Research output per year
Research output per year
Personal profile
Education/Academic qualification
Medicine, PhD, University of Helsinki
Award Date: 16 Dec 2014
Pharmacy, MScPharm, MPharmSc, Uppsala University
Fields of Science
- 3121 General medicine, internal medicine and other clinical medicine
- Clinical Pharmacology
- 3111 Biomedicine
- Genetics
- 318 Medical biotechnology
- Pharmacogenetics
International and National Collaboration
Publications and projects within past five years.
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Screening of 16 major drug glucuronides for time-dependent inhibition of nine drug-metabolizing CYP enzymes – detailed studies on CYP3A inhibitors
Kahma, H., Paludetto, M.-N., Neuvonen, M., Kurkela, M., Filppula, A. M., Niemi, M. & Backman, J. T., 1 Jul 2024, In: European Journal of Pharmaceutical Sciences. 198, 12 p., 106735.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Solanidine is a sensitive and specific dietary biomarker for CYP2D6 activity
Kiiski, J. I., Neuvonen, M., Kurkela, M., Hirvensalo, P., Hämäläinen, K., Tarkiainen, E. K., Sistonen, J., Korhonen, M., Khan, S., Orpana, A., Filppula, A. M., Lehtonen, M. & Niemi, M., 1 Feb 2024, In: Human Genomics. 18, 1, 16 p., 11.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Hydroxychloroquine is Metabolized by Cytochrome P450 2D6, 3A4 and 2C8, and Inhibits Cytochrome P450 2D6, while its Metabolites also Inhibit Cytochrome P450 3A in vitro
Paludetto, M.-N. I. A., Kurkela, M., Kahma, H., Backman, J. T., Niemi, M. & Filppula, A. M., 1 Mar 2023, In: Drug Metabolism and Disposition. 51, 3, p. 293-305 13 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Lisääkö tikagrelorin käyttö rosuvastatiinin lihashaittariskiä?
Lehtisalo, M., Kiander, W., Filppula, A. M., Deng, F., Kidron, H., Korhonen, M., Sinkko, J., Koivula, K. & Niemi, M., 2023, In: Duodecim. 139, 6, p. 463 1 p.Research output: Contribution to journal › Comment/debate › Professional
Open AccessFile -
Real-world pharmacogenetics of statin intolerance: effects of SLCO1B1, ABCG2, and CYP2C9 variants
Lönnberg, K. I., Tornio, A., Hirvensalo, P., Keskitalo, J., Mustaniemi, A.-L., Kiiski, J. I., Filppula, A. M. & Niemi, M., Sept 2023, In: Pharmacogenetics and Genomics. 33, 7, p. 153-160 8 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile
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TransporterPGx - the contribution of transporters to variability in drug response (ERC Starting Grant)
Niemi, M. (Project manager), Hirvensalo, P. (Participant), Neuvonen, M. (Participant), Tornio, A. (Participant), Backman, J. (Participant), Filppula, A. M. (Participant) & Launiainen, T. (Participant)
Project: Research project
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Academy of Finland Project Funding: Mechanism-Based Inactivation of Cytochrome P450 (Palautumaton sytokromi P450-entsyymien esto ja kliinisesti merkittävät lääkeaineyhteisvaikutukset: Yhteisvaikutuksia in vitro tiedosta ennustavien menetelmien kehittäminen)
Backman, J. (Project manager), Niemi, M. (Principal Investigator), Tornio, A. (Participant), Filppula, A. M. (Participant), Neuvonen, P. (Principal Investigator), Neuvonen, M. (Participant), Launiainen, T. (Participant), Kahma, H. (Participant), Kaartinen, T. (Participant) & Itkonen, M. (Participant)
01/09/2014 → 31/08/2018
Project: Research project
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Individual variability in drug response (IndiViDrug)
Ahonen, K. M. (Participant), Backman, J. (Principal Investigator), Fanta, S. I. (Participant), Filppula, A. M. (Participant), Heiskanen, T. (Participant), Hoppu, K. (Principal Investigator), Honkalammi, J. (Participant), Isohanni, M. H. (Participant), Jaakkola, T. A. (Participant), Kajosaari, L. (Participant), Kalliokoski, A. (Participant), Kalso, E. (Principal Investigator), Karjalainen, M. (Participant), Karonen, T. (Participant), Keskitalo, J. (Participant), Lilja, J. (Participant), Malm, H. (Principal Investigator), Neuvonen, P. (Principal Investigator), Niemi, M. (Principal Investigator), Pasanen, M. (Participant), Ruokoniemi, P. (Participant), Schröder, M. (Participant), Tapaninen, T. (Participant), Tornio, A. (Participant) & Xiang, X. (Participant)
24/02/2011 → 24/02/2011
Project: Research Evaluation 2011
Prizes
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Award for best oral presentation at NORPM 2018
Filppula, A. M. (Recipient), 1 Jun 2018
Prize: Prizes and awards
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Best Thesis Award 2014: Finnish Society of Clinical Pharmacology
Filppula, A. M. (Recipient), 23 Apr 2015
Prize: Prizes and awards
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Biomedicum Helsinki Foundation Young Scientist Prize
Filppula, A. M. (Recipient), 23 Oct 2013
Prize: Prizes and awards
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Activities
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European Journal of Clinical Pharmacology (Journal)
Filppula, A. M. (Reviewer)
1 Jan 2020 → 31 Dec 2020Activity: Publication peer-review and editorial work types › Peer review of manuscripts
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Basic & Clinical Pharmacology & Toxicology (Journal)
Filppula, A. M. (Reviewer)
1 Jan 2020 → 31 Dec 2020Activity: Publication peer-review and editorial work types › Peer review of manuscripts
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Xenobiotica (Journal)
Filppula, A. M. (Reviewer)
1 Jan 2020 → 31 Dec 2020Activity: Publication peer-review and editorial work types › Peer review of manuscripts
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The protein kinase inhibitors midostaurin and nintedanib are time-dependent inhibitors of CYP3A4
Filppula, A. M. (Speaker)
30 May 2018Activity: Talk or presentation types › Oral presentation
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Intracellular drug concentrations for improved predictions of drug-drug interactions
Filppula, A. M. (Speaker)
25 Jan 2018Activity: Talk or presentation types › Invited talk
Press/Media
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Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8 [Articles]
15/03/2019
1 item of Media coverage
Press/Media: Press / Media
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Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions [Articles]
Filppula, A. M., Tornio, A., Backman, J. & Neuvonen, P.
11/01/2018
1 item of Media coverage
Press/Media: Press / Media
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Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions [Review Articles]
Filppula, A. M., Backman, J. & Neuvonen, P.
31/12/2015
1 item of Media coverage
Press/Media: Press / Media