Sanna Lehtonen research group

  • Haartmaninkatu 3, B241

    00014 Helsingin yliopisto

Publications 1998 2019

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2019

Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity

Polianskyte-Prause, Z., Tolvanen, T. A., Lindfors, S., Dumont, V., Van, M., Wang, H., Dash, S. N., Berg, M., Naams, J-B., Hautala, L. C., Nisen, H., Mirtti, T., Groop, P-H., Wähälä, K., Tienari, J. & Lehtonen, S., Feb 2019, In : FASEB Journal. 33, 2, p. 2858-2869 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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2017

Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis

Saurus, P., Tolvanen, T. A., Lindfors, S., Kuusela, S., Holthofer, H., Lehtonen, E. & Lehtonen, S., 6 Sep 2017, In : Scientific Reports. 7, 14 p., 10731.

Research output: Contribution to journalArticleScientificpeer-review

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PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease

Dumont, V., Tolvanen, T. A., Kuusela, S., Wang, H., Nyman, T. A., Lindfors, S., Tienari, J., Nisén, H., Suetsugu, S., Plomann, M., Kawachi, H. & Lehtonen, S., Sep 2017, In : FASEB Journal. 31, 18 p.

Research output: Contribution to journalArticleScientificpeer-review

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Sept7b is required for the subcellular organization of cardiomyocytes and cardiac function in zebrafish

Dash, S. N., Narumanchi, S., Paavola, J., Perttunen, S., Wang, H., Lakkisto, P. J., Tikkanen, I. T. & Lehtonen, S. H., May 2017, In : American Journal of Physiology: Heart and Circulatory Physiology. 312, 5, p. H1085-H1095 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Septin 7 reduces nonmuscle myosin IIA activity in the SNAP23 complex and hinders GLUT4 storage vesicle docking and fusion

Wasik, A., Dumont, V., Tienari, J-P., Nyman, T. A., Fogarty, C., Forsblom, C., Lehto, M., Lehtonen, E., Groop, P-H. & Lehtonen, S., 15 Jan 2017, In : Experimental Cell Research. 350, 2, p. 336-348 13 p.

Research output: Contribution to journalArticleScientificpeer-review

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Sticklebacks adapted to divergent osmotic environments show differences in plasticity for kidney morphology and candidate gene expression

Hasan, M. M., De Faveri, J., Kuure, S., Dash, S. N., Lehtonen, S., Merila, J. & McCairns, R. J. S., 15 Jun 2017, In : Journal of Experimental Biology. 220, 12, p. 2175-2186 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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2016

Cu-Catalyzed ligand-free synthesis of rosuvastatin based novel indole derivatives as potential anticancer agents

Kumar, K. S., Rajesham, B., Ramulu, M. S., Bhaskar, B., Dash, S. N., Ashfaq, M. A., Nagarapu, R., Khan, A. A., Lehtonen, S. & Pal, M., 2016, In : RSC Advances. 6, 102, p. 100487-100493 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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Cyclin-dependent kinase 2 protects podocytes from apoptosis

Saurus, P., Kuusela, S., Dumont, V., Lehtonen, E., Fogarty, C. L., Lassenius, M. I., Forsblom, C., Lehto, M., Saleem, M. A., Groop, P-H. & Lehtonen, S., 15 Feb 2016, In : Scientific Reports. 6, 14 p., 21664.

Research output: Contribution to journalArticleScientificpeer-review

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Data supporting the regulation of FOXC2 in podocyte dysfunction

Datta, N., Lindfors, S., Miura, N., Saleem, M. A. & Lehtonen, S., 2016, In : Data in Brief. 6, p. 514 - 520 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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Nephrin Trafficking beyond the Kidney-Role in Glucose-Stimulated Insulin Secretion in beta Cells

Lehtonen, S. & Jalanko, H., Apr 2016, In : Journal of the American Society of Nephrology. 27, 4, p. 965-968 4 p.

Research output: Contribution to journalArticleScientific

Overexpression of transcription factor FOXC2 in cultured human podocytes upregulates injury markers and increases motility

Datta, N., Lindfors, S., Miura, N., Saleem, M. A. & Lehtonen, S., 1 Jan 2016, In : Experimental Cell Research. 340, 1, p. 32-42 11 p.

Research output: Contribution to journalArticleScientificpeer-review

sept7b is required for the differentiation of pancreatic endocrine progenitors

Dash, S., Hakonen, E., Ustinov, J., Otonkoski, T., Andersson, O. & Lehtonen, S., 26 Apr 2016, In : Scientific Reports. 6, 14 p., 24992.

Research output: Contribution to journalArticleScientificpeer-review

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Tankyrase inhibition aggravates kidney injury in the absence of CD2AP

Kuusela, S., Wang, H., Wasik, A., Suleiman, H. & Lehtonen, S., Jul 2016, In : Cell Death and Disease. 7, 13 p.

Research output: Contribution to journalArticleScientificpeer-review

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2015

Early-Onset Diabetic E1-DN Mice Develop Albuminuria and Glomerular Injury Typical of Diabetic Nephropathy

Hyvonen, M. E., Dumont, V., Tienari, J., Lehtonen, E., Ustinov, J., Havana, M., Jalanko, H., Otonkoski, T., Miettinen, P. J. & Lehtonen, S., 2015, In : BioMed Research International. 11 p., 102969.

Research output: Contribution to journalArticleScientificpeer-review

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Expression of toll-like receptors in HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma-an in vivo and in vitro study

Jouhi, L., Datta, N., Renkonen, S., Atula, T., Makitie, A., Haglund, C., Abdirisak, A., Syrjanen, S., Grenman, R., Auvinen, E., Lehtonen, S. & Hagstrom, J., Sep 2015, In : Tumor Biology. 36, 10, p. 7755-7764 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Lack of CD2AP disrupts Glut4 trafficking and attenuates glucose uptake in podocytes

Tolvanen, T., Dash, S. N., Polianskyte-Prause, Z., Dumont, V. & Lehtonen, S., 2015, In : Journal of Cell Science. 128, 24, p. 4588-4600 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway

Saurus, P., Kuusela, S., Lehtonen, E., Hyvönen, M. E., Ristola, M., Fogarty, C. L., Tienari, J., Lassenius, M. I., Forsblom, C., Lehto, M., Saleem, M. A., Groop, P-H., Holthofer, H. & Lehtonen, S., May 2015, In : Cell Death and Disease. 6, 12 p., 1752.

Research output: Contribution to journalArticleScientificpeer-review

Predictive role of toll-like receptors 2, 4, and 9 in oral tongue squamous cell carcinoma

Makinen, L. K., Atula, T., Häyry, J. H. V., Jouhi, L., Datta, N., Lehtonen, S., Abdirisak, A., Makitie, A. A., Haglund, C. & Hagstrom, J., Jan 2015, In : Oral Oncology. 51, 1, p. 96-102 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Tankyrases regulate glucoregulatory mechanisms and somatic growth via the central melanocortin system in zebrafish larvae

Wang, H., Semenova, S., Kuusela, S., Panula, P. & Lehtonen, S., Nov 2015, In : FASEB Journal. 29, 11, p. 4435-4448 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Ezrin Is Down-Regulated in Diabetic Kidney Glomeruli and Regulates Actin Reorganization and Glucose Uptake via GLUT1 in Cultured Podocytes

Wasik, A. A., Koskelainen, S., Hyvonen, M. E., Musante, L., Lehtonen, E., Koskenniemi, K., Tienari, J., Vaheri, A., Kerjaschki, D., Szalay, C., Revesz, C., Varmanen, P., Nyman, T. A., Hamar, P., Holthofer, H. & Lehtonen, S., Jun 2014, In : The American Journal of Pathology. 184, 6, p. 1727-1739 13 p.

Research output: Contribution to journalArticleScientificpeer-review

sept7b is essential for pronephric function and development of left-right asymmetry in zebrafish embryogenesis

Dash, S. N., Lehtonen, E., Wasik, A. A., Schepis, A., Paavola, J., Panula, P., Nelson, W. J. & Lehtonen, S., 1 Apr 2014, In : Journal of Cell Science. 127, 7, p. 1476-1486 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

CD2AP is associated with end-stage renal disease in patients with type 1 diabetes

Hyvönen, M. E., Ihalmo, P., Sandholm, N., Stavarachi, M., Forsblom, C., McKnight, A. J., Lajer, M., Maestroni, A., Lewis, G., Tarnow, L., Maestroni, S., Zerbini, G., Parving, H-H., Maxwell, A. P., Groop, P-H. & Lehtonen, S., Dec 2013, In : Acta Diabetologica. 50, 6, p. 887-897 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Regulation of nephrin gene by the Ets transcription factor, GA-binding protein

Ristola, M., Arpiainen, S., Shimokawa, T., Ra, C., Tienari, J-P., Saleem, M. A., Holthofer, H. & Lehtonen, S., Apr 2013, In : Nephrology, Dialysis, Transplantation. 28, 4, p. 846-855 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Report of the Second European Zebrafish Principal Investigator Meeting in Karlsruhe, Germany, March 21-24, 2012

Cavodeassi, F., Del Bene, F., Fuerthauer, M., Grabher, C., Herzog, W., Lehtonen, S., Linker, C., Mercader, N., Mikut, R., Norton, W., Straehle, U., Tiso, N. & Foulkes, N. S., Mar 2013, In : Zebrafish. 10, 1, p. 119-123 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

INPPL1 is associated with the metabolic syndrome in men with Type 1 diabetes, but not with diabetic nephropathy

Hyvonen, M. E., Ihalmo, P., Forsblom, C., Thorn, L., Sandholm, N., Lehtonen, S. & Groop, P. -H., Dec 2012, In : Diabetic Medicine. 29, 12, p. 1589-1595 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Neph3 associates with regulation of glomerular and neural development in zebrafish

Wang, H., Lehtonen, S., Chen, Y., Heikkilä, E. K., Panula, P. & Holthöfer, H., 2012, In : Differentiation. 83, p. 38-46 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking

Wasik, A. A., Polianskyte-Prause, Z., Dong, M-Q., Shaw, A. S., Yates, J. R., Farquhar, M. G. & Lehtonen, S., 1 Sep 2012, In : Molecular Biology of the Cell. 23, 17, p. 3370-3379 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Transcription of nephrin-Neph3 gene pair is synergistically activated by WT1 and NF-kappa B and silenced by DNA methylation

Ristola, M., Arpiainen, S., Saleem, M. A., Holthöfer, H. & Lehtonen, S., 2012, In : NDT Plus. 27, 5, p. 1737-1745 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia

Saarikangas, J., Mattila, P. K., Varjosalo, M., Bovellan, M., Hakanen, J., Calzada-Wack, J., Tost, M., Jennen, L., Rathkolb, B., Hans, W., Horsch, M., Hyvönen, M. E., Perälä, N., Fuchs, H., Gailus-Durner, V., Esposito, I., Wolf, E., de Angelis, M. H., Frilander, M. J., Savilahti, H. & 6 othersSariola, H., Sainio, K., Lehtonen, S., Taipale, J., Salminen, M. & Lappalainen, P., 2011, In : Journal of Cell Science. 124, 8, p. 1245-1255 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Trans-interaction of nephrin and Neph1/Neph3 induces cell adhesion that associates with decreased tyrosine phosphorylation of nephrin

Heikkilä, E. K., Ristola, M., Havana, M., Jones, N., Holthofer, H. & Lehtonen, S., 2011, In : Biochemical Journal. 435, Part 3, p. 619-628 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

beta-Catenin mediates adriamycin-induced albuminuria and podocyte injury in adult mouse kidneys

Heikkila, E., Juhila, J., Lassila, M., Messing, M., Perälä, N., Lehtonen, E., Lehtonen, S., Verbeek, J. S. & Holthofer, H., 2010, In : Nephrology, Dialysis, Transplantation. 25, 8, p. 2437-2446 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Lipid phosphatase SHIP2 downregulates insulin signalling in podocytes

Hyvönen, M. E., Saurus, P., Wasik, A., Heikkilä, E. K., Havana, M., Trokovic, R., Saleem, M., Holthöfer, H. & Lehtonen, S., 2010, In : Molecular and Cellular Endocrinology. 328, 1-2, p. 70-79 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Luentojen vuorovaikutteisuus motivoi opiskelijoita ja luennoitsijoita

Translated title of the contribution: Encouraging experiences of interactive lecturesLehtonen, S., Linden, A-M., Ojala, P. M., Polvi, A., Sallinen, V. & Viranta, S., 2009, In : Duodecim. 125, 20, p. 2199-2205 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Regulation of Neph3 gene in podocytes - key roles of transcription factors NF-kappaB and Sp1

Ristola, M., Arpiainen, S., Saleem, M. A., Mathieson, P. W., Welsh, G. I., Lehtonen, S. & Holthöfer, H., 2009, In : BMC Molecular Biology. 10, p. 83 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2004

Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin

Lehtonen, S., Lehtonen, S., Lehtonen, E., Kudlicka, K., Holthofer, H. & Farquhar, M. G., 2004, In : The American Journal of Pathology. 165, p. 923-936 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7

Lehto, M., Tienari, J., Lehtonen, S., Lehtonen, E. & Olkkonen, V. M., 2004, In : Cell and Tissue Research. 315, p. 39-57 19 p.

Research output: Contribution to journalArticleScientificpeer-review

2002

Interaction of endogenous nephrin and CD2-associated protein in mouse epithelial M-1 cell line

Palmen, T., Lehtonen, S., Ora, A., Kerjaschki, D., Antignac, C., Lehtonen, E. & Holthofer, H., 2002, In : Journal of the American Society of Nephrology. 13, p. - 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Nephrin TRAP mice lack slit diaphragms and show fibrotic glomeruli and cystic tubular lesions

Rantanen, M., Palmen, T., Patari, A., Ahola, H., Lehtonen, S., Astrom, E., Floss, T., Vauti, F., Wurst, W., Ruiz, P., Kerjaschki, D. & Holthofer, H., 2002, In : Journal of the American Society of Nephrology. 13, p. - 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2001

HMG-17 is an early marker of inductive interactions in the developing mouse kidney

Lehtonen, S. & Lehtonen, E., 2001, In : Differentiation. 67, p. 154-163 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2000

In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2

Lehtonen, S., Ora, A., Olkkonen, V. M., Geng, L., Zerial, M., Somlo, S. & Lehtonen, E., 2000, In : Journal of Biological Chemistry. 275, p. 32888-32893 6 p.

Research output: Contribution to journalArticleScientificpeer-review

1998

HMG-17, a chromosomal non-histone protein, shows developmental regulation during organogenesis

Lehtonen, S., Olkkonen, V. M., Stapleton, M., Zerial, M. & Lehtonen, E., 1998, In : International Journal of Developmental Biology. 42, p. 775-782 8 p.

Research output: Contribution to journalArticleScientificpeer-review