Andrea Ganna

Research output

Research output per year 2012 2022 2023 2024 2025

• 89 Article
• 11 Meeting Abstract
• 2 Comment/debate
• 2 Editorial
• 3 More
  • 1 Conference article
  • 1 Letter
  • 1 Review Article

Research output per year

Research output per year

Search results

• 2025

  Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery

  German, J., Cordioli, M., Tozzo, V., Urbut, S., Arumäe, K., Smit, R. A. J., Lee, J., Li, J. H., Janucik, A., Ding, Y., Akinkuolie, A., Heyne, H. O., Eoli, A., Saad, C., Al-Sarraj, Y., Abdel-latif, R., Mohammed, S., Hail, M. A., Barry, A. & Wang, Z. & 12 others, Cajuso, T., Corbetta, A., Natarajan, P., Ripatti, S., Philippakis, A., Szczerbinski, L., Pasaniuc, B., Kutalik, Z., Mbarek, H., Loos, R. J. F., Vainik, U. & Ganna, A., 18 Apr 2025, In: Nature Medicine. 21 p., 20.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes

  FinnGen, Hiitola, E., Korhonen, J., Kokkonen, H., Koskela, J., Kankainen, M., Alakuijala, M., Liu, A., Lundgren, S., Häppölä, P., Almusa, H., Ellonen, P., Savola, P., Kelkka, T., Leirisalo-Repo, M., Koivuniemi, R., Peltomaa, R., Pirilä, L., Isomäki, P. & Kauppi, M. & 10 others, Kaipiainen-Seppänen, O., Starskaia, I., Virtanen, A. T., Lahesmaa, R., Silvennoinen, O., Genovese, G., Ganna, A., Rantapää-Dahlqvist, S., Mustjoki, S. & Myllymäki, M., 30 Apr 2025, In: Science Advances. 11, 18, 14 p., eadt9846.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Geneettiset riskitekijät selittävät Suomen korkeaa suulakihalkion esiintyvyyttä

  Rahimov, F., Nieminen, P., Kumari, P., Juuri, E., Nikopensius, T., Paraiso, K., German, J., Karvanen, A., Kals, M., Elnahas, A. G., Karjalainen, J., Kurki, M., Palotie, A., Heliövaara, A., Tonu, E., Jukarainen, S., Palta, P., Ganna, A., Patni, A. P. & Mar, D. & 8 others, Bomsztyk, K., Mathieu, J., Ruohola-Baker, H., Visel, A., Fakhouri, W. D., Schutte, B. C., Cornell, R. A. & Rice, D. P., 2025, In: Suomen hammaslääkärilehti. 32, 3

  Research output: Contribution to journal › Article › Scientific › peer-review

• Genetic architectures of childhood maltreatment and causal influence of childhood maltreatment on health outcomes in adulthood

  Chen, T.-T., Chen, C.-Y., Liu, C.-Y., Lee, J., Ganna, A., Feng, Y.-C. A. & Lin, Y. F., 20 Feb 2025, In: Molecular Psychiatry. 9 p., 1164.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Genome-wide association study of long COVID

  Long COVID Host Genetics Initiative, FinnGen, Lammi, V., Nakanishi, T., Jones, S. E., Karjalainen, J., Broberg, M., Haapaniemi, H. H., Pirinen, M., Sinnott-Armstrong, N., Marttila, M. M., Niemi, M. E. K., Cordioli, M., Daly, M. J., Ganna, A. & Ollila, H. M., 21 May 2025, In: Nature Genetics. 57, 23 p., 17.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Polygenic risk score prediction accuracy convergence

  Henches, L., Kim, J., Yang, Z., Rubinacci, S., Pires, G., Albiñana, C., Boetto, C., Julienne, H., Frouin, A., Auvergne, A., Suzuki, Y., Djebali, S., Delaneau, O., Ganna, A., Vilhjálmsson, B., Privé, F. & Aschard, H., 10 Jul 2025, In: Human Genetics and Genomics Advances. 6, 3, 15 p., 100457.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• 2024

  A deep learning model accurately predicts 1-year mortality but at the risk of unfairness

  Vabalas, A. & Ganna, A., 2024, In: Nature Aging. 4, p. 913–914 2 p.

  Research output: Contribution to journal › Comment/debate › Scientific

• Applying a genetic risk score model to enhance prediction of future multiple sclerosis diagnosis at first presentation with optic neuritis

  Geisinger-Regeneron DiscovEHR Collaboration, FinnGen, UKBB Eye & Vision Consortium, Loginovic, P., Wang, F., Li, J., Ferrat, L., Mirshahi, U. L., Rao, H. S., Petzold, A., Tyrrell, J., Green, H. D., Weedon, M. N., Ganna, A., Tuomi, T., Carey, D. J., Oram, R. A. & Braithwaite, T., 2024, In: Nature Communications. 15, 1, 13 p., 1415.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk

  Jermy, B., Läll, K., Wolford, B. N., Wang, Y., Zguro, K., Cheng, Y., Kanai, M., Kanoni, S., Yang, Z., Hartonen, T., Monti, R., Wanner, J., Youssef, O., Lippert, C., van Heel, D., Okada, Y., McCartney, D. L., Hayward, C., Marioni, R. E. & Furini, S. & 10 others, Renieri, A., Martin, A. R., Neale, B. M., Hveem, K., Mägi, R., Palotie, A., Heyne, H., Mars, N., Ganna, A. & Ripatti, S., 2024, In: Nature Communications. 15, 1, 14 p., 5007.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Comparative Penetrance and Pleiotropy of Neuropsychiatric Copy Number Variants and Polygenic Risk Scores in the United States Veteran Population

  Bigdeli, T. B., Gorman, B. R., Genovese, G., Francis, M., Chatzinakos, C., Peterson, R. E., Liu, A., Sacks, M., Voloudakis, G., Ganna, A., Sebat, J., Braff, D. L., Aslan, M., Roussos, P., Harvey, P. D. & Pyarajan, S., Nov 2024, In: Behavior Genetics. 54, 6, p. 580-581 2 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Comparison of disease prediction ability and transferability of polygenic scores vs. EHR-based score across three biobank studies, 1,034,311 individuals, and 18 diseases

  Hartonen, T., Detrois, K., Teder-Laving, M., Lall, K., Yang, Z., Magi, R., Ripatti, S. & Ganna, A., Dec 2024, In: European Journal of Human Genetics. 32, p. 1716-1716 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Deep learning-based prediction of one-year mortality in Finland is an accurate but unfair aging marker

  Vabalas, A., Hartonen, T., Vartiainen, P., Jukarainen, S., Viippola, E., Rodosthenous, R. S., Liu, A., Hägg, S., Perola, M. & Ganna, A., 2024, In: Nature Aging. 4, p. 1014–1027 22 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Estimating polygenic score effects in non-European populations for improved lifetime disease risk estimation

  Int Consortium IntegratiVE Genomics PrEdiction, Wolford, B., Dunca, D., Tozzo, V., Zguro, K., Heyne, H., Mars, N., Ganna, A., Ripatti, S. & Kanoni, S., Dec 2024, In: European Journal of Human Genetics. 32, p. 1699-1700 2 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Evaluation of polygenic scoring methods in five biobanks shows larger variation between biobanks than methods and finds benefits of ensemble learning

  Monti, R., Eick, L., Hudjashov, G., Läll, K., Kanoni, S., Wolford, B. N., Wingfield, B., Pain, O., Wharrie, S., Jermy, B., McMahon, A., Hartonen, T., Heyne, H., Mars, N., Lambert, S., Hveem, K., Inouye, M., van Heel, D. A., Mägi, R. & Marttinen, P. & 3 others, Ripatti, S., Ganna, A. & Lippert, C., 21 Jun 2024, In: American Journal of Human Genetics. 111, 7, p. 1431-1447 17 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Genetic drivers and cellular selection of female mosaic X chromosome loss

  FinnGen, Estonian Biobank Research Team, Breast Cancer Association Consortium, Million Veteran Program, Liu, A., Genovese, G., Zhao, Y., Pirinen, M., Zekavat, S. M., Kentistou, K. A., Yang, Z., Yu, K., Vlasschaert, C., Liu, X., Brown, D. W., Hudjashov, G., Gorman, B. R., Dennis, J., Zhou, W. & Momozawa, Y. & 25 others, Pyarajan, S., Tuzov, V., Pajuste, F. D., Aavikko, M., Sipilä, T. P., Ghazal, A., Huang, W. Y., Freedman, N. D., Song, L., Gardner, E. J., Sankaran, V. G., Palotie, A., Ollila, H. M., Tukiainen, T., Chanock, S. J., Mägi, R., Natarajan, P., Daly, M. J., Bick, A., McCarroll, S. A., Terao, C., Loh, P. R., Ganna, A., Perry, J. R. B. & Machiela, M. J., 12 Jun 2024, In: Nature. 631, 8019, p. 134-141 23 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene

  FinnGen, Estonian Biobank Research Team, Rahimov, F., Nieminen, P., Kumari, P., Juuri, E., Nikopensius, T., Paraiso, K., German, J., Karvanen, A., Kals, M., Elnahas, A. G., Karjalainen, J., Kurki, M., Palotie, A., Heliövaara, A., Esko, T., Jukarainen, S., Palta, P. & Ganna, A. & 10 others, Patni, A. P., Mar, D., Bomsztyk, K., Mathieu, J., Ruohola-Baker, H., Visel, A., Fakhouri, W. D., Schutte, B. C., Cornell, R. A. & Rice, D. P., Dec 2024, In: Nature Communications. 15, 1, 14 p., 9568.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Limited overlap between genetic effects on disease susceptibility and disease survival: evidences from seven biobanks and ten common diseases

  FinnGen, Genes & Hlth Res Team, Genomics England Res Consortium, INTERVENE Consortium, Yang, Z., Pajuste, F.-D., Zguro, K., Cheng, Y., Wanner, J., Jermy, B., Ripatti, S., Mars, N. & Ganna, A., Dec 2024, In: European Journal of Human Genetics. 32, p. 1707-1708 2 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Markers of imminent myocardial infarction

  Gustafsson, S., Lampa, E., Eriksson, K. J., Butterworth, A. S., Elmstahl, S., Engstrom, G., Hveem, K., Johansson, M., Langhammer, A., Lind, L., Lall, K., Masala, G., Metspalu, A., Moreno-Iribas, C., Nilsson, P. M., Perola, M., Simell, B., Sipsma, H., Asvold, B. O. & Ingelsson, E. & 5 others, Hammar, U., Ganna, A., Svennblad, B., Fall, T. & Sundström, J., Feb 2024, In: Nature Cardiovascular Research. 3, 2, p. 130–139 23 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions

  Purdue, M. P., Dutta, D., Machiela, M. J., Gorman, B. R., Winter, T., Okuhara, D., Cleland, S., Ferreiro-Iglesias, A., Scheet, P., Liu, A., Wu, C., Antwi, S. O., Larkin, J., Zequi, S. C., Sun, M., Hikino, K., Hajiran, A., Lawson, K. A., Cárcano, F. & Blanchet, O. & 112 others, Shuch, B., Nepple, K. G., Margue, G., Sundi, D., Diver, W. R., Folgueira, M. A. A. K., van Bokhoven, A., Neffa, F., Brown, K. M., Hofmann, J. N., Rhee, J., Yeager, M., Cole, N. R., Hicks, B. D., Manning, M. R., Hutchinson, A. A., Rothman, N., Huang, W. Y., Linehan, W. M., Lori, A., Ferragu, M., Zidane-Marinnes, M., Serrano, S. V., Magnabosco, W. J., Vilas, A., Decia, R., Carusso, F., Graham, L. S., Anderson, K., Bilen, M. A., Arciero, C., Pellegrin, I., Ricard, S., Scelo, G., Banks, R. E., Vasudev, N. S., Soomro, N., Stewart, G. D., Adeyoju, A., Bromage, S., Hrouda, D., Gibbons, N., Patel, P., Sullivan, M., Protheroe, A., Nugent, F. I., Fournier, M. J., Zhang, X., Martin, L. J., Komisarenko, M., Eisen, T., Cunningham, S. A., Connolly, D. C., Uzzo, R. G., Zaridze, D., Mukeria, A., Holcatova, I., Hornakova, A., Foretova, L., Janout, V., Mates, D., Jinga, V., Rascu, S., Mijuskovic, M., Savic, S., Milosavljevic, S., Gaborieau, V., Abedi-Ardekani, B., McKay, J., Johansson, M., Phouthavongsy, L., Hayman, L., Li, J., Lungu, I., Bezerra, S. M., Souza, A. G., Sares, C. T. G., Reis, R. B., Gallucci, F. P., Cordeiro, M. D., Pomerantz, M., Lee, G. S. M., Freedman, M. L., Jeong, A., Greenberg, S. E., Sanchez, A., Thompson, R. H., Sharma, V., Thiel, D. D., Ball, C. T., Abreu, D., Lam, E. T., Nahas, W. C., Master, V. A., Patel, A. V., Bernhard, J. C., Freedman, N. D., Bigot, P., Reis, R. M., Colli, L. M., Finelli, A., Manley, B. J., Terao, C., Choueiri, T. K., Carraro, D. M., Houlston, R., Eckel-Passow, J. E., Abbosh, P. H., Ganna, A., Brennan, P., Gu, J. & Chanock, S. J., May 2024, In: Nature Genetics. 56, 5, p. 809-818 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Novel loci and biomedical consequences of iron homoeostasis variation

  DBDS Genomic Consortium, FinnGen Consortium, Allara, E., Bell, S., Wang, F., Palotie, A., Daly, M., Mäkelä, T. P., Kaprio, J., Perola, M., Partanen, J., Raivio, T., Ripatti, S., Carpén, O., Raivio, M., Tienari, P., Partanen, J., Färkkilä, M., Koskela, J. & Pikkarainen, S. & 87 others, Eklund, K., Mars, N., Kauppi, P., Vaura, F., Gordin, D., Sinisalo, J., Taskinen, M.-R., Tuomi, T., Hiltunen, T., Reeve, M. P., Ruotsalainen, S., Meretoja, T., Joensuu, H., Mattson, J., Salminen, E., Karihtala, P., Pitkänen, E., Turunen, J. A., Ollila, T., Karjalainen, J., Hannula-Jouppi, K., Pussinen, P., Salminen, A., Salo, T., Rice, D., Nieminen, P., Palotie, U., Laivuori, H., Kurra, V., Heikinheimo, O., Kalliala, I., Aaltonen, L., Djousse, L., Cho, K., Inouye, M., Burgess, S., Benyamin, B., Oexle, K., Swinkels, D. W., Stefansson, K., Magnusson, M., Ganna, A., Gaziano, M., Ivey, K., Danesh, J., Pereira, A., Wood, A. M., Butterworth, A. S., Di Angelantonio, E., Kivinen, K., Tukiainen, T., Ollila, H., Saarentaus, E., Åberg, F., Kurki, M., Havulinna, A., Mehtonen, J., Palta, P., Hassan, S., Della Briotta Parolo, P., Lemmelä, S., Liu, A., Lehisto, A., Llorens, V., Heyne, H., Rämö, J., Rodosthenous, R., Strausz, S., Lee, J., Kajanne, R., Aavikko, M., Cooper, H., Öller, D., Leinonen, R., Lahtela, L. E., Kaunisto, M., Kilpeläinen, E., Sipilä, T. P., Dada, O. A., Ghazal, A., Kytölä, A., Weldatsadik, R., Donner, K. M., Luo, S., Padmanabhuni, S. S., Hovatta, I. & Mäkitie, A., 2024, In: Communications Biology. 7, 1, 17 p., 1631.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Patterns of reproductive health in inflammatory rheumatic diseases and other immune-mediated diseases: a nationwide registry study

  Kerola, A. M., Palomäki, A., Laivuori, H., Laitinen, T., Färkkilä, M., Eklund, K. K., Ripatti, S., Perola, M., Ganna, A., Lindbohm, J. V. & Mars, N., 20 Mar 2024, In: Rheumatology. 63, 10, p. 2701–2710 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Socio-demographic and genetic risk factors for drug adherence and persistence across 5 common medication classes

  FinnGen, Estonian Biobank Research Team, Cordioli, M., Corbetta, A., Kariis, H. M., Jukarainen, S., Vartiainen, P., Kiiskinen, T., Ferro, M., Ganna, A., Ripatti, S., Perola, M., Hudjashov, G., Nelis, M., Mägi, R., Esko, T., Milani, L., Metspalu, A., Niemi, M. & Ripatti, S. & 2 others, Lehto, K. & Ganna, A., Dec 2024, In: Nature Communications. 15, 1, 13 p., 9156.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• The European Health Data Space can be a boost for research beyond borders

  Ganna, A., Carracedo, A., Christiansen, C. F., Di Angelantonio, E., Dykstra, P. A., Dzhambov, A. M., Eils, R., Green, S., Schneider, K. L., Varga, T. V., Vuorinen, A. L., Zuccolo, L., Rod, N. H. & Hoeyer, K., Nov 2024, In: Nature Medicine. 30, 11, p. 3053-3056 4 p.

  Research output: Contribution to journal › Editorial › Scientific
• 2023

  ADuLT: An efficient and robust time-to-event GWAS

  Pedersen, E. M., Agerbo, E., Plana-Ripoll, O., Steinbach, J., Krebs, M. D., Hougaard, D. M., Werge, T., Nordentoft, M., Borglum, A. D., Musliner, K. L., Ganna, A., Schork, A. J., Mortensen, P. B., Mcgrath, J. J., Prive, F. & Vilhjalmsson, B. J., 9 Sept 2023, In: Nature Communications. 14, 1, 12 p., 5553.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• A MULTIDISCIPLINARY APPROACH TO BETTER UNDERSTAND TREATMENT RESISTANT DEPRESSION

  Yi, L., Xiong, Y., Krebs, K., Jermy, B. S., Ganna, A., Sullivan, P. F., Lehto, K. & Landén, M., 2023, In: European Neuropsychopharmacology. 75

  Research output: Contribution to journal › Meeting Abstract › peer-review

• A second update on mapping the human genetic architecture of COVID-19

  Covid 19 Host Genetics Initiative, Kanai, M., Andrews, S., Cordioli, M., Stevens, C., Neale, B. M., Daly, M. J., Ganna, A., Kanai, M., Andrews, S., Cordioli, M., Pathak, G. A., Iwasaki, A., Karjalainen, J., Mehtonen, J., Pirinen, M., Marttila, M. M., Mondal, S., Nakanishi, T. & Niemi, M. E. K. & 21 others, Cordioli, M., Pigazzini, S., Nakanishi, T., Wong, I., Corbetta, A., Niemi, M. E. K., Corbetta, A., Ripatti, S., Jermy, B., Ruotsalainen, S., Kristiansson, K., Koskelainen, S., Perola, M., Donner, K., Kivinen, K., Palotie, A., Kaunisto, M., Bishop, L., Ding, Y., Nakanishi, T. & Zhou, W., 7 Sept 2023, In: Nature. 621, 7977, p. E7–E26 23 p.

  Research output: Contribution to journal › Letter › Scientific › peer-review

  Open Access

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• Characterizing personalized effects of family information on disease risk using graph representation learning

  Wharrie, S., Yang, Z., Ganna, A. & Kaski, S., 2023, In: Proceedings of Machine Learning Research. 219, p. 824-845 22 p.

  Research output: Contribution to journal › Conference article › Scientific › peer-review

  Open Access

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• Data Resource Profile: Nationwide registry data for high-throughput epidemiology and machine learning (FinRegistry)

  Finn Gen, Viippola, E., Kuitunen, S., Rodosthenous, R. S., Vabalas, A., Hartonen, T., Vartiainen, P., Demmler, J., Vuorinen, A.-L., Liu, A., Havulinna, A. S., Llorens, V., Detrois, K. E., Wang, F., Ferro, M., Karvanen, A., German, J., Jukarainen, S., Gracia-Tabuenca, J. & Hiekkalinna, T. & 20 others, Koskelainen, S., Kiiskinen, T., Lahtela, E., Lemmelä, S., Paajanen, T., Siirtola, H., Reeve, M. P., Kristiansson, K., Brunfeldt, M., Aavikko, M., Perola, M., Ganna, A., Kaprio, J., Mäkitie, A., Tienari, P., Hovatta, I., Arvas, M., Hyvärinen, K., Ritari, J. & Partanen, J., 2 Aug 2023, In: International Journal of Epidemiology. 52, 4, p. e195–e200 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Deep phenotyping and genomic data from a nationally representative study on dementia in India

  Lee, J., Petrosyan, S., Khobragade, P., Banerjee, J., Chien, S., Weerman, B., Gross, A., Hu, P., Smith, J. A., Zhao, W., Aksman, L., Jain, U., Shanthi, G. S., Kurup, R., Raman, A., Chakrabarti, S. S., Gambhir, I. S., Varghese, M., John, J. P. & Joshi, H. & 36 others, Koul, P. A., Goswami, D., Talukdar, A., Mohanty, R. R., Yadati, Y. S. R., Padmaja, M., Sankhe, L., Rajguru, C., Gupta, M., Kumar, G., Dhar, M., Jovicich, J., Ganna, A., Ganguli, M., Chatterjee, P., Singhal, S., Bansal, R., Bajpai, S., Desai, G., Bhatankar, S., Rao, A. R., Sivakumar, P. T., Muliyala, K. P., Sinha, P., Loganathan, S., Meijer, E., Angrisani, M., Kim, J. K., Dey, S., Arokiasamy, P., Bloom, D. E., Toga, A. W., Kardia, S. L. R., Langa, K., Crimmins, E. M. & Dey, A. B., 20 Jan 2023, In: Scientific data . 10, 1, 12 p., 45.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Development and validation of DNA methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes

  Cheng, Y., Gadd, D. A., Gieger, C., Monterrubio-Gomez, K., Zhang, Y., Berta, I., Stam, M. J., Szlachetka, N., Lobzaev, E., Wrobel, N., Murphy, L., Campbell, A., Nangle, C., Walker, R. M., Fawns-Ritchie, C., Peters, A., Rathmann, W., Porteous, D. J., Evans, K. L. & McIntosh, A. M. & 6 others, Cannings, T. I., Waldenberger, M., Ganna, A., McCartney, D. L., Vallejos, C. A. & Marioni, R. E., Apr 2023, In: Nature Aging. 3, 4, p. 450-+ 15 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• Evidence from Finland and Sweden on the relationship between early-life diseases and lifetime childlessness in men and women

  Liu, A., Akimova, E. T., Ding, X., Jukarainen, S., Vartiainen, P., Kiiskinen, T., Koskelainen, S., Havulinna, A. S., Gissler, M., Lombardi, S., Fall, T., Mills, M. C. & Ganna, A., Dec 2023, In: Nature Human Behaviour. 15 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata

  Sliz, E., Tyrmi, J. S., Rahmioglu, N., Zondervan, K. T., Becker, C. M., Uimari, O., Kettunen, J., Palotie, A., Daly, M., Riley-Gills, B., Jacob, H., Paul, D., Matakidou, A., Platt, A., Runz, H., John, S., Okafo, G., Lawless, N., Salminen-Mankonen, H. & Plenge, R. & 306 others, Maranville, J., McCarthy, M., Ehm, M. G., Auro, K., Longerich, S., Fox, C., Malarstig, A., Klinger, K., Chatelain, C., Gossel, M., Estrada, K., Graham, R., Yang, R., O'Donnell, C., Mäkelä, T. P., Kaprio, J., Virolainen, P., Hakanen, A., Kilpi, T., Perola, M., Partanen, J., Pitkäranta, A., Raivio, T., Serpi, R., Laitinen, T., Kosma, V.-M., Laukkanen, J., Hautalahti, M., Tuovila, O., Pakkanen, R., Waring, J., Riley-Gillis, B., Rahimov, F., Tachmazidou, I., Chen, C.-Y., Ding, Z., Jung, M., Biswas, S., Pendergrass, R., Pulford, D., Raghavan, N., Huertas-Vazquez, A., Sul, J.-H., Hu, X., Hedman, A., Rivas, M., Waterworth, D., Renaud, N., Obeidat, M., Ripatti, S., Schleutker, J., Arvas, M., Carpen, O., Hinttala, R., Mannermaa, A., Aalto-Setala, K., Kahonen, M., Mäkelä, J., Kalviainen, R., Julkunen, V., Soininen, H., Remes, A., Hiltunen, M., Peltola, J., Raivio, M., Tienari, P., Rinne, J., Kallionpaa, R., Partanen, J., Abbasi, A., Ziemann, A., Smaoui, N., Lehtonen, A., Eaton, S., Lahdenpera, S., Bowers, N., Teng, E., Xu, F., Addis, L., Eicher, J., Li, Q. S., He, K., Khramtsova, E., Färkkilä, M., Koskela, J., Pikkarainen, S., Jussila, A., Kaukinen, K., Blomster, T., Kiviniemi, M., Voutilainen, M., Lu, T., McCarthy, L., Hart, A., Guan, M., Miller, J., Kalpala, K., Miller, M., Eklund, K., Palomaki, A., Isomaki, P., Pirila, L., Kaipiainen-Seppanen, O., Huhtakangas, J., Mars, N., Lertratanakul, A., Hochfeld, M., Gordillo, J. E., Farias, F., Bing, N., Pelkonen, M., Kauppi, P., Kankaanranta, H., Harju, T., Lahesmaa, R., Lassi, G., Chen, H., Betts, J., Mishra, R., Mouded, M., Ngo, D., Niiranen, T., Vaura, F., Salomaa, V., Metsarinne, K., Aittokallio, J., Hernesniemi, J., Gordin, D., Sinisalo, J., Taskinen, M.-R., Tuomi, T., Elliott, A., Reeve, M. P., Ruotsalainen, S., Challis, B., Chu, A., Reilly, D., Mendelson, M., Parkkinen, J., Meretoja, T., Joensuu, H., Mattson, J., Salminen, E., Auranen, A., Karihtala, P., Auvinen, P., Elenius, K., Pitkänen, E., Popovic, R., Schutzman, J., Kulkarni, D., Porello, A., Loboda, A., Lehtonen, H., McDonough, S., Vuoti, S., Kaarniranta, K., Turunen, J. A., Ollila, T., Uusitalo, H., Karjalainen, J., Liu, M., Loomis, S., Strauss, E., Chen, H., Tasanen, K., Huilaja, L., Hannula-Jouppi, K., Salmi, T., Peltonen, S., Koulu, L., Choy, D., Wu, Y., Pussinen, P., Salminen, A., Salo, T., Rice, D., Nieminen, P., Palotie, U., Siponen, M., Suominen, L., Mäntylä, P., Gursoy, U., Anttonen, V., Sipila, K., Laivuori, H., Kurra, V., Kotaniemi-Talonen, L., Heikinheimo, O., Kalliala, I., Aaltonen, L., Jokimaa, V., Vaarasmaki, M., Morin-Papunen, L., Niinimaki, M., Piltonen, T., Kivinen, K., Widen, E., Tukiainen, T., Välimäki, N., Laakkonen, E., Silven, H., Arffman, R., Savukoski, S., Laisk, T., Pujol, N., Kumar, J., Hovatta, I., Isometsä, E., Ollila, H., Suvisaari, J., Als, T. D., Mäkitie, A., Bizaki-Vallaskangas, A., Toppila-Salmi, S., Willberg, T., Saarentaus, E., Aarnisalo, A., Rahikkala, E., Aittomaki, K., Åberg, F., Kurki, M., Havulinna, A., Mehtonen, J., Palta, P., Hassan, S., Parolo, P. D. B., Zhou, W., Maasha, M., Lemmela, S., Liu, A., Lehisto, A., Ganna, A., Llorens, V., Heyne, H., Rämö, J., Rodosthenous, R., Strausz, S., Palotie, T., Palin, K., Garcia-Tabuenca, J., Siirtola, H., Kiiskinen, T., Lee, J., Tsuo, K., Kristiansson, K., Hyvärinen, K., Ritari, J., Pylkas, K., Karjalainen, M., Mantere, T., Kangasniemi, E., Heikkinen, S., Pitkanen, N., Lessard, S., Chatelain, C., Terho, P., Wahlfors, T., Punkka, E., Siltanen, S., Kuopio, T., Jalanko, A., Shen, H.-Y., Kajanne, R., Aavikko, M., Palin, H., Linna, M.-M., Kanai, M., Zheng, Z., Lahtela, L. E., Kaunisto, M., Kilpeläinen, E., Sipila, T. P., Dada, O. A., Ghazal, A., Kytölä, A., Weldatsadik, R., Donner, K., Loukola, A., Laiho, P., Sistonen, T., Kaiharju, E., Laukkanen, M., Jarvensivu, E., Lahteenmaki, S., Mannikko, L., Wong, R., Toivola, A., Brunfeldt, M., Mattsson, H., Koskelainen, S., Hiekkalinna, T., Paajanen, T., Pärn, K., Kals, M., Luo, S., Padmanabhuni, S. S., Niemi, M., Gracia-Tabuenca, J., Helminen, M., Luukkaala, T., Vahatalo, I., Tammerluoto, J., Smith, S., Southerington, T. & Lehto, P., 1 Feb 2023, In: Nature Communications. 14, 542, 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• FinnGen provides genetic insights from a well-phenotyped isolated population

  FinnGen, Kurki, M. I., Karjalainen, J., Palta, P., Sipilä, T. P., Kristiansson, K., Donner, K. M., Reeve, M. P., Laivuori, H., Aavikko, M., Kaunisto, M. A., Loukola, A., Mattsson, H., Laiho, P., Della Briotta Parolo, P., Lehisto, A. A., Mars, N., Rämö, J., Kiiskinen, T. & Heyne, H. O. & 63 others, Rüeger, S., Lemmelä, S., Zhou, W., Ruotsalainen, S., Pärn, K., Hiekkalinna, T., Koskelainen, S., Paajanen, T., Llorens, V., Gracia-Tabuenca, J., Auro, K., Carpen, O., Dada, O. A., Eklund, K., Färkkilä, M., Ganna, A., Ghazal, A., Hovatta, I., Joensuu, H., Julkunen, V., Kajanne, R., Kaprio, J., Kettunen, J., Kilpeläinen, E., Kurra, V., Laukkanen, J., Liu, A., Mäkelä, J., Mäkitie, A., Meretoja, T., Niemi, M. E. K., Niemi, M., Niiranen, T., Ollila, H. M., Palomäki, A., Palotie, T., Partanen, J., Pelkonen, M., Pitkäranta, A., Punkka, E., Pussinen, P., Rodosthenous, R., Saarentaus, E., Salminen, A., Salminen, E., Shen, H.-Y., Silander, K., Soini, S., Tienari, P., Toppila-Salmi, S., Tukiainen, T., Tuomi, T., Turunen, J. A., Vaura, F., Havulinna, A. S., Perola, M., Ripatti, S., Jalanko, A., Laitinen, T., Mäkelä, T. P., Daly, M. J., Palotie, A. & Kanai, M., 19 Jan 2023, In: Nature. 613, 7944, p. 508-+ 20 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases

  FinnGen, Kiiskinen, T., Helkkula, P., Krebs, K., Karjalainen, J., Saarentaus, E., Mars, N., Lehisto, A., Zhou, W., Cordioli, M., Jukarainen, S., Rämö, J. T., Mehtonen, J., Veerapen, K., Räsänen, M., Ruotsalainen, S., Maasha, M., Niiranen, T., Tuomi, T. & Salomaa, V. & 12 others, Kurki, M., Pirinen, M., Palotie, A., Daly, M., Ganna, A., Havulinna, A. S., Milani, L., Ripatti, S., Arvas, M., Hyvärinen, K., Ritari, J. & Partanen, J., Jan 2023, In: Nature Medicine. 29, 1, p. 209–218 28 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

  FinnGen, Mathieson, I., Day, F. R., Barban, N., Ganna, A., Kiiskinen, T., Arvas, M., Hyvärinen, K., Ritari, J. & Partanen, J., 2 Mar 2023, In: Nature Human Behaviour. 7, 5, p. 790-801 15 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity

  Rajagopal, V. M., Ganna, A., Coleman, J. R., Allegrini, A., Voloudakis, G., Grove, J., Als, T. D., Horsdal, H. T., Petersen, L., Appadurai, V., Schork, A., Buil, A., Bulik, C. M., Bybjerg-Grauholm, J., Baekvad-Hansen, M., Hougaard, D. M., Mors, O., Nordentoft, M., Werge, T. & Mortensen, P. B. & 6 others, Breen, G., Roussos, P., Plomin, R., Agerbo, E., Borglum, A. D. & Demontis, D., 9 Jan 2023, In: Scientific Reports. 13, 1, 16 p., 429.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts

  BBJ, BioMe, BioVU, Canadian Partnership for Tomorrow's Health/OHS, China Kadoorie Biobank Collaborative Group, Colorado Center for Personalized Medicine, deCODE Genetics, ESTBB, FinnGen, Generation Scotland, Genes & Health, LifeLines, Mass General Brigham Biobank, Michigan Genomics Initiative, QIMR Berghofer Biobank, Taiwan Biobank, The HUNT Study, UCLA ATLAS Community Health Initiative, UKBB & Wang, Y. & 12 others, Lopera, E., Kerminen, S., Karjalainen, J., Kurki, M., Partanen, J. J., Palta, P., Ganna, A., Koskela, J. T., Palotie, A. V., Daly, M. J., Neale, B. M. & Kaprio, J., 11 Jan 2023, In: Cell genomics. 3, 1, 18 p., 100241.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• HAPNEST: efficient, large-scale generation and evaluation of synthetic datasets for genotypes and phenotypes

  Wharrie, S., Yang, Z., Raj, V., Monti, R., Gupta, R., Wang, Y., Martin, A., O'Connor, L. J., Kaski, S., Marttinen, P., Palamara, P. F., Lippert, C. & Ganna, A., 1 Sept 2023, In: Bioinformatics. 39, 9, 10 p., btad535.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

  FinnGen, Ollila, H. M., Sharon, E., Lin, L., Partinen, M., Perola, M., Palotie, A., Kytölä, A., Ganna, A., Jalanko, A., Liu, A., Lehisto, A., Ghazal, A., Kilpeläinen, E., Widen, E., Saarentaus, E., Pitkänen, E., Ollila, H. M., Laivuori, H. & Heyne, H. & 41 others, Shen, H.-Y., Kaprio, J., Rämö, J., Karjalainen, J. M., Mehtonen, J. M. F., Pitkänen, J., Pärn, K., Donner, K., Kivinen, K., Lahtela, L. E., Niemi, M. E., Kaunisto, M., Mars, N., Dada, O. A., Della Briotta Parolo, P., Palta, P., Weldatsadik, R., Kajanne, R., Rodosthenous, R., Ripatti, S., Ruotsalainen, S., Strausz, S. J., Hassan, S., Padmanabhuni, S. S., Luo, S., Lemmelä, S., Tukiainen, T., Sipilä, T., Kiiskinen, T., Llorens, V., Daly, M., Lee, J., Kurki, M. I., Havulinna, A., Mäkitie, A., Tienari, P., Hovatta, I., Arvas, M., Hyvärinen, K., Ritari, J. & Partanen, J., 15 May 2023, In: Nature Communications. 14, 1, 13 p., 2709.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Nationwide health, socio-economic and genetic predictors of COVID-19 vaccination status in Finland

  FinnGen, Estonian Biobank Research Team, Hartonen, T., Jermy, B., Sonajalg, H., Vartiainen, P., Krebs, K., Vabalas, A., Leino, T., Nohynek, H., Sivelä, J., Mägi, R., Daly, M., Ollila, H. M., Milani, L., Perola, M., Ripatti, S., Ganna, A., Arvas, M. & Hyvärinen, K. & 2 others, Ritari, J. & Partanen, J., Jul 2023, In: Nature Human Behaviour. 7, 7, p. 1069-+ 25 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Patterns of item nonresponse behaviour to survey questionnaires are systematic and associated with genetic loci

  Mignogna, G., Carey, C. E. E., Wedow, R., Baya, N., Cordioli, M., Pirastu, N., Bellocco, R., Malerbi, K. F., Nivard, M. G. G., Neale, B. M., Walters, R. K. K. & Ganna, A., Aug 2023, In: Nature Human Behaviour. 7, 8, p. 1371-+ 21 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Quantifying the causal impact of biological risk factors on healthcare costs

  Lee, J., Jukarainen, S., Karvanen, A., Dixon, P., Davies, N. M., Smith, G. D., Natarajan, P. & Ganna, A., 13 Sept 2023, In: Nature Communications. 14, 1, 11 p., 5672.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Rekisteritutkimus RSV-infektion riskitekijöistä voi auttaa uusien profylaksien kohdentamisessa

  Vartiainen, P., Jukarainen, S., Rhedin, S. A., Prinz, A., Hartonen, T., Vabalas, A., Viippola, E., Rodosthenous, R., Koskelainen, S., Liu, A., Lundholm, C., Smew, A. I., Osvald, E. C., Korvenranta, E., Perola, M., Almqvist, C., Heinonen, S. H. & Ganna, A., 26 Oct 2023, In: Duodecim. 139, 23, p. 1993 1 p.

  Research output: Contribution to journal › Comment/debate › Professional

• Risk factors for severe respiratory syncytial virus infection during the first year of life: development and validation of a clinical prediction model

  Vartiainen, P., Jukarainen, S., Rhedin, S. A., Prinz, A., Hartonen, T., Vabalas, A., Viippola, E., Rodosthenous, R. S., Koskelainen, S., Liu, A., Lundholm, C., Smew, A. I., Osvald, E. C., Helle, E., Perola, M., Almqvist, C., Heinonen, S. & Ganna, A., Nov 2023, In: The Lancet Digital Health. 5, 11, p. e821-e830 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• 2022

  A framework to assess the effects of genetic risk factors on disability-adjusted life years

  Jukarainen, S. & Ganna, A., 2022, In: Nature Medicine. 28, p. 1769–1770 2 p.

  Research output: Contribution to journal › Editorial › Scientific

• Cystatin C is associated with adverse COVID-19 outcomes in diverse populations

  Kleeman, S. O., Cordioli, M., Timmers, P. R. H. J., Khan, A., Tober-Lau, P., Kurth, F., Demichev, V., Meyer, H., Wilson, J. F., Ralser, M., Kiryluk, K., Ganna, A., Baillie, K. & Janowitz, T., 21 Oct 2022, In: iScience. 25, 10, 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Detailed stratified GWAS analysis for severe COVID-19 in four European populations

  COVICAT study group, Aachen Study (COVAS), Norwegian SARS-CoV-2 Study group, Pa Study Group, STORM Study group, The Humanitas Task Force, The Humanitas Gavazzeni Task Force, Degenhardt, F., Ellinghaus, D., Juzenas, S., Ganna, A., Niemi, M. E. K., Cordioli, M. & Pigazzini, S., 2022, In: Human Molecular Genetics. 31, 23, p. 3945-3966 22 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative

  Butler-Laporte, G., Povysil, G., Kosmicki, J. A., Cirulli, E. T., Drivas, T., Furini, S., Saad, C., Schmidt, A., Olszewski, P., Korotko, U., Quinodoz, M., Çelik, E., Kundu, K., Walter, K., Jung, J., Stockwell, A. D., Sloofman, L. G., Jordan, D. M., Thompson, R. C. & Del Valle, D. & 139 others, Simons, N., Cheng, E., Sebra, R., Schadt, E. E., Kim-Schulze, S., Gnjatic, S., Merad, M., Buxbaum, J. D., Beckmann, N. D., Charney, A. W., Przychodzen, B., Chang, T., Pottinger, T. D., Shang, N., Brand, F., Fava, F., Mari, F., Chwialkowska, K., Niemira, M., Pula, S., Kenneth Baillie, J., Stuckey, A., Salas, A., Bello, X., Pardo-Seco, J., Gómez-Carballa, A., Rivero-Calle, I., Martinón-Torres, F., Ganna, A., Karczewski, K. J., Veerapen, K., Bourgey, M., Bourque, G., Eveleigh, R. J. M., Forgetta, V., Morrison, D., Langlais, D., Lathrop, M., Mooser, V., Nakanishi, T., Frithiof, R., Hultström, M., Lipcsey, M., Marincevic-Zuniga, Y., Nordlund, J., Schiabor Barrett, K. M., Lee, W., Bolze, A., White, S., Riffle, S., Tanudjaja, F., Sandoval, E., Neveux, I., Dabe, S., Casadei, N., Motameny, S., Alaamery, M., Massadeh, S., Aljawini, N., Almutairi, M. S., Arabi, Y. M., Alqahtani, S. A., Al Harthi, F. S., Almutairi, A., Alqubaishi, F., Alotaibi, S., Binowayn, A., Alsolm, E. A., Bardisy, H. E., Fawzy, M., Cai, F., Soranzo, N., Butterworth, A., Center, R. G., Geschwind, D. H., Arteaga, S., Stephens, A., Butte, M. J., Boutros, P. C., Yamaguchi, T. N., Tao, S., Eng, S., Sanders, T., Tung, P. J., Broudy, M. E., Pan, Y., Gonzalez, A., Chavan, N., Johnson, R., Pasaniuc, B., Yaspan, B., Smieszek, S., Rivolta, C., Bibert, S., Bochud, P. Y., Dabrowski, M., Zawadzki, P., Sypniewski, M., Kaja, E., Chariyavilaskul, P., Nilaratanakul, V., Hirankarn, N., Shotelersuk, V., Pongpanich, M., Phokaew, C., Chetruengchai, W., Tokunaga, K., Sugiyama, M., Kawai, Y., Hasegawa, T., Naito, T., Namkoong, H., Edahiro, R., Kimura, A., Ogawa, S., Kanai, T., Fukunaga, K., Okada, Y., Imoto, S., Miyano, S., Mangul, S., Abedalthagafi, M. S., Zeberg, H., Grzymski, J. J., Washington, N. L., Ossowski, S., Ludwig, K. U., Schulte, E. C., Riess, O., Moniuszko, M., Kwasniewski, M., Mbarek, H., Ismail, S. I., Verma, A., Goldstein, D. B., Kiryluk, K., Renieri, A., Ferreira, M. A. R. & Brent Richards, J., 3 Nov 2022, In: PLoS Genetics. 18, 11, 26 p., e1010367.

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• Genetic risk factors have a substantial impact on healthy life years

  Jukarainen, S., Kiiskinen, T., Kuitunen, S., Havulinna, A. S., Karjalainen, J., Cordioli, M., Rämö, J. T., Mars, N., Samocha, K. E., Ollila, H. M., Pirinen, M. & Ganna, A., Sept 2022, In: Nature Medicine. 28, p. 1893–1901 27 p.

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• Genome-wide risk prediction of common diseases across ancestries in one million people

  Mars, N., Kerminen, S., Feng, Y.-C. A., Kanai, M., Läll, K., Thomas, L. F., Skogholt, A. H., della Briotta Parolo, P., Neale, B., Smoller, J. W., Gabrielsen, M. E., Hveem, K., Mägi, R., Matsuda, K., Okada, Y., Pirinen, M., Palotie, A., Ganna, A., Martin, A. R. & Ripatti, S., 2022, In: Cell genomics. 2, 4, 16 p., 100118.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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