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Airi Palva

Professori emerita

1981 …2019
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Publications 1981 2019

2019

Crystal structure of basal pilin SpaE reveals the molecular basis of its incorporation in the lactobacillar SpaFED pilus

Megta, A. K., Mishra, A. K., Palva, A., von Ossowski, I. & Krishnan, V., 1 Jul 2019, In : Journal of Structural Biology. 207, 1, p. 74-84 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Molecular ecology of the yet uncultured bacterial Ct85-cluster in the mammalian gut

Hynönen, U., Zoetendal, E. G., Virtala, A-M. K., Shetty, S., Hasan, S., Jakava-Viljanen, M., de Vos, W. M. & Palva, A., 25 Sep 2019, In : Anaerobe.

Research output: Contribution to journalArticleScientificpeer-review

SpaB, an atypically adhesive basal pilin from the lactobacillar SpaCBA pilus: crystallization and X-ray diffraction analysis

Megta, A. K., Palva, A., von Ossowski, I. & Krishnan, V., Dec 2019, In : Acta crystallographica section f-Structural biology communications. 75, 12, p. 731-737 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2018

Bent conformation of a backbone pilin N-terminal domain supports a three-stage pilus assembly mechanism

Chaurasia, P., Pratap, S., Palva, A., von Ossowski, I. & Krishnan, V., 17 Jul 2018, In : Communications Biology. 1, 94, 15 p., 94.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Open Access
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Molecular networks affected by neonatal microbial colonization in porcine jejunum, luminally perfused with enterotoxigenic Escherichia coli, F4ac fimbria or Lactobacillus amylovorus

Trevisi, P., Priori, D., Jansman, A. J. M., Luise, D., Koopmans, S-J., Hynönen, U., Palva, A., Van Der Meulen, J. & Bosi, P., 30 Aug 2018, In : PLoS One. 13, 8, 19 p., 0202160.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Silica-gentamicin nanohybrids: combating antibiotic resistance, bacterial biofilms, and in vivo toxicity

Mosselhy, D. A., He, W., Hynönen, U., Meng, Y., Mohammadi, P., Palva, A., Feng, Q., Hannula, S-P., Nordstrom, K. & Linder, M. B., 2018, In : International Journal of Nanomedicine. 13, p. 7939-7957 19 p.

Research output: Contribution to journalArticleScientificpeer-review

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2017
Open Access

A comparative characterization of different host-sourced Lactobacillus ruminis strains and their adhesive, inhibitory, and immunomodulating functions

Yu, X., Åvall-Jääskeläinen, S., Koort, J., Lindholm, A., Rintahaka, J., von Ossowski, I., Palva, A. & Hynönen, U., 13 Apr 2017, In : Frontiers in Microbiology. 8, 657, 17 p., 657.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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An in silico pan-genomic probe for the molecular traits behind Lactobacillus ruminis gut autochthony

Kant, R., Palva, A. & von Ossowski, I., 17 Apr 2017, In : PLoS One. 12, 4, 26 p., 0175541.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Crystallization and X-ray diffraction analysis of SpaE, a basal pilus protein from the gut-adapted Lactobacillus rhamnosus GG

Mishra, A. K., Megta, A. K., Palva, A., von Ossowski, I. & Krishnan, V., Jun 2017, In : Acta crystallographica section f-Structural biology communications. 73, p. 321-327 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Nanosilver-Silica Composite: Prolonged Antibacterial Effects and Bacterial Interaction Mechanisms for Wound Dressings

Mosselhy, D. A., Granbohm, H., Hynonen, U., Ge, Y., Palva, A., Nordstrom, K. & Hannula, S-P., Sep 2017, In : Nanomaterials. 7, 9, 19 p., 261.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function

Ottman, N., Reunanen, J., Meijerink, M., Pietilä, T., Kainulainen, V., Klievink, J., Huuskonen, L., Aalvink, S., Skurnik, M., Boeren, S., Satokari, R., Mercenier, A., Palva, A., Smidt, H., de Vos, W. M. & Belzer, C., 1 Mar 2017, In : PLoS One. 12, 3, 18 p., 0173004.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Crystallization and X-ray crystallographic analysis of the adhesive SpaC pilin subunit in the SpaCBA pilus of gut-adapted Lactobacillus rhamnosus GG

Kant, A., von Ossowski, I., Palva, A. & Krishnan, V., 2016, In : Protein and Peptide Letters. 23, 4, p. 365-371 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Faecal Metaproteomic Analysis Reveals a Personalized and Stable Functional Microbiome and Limited Effects of a Probiotic Intervention in Adults

Kolmeder, C. A., Salojarvi, J., Ritari, J., de Been, M., Raes, J., Falony, G., Vieira-Silva, S., Kekkonen, R. A., Corthals, G. L., Palva, A., Salonen, A. & de Vos, W. M., 12 Apr 2016, In : PLoS One. 11, 4, 23 p., 0153294.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Genome Sequence of Lactobacillus brevis Strain D6, Isolated from Smoked Fresh Cheese

Kant, R., Uroic, K., Hynönen, U., Kos, B., Suskovic, J. & Palva, A. M., Apr 2016, In : Genome Announcements. 4, 2, 2 p., e00264-16 .

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Isolation and whole genome sequencing of a Ruminococcus-like bacterium, associated with irritable bowel syndrome

Hynönen, U., Rasinkangas, P., Satokari, R., Paulin, L., de Vos, W. M., Pietilä, T. E., Kant, R. & Palva, A., Jun 2016, In : Anaerobe. 39, p. 60-67 8 p.

Research output: Contribution to journalArticleScientificpeer-review

New insights about pilus formation in gut-adapted Lactobacillus rhamnosus GG from the crystal structure of the SpaA backbone-pilin subunit

Chaurasia, P., Pratap, S., von Ossowski, I., Palva, A. & Krishnan, V., 28 Jun 2016, In : Scientific Reports. 6, 17 p., 28664.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Phenotypic characterization of a lactobacillar fimbrial operon through recombinant expression in Lactococcus lactis

Yu, X., Rintahaka, J., Jaatinen, A., Hynönen, U., Åvall-Jääskeläinen, S., Lindholm, A., von Ossowski, I. & Palva, A., 2016, In : Journal of Clinical Gastroenterology. 50, Suppl 2, p. S209 1 p.

Research output: Contribution to journalMeeting AbstractResearch

Physiological Concentration of Exogenous Lactate Reduces Antimycin A Triggered Oxidative Stress in Intestinal Epithelial Cell Line IPEC-1 and IPEC-J2 In Vitro

Kahlert, S., Junnikkala, S., Renner, L., Hynönen, U., Hartig, R., Nossol, C., Barta-Böszörmenyi, A., Dänicke, S., Souffrant, W-B., Palva, A., Rothkötter, H-J. & Kluess, J., 7 Apr 2016, In : PLoS One. 11, 4, 17 p., 0153135.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Polymorphisms, Chromosomal Rearrangements, and Mutator Phenotype Development during Experimental Evolution of Lactobacillus rhamnosus GG

Douillard, F. P., Ribbera, A., Xiao, K., Ritari, J., Rasinkangas, P., Paulin, L., Palva, A., Hao, Y. & de Vos, W. M., Jul 2016, In : Applied and Environmental Microbiology. 82, 13, p. 3783-3792 10 p.

Research output: Contribution to journalArticleScientificpeer-review

The N-Terminal GYPSY Motif Is Required for Pilin-Specific Sortase SrtC1 Functionality in Lactobacillus rhamnosus Strain GG

Douillard, F. P., Rasinkangas, P., Bhattacharjee, A., Palva, A. & de Vos, W. M., 12 Apr 2016, In : PLoS One. 11, 4, 18 p., 0153373.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The role of S-layer in adhesive and immunomodulating properties of probiotic starter culture Lactobacillus brevis D6 isolated from artisanal smoked fresh cheese

Uroic, K., Novak, J., Hynönen, U. E. E., Pietilä, T. E., Lebos Pavunc, A., Kant, R., Kos, B., Palva, A. M. & Suskovic, J., Jun 2016, In : LWT-Food Science and Technology. 69, p. 623-632 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Colonic metaproteomic signatures of active bacteria and the host in obesity

Kolmeder, C. A., Ritari, J., Verdam, F. J., Muth, T., Keskitalo, S., Varjosalo, M., Fuentes, S., Greve, J. W., Buurman, W. A., Reichl, U., Rapp, E., Martens, L., Palva, A., Salonen, A., Rensen, S. S. & de Vos, W. M., Oct 2015, In : Proteomics (Weinheim). 15, 20, p. 3544-3552 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Effect of a multispecies lactobacillus formulation as a feeding supplement on the performance and immune function of piglets

Lähteinen, T., Rinttilä, T., Koort, J. M. K., Kant, R., Levonen, K., Jakava-Viljanen, M., Björkroth, J. & Palva, A., Oct 2015, In : Livestock Science. 180, p. 164-171 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of bowel cleansing on the intestinal microbiota

Jalanka, J., Salonen, A., Salojärvi, J., Ritari, J., Immonen, O., Marciani, L., Gowland, P., Hoad, C., Garsed, K., Lam, C., Palva, A., Spiller, R. C. & de Vos, W. M., Oct 2015, In : Gut. 64, 10, p. 1562-1568 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome Sequence of the Butyrate-Producing Anaerobic Bacterium Anaerostipes hadrus PEL 85

Kant, R., Rasinkangas, P., Satokari, R. M., Pietilä, T. E. & Palva, A., Apr 2015, In : Genome Announcements. 3, 2, 2 p., e00224-15.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Genome Sequences of Four Staphylococcus aureus Strains Isolated from Bovine Mastitis

Kant, R., Taponen, S. S., Koort, J. M. K., Paulin, L. G., Åvall-Jääskeläinen, S. T. & Palva, A. M., Apr 2015, In : Genome Announcements. 3, 2, 2 p., e00334-15.

Research output: Contribution to journalArticleScientificpeer-review

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Lactobacillus rhamnosus GG and its SpaC pilus adhesin modulate inflammatory responsiveness and TLR-related gene expression in the fetal human gut

Ganguli, K., Collado, M. C., Rautava, J., Lu, L., Satokari, R., von Ossowski, I., Reunanen, J., de Vos, W. M., Palva, A., Isolauri, E., Salminen, S., Walker, W. A. & Rautava, S., Apr 2015, In : Pediatric Research. 77, 4, p. 528-535 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Peruseläinlääketieteen laitos (PELL) v. 1995-2009, Eläinlääketieteellisten biotieteiden osasto (EBIO) v. 2010-2014

Palva, A. M., Feb 2015, Eläinlääketieteellinen tiedekunta 20 vuotta 2015. Helsinki: Helsingin yliopisto, Eläinlääketieteellinen tiedekunta, p. 48-49 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapterGeneral public

Piliation of Lactobacillus rhamnosus GG promotes adhesion, phagocytosis, and cytokine modulation in macrophages

Vargas García, C. E., Petrova, M., Claes, I. J. J., De Boeck, I., Verhoeven, T. L. A., Dilissen, E., von Ossowski, I., Palva, A., Bullens, D. M., Vanderleyden, J. & Lebeer, S., 2015, In : Applied and Environmental Microbiology. 81, 6, p. 2050-2062 13 p.

Research output: Contribution to journalArticleScientificpeer-review

X-ray diffraction analysis of two crystals forms of backbone pilin SpaA fragment from Lactobacillus rhamnosus GG

Chaurasia, P., von Ossowski, I., Palva, A. & Krishnan, V., 2015, In : Journal of proteins and proteomics. 6, 1, 1 p., 30.

Research output: Contribution to journalArticleScientific

Open Access
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2014

A comparative pan-genome perspective of niche-adaptable cell-surface protein phenotypes in Lactobacillus rhamnosus

Kant, R., Rintahaka, J., Yu, X., Sigvart-Mattila, P., Paulin, L., Mecklin, J-P., Saarela, M., Palva, A. & von Ossowski, I., 17 Jul 2014, In : PLoS One. 9, 7, 16 p., e102762.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Effect of Lactobacillus brevis ATCC 8287 as a feeding supplement on the performance and immune function of piglets

Lähteinen, T., Lindholm, A., Rinttilä, T., Junnikkala, S., Kant, R., Pietilä, T. E., Levonen, K., von Ossowski, I., Solano-Aguilar, G., Jakava-Viljanen, M. & Palva, A., 15 Mar 2014, In : Veterinary Immunology and Immunopathology. 158, 1-2, p. 14-25 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Faecal microbiota composition and host-microbe cross-talk following gastroenteritis and in postinfectious irritable bowel syndrome.

Jalanka-Tuovinen, J., Salojärvi, J., Salonen, A., Immonen, O., Klara, G., Fiona M., K., Abed, Z., Palva, A., Robin C., S. & Vos de, W. M., 2014, In : Gut. 63, 11, p. 1737-1745 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Functional characterization of probiotic surface layer protein-carrying Lactobacillus amylovorus strains.

Hynönen, U., Kant, R., Lähteinen, T. T., Pietilä, T., Beganovi, J., Smidt, H., Uroic, K., Åvall-Jääskeläinen, S. & Palva, A., 2014, In : BMC Microbiology. 14, 16 p., 199.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Functional identification of conserved residues involved in Lactobacillus rhamnosus strain GG sortase specificity and pilus biogenesis

Douillard, F., Rasinkangas, P., von Ossowski, I., Reunanen, J., Palva, A. & Vos de, W. M., 30 May 2014, In : Journal of Biological Chemistry. 289, 22, p. 15764-15775 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Genomic Characterization of Non-Mucus-Adherent Derivatives of Lactobacillus rhamnosus GG Reveals Genes Affecting Pilus Biogenesis

Rasinkangas, P., Reunanen, J., Douillard, F. P., Ritari, J., Uotinen, V., Palva, A. & de Vos, W. M., Nov 2014, In : Applied and Environmental Microbiology. 80, 22, p. 7001-7009 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Immunostimulatory CpG motifs in the genomes of gut bacteria and their role in human health and disease

Kant, R., Vos de, W. M., Palva, A. & Satokari, R. M., 2014, In : Journal of Medical Microbiology. 63, Pt. 2, p. 293-308 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Phenotypical analysis of the Lactobacillus rhamnosus GG fimbrial spaFED operon: Surface expression and functional characterization of recombinant SpaFED pili in Lactococcus lactis

Rintahaka, J., Yu, X., Kant, R., Palva, A. & von Ossowski, I., 21 Nov 2014, In : PLoS One. 9, 11, 31 p., e113922.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The structure of Lactobacillus brevis surface layer reassembled on liposomes differs from native structure as revealed by SAXS

Kontro, I., Wiedmer, S., Hynönen, U., Penttilä, P. A., Palva, A. & Serimaa, R., Aug 2014, In : Biochimica et Biophysica Acta. Biomembranes. 1838, 8, p. 2099-2104 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Adhesion and nanomechanics of pili from the probiotic Lactobacillus rhamnosus GG

Tripathi, P., Beaussart, A., Alsteens, D., Dupres, V., Claes, I., von Ossowski, I., de Vos, W. M., Palva, A., Lebeer, S., Vanderleyden, J. & Dufrene, Y. F., Apr 2013, In : ACS Nano. 7, 4, p. 3685-3697 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Associations between the human intestinal microbiota, Lactobacillus rhamnosus GG and serum lipids indicated by integrated analysis of high-throughput profiling data

Lahti, L., Salonen, A., Kekkonen, R. A., Salojärvi, J., Jalanka-Tuovinen, J., Palva, A., Orešič, M. & Vos de, W. M., 2013, In : PeerJ. 1, 25 p., e32.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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BopA Does Not Have a Major Role in the Adhesion of Bifidobacterium bifidum to Intestinal Epithelial Cells, Extracellular Matrix Proteins, and Mucus

Kainulainen, V., Reunanen, J., Hiippala, K., Guglielmetti, S., Vesterlund, S., Palva, A. & Satokari, R., Nov 2013, In : Applied and Environmental Microbiology. 79, 22, p. 6989-6997 9 p.

Research output: Contribution to journalArticleScientificpeer-review