Photo of Anne M Filppula

Anne M Filppula

PhD, MScPharm

  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

20102019
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Publications 2010 2019

2010
2011
2012

Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates

Filppula, A. M., Laitila, J., Neuvonen, P. J. & Backman, J. T., 2012, In : British Journal of Pharmacology. 165, 8, p. 2787-2798 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2013
2014

Glucuronidation Converts Clopidogrel to a Strong Time-Dependent Inhibitor of CYP2C8: A Phase II Metabolite as a Perpetrator of Drug-Drug Interactions

Tornio, A., Filppula, A. M., Kailari, O., Neuvonen, M., Nyrönen, T. H., Tapaninen, T., Neuvonen, P. J., Niemi, M. & Backman, J. T., Oct 2014, In : Clinical Pharmacology and Therapeutics. 96, 4, p. 498-507 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60-year-old Caucasian woman with ovarian carcinoma

Bergmann, T. K., Filppula, A. M., Launiainen, T., Nielsen, F., Backman, J. T. & Brosen, K., Feb 2016, In : British Journal of Clinical Pharmacology. 81, 2, p. 313-315 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions

Backman, J. T., Filppula, A. M., Niemi, M. & Neuvonen, P. J., Jan 2016, In : Pharmacological Reviews. 68, 1, p. 168-241 74 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2018

Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8-Mediated Metabolism of Montelukast in Humans.

Itkonen, M. K., Tornio, A., Filppula, A. M., Neuvonen, M., Neuvonen, P. J., Niemi, M. & Backman, J. T., Sep 2018, In : Clinical Pharmacology and Therapeutics. 104, 3, p. 495-504 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions

Kahma, H., Filppula, A. M., Neuvonen, M., Tarkiainen, E. K., Tornio, A., Holmberg, M. T., Itkonen, M. K., Finel, M., Neuvonen, P. J., Niemi, M. & Backman, J. T., 1 Feb 2018, In : Drug Metabolism and Disposition. 46, 2, p. 141-150 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2019
Open Access
File

Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8

Kahma, H., Filppula, A. M., Launiainen, T., Viinamäki, J., Neuvonen, M., Evangelista, E. A., Totah, R. A. & Backman, J. T., 1 Apr 2019, In : Drug Metabolism and Disposition. 47, 4, p. 436-443 8 p.

Research output: Contribution to journalArticleScientificpeer-review