Photo of Alex Edwin Bunker

Alex Edwin Bunker

Adjunct Professor, Department of Chemistry, Faculty of Science

  • PL 56 (Viikinkaari 5)

    00014

    Finland

20052020

Research output per year

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Personal profile

Description of research and teaching

Research:

Myself, along with Dr. Tapani Viitala, share leadership of the Pharmaceutical Biophysics group. Our research combines my computational research methodologies with the experimental research methodologies of Dr. Tapani Viitala, to the development of a mechanistic understanding of the interactions between the three fundamental elements of bionanovectors: lipid membranes, proteins and polymers. We study their behaviour in the bloodstream and, on a more general level, the design principles of safe and efficient drug delivery systems and their interaction with biological membranes and cells. The group is founded on the combined expertise of the two principle investigators with established track records in this field: the experimental research of Dr. Tapani Viitala and the computational research of Dr. Alex Bunker. The combination provides a synergistic framework that, as collaboration, has already provided new insights from new combined experimental-computational methodologies for the analysis of these systems.

Teaching:

I currently teach two courses “advanced mathematical tools for pharmaceutical research” Course #590337 and “Fundamentals of Molecular Modelling and drug design” Course #590287, both at the faculty of pharmacy. Course #590337 is an refresher course in the applied mathematical tools needed for pharmacy research in areas including physical pharmacy, pharmacokinetics and molecular modelling. Course #590287 is an introductory course in molecular modelling taught from the ground up to give the students who have no initial background a basic understanding of the growing use of molecular modelling techniques in pharmaceutical research. 

Curriculum vitae

Tekstiä

Fields of Science

  • 317 Pharmacy
  • 114 Physical sciences
  • 118 Biological sciences
  • 116 Chemical sciences
  • 221 Nano-technology

International and National Collaboration Publications and projects within past five years.

Publications

Bitopic and Peripheral Membrane Proteins as Drug Targets: Broader Biophysical Insight from Biomembrane Simulations that Transcends the "Lock and Key'' Paradigm

Bunker, A., 7 Feb 2020, In : Biophysical Journal. 118, 3, p. 160A-160A 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Cholesterol Reduces Partitioning of Antifungal Drug Itraconazole into Lipid Bilayers

Poojari, C., Zak, A., Dzieciuch-Rojek, M., Bunker, A., Kepczynski, M. & Rog, T., 19 Mar 2020, In : Journal of Physical Chemistry B. 124, 11, p. 2139-2148 10 p.

Research output: Contribution to journalArticleScientificpeer-review

In Vitro and in Vivo Behavior of Liposomes Decorated with PEGs with Different Chemical Features

Mastrotto, F., Brazzale, C., Bellato, F., De Martin, S., Grange, G., Mahmoudzadeh, M., Magarkar, A., Bunker, A., Salmaso, S. & Caliceti, P., Feb 2020, In : Molecular Pharmaceutics. 17, 2, p. 472-487 16 p.

Research output: Contribution to journalArticleScientificpeer-review

A potent partial agonist of PKC orients in membranes like the biological activator diacylglycerol

Lautala, S., Koivuniemi, A., Kulig, W., Rog, T., Talman, V., Tuominen, R. & Bunker, A., Jul 2019, In : European Biophysics Journal. 48, p. S122-S122 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Open Access
File

Determinants of Orexin Receptor Binding and Activation—A Molecular Dynamics Study

Karhu, L., Magarkar, A., Bunker, A. & Xhaard, H., 28 Mar 2019, In : Journal of Physical Chemistry B. 123, 12, p. 2609-2622 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Projects

Medimmune collaboration research

Bunker, A. E. & Magarkar, A.

01/05/201630/09/2016

Project: Research project

Molecular dynamics simulation as a tool to investigate novel formulations for –some based drug delivery systems

Bunker, A. E., Magarkar, A., Karhu, L., Momeni, S. & Mahmoudzadeh, M.

01/09/201531/08/2019

Project: Research project

Surface Structure of Nanoparticles

Magarkar, A., Bunker, A. E., Urtti, A., Yliperttula, M. & Rog, T.

02/08/201031/08/2015

Project: Research project

Molecular dynamics simulation of DNA - dendrimer interactions

Bunker, A. E. & maiti, P.

10/10/200831/12/2015

Project: Research project

Activities

6th European Joint Theoretical Experimental Meeting on Membranes

Tapani Viitala (Chair of organizing committee), Alexander Edwin Bunker (Chair of organizing committee)
12 Dec 201814 Dec 2018

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Department of Mathematics and Computer Science, Eindhoven University

Alex Edwin Bunker (Visiting researcher)
11 Apr 201612 Apr 2016

Activity: Visiting an external institution typesAcademic visit to other institution

Journal of Physical Chemistry (Journal)

Alex Edwin Bunker (Reviewer)
10 Nov 2016

Activity: Publication peer-review and editorial work typesPeer review of manuscripts

Journal of Molecular Biology (Journal)

Alex Edwin Bunker (Reviewer)
25 Nov 2016

Activity: Publication peer-review and editorial work typesPeer review of manuscripts

Langmuir (Journal)

Alex Edwin Bunker (Reviewer)
20 Jul 2016

Activity: Publication peer-review and editorial work typesPeer review of manuscripts

Press / Media

Interview for article in "Inside Science"

Alex Edwin Bunker

25/08/2016

1 Media contribution

Press/Media: Press / Media