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Publications 2007 2019

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2019

Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

Haikala, H. M., Anttila, J. M., Marques, E., Raatikainen, T., Ilander, M., Hakanen, H., Ala-Hongisto, H., Savelius, M., Balboa, D., Von Eyss, B., Eskelinen, V., Munne, P., Nieminen, A. I., Otonkoski, T., Schüler, J., Laajala, T. D., Aittokallio, T., Sihto, H., Mattson, J., Heikkilä, P. & 7 othersLeidenius, M., Joensuu, H., Mustjoki, S., Kovanen, P., Eilers, M., Leverson, J. D. & Klefström, J., 6 Feb 2019, In : Nature Communications. 10, 17 p., 620.

Research output: Contribution to journalArticleScientificpeer-review

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2013

Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis

Nieminen, A. I., Eskelinen, V. M., Haikala, H. M., Tervonen, T. A., Yan, Y., Partanen, J. I. & Klefström, J., 14 May 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 20, p. E1839-E1848 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Regulation of cell death in human fetal and adult ovaries-Role of Bok and Bcl-X-L

Jääskeläinen, M., Nieminen, A., Pökkylä, R-M., Kauppinen, M., Liakka, A., Heikinheimo, M., Vaskivuo, T. E., Klefström, J. & Tapanainen, J. S., 2010, In : Molecular and Cellular Endocrinology. 330, p. 17-24 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

3D view to tumor suppression Lkb1, polarity and the arrest of oncogenic c-Myc

Partanen, J. I., Nieminen, A. I. & Klefström, J., 2009, In : Cell Cycle. 8, p. 716-724 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation

Rajecki, M., af Hällström, T., Hakkarainen, T., Nokisalmi, P., Hautaniemi, S., Nieminen, A. I., Tenhunen, M., Rantanen, V., Desmond, R. A., Chen, D-T., Guse, K., Stenman, U-H., Gargini, R., Kapanen, M., Klefström, J., Kanerva, A., Pesonen, S., Ahtiainen, L. & Hemminki, A., 2009, In : International Journal of Cancer. 125, 10, p. 2441-2449 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer

Heinonen, H., Nieminen, A., Saarela, M., Kallioniemi, A., Klefström, J., Hautaniemi, S. & Monni, O., 2008, In : BMC Genomics. 9, 348, p. 1-12 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

c-Myc blazing a trail of death: coupling of the mitochondrial and death receptor apoptosis pathways by c-Myc

Nieminen, A., Partanen, J. & Klefström, J., 2007, In : Cell Cycle. 6, 20, p. 2464-2472 9 p.

Research output: Contribution to journalArticleScientificpeer-review

c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis

Nieminen, A., Partanen, J., Hau, A. & Klefström, J., 2007, In : EMBO Journal. 26, p. 1055-1067 13 p.

Research output: Contribution to journalArticleScientificpeer-review