Photo of Andrii Domans'kyi

Andrii Domanskyi

Docent in Molecular Genetics

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

20002020

Research output per year

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Publications

2020

Back and to the Future: From Neurotoxin-Induced to Human Parkinson's Disease Models

Airavaara, M., Parkkinen, I., Konovalova, J., Albert, K., Chmielarz, P. & Domanskyi, A., 12 Feb 2020, In : Current Protocols in Neuroscience. 91, 1, 33 p., e88.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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GDNF/RETSignaling Pathway Activation Eliminates Lewy Body Pathology in Midbrain Dopamine Neurons

Chmielarz, P., Er, S., Konovalova, J., Bandres, L., Hlushchuk, I., Albert, K., Panhelainen, A., Luk, K., Airavaara, M. & Domanskyi, A., 16 Sep 2020, In : Movement Disorders. 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Glial cell line-derived neurotrophic factor receptor REarranged during transfection agonist supports dopamine neurons in Vitro and enhances dopamine release In Vivo

Mahato, A. K., Kopra, J., Renko, J-M., Visnapuu, T., Korhonen, I., Pulkkinen, N., Bespalov, M. M., Domanskyi, A., Ronken, E., Piepponen, T. P., Voutilainen, M. H., Tuominen, R. K., Karelson, M., Sidorova, Y. A. & Saarma, M., Feb 2020, In : Movement Disorders. 35, 2, p. 245-255 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2019

Activation of pro-survival signaling inhibits alpha-synuclein aggregation in dopaminergic neurons

Konovalova, J., Chmielarz, P., Er, S. & Domanskyi, A., Jul 2019, In : FEBS open bio. 9, p. 228-228 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Activation of RET tyrosine kinase prevents accumulation of misfolded alpha-synuclein induced by exogenous preformed fibrils

Chmielarz, P., Er, S., Banders, L., Alberts, K., Airavaara, M., Konovalova, J. & Domanskyi, A., Jul 2019, In : FEBS open bio. 9, p. 41-41 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Effects of Neurotrophic Factors in Glial Cells in the Central Nervous System: Expression and Properties in Neurodegeneration and Injury

Poyhonen, S., Er, S., Domanskyi, A. & Airavaara, M., 26 Apr 2019, In : Frontiers in Physiology. 10, 20 p., 486.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Identification of a factor reducing PFF-induced Lewy Body pathology in dopamine neurons

Er, S., Chmielarz, P., Konovalova, J., Bandres, L., Albert, K., Airavaara, M. & Domanskyi, A., 4 Jun 2019.

Research output: Conference materialsPoster

Interplay between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases

Konovalova, J., Gerasymchuk, D., Parkkinen, I., Chmielarz, P. & Domanskyi, A., Dec 2019, In : International Journal of Molecular Sciences. 20, 23, 26 p., 6055.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Mice with selective loss of noradrenergic neurons as a potential novel model to study presymptomatic phase of Parkinson's disease

Barut, J., Jurga, A., Rafa-Zablocka, K., Baginska, M., Parlato, R., Domanskyi, A., Nalepa, I. & Krainer, G., Jul 2019, In : FEBS open bio. 9, p. 231-231 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats

Back, S., Necarsulmer, J., Whitaker, L. R., Coke, L. M., Koivula, P., Heathward, E. J., Fortuno, L., Zhang, Y., Yeh, C. G., Baldwin, H. A., Spencer, M. D., Mejias-Aponte, C. A., Pickel, J., Hoffman, A. F., Spivak, C. E., Lupica, C. R., Underhill, S. M., Amara, S. G., Domanskyi, A., Anttila, J. E. & 5 others, Airavaara, M., Hope, B. T., Hamra, F. K., Richie, C. T. & Harvey, B. K., 3 Apr 2019, In : Neuron. 102, 1, p. 105-+ 23 p.

Research output: Contribution to journalArticleScientificpeer-review

2018

Investigating the role of microRNA biogenesis pathway in neuroprotection in primary neuronal culture model of Parkinson's disease

Konovalova, J., Er, S., Soleimanbeigi, S., Chmielarz, P. & Domanskyi, A., Oct 2018, In : Movement Disorders. 33, p. S815-S815 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke

Tseng, K-Y., Anttila, J. E., Khodosevich, K., Tuominen, R. K., Lindahl, M., Domanskyi, A. & Airavaara, M., 3 Jan 2018, In : Molecular therapy. 26, 1, p. 238-255 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Pre-α-pro-GDNF and Pre-β-pro-GDNF Isoforms Are Neuroprotective in the 6-hydroxydopamine Rat Model of Parkinson's Disease

Penttinen, A-M., Parkkinen, I., Voutilainen, M. H., Koskela, M., Bäck, S., Their, A., Richie, C. T., Domanskyi, A., Harvey, B. K., Tuominen, R. K., Nevalaita, L., Saarma, M. & Airavaara, M., 20 Jun 2018, In : Frontiers in neurology. 9, 14 p., 457.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

AAV Vector-Mediated Gene Delivery to Substantia Nigra Dopamine Neurons: Implications for Gene Therapy and Disease Models

Albert, K., Voutilainen, M. H., Domanskyi, A. & Airavaara, M., Feb 2017, In : Genes. 8, 2, 15 p., 63.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Can we treat neurodegenerative diseases by preventing an age-related decline in microRNA expression?

Vinnikov, I. A. & Domanskyi, A., Oct 2017, In : Neural regeneration research. 12, 10, p. 1602-1604 3 p.

Research output: Contribution to journalEditorialScientificpeer-review

Open Access
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Continuous Delivery of Oligonucleotides into the Brain

Vinnikov, I., Domanskyi, A. & Konopka, W., 2017, MicroRNA Technologies. Min, J. K. (ed.). New York: Springer, p. 89-117 28 p. (Neuromethods; no. 128).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Dicer and microRNAs protect adult dopamine neurons

Chmielarz, P., Konovalova, J., Najam, S. S., Alter, H., Piepponen, T. P., Erfle, H., Sonntag, K. C., Schutz, G., Vinnikov, I. A. & Domanskyi, A., 25 May 2017, In : Cell Death and Disease. 8, 5, 9 p., 2813.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models

Evsyukov, V., Domanskyi, A., Bierhoff, H., Gispert, S., Mustafa, R., Schlaudraff, F., Liss, B. & Parlato, R., 1 May 2017, In : Disease Models & Mechanisms. 10, 5, p. 633-643 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex

Tseng, K-Y., Danilova, T., Domanskyi, A., Saarma, M., Lindahl, M. S. & Airavaara, M. T., 29 Sep 2017, In : eNeuro. 4, 5, 21 p., e0214-17.2017.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Pancreatic beta-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF)

Cunha, D. A., Cito, M., Grieco, F. A., Cosentino, C., Danilova, T., Ladriere, L., Lindahl, M., Domanskyi, A., Bugliani, M., Marchetti, P., Eizirik, D. L. & Cnop, M., 8 Sep 2017, In : Journal of Biological Chemistry. 292, 36, p. 14977-14988 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Somatic Transgenesis (Viral Vectors)

Grinevich, V., Knobloch‐Bollmann, S., Roth, L., Althammer, F., Domanskyi, A., Vinnikov, I., Eliava, M., Stanifer, M. & Boulant, S., 2016, Molecular Neuroendocrinology: From Genome to Physiology. 1st ed. John Wiley & Sons Ltd. , p. 243-274 32 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

2015

Prospects of Neurotrophic Factors for Parkinson's Disease: Comparison of Protein and Gene Therapy

Domanskyi, A., Saarma, M. & Airavaara, M., 1 Aug 2015, In : Human Gene Therapy. 26, 8, p. 550-559 10 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2014

Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance

Domanskyi, A., Alter, H., Vogt, M. A., Gass, P. & Vinnikov, I. A., 9 Sep 2014, In : Frontiers in Cellular Neuroscience. 8, 11 p., 275.

Research output: Contribution to journalArticleScientificpeer-review

2011

Nucleolar Disruption in Dopaminergic Neurons Leads to Oxidative Damage and Parkinsonism through Repression of Mammalian Target of Rapamycin Signaling

Rieker, C., Engblom, D., Kreiner, G., Domanskyi, A., Schober, A., Stotz, S., Neumann, M., Yuan, X., Grummt, I., Schuetz, G. & Parlato, R., 12 Jan 2011, In : Journal of Neuroscience. 31, 2, p. 453-460 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models

Domanskyi, A., Geissler, C., Vinnikov, I. A., Alter, H., Schober, A., Vogt, M. A., Gass, P., Parlato, R. & Schuetz, G., Sep 2011, In : FASEB Journal. 25, 9, p. 2898-2910 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Androgen receptor-dependent and independent functions of ARIP4

Domanskyi, A., 2007, Helsinki: Helsingin yliopisto. 68 p.

Research output: ThesisDoctoral ThesisMonograph

Expression and localization of androgen receptor-interacting protein-4 in the testis

Domanskyi, A., Zhang, F-P., Nurmio, M., Palvimo, J., Toppari, J. & Jänne, O., 2007, In : American Journal of Physiology: Endocrinology and Metabolism. 292, p. E513-E522

Research output: Contribution to journalArticleScientificpeer-review

2006

Biochemical characterization of androgen receptor-interacting protein 4

Domanskyi, A., Virtanen, K., Palvimo, J. & Jänne, O., 2006, In : Biochemical Journal. 393, p. 789-795 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2002

Enhancer activity of solitary long terminal repeat of human endogenous retrovirus K

Domansky, AN., Akopov, SB., Lebedev, YB., Nikolaev, LG. & Sverdlov, ED., 2002, In : Russian Journal of Bioorganic Chemistry. 28, 4, p. 308-311 4 p.

Research output: Contribution to journalArticleScientificpeer-review

2000

Solitary HERV-K LTRs possess bi-directional promoter activity and contain a negative regulatory element in the U5 region

Domansky, AN., Kopantzev, EP., Snezhkov, EV., Lebedev, YB., Leib-Mosch, C. & Sverdlov, ED., 28 Apr 2000, In : FEBS Letters. 472, 2-3, p. 191-195 5 p.

Research output: Contribution to journalArticleScientificpeer-review