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Publications 1966 2019

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2019

1-Hour Post-OGTT Glucose Improves the Early Prediction of Type 2 Diabetes by Clinical and Metabolic Markers

Peddinti, G., Bergman, M., Tuomi, T. & Groop, L., Apr 2019, In : Journal of Clinical Endocrinology and Metabolism. 104, 4, p. 1131-1140 10 p.

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A Bifidobacterial pilus-associated protein promotes colonic epithelial proliferation

Motherway, M. OC., Houston, A., O'Callaghan, G., Reunanen, J., O'Brien, F., O'Driscoll, T., Casey, P. G., de Vos, W. M., van Sinderen, D. & Shanahan, F., Jan 2019, In : Molecular Microbiology. 111, 1, p. 287-301 15 p.

Research output: Contribution to journalArticleScientificpeer-review

A catalog of genetic loci associated with kidney function from analyses of a million individuals

LifeLines Cohort Study, Wuttke, M., Li, Y., Li, M., Mishra, P. P., Perola, M., Kuokkanen, M., Hutri-Kähönen, N., Kähönen, M., Nikus, K., Kastarinen, M., Kuusisto, J., Laakso, M., Salomaa, V., Lehtimäki, T., Mononen, N., Lyytikäinen, L-P. & Raitakari, O. T., Jun 2019, In : Nature Genetics. 51, 6, p. 957-+ 19 p.

Research output: Contribution to journalArticleScientificpeer-review

A comparative map of macroautophagy and mitophagy in the vertebrate eye

McWilliams, T., Alan R., P., Villarejo-Zori, B., Ball, G., Boya, P. & Ganley, I. G., 21 Feb 2019, In : Autophagy. p. 1 13 p.

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A comprehensive screening of copy number variability in dementia with Lewy bodies

Kun-Rodrigues, C., Orme, T., Carmona, S., Hernandez, D. G., Ross, O. A., Eicher, J. D., Shepherd, C., Parkkinen, L., Darwent, L., Heckman, M. G., Scholz, S. W., Troncoso, J. C., Pletnikova, O., Dawson, T., Rosenthal, L., Ansorge, O., Clarimonm, J., Lleo, A., Morenas-Rodriguez, E., Clark, L. & 48 othersHonig, L. S., Marder, K., Lemstra, A., Rogaeva, E., St George-Hyslop, P., Londos, E., Zetterberg, H., Barber, I., Braae, A., Brown, K., Morgan, K., Troakes, C., Al-Sarraj, S., Lashley, T., Holton, J., Compta, Y., Van Deerlin, V., Serrano, G. E., Beach, T. G., Lesage, S., Galasko, D., Masliah, E., Santana, I., Pastor, P., Diez-Fairen, M., Aguilar, M., Tienari, P. J., Myllykangas, L., Oinas, M., Revesz, T., Lees, A., Boeve, B. F., Petersen, R. C., Ferman, T. J., Escott-Price, V., Graff-Radford, N., Cairns, N. J., Morris, J. C., Pickering-Brown, S., Mann, D., Halliday, G. M., Hardy, J., Trojanowski, J. Q., Dickson, D. W., Singleton, A., Stone, D. J., Guerreiro, R. & Bras, J., Mar 2019, In : Neurobiology of Aging. 75, 10 p., ARTN 223.e1.

Research output: Contribution to journalArticleScientificpeer-review

A distinctive DNA methylation pattern in insufficient sleep

Lahtinen, A., Puttonen, S., Vanttola, P., Viitasalo, K., Sulkava, S., Pervjakova, N., Joensuu, A., Salo, P., Toivola, A., Härmä, M., Milani, L., Perola, M. & Paunio, T., 4 Feb 2019, In : Scientific Reports. 9, 9 p., 1193.

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A High Prevalence of Gastrointestinal Manifestations in Common Variable Immunodeficiency

Pikkarainen, S., Martelius, T., Ristimäki, A., Siitonen, S., Seppanen, M. R. J. & Färkkilä, M., Apr 2019, In : American Journal of Gastroenterology. 114, 4, p. 648-655 8 p.

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A Joint Modeling Approach for Childhood Meat, Fish and Egg Consumption and the Risk of Advanced Islet Autoimmunity

Syrjälä, E., Nevalainen, J., Peltonen, J., Takkinen, H-M., Hakola, L., Åkerlund, M., Veijola, R., Ilonen, J., Toppari, J., Knip, M. & Virtanen, S. M., 23 May 2019, In : Scientific Reports. 9, 10 p., 7760.

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Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1(-/7) mice

van der Lugt, B., van Beek, A. A., Aalvink, S., Meijer, B., Sovran, B., Vermeij, W. P., Brandt, R. M. C., de Vos, W. M., Savelkoul, H. F. J., Steegenga, W. T. & Belzer, C., 8 Mar 2019, In : Immunity & Ageing. 16, 17 p., 6.

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Alcohol use and personality trait change: pooled analysis of six cohort studies

Hakulinen, C. & Jokela, M., Jan 2019, In : Psychological Medicine. 49, 2, p. 224-231 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy

Rajendran, J., Purhonen, J., Tegelberg, S., Smolander, O-P., Mörgelin, M., Rozman, J., Gailus-Durner, V., Fuchs, H., de Angelis, M. H., Auvinen, P., Mervaala, E., Jacobs, H. T., Szibor, M., Fellman, V. & Kallijärvi, J., Jan 2019, In : EMBO molecular medicine. 11, 1, 19 p., 9456.

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A multiethnic meta-analysis defined the association of rs12946942 with severe adolescent idiopathic scoliosis

Japan Scoliosis Clinical Res Grp, Takeda, K., Kou, I., Otomo, N., Einarsdottir, E., Kere, J. & Yagi, M., May 2019, In : Journal of Human Genetics. 64, 5, p. 493-498 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Anagrelide for Gastrointestinal Stromal Tumor

Pulkka, O-P., Gebreyohannes, Y. K., Wozniak, A., Mpindi, J-P., Tynninen, O., Icay, K., Cervera, A., Keskitalo, S., Murumägi, A., Kulesskiy, E., Laaksonen, M., Wennerberg, K., Varjosalo, M., Laakkonen, P., Lehtonen, R., Hautaniemi, S., Kallioniemi, O., Schöffski, P., Sihto, H. & Joensuu, H., 1 Mar 2019, In : Clinical Cancer Research. 25, 5, p. 1676-1687 12 p.

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A nebulin super-repeat panel reveals stronger actin binding toward the ends of the super-repeat region

Laitila, J., Lehtonen, J., Lehtokari, V-L., Sagath, L., Wallgren-Pettersson, C., Grönholm, M. & Pelin, K., Jan 2019, In : Muscle & Nerve. 59, 1, p. 116-121 6 p.

Research output: Contribution to journalArticleScientificpeer-review

An Ex Vivo Tissue Culture Model for Fibrovascular Complications in Proliferative Diabetic Retinopathy

Gucciardo, E., Loukovaara, S., Korhonen, A. & Lehti, K., Jan 2019, In : Journal of Visualized Experiments. 143, 9 p., 59090.

Research output: Contribution to journalArticleScientificpeer-review

A novel KRT71 variant in curly-coated dogs

Salmela, E., Niskanen, J., Arumilli, M., Donner, J., Lohi, H. & Hytönen, M. K., Feb 2019, In : Animal Genetics. 50, 1, p. 101-104 4 p.

Research output: Contribution to journalArticleScientificpeer-review

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria

Ahluwalia, T. S., Schulz, C-A., Waage, J., Skaaby, T., Sandholm, N., van Zuydam, N., Charmet, R., Bork-Jensen, J., Almgren, P., Thuesen, B. H., Bedin, M., Brandslund, I., Christensen, C. K., Linneberg, A., Ahlqvist, E., Groop, P-H., Hadjadj, S., Tregouet, D-A., Jorgensen, M. E., Grarup, N. & 9 othersPedersen, O., Simons, M., Groop, L., Orho-Melander, M., McCarthy, M. I., Melander, O., Rossing, P., Kilpeläinen, T. O. & Hansen, T., Feb 2019, In : Diabetologia. 62, 2, p. 292-305 14 p.

Research output: Contribution to journalArticleScientificpeer-review

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A Proposal to Revise the Histopathologic Grading System of Early Oral Tongue Cancer Incorporating Tumor Budding

Elseragy, A., Salo, T., Coletta, R. D., Kowalski, L. P., Haglund, C., Nieminen, P., Mäkitie, A. A., Leivo, I. & Almangush, A., May 2019, In : American Journal of Surgical Pathology. 43, 5, p. 703-709 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

PRACTICAl Consortium, Law, P. J., Timofeeva, M., Fernandez-Rozadilla, C., Palin, K., Hänninen, U. A., Cajuso, T., Tanskanen, T., Kondelin, J., Kaasinen, E., Sarin, A-P., Eriksson, J. G., Jousilahti, P., Ripatti, S., Palotie, A., Renkonen-Sinisalo, L., Lepistö, A., Aaltonen, L. A., Rissanen, H., Salomaa, V. & 3 othersBöhm, J., Mecklin, J-P. & Pukkala, E., 14 May 2019, In : Nature Communications. 10, 15 p., 2154.

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Association between dog ownership and type 2 diabetes in later life: the Helsinki birth cohort study

Laine, M. K., Wasenius, N. S., Lohi, H., Simonen, M., Tiira, K., Eriksson, J. G. & Salonen, M. K., 1 Jan 2019, In : International Journal of Circumpolar Health. 78, 1, 6 p., 1611328.

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Associations of increased physical performance and change in body composition with molecular pathways of heart disease and diabetes risk

Kettunen, J., Joensuu, A., Hagnäs, M., Mikkola, I., Wennerström, A., Lee, J. H., Terwilliger, J. D., Borodulin, K., Jousilahti, P., Jauhiainen, M., Jokelainen, J. J., Keinänen-Kiukaanniemi, S. & Perola, M., Feb 2019, In : American Journal of Physiology: Endocrinology and Metabolism. 316, 2, p. E221-E229 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Astroprincin (FAM171A1, C10orf38): A regulator of human cell shape and invasive growth

Rasila, T., Saavalainen, O., Attalla, H., Lankila, P., Haglund, C., Hölttä, E. & Andersson, L. C., Jan 2019, In : The American Journal of Pathology. 189, 1, p. 177-189 13 p.

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A urinary biosignature for mitochondrial myopathy, encephalopathy, lactic acidosis and stroke like episodes (MELAS)

Esterhuizen, K., Lindeque, J. Z., Mason, S., van der Westhuizen, F. H., Suomalainen, A., Hakonen, A. H., Carroll, C. J., Rodenburg, R. J., de Laat, P. B., Janssen, M. C. H., Smeitink, J. A. M. & Louw, R., Mar 2019, In : Mitochondrion. 45, p. 38-45 8 p.

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A variant in MRPS14 (uS14m) causes perinatal hypertrophic cardiomyopathy with neonatal lactic acidosis, growth retardation, dysmorphic features and neurological involvement

Jackson, C. B., Huemer, M., Bolognini, R., Martin, F., Szinnai, G., Donner, B. C., Richter, U., Battersby, B. J., Nuoffer, J-M., Suomalainen, A. & Schaller, A., 15 Feb 2019, In : Human Molecular Genetics. 28, 4, p. 639-649 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Biohybrid Vaccines for Improved Treatment of Aggressive Melanoma with Checkpoint Inhibitor

Fontana, F., Fusciello, M., Groeneveldt, C., Capasso, C., Chiaro, J., Feola, S., Liu, Z., Mäkilä, E., Salonen, J., Hirvonen, J., Cerullo, V. & Santos, H. A., Jun 2019, In : ACS Nano. 13, 6, p. 6477-6490 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Biomarker panels associated with progression of renal disease in type 1 diabetes

Colombo, M., Valo, E., McGurnaghan, S. J., Sandholm, N., Blackbourn, L. A. K., Dalton, R. N., Dunger, D., Groop, P-H., McKeigue, P. M., Forsblom, C., Colhoun, H. M. & Collaboration, O. B. O. T. F. S. G. A. T. S. D. R. N. SDRN. T. . B., 20 Jun 2019, In : Diabetologia. 62, 9, p. 1616-1627 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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BRAF immunohistochemistry predicts sentinel lymph node involvement in intermediate thickness melanomas

Manninen, A. A., Gardberg, M., Juteau, S., Ilmonen, S., Jukonen, J., Andersson, N. & Carpen, O., 30 Apr 2019, In : PLoS One. 14, 4, 13 p., 0216043.

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BRAF V600E expression in ameloblastomas-A 36-patient cohort from Helsinki University Hospital

Kelppe, J., Thoren, H., Ristimäki, A., Haglund, C., Sorsa, T. & Hagström, J., May 2019, In : Oral Diseases. 25, 4, p. 1169-1174 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Breast cancer outcome prediction with tumour tissue images and machine learning

Turkki, R., Byckhov, D., Lundin, M., Isola, J., Nordling, S., Kovanen, P. E., Verrill, C., von Smitten, K., Joensuu, H., Lundin, J. & Linder, N., 22 May 2019, In : Breast Cancer Research and Treatment. 177, 1, p. 41-52 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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Breed-specific reference ranges for standard echocardiographic measurements in salukis

Giraut, S., Häggström, J., Koskinen, L. L. E., Lohi, H. & Wiberg, M., Jun 2019, In : Journal of Small Animal Practice. 60, 6, p. 374-378 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Candidate susceptibility variants in angioimmunoblastic T-cell lymphoma

Donner, I., Katainen, R., Kaasinen, E., Aavikko, M., Sipilä, L. J., Pukkala, E. & Aaltonen, L. A., Jan 2019, In : Familial Cancer. 18, 1, p. 113-119 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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Canine models of human amelogenesis imperfecta: identification of novel recessive ENAM and ACP4 variants

Hytönen, M. K., Arumilli, M., Sarkiala, E., Nieminen, P. & Lohi, H., May 2019, In : Human Genetics. 138, 5, p. 525-533 9 p.

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Characterization of an X-chromosome-linked telomere biology disorder in females with DKC1 mutation

Hirvonen, E. A. M., Peuhkuri, S., Norberg, A., Degerman, S., Hannula-Jouppi, K., Välimaa, H., Kilpivaara, O. & Wartiovaara-Kautto, U., Jan 2019, In : Leukemia. 33, 1, p. 275-278 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Characterization of vB_ApiM_fHyAci03, a novel lytic bacteriophage that infects clinical Acinetobacter strains

Pulkkinen, E., Wicklund, A., Oduor, J. M. O., Skurnik, M. & Kiljunen, S., Aug 2019, In : Archives of Virology. 164, 8, p. 2197-2199 3 p.

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Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study

PRACTICAl Consortium, Adams, C. D., Richmond, R., Ferreira, D. L. S., Wurtz, P. & Penney, K. L., Jan 2019, In : Cancer Epidemiology, Biomarkers & Prevention. 28, 1, p. 208-216 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Clinical and MRI Features of Cerebral Small-Vessel Disease in Type 1 Diabetes

Thorn, L. M., Shams, S., Gordin, D., Liebkind, R., Forsblom, C., Summanen, P., Hägg-Holmberg, S., Tatlisumak, T., Salonen, O., Putaala, J., Martola, J. & Groop, P-H., 1 Feb 2019, In : Diabetes Care. 42, 2, p. 327-330 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Clinical features and outcome of the patients with sinonasal tract diffuse large B-cell lymphoma in the pre-rituximab and rituximab eras

Vähämurto, P., Mannisto, S., Pollari, M., Karjalainen-Lindsberg, M-L., Mäkitie, A. A. & Leppä, S., Jun 2019, In : European Journal of Haematology. 102, 6, p. 457-464 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Combined epithelial marker analysis of tumour budding in stage II colorectal cancer

Slik, K., Blom, S., Turkki, R., Välimäki, K., Kurki, S., Mustonen, H., Haglund, C., Carpén, O., Kallioniemi, O., Korkeila, E., Sundström, J. & Pellinen, T., Jan 2019, In : The Journal of Pathology: Clinical Research. 5, 1, p. 63-78 16 p.

Research output: Contribution to journalArticleScientificpeer-review

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Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes

Lamichhane, S., Ahonen, L., Dyrlund, T. S., Dickens, A. M., Siljander, H., Hyöty, H., Ilonen, J., Toppari, J., Veijola, R., Hyötyläinen, T., Knip, M. & Oresic, M., Jan 2019, In : Biomolecules. 9, 1, 9 p., 33.

Research output: Contribution to journalArticleScientificpeer-review

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Cortical Excitability and Activation of TrkB Signaling During Rebound Slow Oscillations Are Critical for Rapid Antidepressant Responses

Kohtala, H. S., Theilmann, W., Rosenholm, M., Penna, L., Karabulut, G., Uusitalo, S., Järventausta, K., Yli-Hankala, A., Yalcin, I., Matsui, N., Wigren, H-K. & Rantamäki, T., Jun 2019, In : Molecular Neurobiology. 56, 6, p. 4163-4174 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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CRISPR-Cas9 interrogation of a putative fetal globin repressor in human erythroid cells

Chung, J. E., Magis, W., Vu, J., Heo, S-J., Wartiovaara, K., Walters, M. C., Kurita, R., Nakamura, Y., Boffelli, D., Martin, D. I. K., Corn, J. E. & Dewitt, M. A., 15 Jan 2019, In : PLoS One. 14, 1, 17 p., 0208237.

Research output: Contribution to journalArticleScientificpeer-review

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Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8

Kahma, H., Filppula, A. M., Launiainen, T., Viinamäki, J., Neuvonen, M., Evangelista, E. A., Totah, R. A. & Backman, J. T., 1 Apr 2019, In : Drug Metabolism and Disposition. 47, 4, p. 436-443 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Crosstalk Between Chaperone-Mediated Protein Disaggregation and Proteolytic Pathways in Aging and Disease

Feleciano, D. R., Juenemann, K., Iburg, M., Bras, I. C., Holmberg, C. & Kirstein, J., 29 Jan 2019, In : Frontiers in aging neuroscience. 11, 16 p., 9.

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