Viral Zoonosis Research Unit

Publications

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2020

Anopheles daciae, a new country record for Finland

Culverwell, C. L., Vapalahti, O. P. & Harbach, R. E., Jun 2020, In : Medical & Veterinary Entomology. 34, 2, p. 145-150 6 p.

Research output: Contribution to journalArticleScientificpeer-review

A serological assay to detect SARS-CoV-2 seroconversion in humans

Amanat, F., Stadlbauer, D., Strohmeier, S., Nguyen, T. H. O., Chromikova, V., McMahon, M., Jiang, K., Arunkumar, G. A., Jurczyszak, D., Polanco, J., Bermudez-Gonzalez, M., Kleiner, G., Aydillo, T., Miorin, L., Fierer, D. S., Lugo, L. A., Kojic, E. M., Stoever, J., Liu, S. T. H., Cunningham-Rundles, C. & 10 others, Felgner, P. L., Moran, T., Garcia-Sastre, A., Caplivski, D., Cheng, A. C., Kedzierska, K., Vapalahti, O., Hepojoki, J. M., Simon, V. & Krammer, F., 12 May 2020, In : Nature Medicine. 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Comparison of Streptococcus halichoeri isolates from canine and fur animal infections: biochemical patterns, molecular characteristics and genetic relatedness

Eklund, M., Aaltonen, K., Sironen, T., Raunio-Saarnisto, M., Grönthal, T., Nordgren, H., Pitkälä, A., Vapalahti, O. & Rantala, M., 3 Jun 2020, In : Acta Veterinaria Scandinavica. 62, 1, 11 p., 26.

Research output: Contribution to journalArticleScientificpeer-review

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Detection of dengue virus type 2 of Indian origin in acute febrile patients in rural Kenya

Masika, M. M., Korhonen, E. M., Smura, T., Uusitalo, R., Vapalahti, K., Mwaengo, D., Jääskeläinen, A. J., Anzala, O., Vapalahti, O. & Huhtamo, E., 3 Mar 2020, In : PLoS Neglected Tropical Diseases. 14, 3, 17 p., 0008099.

Research output: Contribution to journalArticleScientificpeer-review

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Development and validation of nucleic acid tests to diagnose Aleutian mink disease virus

Virtanen, J., Aaltonen, K., Vapalahti, O. & Sironen, T., May 2020, In : Journal of Virological Methods. 279, 6 p., 113776.

Research output: Contribution to journalArticleScientificpeer-review

Differences in Tissue and Species Tropism of Reptarenavirus Species Studied by Vesicular Stomatitis Virus Pseudotypes

Korzyukov, Y., Iheozor-Ejiofor, R., Levanov, L., Smura, T., Hetzel, U., Szirovicza, L., de la Torre, J. C., Martinez-Sobrido, L., Kipar, A., Vapalahti, O. & Hepojoki, J., Apr 2020, In : Viruses. 12, 4, 16 p., 395.

Research output: Contribution to journalArticleScientificpeer-review

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First Report of Coronaviruses in Northern European Bats

Kivisto, I., Tidenberg, E-M., Lilley, T., Suominen, K., Forbes, K. M., Vapalahti, O., Huovilainen, A. & Sironen, T., 1 Feb 2020, In : Vector Borne and Zoonotic Diseases. 20, 2, p. 155-158 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Identification of Reptarenaviruses, Hartmaniviruses, and a Novel Chuvirus in Captive Native Brazilian Boa Constrictors with Boid Inclusion Body Disease

BIBD Grp, Argent, F. F., Hepojoki, J., Smura, T., Szirovicza, L., Hammerschmitt, M. E., Driemeier, D., Kipar, A. & Hetzel, U., Jun 2020, In : Journal of Virology. 94, 11, 19 p., e00001-20.

Research output: Contribution to journalArticleScientificpeer-review

Multi-laboratory evaluation of ReaScan TBE IgM rapid test, 2016 to 2017

Albinsson, B., Jääskeläinen, A. E., Värv, K., Jelovšek, M., GeurtsvanKessel, C., Vene, S., Järhult, J. D., Reusken, C., Golovljova, I., Avšič-Županc, T., Vapalahti, O. & Lundkvist, Å., 26 Mar 2020, In : Eurosurveillance. 25, 12, p. 27-36 10 p., 1900427.

Research output: Contribution to journalArticleScientificpeer-review

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Orthohantavirus Isolated in Reservoir Host Cells Displays Minimal Genetic Changes and Retains Wild-Type Infection Properties

Strandin, T., Smura, T., Ahola, P., Aaltonen, K., Sironen, T., Hepojoki, J., Eckerle, I., Ulrich, R. G., Vapalahti, O., Kipar, A. & Forbes, K. M., Apr 2020, In : Viruses. 12, 4, 14 p., 457.

Research output: Contribution to journalArticleScientificpeer-review

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Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020

Haveri, A., Smura, T., Kuivanen, S., Österlund, P., Hepojoki, J., Ikonen, N., Pitkäpaasi, M., Blomqvist, S., Rönkkö, E., Kantele, A., Strandin, T., Kallio-Kokko, H., Mannonen, L., Lappalainen, M., Broas, M., Jiang, M., Siira, L., Salminen, M., Puumalainen, T., Sane, J. & 3 others, Melin, M., Vapalahti, O. & Savolainen-Kopra, C., 19 Mar 2020, In : Eurosurveillance. 25, 11, p. 16-21 6 p., 2000266.

Research output: Contribution to journalArticleScientificpeer-review

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Snake Deltavirus Utilizes Envelope Proteins of Different Viruses To Generate Infectious Particles

Szirovicza, L., Hetzel, U., Kipar, A., Martinez-Sobrido, L., Vapalahti, O. & Hepojoki, J., 28 Apr 2020, In : mBio. 11, 2, 19 p., e03250-19.

Research output: Contribution to journalArticleScientificpeer-review

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Specialist laboratory networks as preparedness and response tool - the Emerging Viral Diseases-Expert Laboratory Network and the Chikungunya outbreak, Thailand, 2019

CHIKV-Working Grp, Venturi, G., Aberle, S. W., Avsic-Zupanc, T., Jääskeläinen, A. J. & Reusken, C. B., 2 Apr 2020, In : Eurosurveillance. 25, 13, p. 31-37 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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Streptococcus halichoeri: Comparative Genomics of an Emerging Pathogen

Aaltonen, K., Kant, R., Eklund, M., Raunio-Saarnisto, M., Paulin, L., Vapalahti, O., Grönthal, T., Rantala, M. & Sironen, T., 18 Feb 2020, In : International journal of genomics. 2020, 9 p., 8708305.

Research output: Contribution to journalArticleScientificpeer-review

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The tree that hides the forest: cryptic diversity and phylogenetic relationships in the Palaearctic vector Obsoletus/Scoticus Complex (Diptera: Ceratopogonidae) at the European level

Mignotte, A., Garros, C., Gardes, L., Balenghien, T., Duhayon, M., Rakotoarivony, I., Tabourin, L., Poujol, L., Mathieu, B., Ibanez-Justicia, A., Deniz, A., Cvetkovikj, A., Purse, B., Ramilo, D. W., Stougiou, D., Werner, D., Pudar, D., Petric, D., Veronesi, E., Jacobs, F. & 28 others, Kampen, H., da Fonseca, I. P., Lucientes, J., Navarro, J., de la Puente, J. M., Stefanovska, J., Searle, K. R., Khallaayoune, K., Culverwell, C. L., Larska, M., Bourquia, M., Goffredo, M., Bisia, M., England, M., Robin, M., Quaglia, M., Miranda-Chueca, M. A., Bodker, R., Estrada-Pena, R., Carpenter, S., Tchakarova, S., Boutsini, S., Sviland, S., Schafer, S. M., Ozolina, Z., Seglina, Z., Vatansever, Z. & Huber, K., 20 May 2020, In : Parasites & vectors. 13, 1, 13 p.

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2019

An evaluation of serological methods to diagnose tick-borne encephalitis from serum and cerebrospinal fluid

Reusken, C., Boonstra, M., Rugebregt, S., Scherbeijn, S., Chandler, F., Avsic-Zupanc, T., Vapalahti, O., Koopmans, M. & GeurtsvanKessel, C. H., Nov 2019, In : Journal of Clinical Virology. 120, p. 78-83 6 p.

Research output: Contribution to journalArticleScientificpeer-review

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Antibody response in snakes with boid inclusion body disease

Windbichler, K., Michalopoulou, E., Palamides, P., Pesch, T., Jelinek, C., Vapalahti, O., Kipar, A., Hetzel, U. & Hepojoki, J., 9 Sep 2019, In : PLoS One. 14, 9, 28 p., e0221863.

Research output: Contribution to journalArticleScientificpeer-review

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Arbovirusuhkat muuttuvassa ympäristössä

Kakkola, L., Huhtamo, E. & Vapalahti, O., 2019, In : Moodi.. 43, 1, p. 10-13 4 p.

Research output: Contribution to journalArticleProfessional

Asian and African lineage Zika viruses show differential replication and innate immune responses in human dendritic cells and macrophages

Österlund, P., Jiang, M., Westenius, V., Kuivanen, S., Järvi, R., Kakkola, L., Lundberg, R., Melen, K., Korva, M., Avsic-Zupanc, T., Vapalahti, O. & Julkunen, I., 31 Oct 2019, In : Scientific Reports. 9, 15 p., 15710.

Research output: Contribution to journalArticleScientificpeer-review

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Bombali Virus in Mops condylurus Bat, Kenya

Forbes, K. M., Webala, P. W., Jääskeläinen, A. J., Abdurahman, S., Ogola, J., Masika, M. M., Kivistö, I., Alburkat, H., Plyusnin, I., Levanov, L., Korhonen, E. M., Huhtamo, E., Mwaengo, D., Smura, T., Mirazimi, A., Anzala, O., Vapalahti, O. & Sironen, T., May 2019, In : Emerging Infectious Diseases. 25, 5, p. 955-957 3 p.

Research output: Contribution to journalArticleScientificpeer-review

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Co-circulation of highly diverse Aleutian mink disease virus strains in Finland

Virtanen, J., Smura, T., Aaltonen, K., Moisander-Jylhä, A-M., Knuuttila, A., Vapalahti, O. & Sironen, T., Feb 2019, In : Journal of General Virology. 100, 2, p. 227-236 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis

Bösl, K., Ianevski, A., Than, T. T., Andersen, P. I., Kuivanen, S., Teppor, M., Zusinaite, E., Dumpis, U., Vitkauskiene, A., Cox, R. J., Kallio-Kokko, H., Bergqvist, A., Tenson, T., Merits, A., Oksenych, V., Bjørås, M., Anthonsen, M. W., Shum, D., Kaarbø, M., Vapalahti, O. & 5 others, Windisch, M. P., Superti-Furga, G., Snijder, B., Kainov, D. & Kandasamy, R. K., 4 Oct 2019, In : Frontiers in Immunology. 10, 12 p., 2186.

Research output: Contribution to journalArticleScientificpeer-review

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Detection of novel tick-borne pathogen, Alongshan virus, in Ixodes ricinus ticks, south-eastern Finland, 2019

Kuivanen, S., Levanov, L., Kareinen, L., Sironen, T., Jääskeläinen, A. J., Plyusnin, I., Zakham, F., Emmerich, P., Schmidt-Chanasit, J., Hepojoki, J., Smura, T. & Vapalahti, O., 4 Jul 2019, In : Eurosurveillance. 24, 27, p. 9-16 8 p., 1900394.

Research output: Contribution to journalArticleScientificpeer-review

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Development, validation and clinical evaluation of a broad-range pan-filovirus RT-qPCR

Jääskeläinen, A. J., Sironen, T., Diagne, C. T., Diagne, M. M., Faye, M., Faye, O., Faye, O., Hewson, R., Mölsä, M., Weidmanng, M. W., Watson, R., Sall, A. A. & Vapalahti, O., May 2019, In : Journal of Clinical Virology. 114, p. 26-31 6 p.

Research output: Contribution to journalArticleScientificpeer-review

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Evaluation of Real-Time RT-PCR for Diagnostic Use in Detection of Puumala Virus

Niskanen, S., Jääskeläinen, A., Vapalahti, O. & Sironen, T., Jul 2019, In : Viruses. 11, 7, 9 p., 661.

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Identification of a Novel Deltavirus in Boa Constrictors

Hetzel, U., Szirovicza, L., Smura, T., Prahauser, B., Vapalahti, O., Kipar, A. & Hepojoki, J., 2019, In : mBio. 10, 2, 8 p., ARTN e00014-19.

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Immunoassay for serodiagnosis of Zika virus infection based on time-resolved Förster resonance energy transfer

Kareinen, L., Hepojoki, S., Huhtamo, E., Korhonen, E. M., Schmidt-Chanasit, J., Hedman, K., Hepojoki, J. & Vapalahti, O., 23 Jul 2019, In : PLoS One. 14, 7, p. e0219474 13 p., 0219474.

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Introduction and Dispersal of Sindbis Virus from Central Africa to Europe

Ling, J., Smura, T., Lundström, J. O., Pettersson, J. H-O., Sironen, T., Vapalahti, O., Lundkvist, Å. & Hesson, J. C., Aug 2019, In : Journal of Virology. 93, 16, 21 p., e00620-19.

Research output: Contribution to journalArticleScientificpeer-review

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LFRET, a novel rapid assay for anti-tissue transglutaminase antibody detection

Rusanen, J., Toivonen, A., Hepojoki, J., Hepojoki, S., Arikoski, P., Heikkinen, M., Vaarala, O., Ilonen, J. & Hedman, K., 29 Nov 2019, In : PLoS One. 14, 11, 12 p., e0225851.

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Mycoplasma pneumoniae outbreak, Southeastern Finland, 2017–2018: molecular epidemiology and laboratory diagnostic lessons

Kurkela, S., Puolakkainen, M., Hokynar, K., Nieminen, T., Saxen, H., Mannonen, L. & Pietikäinen, R., Oct 2019, In : European Journal of Clinical Microbiology & Infectious Diseases. 38, 10, p. 1867-1871 5 p.

Research output: Contribution to journalArticleScientificpeer-review

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No Association Between Ljungan Virus Seropositivity and the Beta-cell Damaging Process in the Finnish Type 1 Diabetes Prediction and Prevention Study Cohort

Jääskeläinen, A. J., Nurminen, N., Kolehmainen, P., Smura, T., Tauriainen, S., Toppari, J., Ilonen, J., Veijola, R., Knip, M., Hyöty, H., Vapalahti, O. & Kallio-Kokko, H., Mar 2019, In : Pediatric Infectious Disease Journal. 38, 3, p. 314-316 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Occupational Animal Contact in Southern and Central Vietnam

VIZIONS Consortium, Nguyen Thi Kha Tu, Ngo Tri Tue, Vapalahti, O., Virtala, A-M. K., Le Van Tan, Rabaa, M. A., Carrique-Mas, J., Thwaites, G. E. & Baker, S., Dec 2019, In : EcoHealth. 16, 4, 13 p.

Research output: Contribution to journalArticleScientificpeer-review

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Parachlamydia acanthamoebae Detected during a Pneumonia Outbreak in Southeastern Finland, in 2017-2018

Hokynar, K., Kurkela, S., Nieminen, T., Saxen, H., Vesterinen, E. J., Mannonen, L., Pietikäinen, R. & Puolakkainen, M., May 2019, In : Microorganisms. 7, 5, 9 p., 141.

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Plasma bradykinin concentrations during septic shock determined by a novel LC-MS/MS assay

Lindström, M., Valkonen, M., Tohmola, N., Renkonen, R., Strandin, T., Vaheri, A. & Itkonen, O., Jun 2019, In : Clinica Chimica Acta. 493, p. 20-24 5 p.

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Predictive mapping of mosquito distribution based on environmental and anthropogenic factors in Taita Hills, Kenya

Uusitalo, R. J., Siljander, M., Culverwell, C. L., Mutai, N., Forbes, K. M., Vapalahti, O. & Pellikka, P. K. E., Apr 2019, In : International Journal of Applied Earth Observation and Geoinformation. 76, p. 84-92 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Recent establishment of tick-borne encephalitis foci with distinct viral lineages in the Helsinki area, Finland

Smura, T., Tonteri, E., Jääskeläinen, A., von Troil, G., Kuivanen, S., Huitu, O., Kareinen, L., Uusitalo, J., Uusitalo, R., Hannila-Handelberg, T., Voutilainen, L., Nikkari, S., Sironen, T., Sane, J., Castrén, J. & Vapalahti, O., 14 May 2019, In : Emerging microbes & infections. 8, 1, p. 675-683 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Respiratory viruses in individuals with a high frequency of animal exposure in southern and highland Vietnam

Nguyen, T. T. K., Ngo, T. T., Tran, P. M., Pham, T. T. T., Vu, H. T. T., Nguyen, N. T. H., Thwaites, G., Virtala, A-M. K., Vapalahti, O., Baker, S. & Van, T. L., 12 Dec 2019, In : Journal of Medical Virology. 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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Taxonomy of the order Bunyavirales: update 2019

Abudurexiti, A., Adkins, S., Alioto, D., Alkhovsky, S. V., Avsic-Zupanc, T., Ballinger, M. J., Bente, D. A., Beer, M., Bergeron, E., Blair, C. D., Briese, T., Buchmeier, M. J., Burt, F. J., Calisher, C. H., Chang, C., Charrel, R. N., Choi, I. R., Clegg, J. C. S., de la Torre, J. C., de Lamballerie, X. & 83 others, Deng, F., Di Serio, F., Digiaro, M., Drebot, M. A., Duan, X., Ebihara, H., Elbeaino, T., Ergunay, K., Fulhorst, C. F., Garrison, A. R., Gao, G. F., Gonzalez, J-P. J., Groschup, M. H., Guenther, S., Haenni, A-L., Hall, R. A., Hepojoki, J., Hewson, R., Hu, Z., Hughes, H. R., Jonson, M. G., Junglen, S., Klempa, B., Klingstrom, J., Kou, C., Laenen, L., Lambert, A. J., Langevin, S. A., Liu, D., Lukashevich, I. S., Luo, T., Lu, C., Maes, P., de Souza, W. M., Marklewitz, M., Martelli, G. P., Matsuno, K., Mielke-Ehret, N., Minutolo, M., Mirazimi, A., Moming, A., Muehlbach, H-P., Naidu, R., Navarro, B., Teixeira Nunes, M. R., Palacios, G., Papa, A., Pauvolid-Correa, A., Paweska, J. T., Qiao, J., Radoshitzky, S. R., Resende, R. O., Romanowski, V., Sall, A. A., Salvato, M. S., Sasaya, T., Shen, S., Shi, X., Shirako, Y., Simmonds, P., Sironi, M., Song, J-W., Spengler, J. R., Stenglein, M. D., Su, Z., Sun, S., Tang, S., Turina, M., Wang, B., Wang, C., Wang, H., Wang, J., Wei, T., Whitfield, A. E., Zerbini, F. M., Zhang, J., Zhang, L., Zhang, Y., Zhang, Y-Z., Zhang, Y., Zhou, X., Zhu, L. & Kuhn, J. H., Jul 2019, In : Archives of Virology. 164, 7, p. 1949-1965 17 p.

Research output: Contribution to journalArticleScientificpeer-review

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The Finnish New Variant of Chlamydia trachomatis with a Single Nucleotide Polymorphism in the 23S rRNA Target Escapes Detection by the Aptima Combo 2 Test

Hokynar, K., Rantakokko-Jalava, K., Hakanen, A., Havana, M., Mannonen, L., Jokela, P., Kurkela, S., Lappalainen, M., Unemo, M. & Puolakkainen, M., Aug 2019, In : Microorganisms. 7, 8, 12 p., 227.

Research output: Contribution to journalArticleScientificpeer-review

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Urine and Free Immunoglobulin Light Chains as Analytes for Serodiagnosis of Hantavirus Infection

Hepojoki, S., Kareinen, L., Strandin, T., Vaheri, A., Holthöfer, H., Mustonen, J., Mäkelä, S., Hedman, K., Vapalahti, O. & Hepojoki, J., Sep 2019, In : Viruses. 11, 9, 14 p., 809.

Research output: Contribution to journalArticleScientificpeer-review

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Viral haemorrhagic fevers in the Middle East

Zakham, F., Alaloui, A., Levanov, L. & Vapalahti, O., Apr 2019, In : OIE Revue Scientifique et Technique. 38, 1, p. 185-198 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Zika Virus Non-Structural Protein NS5 Inhibits the RIG-I Pathway and Interferon Lambda 1 Promoter Activation by Targeting IKK Epsilon

Lundberg, R., Melen, K., Westenius, V., Jiang, M., Österlund, P., Khan, H., Vapalahti, O., Julkunen, I. & Kakkola, L., Nov 2019, In : Viruses. 11, 11, 20 p., 1024.

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2018

Characterization of Haartman Institute snake virus-1 (HISV-1) and HISV-like viruses-The representatives of genus Hartmanivirus, family Arenaviridae

Hepojoki, J., Hepojoki, S., Smura, T., Szirovicza, L., Dervas, E., Prahauser, B., Nufer, L., Schraner, E. M., Vapalahti, O., Kipar, A. & Hetzel, U., Nov 2018, In : PLoS Pathogens. 14, 11, 29 p., 1007415.

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Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome

Bellomo, C., Korva, M., Papa, A., Mäkelä, S., Mustonen, J., Avsic-Zupanc, T., Vaheri, A., Martinez, V. P. & Strandin, T., Feb 2018, In : Open Forum Infectious Diseases. 5, 2, 4 p., 021.

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Dobrava hantavirus variants found in Apodemus flavicollis mice in Krklareli Province, Turkey

Polat, C., Sironen, T., Plyusnina, A., Karatas, A., Sozen, M., Matur, F., Vapalahti, O., Oktem, I. M. A. & Plyusnin, A., May 2018, In : Journal of Medical Virology. 90, 5, p. 810-818 9 p.

Research output: Contribution to journalArticleScientificpeer-review