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Adrian Goldman

  • PL 65 (Viikinkaari 9)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

20032020

Research activity per year

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Personal profile

Description of research and teaching

More than 50%  of current drugs affect membrane proteins and membrane protein systems.  It is thus clear that membranes and the proteins embedded in/associated  with them are key both biologically and medicinally. The proteins and  protein complexes in the membrane create electrochemical gradients,  mediate self:non-self interactions, and control the passage of molecules  and responses to extracellular signals. Despite this, such systems have  been less thoroughly studied than soluble proteins (Engelman, 2005, Nature, 438,  578-80). Steady advances in techniques have made it possible to study  them in lower amounts and with more spatial and temporal precision than  before.

 

Our work, which aims at spatial cellular/structural biology, thus  focuses on proteins and protein complexes that are at and close to the  cell surface, looking at at neuronal protein interactions  (e.g.  GDNF-GFRα-RET, MANF, and neuronal LRR-proteins) and at host-pathogen  interactions, such as those involving trimeric autotransporters, factor H  and complement. 

 

External positions

PI, Marie Curie ITN ViBrANT

1 Jan 201831 Dec 2021

coPI, Marie Curie ITN RAMP

1 Apr 201731 Mar 2021

Fields of Science

  • 1182 Biochemistry, cell and molecular biology

International and National Collaboration

Publications and projects within past five years.
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