Photo of Adrian Goldman
  • PL 65 (Viikinkaari 9)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

20032019
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Personal profile

Description of research and teaching

More than 50%  of current drugs affect membrane proteins and membrane protein systems.  It is thus clear that membranes and the proteins embedded in/associated  with them are key both biologically and medicinally. The proteins and  protein complexes in the membrane create electrochemical gradients,  mediate self:non-self interactions, and control the passage of molecules  and responses to extracellular signals. Despite this, such systems have  been less thoroughly studied than soluble proteins (Engelman, 2005, Nature, 438,  578-80). Steady advances in techniques have made it possible to study  them in lower amounts and with more spatial and temporal precision than  before.

 

Our work, which aims at spatial cellular/structural biology, thus  focuses on proteins and protein complexes that are at and close to the  cell surface, looking at at neuronal protein interactions  (e.g.  GDNF-GFRα-RET, MANF, and neuronal LRR-proteins) and at host-pathogen  interactions, such as those involving trimeric autotransporters, factor H  and complement. 

 

External positions

PI, Marie Curie ITN ViBrANT

1 Jan 201831 Dec 2021

coPI, Marie Curie ITN RAMP

1 Apr 201731 Mar 2021

Fields of Science

  • 1182 Biochemistry, cell and molecular biology

International and National Collaboration Publications and projects within past five years.

Publications 2003 2019

Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation

Tsai, J-Y., Tang, K-Z., Li, K-M., Hsu, B-L., Chiang, Y-W., Goldman, A. & Sun, Y-J., 5 Apr 2019, In : Journal of Molecular Biology. 431, 8, p. 1619-1632 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Structure of the UspA1 protein fragment from Moraxella catarrhalis responsible for C3d binding

Mikula, K. M., Kolodziejczyk, R. & Goldman, A., 7 Aug 2019, In : Journal of Structural Biology.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Projects 2004 2018

Activities 2003 2018

European Crystallographic Meeting

Adrian Goldman (Attendee)
22 Aug 201827 Aug 2018

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

INPEC Meeting, Kolkata, India

Adrian Goldman (Attendee)
9 Nov 201711 Nov 2017

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

The 15th Finnish Microbial Pathogenesis Days

Adrian Goldman (Attendee)
21 Aug 201723 Aug 2017

Activity: Participating in or organising an event typesPublic Talks

Indian Inst Sci, Indian Institute of Science (IISC) - Banglore, Ctr High Energy Phys

Adrian Goldman (Visiting researcher)
20 Nov 2016

Activity: Visiting an external institution typesAcademic visit to other institution

Nankai University

Adrian Goldman (Visiting researcher)
1 May 201615 May 2016

Activity: Visiting an external institution typesAcademic visit to other institution