Tiina Sikanen / Chemical Microsystems Lab

  • PL 56 (Viikinkaari 5), Biocenter 2

    00014 HELSINGIN YLIOPISTO

    Finland

Publications 2011 2019

2019

Environmental drug load can be reduced

Nysten, T., Äystö, L., Laitinen, J., Mehtonen, J., Alhola, K., Leppänen, M. T., Perkola, N., Vieno, N., Sikanen, T., Yli-Kauhaluoma, J., Karlsson, S., Virtanen, V. & Teräsalmi, E., 17 May 2019, Helsinki: Finnish Environment Institute. 4 p. (SYKE Policy Brief: Views on Environmental Policy; no. 17.5.2019)

Research output: Book/ReportCommissioned reportProfessional

Open Access

Immobilization of proteolytic enzymes on replica-molded thiol-ene micropillar reactors via thiol-gold interaction

Tähkä, S., Sarfraz, J., Urvas, L., Provenzani, R., Wiedmer, S. K., Peltonen, J., Jokinen, V. & Sikanen, T., Apr 2019, In : Analytical and Bioanalytical Chemistry. 411, 11, p. 2339–2349 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Lääkeaineet lääketeollisuuden ympäristöluvissa

Äystö, L., Mehtonen, J., Vieno, N., Ahkola, H., Leppänen, M. T., Sikanen, T., Yli-Kauhaluoma, J. & Nystén, T., 3 May 2019, Helsinki: Finnish Environment Institute. 59 p. (Suomen ympäristökeskuksen raportteja; no. 20)

Research output: Book/ReportCommissioned reportProfessional

Open Access

Lääkeaineiden ympäristöluokittelun käyttöönoton mahdollisuudet Suomessa

Vieno, N., Karlsson, S., Äystö, L., Mehtonen, J., Sikanen, T., Kärkkäinen, R., Yli-Kauhaluoma, J. & Nystén, T., 9 May 2019, Helsinki: Finnish Environment Institute. 37 p. (Suomen ympäristökeskuksen raportteja; no. 19)

Research output: Book/ReportCommissioned reportProfessional

Open Access

Overcoming the Pitfalls of Cytochrome P450 Immobilization Through the Use of Fusogenic Liposomes

Kiiski, I. M. A., Pihlaja, T. L. M., Urvas, L. M., Wiedmer, S. K., Witos, J. M., Jokinen, V. P. & Sikanen, T. M., Jan 2019, In : Advanced Biosystems. 3, 1, 6 p., 1800245.

Research output: Contribution to journalArticleScientificpeer-review

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Open Access
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Sustainable Drug Discovery and Development: SUDDEN Project (ORGN 141 & Sci-Mix)

Karlsson, S., Kauppi, S., Kärkkäinen, R., Lundström, M., Martikainen, J., Miettinen, M., Mänttäri, M., Sikanen, T., Sokero, M., Xhaard, H. & Yli-Kauhaluoma, J., 2019.

Research output: Conference materialsPosterResearchpeer-review

Ympäristöön päätyvää lääkekuormaa voidaan vähentää

Nysten, T., Äystö, L., Laitinen, J., Mehtonen, J., Alhola, K., Leppänen, M. T., Perkola, N., Vieno, N., Sikanen, T., Yli-Kauhaluoma, J., Karlsson, S., Virtanen, V. & Teräsalmi, E., 17 May 2019, Helsinki: Finnish Environment Institute. 4 p. (SYKE Policy Brief: Näkökulmia ympäristöpolitiikkaan; no. 17.5.2019)

Research output: Book/ReportCommissioned reportProfessional

Open Access
2018

Advances in Optics and Integration Possibilities of 3D Printed Methacrylate Microdevices

Haapala, M. J., Nordman, N. M., Kostiainen, R. K. & Sikanen, T. M., 24 Sep 2018.

Research output: Conference materialsAbstractResearchpeer-review

Capillary Isoelectric Focusing on 3D Printed Methacrylate Microchips

Haapala, M. J., Nordman, N. M., Kostiainen, R. K. & Sikanen, T. M., 14 May 2018.

Research output: Conference materialsAbstractResearch

Fabrication of Concave Microwells via Single Step lithography of Organically Modified Ceramics

Bonabi, A., Jokinen, V. & Sikanen, T. M., 19 May 2018, p. 59. 1 p.

Research output: Conference materialsAbstractResearchpeer-review

Immobilization of Membrane-Bound Enzymes on Micropillar Arrays via Fusogenic Liposomes

Kiiski, I. M. A., Pihlaja, T. L. M., Urvas, L. M., Jokinen, V. P. & Sikanen, T. M., 11 Nov 2018, p. 2121-2123. 3 p.

Research output: Conference materialsAbstractResearchpeer-review

Interfacing Digital Microfluidics with Ambient Mass Spectrometry Using SU-8 as Dielectric Layer

Sathyanarayanan, G., Haapala, M. & Sikanen, T., Dec 2018, In : Micromachines. 9, 12, 15 p., 649.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Microfluidic Lateral Flow Cytochrome P450 Assay on a Novel Printed Functionalized Calcium Carbonate-Based Platform for Rapid Screening of Human Xenobiotic Metabolism

Jutila, E., Koivunen, R., Kiiski, I., Bollström, R., Sikanen, T. & Gane, P., 1 Aug 2018, In : Advanced Functional Materials. 28, 31, 11 p., 1802793.

Research output: Contribution to journalArticleScientificpeer-review

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2017

Analysis of morphine from mouse plasma by microchip electrophoresis-electrochemical detection

Ollikainen, A. E. K., Koburg, M., Aitta-aho, T. H. J., Kostiainen, R. K. & Sikanen, T. M., 22 Jun 2017.

Research output: Conference materialsPosterResearchpeer-review

Core/Shell Nanocomposites Produced by Superfast Sequential Microfluidic Nanoprecipitation

Liu, D., Zhang, H., Cito, S., Fan, J., Mäkilä, E., Salonen, J., Hirvonen, J., Sikanen, T. M., Weitz, D. A. & Santos, H. A., Feb 2017, In : Nano Letters. 17, 2, p. 606-614 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Digital microfluidic enzyme reactor with integrated low-cost printed microheater

Sathyanarayanan, G., Haapala, M. J. & Sikanen, T. M., Sep 2017, p. 310. 1 p.

Research output: Conference materialsPosterResearch

Evaluation of the stability of cytochrome P450 immobilized enzyme microreactors

Pihlaja, T., 2017, Helsinki: Tea Pihlaja. 77 p.

Research output: ThesisMaster's thesisTheses

Fabrication of concave micromirrors for single cell imaging via controlled over-exposure of organically modified ceramics in single step lithography

Bonabi, A., Cito, S., Tammela, P., Jokinen, V. & Sikanen, T., May 2017, In : Biomicrofluidics. 11, 3, 11 p., 034118.

Research output: Contribution to journalArticleScientificpeer-review

Generation Green Incorporates Environmental Aspects to the Pharmaceutical Education and More

Sikanen, T. M. & Yli-Kauhaluoma, J. T., 2017, p. P-26.

Research output: Conference materialsPosterResearchpeer-review

The Impact of Porous Silicon Nanoparticles on Human Cytochrome P450 Metabolism in Human Liver Microsomes In Vitro

Ollikainen, E., Liu, D., Kallio, A., Mäkilä, E., Zhang, H., Salonen, J., Almeida Santos, H. & Sikanen, T. M., 15 Jun 2017, In : European Journal of Pharmaceutical Sciences. 104, p. 124–132 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Thiol-ene -based on-chip toxicity assays for chemical toxicity screening

Kiiski, I. M. A., Järvinen, P. P., Tähkä, S., Tammela, P. S. M., Jokinen, V. & Sikanen, T. M., 22 Oct 2017.

Research output: Conference materialsPosterResearchpeer-review

Thiol-ene micropillar array electrospray ionization platform for zeptomole level bioanalysis

Lipponen, K., Tähkä, S., Sikanen, T., Jokinen, V., Tatikonda, A., Franssila, S., Kostiainen, R. & Kotiaho, T., 21 Jul 2017, In : Analyst. 142, 14, p. 2552-2557 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Thiol-ene surface modifications for microchip electrophoresis based interaction assays

Tähkä, S., Batelic, L., Capasso, C., Wiedmer, S. K., Cerullo, V. & Sikanen, T. M., Oct 2017, p. 1535-1536. 2 p.

Research output: Conference materialsAbstractResearchpeer-review

TiO2 Photocatalysis-DESI-MS Rotating Array Platform for High-Throughput Investigation of Oxidation Reactions

Ruokolainen, M., Miikkulainen, V., Ritala, M., Sikanen, T., Kotiaho, T. & Kostiainen, R., 7 Nov 2017, In : Analytical Chemistry. 89, 21, p. 11214-11218 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Advances in Metallization Of Organically Modified Ceramics

Bonabi, A., Jokinen, V. & Sikanen, T. M., 2016, Proceedings of the 19th International Conference Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015). San Diego: Chemical and Biological Microsystems Society, p. 1445-1448 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Comparison of TiO2 photocatalysis, electrochemically assisted Fenton reaction and direct electrochemistry for simulation of phase I metabolism reactions of drugs

Ruokolainen, M., Gul, T., Permentier, H., Sikanen, T., Kostiainen, R. & Kotiaho, T., 15 Feb 2016, In : European Journal of Pharmaceutical Sciences. 83, p. 36-44 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Fabrication of thiol-ene based electrophoresis chips with fully integrated electrospray ionization emitter by replication

Tähkä, S. M., Bonabi, A., Jokinen, V. & Sikanen, T. M., 2016, Proceedings of the 19th International Conference Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015). Chemical and Biological Microsystems Society, p. 1758-1760 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Feasibility of Microchip Electrophoresis-Electrochemical Detection for Environmental Monitoring

Ollikainen, A. E. K., Lenic, I. & Sikanen, T. M., 2016, Proceedings of the 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015). San Diego: Chemical and Biological Microsystems Society, p. 2005-2007 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Immobilized cytochrome P450 microreactors with integrated heaters

Kiiski, I. M. A., Tähkä, S., Sathyanarayanan, G., Haapala, M., Jokinen, V. & Sikanen, T. M., 2016, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences 9-13 October, 2016, Dublin, Ireland. Chemical and Biological Miniaturisation Society, CBMS, p. 645-646 2 p. (Micro total analysis systems).

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Inkjet Printed Silver Electrodes on Macroporous Paper for a Paper-Based Isoelectric Focusing Device

Gaspar, C., Sikanen, T. M., Franssila, S. & Jokinen, V., 2016, In : Biomicrofluidics. 10, 6, 10 p., 064120.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Oxidation of Tyrosine-Phosphopeptides by Titanium Dioxide Photocatalysis

Ruokolainen, M., Ollikainen, E., Sikanen, T., Kotiaho, T. & Kostiainen, R., 22 Jun 2016, In : Journal of the American Chemical Society. 138, 24, p. 7452-7455 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Rapid separation of phosphopeptides by microchip electrophoresis-electrospray ionization mass spectrometry

Ollikainen, E., Bonabi, A., Nordman, N., Jokinen, V., Kotiaho, T., Kostiainen, R. & Sikanen, T., 1 Apr 2016, In : Journal of Chromatography. A. 1440, p. 249-254 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Reaction Platforms for Enzymatic Testing

Jutila, E., Koivunen, R., Bollström, R., Sikanen, T. & Gane, P., 2016, Advances in Printing and Media Technology: Proceedings of the 43rd International Research Conference of iarigai Toronto, Canada, August 2016. Gane, P. (ed.). Darmstadt: The International Association of Research Organizations for the Information, Media and Graphic Arts Industries (IARIGAI), Vol. 43. p. 39-49 10 p. (Advances in Printing and Media Technology; vol. 43).

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Thiol-ene based, replicated, high-aspect ratio micropillar arrays as immobilized chymotrypsin reactors

Tähkä, S., Provenzani, R., Boije af Gennäs, P. G., Yli-Kauhaluoma, J. T., Jokinen, V. & Sikanen, T. M., 2016, p. 1491-1492. 2 p.

Research output: Conference materialsPosterResearchpeer-review

Visualization of Local "Hot Spots" During Isoelectric Focusing on Chip by IR Thermography

Nordman, N., Haapala, M. J., Kostiainen, R. & Sikanen, T. M., Nov 2016.

Research output: Conference materialsPosterResearchpeer-review

Ympäristövaikutukset lääkkeen elinkaaressa

Sikanen, T., 2016, In : Sic! Lääketietoa Fimeasta. 6, 3, p. 37-39 3 p.

Research output: Contribution to journalArticleProfessional

Open Access
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2015

Interfacing microchip isoelectric focusing with on-chip electrospray ionization mass spectrometry

Nordman, N., Lauren, S., Kotiaho, T., Franssila, S., Kostiainen, R. & Sikanen, T., 12 Jun 2015, In : Journal of Chromatography. A. 1398, p. 121-126 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Kolumni: Vastuu ympäristöstä osaksi ammattitaitoa

Sikanen, T. M., Dec 2015, In : Suomen apteekkarilehti. 104, 6, p. 27 1 p.

Research output: Contribution to journalArticleProfessional

Simple microfluidic approach to fabricate monodisperse hollow microparticles for multidrug delivery

Vasiliauskas, R., Liu, D., Cito, S., Zhang, H., Shahbazi, M-A., Sikanen, T., Mazutis, L. & Santos, H. A., 15 Jul 2015, In : ACS Applied Materials & Interfaces. 7, 27, p. 14822-14832 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Thiol-ene microfluidic devices for microchip electrophoresis: Effects of curing conditions and monomer composition on surface properties

Tähkä, S. M., Bonabi, A., Nordberg, M-E., Kanerva, M., Jokinen, V. & Sikanen, T. M., 26 Nov 2015, In : Journal of Chromatography. A. 1426, p. 233-240

Research output: Contribution to journalArticleScientificpeer-review