Photo of Adrian Goldman
  • Finland

  • PL 65 (Viikinkaari 9)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

20032019
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Personal profile

Description of research and teaching

More than 50%  of current drugs affect membrane proteins and membrane protein systems.  It is thus clear that membranes and the proteins embedded in/associated  with them are key both biologically and medicinally. The proteins and  protein complexes in the membrane create electrochemical gradients,  mediate self:non-self interactions, and control the passage of molecules  and responses to extracellular signals. Despite this, such systems have  been less thoroughly studied than soluble proteins (Engelman, 2005, Nature, 438,  578-80). Steady advances in techniques have made it possible to study  them in lower amounts and with more spatial and temporal precision than  before.

 

Our work, which aims at spatial cellular/structural biology, thus  focuses on proteins and protein complexes that are at and close to the  cell surface, looking at at neuronal protein interactions  (e.g.  GDNF-GFRα-RET, MANF, and neuronal LRR-proteins) and at host-pathogen  interactions, such as those involving trimeric autotransporters, factor H  and complement. 

 

External positions

PI, Marie Curie ITN ViBrANT

1 Jan 201831 Dec 2021

coPI, Marie Curie ITN RAMP

1 Apr 201731 Mar 2021

Keywords

  • 1182 Biochemistry, cell and molecular biology

International and National Collaboration Publications and projects within past five years.

Publications 2003 2019

Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation

Tsai, J-Y., Tang, K-Z., Li, K-M., Hsu, B-L., Chiang, Y-W., Goldman, A. & Sun, Y-J., 5 Apr 2019, In : Journal of Molecular Biology. 431, 8, p. 1619-1632 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Affimer proteins inhibit immune complex binding to Fc gamma RIIIa with high specificity through competitive and allosteric modes of action

Robinson, J. I., Baxter, E. W., Owen, R. L., Thomsen, M., Tomlinson, D. C., Waterhouse, M. P., Win, S. J., Nettleship, J. E., Tiede, C., Foster, R. J., Owens, R. J., Fishwick, C. W. G., Harris, S. A., Goldman, A., McPherson, M. J. & Morgan, A. W., 2 Jan 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 1, p. E72-E81 10 p.

Research output: Contribution to journalArticleScientificpeer-review

A high-throughput method for orthophosphate determination of thermostable membrane-bound pyrophosphatase activity

Vidilaseris, K., Kellosalo, J. & Goldman, A., 14 Feb 2018, In : Analytical Methods. 10, 6, p. 646-651 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

A Simple Strategy to Determine the Dependence of Membrane-Bound Pyrophosphatases on K+ as a Cofactor

Strauss, J., Wilkinson, C., Vidilaseris, K., Harborne, S. P. D. & Goldman, A., 2018, Phosphatases. Allen, K. N. (ed.). ACADEMIC PRESS INC ELSEVIER SCIENCE, p. 131-156 26 p. (Methods in Enzymology; vol. 607).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Projects 2004 2018

Activities 2003 2018

European Crystallographic Meeting

Adrian Goldman (Attendee)
22 Aug 201827 Aug 2018

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

INPEC Meeting, Kolkata, India

Adrian Goldman (Attendee)
9 Nov 201711 Nov 2017

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

The 15th Finnish Microbial Pathogenesis Days

Adrian Goldman (Attendee)
21 Aug 201723 Aug 2017

Activity: Participating in or organising an event typesPublic Talks

International Centre for Genetic Engineering & Biotechnology

Adrian Goldman (Visiting researcher)
24 Nov 2016

Activity: Visiting an external institution typesAcademic visit to other institution

INPEC (International Nodes of Protein Engineering Centers)

Adrian Goldman (Attendee)
4 Nov 201610 Nov 2016

Activity: Participating in or organising an event typesPublic Talks