Photo of Adrian Goldman
  • PL 65 (Viikinkaari 9)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

20032020

Research output per year

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Personal profile

Description of research and teaching

More than 50%  of current drugs affect membrane proteins and membrane protein systems.  It is thus clear that membranes and the proteins embedded in/associated  with them are key both biologically and medicinally. The proteins and  protein complexes in the membrane create electrochemical gradients,  mediate self:non-self interactions, and control the passage of molecules  and responses to extracellular signals. Despite this, such systems have  been less thoroughly studied than soluble proteins (Engelman, 2005, Nature, 438,  578-80). Steady advances in techniques have made it possible to study  them in lower amounts and with more spatial and temporal precision than  before.

 

Our work, which aims at spatial cellular/structural biology, thus  focuses on proteins and protein complexes that are at and close to the  cell surface, looking at at neuronal protein interactions  (e.g.  GDNF-GFRα-RET, MANF, and neuronal LRR-proteins) and at host-pathogen  interactions, such as those involving trimeric autotransporters, factor H  and complement. 

 

External positions

PI, Marie Curie ITN ViBrANT

1 Jan 201831 Dec 2021

coPI, Marie Curie ITN RAMP

1 Apr 201731 Mar 2021

Fields of Science

  • 1182 Biochemistry, cell and molecular biology

International and National Collaboration Publications and projects within past five years.

Publications

Discovery of membrane-bound pyrophosphatase inhibitors derived from an isoxazole fragment

Johansson, N. G., Turku, A., Vidilaseris, K., Dreano, L., Khattab, A., Ayuso Perez, D., Wilkinson, A., Zhang, Y., Tamminen, M., Grazhdankin, E., Kiriazis, A., Fishwick, C., Meri, S., Yli-Kauhaluoma, J., Goldman, A., Boije af Gennäs, G. & Xhaard, H., 10 Feb 2020, (Accepted/In press) In : ACS Medicinal Chemistry Letters.

Research output: Contribution to journalArticleScientificpeer-review

Evolving a lipase for hydrolysis of natural triglycerides along with enhanced tolerance towards a protease and surfactants

Alfaro-Chavez, A. L., Liu, J-W., Stevenson, B. J., Goldman, A. & Ollis, D. L., Mar 2019, In : Protein Engineering, Design and Selection. 32, 3, p. 129-143 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Glutamate transporters: a broad review of the most recent archaeal and human structures

Pavic, A., Holmes, A. O. M., Postis, V. L. G. & Goldman, A., 30 Aug 2019, In : Biochemical Society Transactions. 47, p. 1197-1207 11 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access

Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targets

Thibau, A., Dichter, A. A., Vaca, D. J., Linke, D., Goldman, A. & Kempf, V. A. J., 1 Dec 2019, In : Medical Microbiology and Immunology. 21 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Projects

Activities

European Crystallographic Meeting

Adrian Goldman (Attendee)
22 Aug 201827 Aug 2018

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

The 15th Finnish Microbial Pathogenesis Days

Adrian Goldman (Attendee)
21 Aug 201723 Aug 2017

Activity: Participating in or organising an event typesPublic Talks

INPEC Meeting, Kolkata, India

Adrian Goldman (Attendee)
9 Nov 201711 Nov 2017

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Indian Inst Sci, Indian Institute of Science (IISC) - Banglore, Ctr High Energy Phys

Adrian Goldman (Visiting researcher)
20 Nov 2016

Activity: Visiting an external institution typesAcademic visit to other institution

International Centre for Genetic Engineering & Biotechnology

Adrian Goldman (Visiting researcher)
24 Nov 2016

Activity: Visiting an external institution typesAcademic visit to other institution