Annukka Pasanen

Publications

Research output per year 2015 2017 2018 2020 2021 2022 2023 2024

• 47 Article
• 2 Review Article
• 1 Meeting Abstract
• 1 Doctoral Thesis

Research output per year

Research output per year

Search results

• 2024

  Asparaginase-like protein 1 as a prognostic tissue biomarker in clinicopathologically and molecularly characterized endometrial cancer

  Loukovaara, M. J., Huvila, J. K., Pasanen, A. M. & Bützow, R. C., Sept 2024, In: European Journal of Obstetrics and Gynecology and Reproductive Biology. 300, p. 23-28 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Clinical and molecular risk factors for repeat interventions due to symptomatic uterine leiomyomas

  Khamaiseh, S., Äyräväinen, A., Arffman, M., Reinikka, S., Mehine, M., Härkki, P., Bützow, R., Pasanen, A. & Vahteristo, P., 2024, (E-pub ahead of print) In: American Journal of Obstetrics and Gynecology. 23 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Stage distribution and prognostic accuracy of the 2023 FIGO (the International Federation of Gynecology & Obstetrics) staging system for endometrial cancer: A retrospective cohort study

  Loukovaara, M., Pasanen, A. & Bützow, R., 2024, In: International Journal of Gynecology and Obstetrics.

  Research output: Contribution to journal › Article › Scientific › peer-review

• The impact of estrogen receptor and L1 cell adhesion molecule expression on endometrial cancer outcome correlates with clinicopathological risk group and molecular subgroup

  Aro, K., Pasanen, A., Bützow, R. & Loukovaara, M., Oct 2024, In: Gynecologic Oncology. 189, p. 9-15 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access
• 2023

  3 ' RNA and whole-genome sequencing of archival uterine leiomyomas reveal a tumor subtype with chromosomal rearrangements affecting either HMGA2, HMGA1, or PLAG1

  Jokinen, V., Mehine, M., Reinikka, S., Khamaiseh, S., Ahvenainen, T., Äyräväinen, A., Härkki, P., Butzow, R., Pasanen, A. & Vahteristo, P., Jan 2023, In: Genes, Chromosomes & Cancer. 62, 1, p. 27-38 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• A Risk-scoring Model for Predicting Post-recurrence Survival in Patients With Endometrial Carcinoma

  Kolehmainen, A., Pasanen, A., Koivisto-Korander, R., Bützow, R. & Loukovaara, M., Jul 2023, In: Clinical Oncology. 35, 7, p. 472-477 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Boosting cytotoxicity of adoptive allogeneic NK cell therapy with an oncolytic adenovirus encoding a human vIL-2 cytokine for the treatment of human ovarian cancer

  Quixabeira, D. C. A., Pakola, S., Jirovec, E., Havunen, R., Basnet, S., Santos, J. M., Kudling, T. V., Clubb, J. H. A., Haybout, L., Arias, V., Grönberg-Vähä-Koskela, S., Cervera-Carrascon, V., Kerkelä, E., Pasanen, A., Anttila, M., Tapper, J., Kanerva, A. & Hemminki, A., 10 Nov 2023, In: Cancer Gene Therapy. 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Improving the cytotoxic response of tumor-infiltrating lymphocytes towards advanced stage ovarian cancer with an oncolytic adenovirus expressing a human vIL-2 cytokine

  Quixabeira, D. C. A., Jirovec, E., Pakola, S., Havunen, R., Basnet, S., Santos, J. M., Kudling, T. V., Clubb, J. H. A., Haybout, L., Arias, V., Grönberg-Vähä-Koskela, S., Cervera-Carrascon, V., Pasanen, A., Anttila, M., Tapper, J., Kanerva, A. & Hemminki, A., Nov 2023, In: Cancer Gene Therapy. 30, 11, p. 1543-1553 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Inherited mutations affecting the SRCAP complex are central in moderate-penetrance predisposition to uterine leiomyomas

  Välimäki, N., Jokinen, V., Cajuso, T., Kuisma, H., Taira, A., Dagnaud, O., Ilves, S., Kaukomaa, J., Pasanen, A., Palin, K., Heikinheimo, O., Bützow, R., Aaltonen, L. A. & Karhu, A., 2 Mar 2023, In: American Journal of Human Genetics. 110, 3, p. 460-474 16 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Molecular subclass of uterine fibroids predicts tumor shrinkage in response to ulipristal acetate

  Kolterud, A., Välimäki, N., Kuisma, H., Patomo, J., Ilves, S. T., Mäkinen, N., Kaukomaa, J., Palin, K., Kaasinen, E., Karhu, A., Pasanen, A., Bützow, R., Heikinheimo, O., Kallner, H. K. & Aaltonen, L. A., Apr 2023, In: Human Molecular Genetics. 32, 7, p. 1063–1071 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• 2022

  A novel uterine leiomyoma subtype exhibits NRF2 activation and mutations in genes associated with neddylation of the Cullin 3-RING E3 ligase

  Mehine, M., Ahvenainen, T., Khamaiseh, S., Härkönen, J., Reinikka, S., Heikkinen, T., Äyräväinen, A., Pakarinen, P., Härkki, P., Pasanen, A., Levonen, A-L., Bützow, R. & Vahteristo, P., 7 Sept 2022, In: Oncogenesis. 11, 1, 10 p., 52.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Clinical factors and biomarker profiles associated with patient outcome in endometrioid ovarian carcinoma - Emphasis on tumor grade

  Soovares, P., Pasanen, A., Similä-Maarala, J., Bützow, R. & Lassus, H., Jan 2022, In: Gynecologic Oncology. 164, 1, p. 187-194 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Clinicopathologic vs. Molecular Integrated Prognostication of Endometrial Carcinoma by European Guidelines

  Loukovaara, M., Pasanen, A. & Bützow, R., Feb 2022, In: Cancers. 14, 3, 9 p., 651.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Histopathologic and Molecular Characterization of Uterine Leiomyoma-like Inflammatory Myofibroblastic Tumor Comparison to Molecular Subtypes of Uterine Leiomyoma

  Kuisma, H., Jokinen, V., Pasanen, A., Heikinheimo, O., Karhu, A., Välimäki, N., Aaltonen, L. & Bützow, R., Aug 2022, In: American Journal of Surgical Pathology. 46, 8, p. 1126-1136 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Interpretable prognostic modeling of endometrial cancer

  Zagidullin, B., Pasanen, A., Loukovaara, M., Bützow, R. & Tang, J., Dec 2022, In: Scientific Reports. 12, 1, 11 p., 21543.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• TCGA molecular classification in endometriosis-associated ovarian carcinomas: Novel data on clear cell carcinoma

  Similä-Maarala, J., Soovares, P., Pasanen, A., Ahvenainen, T., Vahteristo, P., Bützow, R. & Lassus, H., Jun 2022, In: Gynecologic Oncology. 165, 3, p. 577-584 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Testing for Lynch Syndrome in Endometrial Carcinoma: From Universal to Age-Selective MLH1 Methylation Analysis

  Pasanen, A., Loukovaara, M., Kaikkonen, E., Olkinuora, A., Pylvänäinen, K., Alhopuro, P., Peltomäki, P., Mecklin, J-P. & Bützow, R., Mar 2022, In: Cancers. 14, 5, 11 p., 1348.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• 2021

  Deficient H2A.Z deposition is associated with genesis of uterine leiomyoma

  Berta, D. G., Kuisma, H., Välimäki, N., Räisänen, M., Jäntti, M., Pasanen, A., Karhu, A., Kaukomaa, J., Taira, A., Cajuso, T., Nieminen, S., Penttinen, R-M., Ahonen, S., Lehtonen, R., Mehine, M., Vahteristo, P., Jalkanen, J., Sahu, B., Ravantti, J., Mäkinen, N., & 7 othersRajamäki, K., Palin, K., Taipale, J., Heikinheimo, O., Bützow, R., Kaasinen, E. & Aaltonen, L. A., 19 Aug 2021, In: Nature. 596, 7872, 34 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Detection of microsatellite instability with Idylla MSI assay in colorectal and endometrial cancer

  Ukkola, I., Nummela, P., Pasanen, A., Kero, M., Lepistö, A., Kytölä, S., Bützow, R. & Ristimäki, A., Sept 2021, In: Virchows Archiv. 479, 3, p. 471-479 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Differential impact of clinicopathological risk factors within the 2 largest ProMisE molecular subgroups of endometrial carcinoma

  Pasanen, A., Loukovaara, M., Ahvenainen, T., Vahteristo, P. & Bützow, R., 2 Sept 2021, In: PLoS One. 16, 9, 11 p., 0253472.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Low Expression of Stanniocalcin 1 (STC-1) Protein Is Associated With Poor Clinicopathologic Features of Endometrial Cancer

  Khatun, M., Urpilainen, E., Ahtikoski, A., Arffman, R. K., Pasanen, A., Puistola, U., Tapanainen, J. S., Andersson, L. C., Butzow, R., Loukovaara, M. & Piltonen, T. T., 28 Sept 2021, In: Pathology and oncology research. 27, 9 p., 1609936.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Molecularly Classified Endometrial Carcinoma

  Loukovaara, M., Pasanen, A. & Bützow, R., Jul 2021, In: Cancers. 13, 13, 11 p., 3124.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Mismatch repair protein and MLH1 methylation status as predictors of response to adjuvant therapy in endometrial cancer

  Loukovaara, M., Pasanen, A. & Bützow, R., Feb 2021, In: Cancer medicine . 10, 3, p. 1034-1042 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Molecular characterization in the prediction of disease extent in endometrial carcinoma

  Kolehmainen, A. M., Pasanen, A. M., Koivisto-Korander, R. L., Bützow, R. C. & Loukovaara, M. J., Jan 2021, In: European Journal of Obstetrics, and Gynecology ,and Reproductive Biology. 256, p. 478-483 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Parity associates with chromosomal damage in uterine leiomyomas

  Kuisma, H., Bramante, S., Rajamäki, K., Sipilä, L. J., Kaasinen, E., Kaukomaa, J., Palin, K., Mäkinen, N., Sjöberg, J., Sarvilinna, N., Taipale, J., Kauppi, L., Tumiati, M., Hassinen, A., Pitkäniemi, J., Jalkanen, J., Heikkinen, S., Pasanen, A., Heikinheimo, O., Bützow, R., & 2 othersVälimäki, N. & Aaltonen, L. A., 14 Sept 2021, In: Nature Communications. 12, 1, 10 p., 5448.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• 2020

  3 ' RNA Sequencing Accurately Classifies Formalin-Fixed Paraffin-Embedded Uterine Leiomyomas

  Mehine, M., Khamaiseh, S., Ahvenainen, T., Heikkinen, T., Äyräväinen, A., Pakarinen, P., Härkki, P., Pasanen, A., Bützow, R. & Vahteristo, P., Dec 2020, In: Cancers. 12, 12, 12 p., 3839.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Altered glycosylation of glycodelin in endometrial carcinoma

  Hautala, L. C., Pang, P-C., Antonopoulos, A., Pasanen, A., Lee, C-L., Chiu, P. C. N., Yeung, W. S. B., Loukovaara, M., Bützow, R., Haslam, S. M., Dell, A. & Koistinen, H., Jul 2020, In: Laboratory Investigation. 100, 7, p. 1014-1025 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Clinical factors as prognostic variables among molecular subgroups of endometrial cancer

  Kolehmainen, A., Pasanen, A., Tuomi, T., Koivisto-Korander, R., Bützow, R. & Loukovaara, M., 24 Nov 2020, In: PLoS One. 15, 11, 12 p., 0242733.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Clinicopathological significance of deficient DNA mismatch repair and MLH1 promoter methylation in endometrioid endometrial carcinoma

  Pasanen, A., Loukovaara, M. & Bützow, R., Jul 2020, In: Modern Pathology. 33, 7, p. 1443-1452 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• PD-L1 Expression in Endometrial Carcinoma Cells and Intratumoral Immune Cells Differences Across Histologic and TCGA-based Molecular Subgroups

  Pasanen, A., Ahvenainen, T., Pellinen, T., Vahteristo, P., Loukovaara, M. & Bützow, R., Feb 2020, In: American Journal of Surgical Pathology. 44, 2, p. 174-181 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Systematic molecular and clinical analysis of uterine leiomyomas from fertile-aged women undergoing myomectomy

  Äyräväinen, A., Pasanen, A., Ahvenainen, T., Heikkinen, T., Pakarinen, P., Härkki, P. & Vahteristo, P., Oct 2020, In: Human Reproduction. 35, 10, p. 2237-2244 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• 2019

  American Society of Anesthesiologists physical status score as a predictor of long-term outcome in women with endometrial cancer

  Kolehmainen, A. M., Pasanen, A., Tuomi, T., Koivisto-Korander, R., Butzow, R. & Loukovaara, M., Jun 2019, In: International Journal of Gynecological Cancer. 29, 5, p. 879-885 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• 2018

  Converging endometrial and ovarian tumorigenesis in Lynch syndrome: Shared origin of synchronous carcinomas

  Niskakoski, A., Pasanen, A., Porkka, N., Eldfors, S., Lassus, H., Renkonen-Sinisalo, L., Kaur, S., Mecklin, J-P., Bützow, R. & Peltomäki, P., 30 Apr 2018, In: Gynecologic Oncology. 150, 1, p. 92-98 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability

  Valimaki, N., Kuisma, H., Pasanen, A., Heikinheimo, O., Sjoberg, J., Butzow, R., Sarvilinna, N., Heinonen, H-R., Tolvanen, J., Bramante, S., Tanskanen, T., Auvinen, J., Uimari, O., Alkodsi, A., Lehtonen, R., Kaasinen, E., Palin, K. & Aaltonen, L. A., 18 Sept 2018, In: eLife. 7, 50 p., 37110.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Loss of ATRX/DAXX expression and alternative lengthening of telomeres in uterine leiomyomas

  Ahvenainen, T. V., Mäkinen, N. M., von Nandelstadh, P., Vahteristo, M. E. A., Pasanen, A. M., Bützow, R. C. & Vahteristo, P. M., 15 Dec 2018, In: Cancer. 124, 24, p. 4650-4656 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• MED12 mutations and fumarate hydratase inactivation in uterine adenomyomas

  Heikkinen, T. A., Äyräväinen, A. K. E., Hänninen, J. T. O., Ahvenainen, T. V., Butzow, R. C., Pasanen, A. M. & Vahteristo, P. M., 2018, In: Human reproduction open. 4/2018

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• Molecular changes preceding endometrial and ovarian cancer: a study of consecutive endometrial specimens from Lynch syndrome surveillance

  Niskakoski, A., Pasanen, A., Lassus, H., Renkonen-Sinisalo, L., Kaur, S., Mecklin, J-P., Butzow, R. & Peltomäki, P., Aug 2018, In: Modern Pathology. 31, 8, p. 1291-1301 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2017

  Global metabolomic profiling of uterine leiomyomas

  Heinonen, H-R., Mehine, M., Mäkinen, N., Pasanen, A., Pitkänen, E., Karhu, A., Sarvilinna, N. S., Sjöberg, J., Heikinheimo, O., Bützow, R., Aaltonen, L. A. & Kaasinen, E., 5 Dec 2017, In: British Journal of Cancer. 117, 12, p. 1855-1864 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• L1CAM expression associates with poor outcome in endometrioid, but not in clear cell ovarian carcinoma

  Soovares, P., Pasanen, A., Butzow, R. & Lassus, H., Sept 2017, In: Gynecologic Oncology. 146, 3, p. 615-622 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Multiple clinical characteristics separate MED12-mutation-positive and -negative uterine leiomyomas

  Heinonen, H-R., Pasanen, A., Heikinheimo, O., Tanskanen, T., Palin, K., Tolvanen, J., Vahteristo, P., Sjoberg, J., Pitkänen, E., Butzow, R., Makinen, N. & Aaltonen, L. A., 21 Apr 2017, In: Scientific Reports. 7, 7 p., 1015.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Prediction of lymphatic dissemination in endometrioid endometrial cancer: Comparison of three risk-stratification models in a single-institution cohort

  Tuomi, T., Pasanen, A., Leminen, A., Butzow, R. & Loukovaara, M., Mar 2017, In: Gynecologic Oncology. 144, 3, p. 510-514 5 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Prediction of Site-Specific Tumor Relapses in Patients With Stage I-II Endometrioid Endometrial Cancer

  Tuomi, T., Pasanen, A., Leminen, A., Butzow, R. & Loukovaara, M., Jun 2017, In: International Journal of Gynecological Cancer. 27, 5, p. 923-930 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Preoperative Risk Stratification of Endometrial Carcinoma: L1CAM as a Biomarker

  Pasanen, A., Loukovaara, M., Tuomi, T. & Butzow, R., Sept 2017, In: International Journal of Gynecological Cancer. 27, 7, p. 1318-1324 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• 2016

  Incidence of and risk factors for surgical site infections in women undergoing hysterectomy for endometrial carcinoma

  Tuomi, T., Pasanen, A., Leminen, A., Butzow, R. & Loukovaara, M., Apr 2016, In: Acta Obstetricia et Gynecologica Scandinavica. 95, 4, p. 480-485 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers

  Mehine, M., Kaasinen, E., Heinonen, H-R., Makinen, N., Kampjarvi, K., Sarvilinna, N., Aavikko, M., Vaharautio, A., Pasanen, A., Butzow, R., Heikinheimo, O., Sjoberg, J., Pitkanen, E., Vahteristo, P. & Aaltonen, L. A., 2 Feb 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 5, p. 1315-1320 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• L1 Cell Adhesion Molecule as a Predictor of Disease-Specific Survival and Patterns of Relapse in Endometrial Cancer

  Pasanen, A., Tuomi, T., Isola, J., Staff, S., Butzow, R. & Loukovaara, M., Oct 2016, In: International Journal of Gynecological Cancer. 26, 8, p. 1465-1471 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2015

  Risk-stratification of endometrial carcinomas revisited: A combined preoperative and intraoperative scoring system for a reliable prediction of an advanced disease

  Tuomi, T., Pasanen, A., Luomaranta, A., Leminen, A., Butzow, R. & Loukovaara, M., Apr 2015, In: Gynecologic Oncology. 137, 1, p. 23-27 5 p.

  Research output: Contribution to journal › Article › Scientific › peer-review