Photo of Andrey Anisimov
  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

20072018
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Publications 2007 2018

2018

Chymase released from hypoxia-activated cardiac mast cells cleaves human apoA-I at Tyr192 and compromises its cardioprotective activity

Kareinen, I., Baumann, M., Su Duy Nguyen, Maaninka, K., Anisimov, A., Tozuka, M., Jauhiainen, M., Lee-Rueckert, M. & Kovanen, P. T., Jun 2018, In : Journal of Lipid Research. 59, 6, p. 945-957 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Consensus guidelines for the use and interpretation of angiogenesis assays

Nowak-Sliwinska, P., Alitalo, K., Allen, E., Anisimov, A., Aplin, A. C., Auerbach, R., Augustin, H. G., Bates, D. O., van Beijnum, J. R., Bender, R. H. F., Bergers, G., Bikfalvi, A., Bischoff, J., Boeck, B. C., Brooks, P. C., Bussolino, F., Cakir, B., Carmeliet, P., Castranova, D., Cimpean, A. M. & 66 othersCleaver, O., Coukos, G., Davis, G. E., De Palma, M., Dimberg, A., Dings, R. P. M., Djonov, V., Dudley, A. C., Dufton, N. P., Fendt, S-M., Ferrara, N., Fruttiger, M., Fukumura, D., Ghesquiere, B., Gong, Y., Griffin, R. J., Harris, A. L., Hughes, C. C. W., Hultgren, N. W., Iruela-Arispe, M. L., Irving, M., Jain, R. K., Kalluri, R., Kalucka, J., Kerbel, R. S., Kitajewski, J., Klaassen, I., Kleinmann, H. K., Koolwijk, P., Kuczynski, E., Kwak, B. R., Marien, K., Melero-Martin, J. M., Munn, L. L., Nicosia, R. F., Noel, A., Nurro, J., Olsson, A-K., Petrova, T. V., Pietras, K., Pili, R., Pollard, J. W., Post, M. J., Quax, P. H. A., Rabinovich, G. A., Raica, M., Randi, A. M., Ribatti, D., Ruegg, C., Schlingemann, R. O., Schulte-Merker, S., Smith, L. E. H., Song, J. W., Stacker, S. A., Stalin, J., Stratman, A. N., Van de Velde, M., van Hinsbergh, V. W. M., Vermeulen, P. B., Waltenberger, J., Weinstein, B. M., Xin, H., Yetkin-Arik, B., Yla-Herttuala, S., Yoder, M. C. & Griffioen, A. W., Aug 2018, In : Angiogenesis. 21, 3, p. 425-532 108 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2017

Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis

Rademakers, T., van der Vorst, E. P. C., Daissormont, I. T. M. N., Otten, J. J. T., Theodorou, K., Theelen, T. L., Gijbels, M., Anisimov, A., Nurmi, H., Lindeman, J. H. N., Schober, A., Heeneman, S., Alitalo, K. & Biessen, E. A. L., 28 Mar 2017, In : Scientific Reports. 7, 10 p., 45263.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Ischemia-Reperfusion Injury Enhances Lymphatic Endothelial VEGFR3 and Rejection in Cardiac Allografts

Dashkevich, A., Raissadati, A., Syrjala, S. O., Zarkada, G., Keranen, M. A. I., Tuuminen, R., Krebs, R., Anisimov, A., Jeltsch, M., Leppanen, V. -M., Alitalo, K., Nykanen, A. I. & Lemstrom, K. B., Apr 2016, In : American Journal of Transplantation. 16, 4, p. 1160-1172 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD

Bui, H. M., Enis, D., Robciuc, M. R., Nurmi, H. J., Cohen, J., Chen, M., Yang, Y., Dhillon, V., Johnson, K., Zhang, H., Kirkpatrick, R., Traxler, E., Anisimov, A., Alitalo, K. & Kahn, M. L., 2016, In : Journal of Clinical Investigation. 126, 6, p. 2167-2180 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Tie1 controls angiopoietin function in vascular remodeling and inflammation

Korhonen, E. A., Lampinen, A., Giri, H., Anisimov, A., Kim, M., Allen, B., Fang, S., D'Amico, G., Sipila, T. J., Lohela, M., Strandin, T., Vaheri, A., Yla-Herttuala, S., Koh, G. Y., McDonald, D. M., Alitalo, K. & Saharinen, P., Sep 2016, In : Journal of Clinical Investigation. 126, 9, p. 3495-3510 16 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling

Holopainen, T., Rasanen, M., Anisimov, A., Tuomainen, T., Zheng, W., Tvorogov, D., Hulmi, J. J., Andersson, L. C., Cenni, B., Tavi, P., Mervaala, E., Kivela, R. & Alitalo, K., 20 Oct 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 42, p. 13063-13068 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Therapeutic use of VEGF-C and CCBE1

Alitalo, K., Jeltsch, M. & Anisimov, A., 19 Feb 2015, WIPO, Patent No. WO2015/022447, 15 Feb 2015, Priority date 14 Aug 2013, Priority No. 20135832 (FI)

Research output: PatentScientific

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2014

CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3-Mediated Vascular Endothelial Growth Factor-C Activation

Jeltsch, M., Jha, S. K., Tvorogov, D., Anisimov, A., Leppanen, V-M., Holopainen, T., Kivela, R., Ortega, S., Karpanen, T. & Alitalo, K., 13 May 2014, In : Circulation . 129, 19, p. 1962-1971 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Intraluminal Cell Transplantation Prevents Growth and Rupture in a Model of Rupture-Prone Saccular Aneurysms

Marbacher, S., Frosen, J., Marjamaa, J., Anisimov, A., Honkanen, P., von Gunten, M., Abo Ramadan, U., Hernesniemi, J. & Niemela, M., Dec 2014, In : Stroke. 45, 12, p. 3684-+ 23 p.

Research output: Contribution to journalArticleScientificpeer-review

Pulmonary Lymphangiectasia Resulting From Vascular Endothelial Growth Factor-C Overexpression During a Critical Period

Yao, L-C., Testini, C., Tvorogov, D., Anisimov, A., Vargas, S. O., Baluk, P., Pytowski, B., Claesson-Welsh, L., Alitalo, K. & McDonald, D. M., 28 Feb 2014, In : Circulation Research. 114, 5, p. 806-822 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy

D'Amico, G., Korhonen, E. A., Anisimov, A., Zarkada, G., Holopainen, T., Haegerling, R., Kiefer, F., Eklund, L., Sormunen, R., Elamaa, H., Brekken, R. A., Adams, R. H., Koh, G. Y., Saharinen, P. & Alitalo, K., Feb 2014, In : Journal of Clinical Investigation. 124, 2, p. 824-834 11 p.

Research output: Contribution to journalArticleScientificpeer-review

VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

Kivelä, M. R., Bry, M., Robciuc, M. R., Räsänen, M., Taavitsainen, M., Silvola, J. M. U., Saraste, A., Hulmi, J. J., Anisimov, A., Mayranpaa, M. I., Lindeman, J. H., Eklund, L., Hellberg, S., Hlushchuk, R., Zhuang, Z. W., Simons, M., Djonov, V., Knuuti, J., Mervaala, E. & Alitalo, K., Mar 2014, In : EMBO molecular medicine. 6, 3, p. 307-321 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2013

Activation of Hypoxia Response in Endothelial Cells Contributes to Ischemic Cardioprotection

Kerkela, R., Karsikas, S., Szabo, Z., Serpi, R., Magga, J., Gao, E., Alitalo, K., Anisimov, A., Sormunen, R., Pietila, I., Vainio, L., Koch, W. J., Kivirikko, K. I., Myllyharju, J. & Koivunen, P., Aug 2013, In : Molecular and Cellular Biology. 33, 16, p. 3321-3329 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Comparison of vascular growth factors in the murine brain reveals placenta growth factor as prime candidate for CNS revascularization

Gaal, E. I., Tammela, T., Anisimov, A., Marbacher, S., Honkanen, P., Zarkada, G., Leppänen, V-M., Tatlisumak, T., Hernesniemi, J., Niemelä, M. & Alitalo, K., 1 Aug 2013, In : Blood. 122, 5, p. 658-665 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Ex vivo intracoronary gene transfer of adeno-associated virus 2 leads to superior transduction over serotypes 8 and 9 in rat heart transplants

Raissadati, A., Jokinen, J. J., Syrjala, S. O., Keränen, M. A. I., Krebs, R., Tuuminen, R., Arnaudova, R., Rouvinen, E., Anisimov, A., Soronen, J., Pajusola, K., Alitalo, K., Nykänen, A. I. & Lemström, K. B., Nov 2013, In : Transplant International. 26, 11, p. 1126-1137 12 p.

Research output: Contribution to journalArticleScientificpeer-review

PHD2 regulates arteriogenic macrophages through TIE2 signalling

Hamm, A., Veschini, L., Takeda, Y., Costa, S., Delamarre, E., Squadrito, M. L., Henze, A-T., Wenes, M., Serneels, J., Pucci, F., Roncal, C., Anisimov, A., Alitalo, K., De Palma, M. & Mazzone, M., Jun 2013, In : EMBO molecular medicine. 5, 6, p. 843-857 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation

Leppänen, V-M., Tvorogov, D., Kisko, K., Prota, A. E., Jeltsch, M., Anisimov, A., Markovic-Mueller, S., Stuttfeld, E., Goldie, K. N., Ballmer-Hofer, K. & Alitalo, K., 6 Aug 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 32, p. 12960-12965 6 p.

Research output: Contribution to journalArticleScientificpeer-review

The Basis for the Distinct Biological Activities of Vascular Endothelial Growth Factor Receptor-1 Ligands

Anisimov, A., Leppanen, V-M., Tvorogov, D., Zarkada, G., Jeltsch, M., Holopainen, T., Kaijalainen, S. & Alitalo, K., 2 Jul 2013, In : Science signaling. 6, 282, p. ra52 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Vascular Endothelial Growth Factor-Angiopoietin Chimera With Improved Properties for Therapeutic Angiogenesis

Anisimov, A., Tvorogov, D., Alitalo, A., Leppänen, V-M., An, Y., Han, E. C., Orsenigo, F., Gaal, E. I., Holopainen, T., Koh, Y. J., Tammela, T., Korpisalo, P., Keskitalo, S., Jeltsch, M., Yla-Herttuala, S., Dejana, E., Koh, G. Y., Choi, C., Saharinen, P. & Alitalo, K., 2013, In : Circulation . 127, 4, p. 424-434 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

AAV9-mediated VEGF-B Gene Transfer Improves Systolic Function in Progressive Left Ventricular Hypertrophy

Huusko, J., Lottonen, L., Merentie, M., Gurzeler, E., Anisimov, A., Miyanohara, A., Alitalo, K., Tavi, P. & Yla-Herttuala, S., Dec 2012, In : Molecular therapy. 20, 12, p. 2212-2221 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Angiopoietin-Like 4 Mediates PPAR Delta Effect on Lipoprotein Lipase-Dependent Fatty Acid Uptake but Not on Beta-Oxidation in Myotubes

Robciuc, M. R., Skrobuk, P., Anisimov, A., Olkkonen, V., Alitalo, K., Eckel, R., Koistinen, H. A., Jauhiainen, M. & Ehnholm, C., 4 Oct 2012, In : PLoS One. 7, 10, p. e46212 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis

Holopainen, T. T., Saharinen, P. I., D Amico Lago, G. V., Lampinen, A., Eklund, L., Sormunen, R., Anisimov, A., Zarkada, G., Lohela, M. K., Heloterä, H., Tammela, T., Benjamin, L., Ylä-Herttuala, S., Leow, C. C., Koh, G. Y. & Alitalo, K., 21 Mar 2012, In : Journal of the National Cancer Institute. 104, 6, p. 461-475 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Gene-Targeting of Phd2 Improves Tumor Response to Chemotherapy and Prevents Side-Toxicity

de Oliveira, R. L., Deschoemaeker, S., Henze, A-T., Debackere, K., Finisguerra, V., Takeda, Y., Roncal, C., Dettori, D., Tack, E., Jönsson, Y., Veschini, L., Peeters, A., Anisimov, A., Hofmann, M., Alitalo, K., Baes, M., D'hooge, J., Carmeliet, P. & Mazzone, M., 14 Aug 2012, In : Cancer Cell. 22, 2, p. 263-277 15 p.

Research output: Contribution to journalArticleScientificpeer-review

VEGFR-2-specific forms of VEGF-D and VEGF-C and uses thereof

Alitalo, K. K., Jeltsch, M. M., Leppänen, V-M., Aho, K. K., Anisimov, A. & Tvorogov, D., 5 Jul 2012, WIPO, Patent No. WO2012/088563, 2 Jul 2012, Priority date 24 Nov 2010, Priority No. 61/458,517 (US)

Research output: PatentScientific

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2011

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis.

Takeda, Y., Costa, S., Delamarre, E., Roncal, C., Oliveira, R. L. D., Squadrito, M. L., Finisguerra, V., Deschoemaeker, S., Bruyere, F., Wenes, M., Hamm, A., Serneels, J., Magat, J., Bhattacharyya, T., Anisimov, A., Jordan, B., Alitalo, K., Maxwell, P., Gallez, B., Zhuang, Z. & 4 othersSaito, Y., Simons, M., Palma, M. D. & Mazzone, M., 9 Oct 2011, In : Nature. 479, 7371, p. 122-126 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor

Zheng, W., Tammela, T., Yamamoto, M., Anisimov, A., Holopainen, T., Kaijalainen, S., Kärpänen, T. H., Lehti, K., Yla-Herttuala, S. & Alitalo, K., 2011, In : Blood. 118, 4, p. 1154-1162 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Structural determinants of vascular endothelial growth factor-D receptor binding and specificity

Leppänen, V-M., Jeltsch, M., Anisimov, A., Tvorogov, D., Aho, K., Kalkkinen, N., Toivanen, P., Ylä-Herttuala, S., Ballmer-Hofer, K. & Alitalo, K., 2011, In : Blood. 117, 5, p. 1507-1515 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization

Tvorogov, D., Anisimov, A., Zheng, W., Leppänen, V-M., Tammela, T., Laurinavicius, S., Holnthoner, W., Heloterä, H., Holopainen, T., Jeltsch, M., Kalkkinen, N., Lankinen, H., Ojala, P. M. & Alitalo, K., 2010, In : Cancer Cell. 18, 6, p. 630-640 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Structural determinants of growth factor binding and specificity by VEGF receptor 2

Leppänen, V-M., Prota, A. E., Jeltsch, M., Anisimov, A., Kalkkinen, N., Strandin, T., Lankinen, H., Goldman, A., Ballmer-Hofer, K. & Alitalo, K., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 6, p. 2425-2430 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation

Bry, M., Kivelä, R., Holopainen, T., Anisimov, A., Tammela, T., Soronen, J., Silvola, J., Saraste, A., Jeltsch, M., Korpisalo, P., Carmeliet, P., Lemström, K. B., Shibuya, M., Yla-Herttuala, S., Alhonen, L., Mervaala, E., Andersson, L. C., Knuuti, J. & Alitalo, K., 2010, In : Circulation . 122, 17, p. 1725-1733 9 p.

Research output: Contribution to journalArticleScientificpeer-review

VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts

Nilsson, I., Bahram, F., Li, X., Gualandi, L., Koch, S., Jarvius, M., Soderberg, O., Anisimov, A., Kholova, I., Pytowski, B., Baldwin, M., Yla-Herttuala, S., Alitalo, K. & Kreuger, J., 2010, In : EMBO Journal. 29, 8, p. 1377-1388 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2009

Activated Forms of VEGF-C and VEGF-D Provide Improved Vascular Function in Skeletal Muscle

Anisimov, A., Alitalo, A., Korpisalo, P., Soronen, J., Kaijalainen, S., Leppanen, V-M., Jeltsch, M., Yla-Herttuala, S. & Alitalo, K., 2009, In : Circulation Research. 104, p. 1302-U156 25 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts

Saharinen, P., Eklund, L., Miettinen, J., Wirkkala, R., Anisimov, A., Winderlich, M., Nottebaum, A., Vestweber, D., Deutsch, U., Koh, G. Y., Olsen, B. R. & Alitalo, K., 2008, In : Nature Cell Biology. 10, 5, p. 527-537 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

Cloning of new rubisco promoters from Brassica rapa and determination of their activity in stably transformed Brassica napus and Nicotiana tabacum plants

Anisimov, A., Koivu, K., Kanerva, A., Kaijalainen, S., Juntunen, K. & Kuvshinov, V., 2007, In : Molecular Breeding. 19, 3, p. 241-253 13 p.

Research output: Contribution to journalArticleScientificpeer-review