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  • PL 63 (Haartmaninkatu 8), C428a

    HELSINGIN YLIOPISTO

    Finland

20032020
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Publications 2003 2019

  • 26 Article
  • 7 Review Article
  • 3 Meeting Abstract
  • 2 Conference article
2019

Effect of Donor Simvastatin Treatment on Gene Expression Profiles in Human Cardiac Allografts during Ischemia-Reperfusion Injury

Krebs, R., Kankainen, M., Holmström, E., Dhaygude, K., Lukac, J., Ojala, T., Mattila, P., Nykänen, A. & Lemström, K., Apr 2019, In : Journal of Heart and Lung Transplantation. 38, 4, Supplement, p. S75-S76

Research output: Contribution to journalConference articleScientificpeer-review

Hypoxia-inducible factor controls immunoregulatory properties of myeloid cells in mouse cardiac allografts - an experimental study

Keränen, M. A. I., Raissadati, A., Nykänen, A. I., Dashkevich, A., Tuuminen, R., Krebs, R., Johnson, R. S., Syrjälä, S. O. & Lemström, K. B., Jan 2019, In : Transplant International. 32, 1, p. 95-106 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Label-Free Proteomics Approach Characterizes Plasma Protein Signature of Donor Brain Death

Lukac, J., Saraswata, M., Joenvääräa, S., Holmström, E., Dhaygude, K., Krebs, R., Nykänen, A., Renkonen, R. & Lemström, K., Apr 2019, In : Journal of Heart and Lung Transplantation. 38, 4, Supplement, p. S159

Research output: Contribution to journalConference articleScientificpeer-review

2018

(245) - Proinflammatory Cytokines as Biomarkers for Severe Primary Graft Dysfunction After Heart Transplantation: ISHLT 38th Annual Meeting and Scientific Sessions

Holmström, E., Tuuminen, R., Syrjälä, S., Krebs, R., Rouvinen, E., Nykänen, A. & Lemström, K., Apr 2018, In : Journal of Heart and Lung Transplantation. 37, 4, Supplement, p. S104

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Donor Simvastatin Treatment Alters Protein Expression in the Recipient after Heart Transplantation: ISHLT 38th Annual Meeting and Scientific Sessions

Lukac, J., Holmström, E., Joenväärä, S., Saraswat, M., Krebs, R., Tohmola, T., Nykänen, A., Renkonen, R. & Lemström, K., Apr 2018, In : Journal of Heart and Lung Transplantation. 37, 4, p. S169-S170 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

2016

Increased myeloid cell hypoxia-inducible factor-1 delays obliterative airway disease in the mouse

Ropponen, J. O., Keränen, M. A., Raissadati, A., Nykänen, A. I., Krebs, R., Lemstrom, K. B. & Tikkanen, J. M., May 2016, In : Journal of Heart and Lung Transplantation. 35, 5, p. 671-678 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Ischemia-Reperfusion Injury Enhances Lymphatic Endothelial VEGFR3 and Rejection in Cardiac Allografts

Dashkevich, A., Raissadati, A., Syrjala, S. O., Zarkada, G., Keranen, M. A. I., Tuuminen, R., Krebs, R., Anisimov, A., Jeltsch, M., Leppanen, V. -M., Alitalo, K., Nykanen, A. I. & Lemstrom, K. B., Apr 2016, In : American Journal of Transplantation. 16, 4, p. 1160-1172 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Platelet-derived Growth Factor-B Protects Rat Cardiac Allografts From Ischemia-reperfusion Injury

Tuuminen, R., Dashkevich, A., Keränen, M. A. I., Raissadati, A., Krebs, R., Jokinen, J. J., Arnaudova, R., Rouvinen, E., Yla-Herttuala, S., Nykänen, A. & Lemstrom, K. B., Feb 2016, In : Transplantation. 100, 2, p. 303-313 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Vasemman kammion mekaaninen tukihoito : siltahoito tai vaihtoehto sydämensiirrolle

Lemström, K., Jokinen, J. J., Kiss, J., Nykänen, A., Yesil, C., Lommi, J., Pentikäinen, M., Suojaranta-Ylinen, R. & Hiippala, S., 2016, In : Suomen lääkärilehti. 71, 34, p. 2043-2050 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File

VEGF Pathways in the Lymphatics of Healthy and Diseased Heart

Dashkevich, A., Hagl, C., Beyersdorf, F., Nykänen, A. & Lemstrom, K. B., Jan 2016, In : Microcirculation. 23, 1, p. 5-14 10 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2015

Donor Heart Treatment With COMP-Ang1 Limits Ischemia-Reperfusion Injury and Rejection of Cardiac Allografts

Syrjala, S. O., Nykänen, A. I., Tuuminen, R., Raissadati, A., Keränen, M. A. I., Arnaudova, R., Krebs, R., Koh, G. Y., Alitalo, K. & Lemstrom, K. B., Aug 2015, In : American Journal of Transplantation. 15, 8, p. 2075-2084 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Systemic overexpression of matricellular protein CCN1 exacerbates obliterative bronchiolitis in mouse tracheal allografts

Raissadati, A., Nykänen, A. I., Tuuminen, R., Syrjala, S. O., Krebs, R., Arnaudova, R., Rouvinen, E., Wang, X., Poller, W. & Lemstrom, K. B., Dec 2015, In : Transplant International. 28, 12, p. 1416-1425 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Angiopoietin-2 Inhibition Prevents Transplant Ischemia- Reperfusion Injury and Chronic Rejection in Rat Cardiac Allografts

Syrjala, S. O., Tuuminen, R., Nykanen, A. I., Raissadati, A., Dashkevich, A., Keranen, M. A. I., Arnaudova, R., Krebs, R., Leow, C. C., Saharinen, P., Alitalo, K. & Lemstrom, K. B., May 2014, In : American Journal of Transplantation. 14, 5, p. 1096-1108 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Emfyseeman kirurginen hoito

Sihvo, E., Nykänen, A. & Halme, M., 2014, In : Suomen lääkärilehti. 69, 3, p. 133-138 6 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Keuhkosyövän tähystyskirurgia

Nykänen, A., Räsänen, J., Salo, J. & Sihvo, E., 2014, In : Duodecim. 130, 2, p. 145-151 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2013

Differential Effects of Pharmacological HIF Preconditioning of Donors Versus Recipients in Rat Cardiac Allografts

Keränen, M. A. I., Tuuminen, R., Syrjala, S., Krebs, R., Walkinshaw, G., Flippin, L. A., Arend, M., Koskinen, P. K., Nykänen, A. & Lemström, K. B., Mar 2013, In : American Journal of Transplantation. 13, 3, p. 600-610 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Donor simvastatin treatment and cardiac allograft ischemia/reperfusion injury

Nykänen, A. I., Tuuminen, R. & Lemstrom, K. B., Apr 2013, In : Trends in Cardiovascular Medicine. 23, 3, p. 85-90 6 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Donor Simvastatin Treatment Prevents Ischemia-Reperfusion and Acute Kidney Injury by Preserving Microvascular Barrier Function

Tuuminen, R., Nykänen, A., Saharinen, P., Gautam, P., Keränen, M. A. I., Arnaudova, R., Rouvinen, E., Helin, H., Tammi, R., Rilla, K., Krebs, R. & Lemström, K. B., Aug 2013, In : American Journal of Transplantation. 13, 8, p. 2019-2034 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Ex vivo intracoronary gene transfer of adeno-associated virus 2 leads to superior transduction over serotypes 8 and 9 in rat heart transplants

Raissadati, A., Jokinen, J. J., Syrjala, S. O., Keränen, M. A. I., Krebs, R., Tuuminen, R., Arnaudova, R., Rouvinen, E., Anisimov, A., Soronen, J., Pajusola, K., Alitalo, K., Nykänen, A. I. & Lemström, K. B., Nov 2013, In : Transplant International. 26, 11, p. 1126-1137 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Effect of Triclosan-Coated Sutures on the Incidence of Surgical Wound Infection After Lower Limb Revascularization Surgery: A Randomized Controlled Trial

Turtiainen, J., Saimanen, E. I. T., Makinen, K. T., Nykänen, A. I., Venermo, M. A., Uurto, I. T. & Hakala, T., 1 Oct 2012, In : World Journal of Surgery. 36, 10, p. 2528-2536 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Donor Simvastatin Treatment Abolishes Rat Cardiac Allograft Ischemia/Reperfusion Injury and Chronic Rejection Through Microvascular Protection

Tuuminen, R., Syrjala, S., Krebs, R., Keränen, M. A. I., Koli, K., Abo Ramadan, U., Neuvonen, P. J., Tikkanen, J. M., Nykänen, A. & Lemström, K. B., 2011, In : Circulation . 124, 10, p. 1138-1150 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Innate and adaptive immune responses in obliterative airway disease in rat tracheal allografts

Ropponen, J. O., Syrjala, S. O., Krebs, R., Nykanen, A., Tikkanen, J. M. & Lemström, K. B., 2011, In : Journal of Heart and Lung Transplantation. 30, 6, p. 707-716 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Cardiomyocyte-targeted HIF-1 alpha gene therapy inhibits cardiomyocyte apoptosis and cardiac alllograft vasculopathy in the rat

Keränen, M. A. I., Nykänen, A., Krebs, R., Pajusola, K., Tuuminen, R., Alitalo, K. & Lemström, K. B., 2010, In : Journal of Heart and Lung Transplantation. 29, 9, p. 1058-1066 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Increased Th17 rather than Th1 alloimmune response is associated with cardiac allograft vasculopathy after hypothermic preservation in the rat

Syrjälä, S. O., Keränen, M. A. I., Tuuminen, R., Nykänen, A., Tammi, M., Krebs, R. & Lemström, K. B., 2010, In : Journal of Heart and Lung Transplantation. 29, 9, p. 1047-1057 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Targeting Lymphatic Vessel Activation and CCL21 Production by Vascular Endothelial Growth Factor Receptor-3 Inhibition Has Novel Immunomodulatory and Antiarteriosclerotic Effects in Cardiac Allografts

Nykänen, A., Sandelin, H., Krebs, R., Keränen, M. A. I., Tuuminen, R., Kärpänen, T., Wu, Y., Pytowski, B., Koskinen, P. K., Yla-Herttuala, S., Alitalo, K. & Lemström, K. B., 2010, In : Circulation . 121, 12, p. 1413-1422 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Vascular endothelial growth factor in chronic rat allograft nephropathy

Malmström, N. K., Kallio, E. A., Rintala, J. M., Nykänen, A., Räisänen-Sokolowski, A. K., Paavonen, T., Lemström, K. B. & Koskinen, P. K., 2008, In : Transplant Immunology. 19, 2, p. 136-144 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

VEGFR-1 and -2 regulate inflammation, myocardial angiogenesis, and arteriosclerosis in chronically rejecting cardiac allografts

Raisky, O., Nykänen, A. I., Krebs, R., Hollmen, M., Keränen, M. A. I., Tikkanen, J. M., Sihvola, R., Alhonen, L., Salven, P., Wu, Y., Hicklin, D. J., Alitalo, K., Koskinen, P. K. & Lemström, K. B., 2007, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 27, p. 819-825 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Angiogenic growth factors in cardiac allograft rejection.

Nykänen, A. I., Tikkanen, J. M., Krebs, R., Keränen, M. A., Sihvola, R., Sandelin, H., Tuuminen, R., Raisky, O., Koskinen, P. K., Lemström, K. & Keränen, M. A., 2006, In : Transplantation. 82, Suppl. 1, p. 22-24 3 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Effect of graft preservation and acute rejection on hypoxia-inducible factor-1 in rat cardiac allografts

Keränen, M. A. I., Nykänen, A. I., Krebs, R., Tuuminen, R., Sandelin, H., Koskinen, P. K., Lemström, K. & Keränen, M., 2006, In : Transplantation Proceedings. 38, 10, p. 3372-3373 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Role of platelet-derived growth factor and vascular endothelial growth factor in obliterative airway disease

Tikkanen, J. M., Hollmen, M., Nykänen, A. I., Wood, J., Koskinen, P. K., Lemström, K., Lemström, K. B. & Holmen, M., 2006, In : American Journal of Respiratory and Critical Care Medicine. 174, p. 1145-1152 8 p.

Research output: Contribution to journalArticleScientificpeer-review

The effect of platelet-derived growth factor ligands in rat cardiac allograft vasculopathy and fibrosis

Tuuminen, R., Nykänen, A. I., Keränen, M., Krebs, R., Alitalo, K., Koskinen, P. K., Lemström, K. & Keränen, M., 2006, In : Transplantation Proceedings. 38, 10, p. 3271-3273 3 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

Dual role of vascular endothelial growth factor in experimental obliterative bronchiolitis

Krebs, R., Tikkanen, J. M., Nykänen, A. I., Wood, J., Jeltsch, M., Ylä-Herttuala, S., Koskinen, P. K. & Lemström, K., 2005, In : American Journal of Respiratory and Critical Care Medicine. 171, 12, p. 1421-1429 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2004

Onko krooninen hyljintä voitettavissa - verisuonikasvutekijät mielenkiinnon kohteena.

Koskinen, P., Nykänen, A., Tikkanen, J., Sihvola, R., Krebs, R. & Lemström, K. B., 2004, In : Duodecim. 120, p. 1401-1409 9 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2003

Angiopoietin-1 protects against the development of cardiac allograft arteriosclerosis

Nykänen, A. I., Krebs, R., Saaristo, A., Turunen, P., Alitalo, K., Ylä-Herttuala, S., Koskinen, P. K. & Lemström, K. B., 2003, In : Circulation . 107, p. 1308-1314 7 p.

Research output: Contribution to journalArticleScientificpeer-review