Variant Associates With an Increased Risk of Ischemic Cardiovascular Death After First-ever Stroke.

Ijas, P., Melkas, S., Saksi, J., Jula, A., Jauhiainen, M., Pohjasvaara, T., Kaste, M., Karhunen, P. J., Lindsberg, P. & Erkinjuntti, T., Feb 2016, In : Stroke. 47, 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Hereditary cataract in Bichon Frise dogs: Genome-wide association study suggests a new preliminary locus finding

Kaukonen, M. K., Ahonen, S. J. & Lohi, H., Apr 2014, In : Investigative Ophthalmology & Visual Science. 55, 13, 2 p.

Research output: Contribution to journalMeeting AbstractResearch

High Amount of PD-L1+Tumor Associated Macrophages Is Associated with Better Survival in Patients with Primary Testicular Lymphoma

Pollari, M., Bruck, O., Leivonen, S-K., Pellinen, T., Vahamurto, P., Karjalainen-Lindsberg, M-L., Mannisto, S., Kellokumpu-Lehtinen, P-L., Mustjoki, S. & Leppa, S., 7 Dec 2017, In : Blood. 130, Suppl 1, p. Meeting Abstract: 2761 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

High-throughput drug screening and molecular profiling for therapeutic targeting of NUP98-NSD1-positive AML

Kontro, M. P., Pemovska, T., Heckman, C. A., Kallioniemi, O-P., Wennerberg, J. K. & Porkka, K. V. K., Feb 2013, In : Annals of Hematology. 92, Supplement 1, p. S18

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Homology between cancer and viral epitopes as criteria to design improved cancer vaccines

Capasso, C., Whalley, T., Marwah, V. S., Serafin, A., Fusciello, M., Feola, S., Martins, B., Greco, D., Szomolay, B. & Cerullo, V., Dec 2017, In : Annals of Oncology. 28, 1 p., 63P.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Hunting new anxiety genes with the help of man's best friend, the dog

Hakosalo, O., Tiira, K., James, F., Jokinen, T., Sarviaho, R., Sillanpaa, M., Kere, J. & Lohi, H., 2014, In : International Journal of Molecular Medicine. 34, p. S88-S88 1 p.

Research output: Contribution to journalMeeting AbstractResearch

Hyperglycaemic E1-DN mice develop albuminuria and glomerular injury

Hyvonen, M. E., Ustinov, J., Otonkoski, T., Miettinen, P. J. & Lehtonen, S., Sep 2011, In : Diabetologia. 54, p. S432-S432 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Identification of Novel Candidate Genes in Canine Noise Phobia - A Model for Human Phobias

Hakosalo, O., Tiira, K., Sarviaho, R., Sillanpaa, M., Kere, J. & Lohi, H., 1 May 2015, In : Biological Psychiatry. 77, 9, p. 80S-81S 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Identification of Novel Germline Variants in Early-Onset Familial Classical Hodgkin Lymphoma with Exome Sequencing

Kilpivaara, O., Ristolainen, H., Kamper, P., Taskinen, M., Saarinen, S., Leppa, S., d'Amore, F. & Lauri, A. A., 6 Dec 2014, In : Blood. 124, 21, p. 4402 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Immune cell profiling in CML bone marrow by multiplex IHC

Bruck, O., Blom, S., Turkki, R., Kovanen, P., Ribeiro, A., Linder, N., Lundin, J., Kallioniemi, O., Pellinen, T. & Mustjoki, S., Nov 2016, In : Annals of Oncology. 27, 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Immune Cell Profiling in CML Bone Marrow By Multiplex Immunohistochemistry

Oscar, B., Blom, S., Turkki, R., Kovanen, P. E., Ribeiro, A., Linder, N., Lundin, J., Kallioniemi, O., Pellinen, T. & Mustjoki, S., 2 Dec 2016, In : Blood. 128, 22, 4 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

IMMUNOLOGICAL CHARACTERIZATION OF PH plus ALL BONE MARROW BY MULTIPLEX IMMUNOHISTOCHEMISTRY

Hohtari, H., Bruck, O., Blom, S., Turkki, R., Ribeiro, A., Sinisalo, M., Kovanen, P., Kallioniemi, O., Pellinen, T., Porkka, K. & Mustjoki, S., 26 Jun 2017, In : Haematologica. 102, p. 654-654 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review