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Publications 1999 2019

2019

Porous Silicon as a Platform for Radiation Theranostics Together with a Novel RIB-Based Radiolanthanoid

Jakobsson, U., Mäkilä, E., Airaksinen, A. J., Alanen, O., Etile, A., Köster, U., Ranjan, S., Salonen, J., Santos, H. A. & Helariutta, K., 12 Mar 2019, In : Contrast Media & Molecular Imaging. 2019, 9 p., 3728563.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Radiolabeled Molecular Imaging Probes for the in Vivo Evaluation of Cellulose Nanocrystals for Biomedical Applications

Imlimthan, S., Otaru, S., Keinänen, O., Correia, A., Lintinen, K., Almeida Santos, H., Airaksinen, A., Kostiainen, M. & Sarparanta, M., Feb 2019, In : Biomacromolecules. 20, 2, p. 674–683 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Recycling of O-18 enriched water used in F-18 cyclotron production

Todorov, B., Belovezhdova, I., Alanen, O., Airaksinen, A. J. & Djingova, R., Mar 2019, In : Applied Radiation and Isotopes. 145, p. 109-115 7 p.

Research output: Contribution to journalArticleScientificpeer-review

The Radiopharmaceutical Chemistry of Fluorine-18: Next-Generation Fluorinations

Airaksinen, A., 2019, Radiopharmaceutical Chemistry. Lewis, J. S., Windhorst, A. D. & Zeglis, B. M. (eds.). Cham: Springer International Publishing AG, p. 297-310 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

2018

Abscopal Effect in Non-injected Tumors Achieved with Cytokine-Armed Oncolytic Adenovirus

Havunen, R., Santos, J. M., Sorsa, S., Rantapero, T., Lumen, D., Siurala, M., Airaksinen, A. J., Cervera-Carrascon, V., Tähtinen, S., Kanerva, A. & Hemminki, A., 21 Dec 2018, In : Molecular Therapy - Oncolytics. 11, p. 109-121 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Delivery of Agents Into Articular Cartilage With Electric Spark-Induced Sound Waves

Pérez, A. G., Nieminen, H. J., Finnilä, M., Salmi, A., Pritzker, K. P. H., Lampsijärvi, E., Paulin, T., Airaksinen, A. J., Saarakkala, S. & Haeggström, E., 16 Oct 2018, In : Frontiers in Physics. 6, 7 p., 116.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Efficient cartridge purification for producing high molar activity [18F]fluoro-glycoconjugates via oxime formation

Keinänen, O., Partelová, D., Alanen, O., Antopolsky, M., Sarparanta, M. & Airaksinen, A. J., 2018, In : Nuclear Medicine and Biology. 67, p. 27-35 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Multimodality Imaging of Silica and Silicon Materials In Vivo

Şen, K. D., P., S. M., M., R. J. & J., A. A., 13 Jun 2018, In : Advanced Materials. 30, 24, 26 p., 1703651.

Research output: Contribution to journalReview ArticleScientificpeer-review

2017

Comparison of 68Ga-DOTA-Siglec-9 and 18F-Fluorodeoxyribose-Siglec-9: Inflammation Imaging and Radiation Dosimetry

Virtanen, H., Silvola, J. M. U., Autio, A., Li, X-G., Liljenback, H., Hellberg, S., Siitonen, R., Ståhle, M., Käkelä, M., Airaksinen, A. J., Helariutta, K., Tolvanen, T., Veres, T. Z., Saraste, A., Knuuti, J., Jalkanen, S. & Roivainen, A., 2017, In : Contrast Media & Molecular Imaging. p. 1-10 10 p., 7645070.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Drug-loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling

Ferreira, M. P. A., Ranjan, S., Kinnunen, S., Correia, A., Talman, V., Mäkilä, E., Barrios-Lopez, B., Kemell, M., Balasubramanian, V., Salonen, J., Hirvonen, J., Ruskoaho, H., Airaksinen, A. J. & Santos, H. A., 6 Sep 2017, In : Small. 13, 33, 14 p., 1701276.

Research output: Contribution to journalArticleScientificpeer-review

Pretargeted PET Imaging of trans-Cyclooctene-Modified Porous Silicon Nanoparticles

Keinänen, O., Mäkilä, E. M., Lindgren, R., Virtanen, H., Liljenbäck, H., Oikonen, V., Sarparanta, M., Molthoff, C., Windhorst, A. D., Roivainen, A., Salonen, J. J. & Airaksinen, A. J., 31 Jan 2017, In : ACS Omega. 2, 1, p. 62-69 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Pretargeting of internalizing trastuzumab and cetuximab with a 18F-tetrazine tracer in xenograft models

Keinänen, O., Fung, K. E., Pourat, J., Jallinoja, V., Vivier, D., Pillarsetty, N. K., Airaksinen, A., Lewis, J. S., Zeglis, B. M. & Sarparanta, M., 2 Dec 2017, In : EJNMMI Research. 2017, 7, 12 p., 95.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Theranostic Imaging with Porous Silicon

Airaksinen, A., 2017, Handbook of Porous Silicon. Canham, L. (ed.). Continuously updated edition ed. Cham: Springer International Publishing , 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

2016

Adenoviral Delivery of Tumor Necrosis Factor-alpha and Interleukin-2 Enables Successful Adoptive Cell Therapy of Immunosuppressive Melanoma

Siurala, M., Havunen, R., Saha, D., Lumen, D., Airaksinen, A. J., Tähtinen, S., Cervera-Carrascon, V., Bramante, S., Parviainen, S., Vaha-Koskela, M., Kanerva, A. & Hemminki, A., Aug 2016, In : Molecular therapy. 24, 8, p. 1435-1443 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

A New Highly Reactive and Low Lipophilicity Fluorine-18 Labeled Tetrazine Derivative for Pretargeted PET Imaging

Keinänen, O., Li, X-G., Chenna, N. K., Lumen, D., Ott, J., Molthoff, C. F. M., Sarparanta, M., Helariutta, K., Vuorinen, T., Windhorst, A. D. & Airaksinen, A. J., Jan 2016, In : ACS Medicinal Chemistry Letters. 7, 1, p. 62-66 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Comparison of somatostatin receptor 2-targeting PET tracers in the detection of mouse atherosclerotic plaques.

Petteri, R., Hellberg, S., Kiugel, M., Virta, J., Li, X-G., Käkelä, M., Helariutta, K., Luoto, P., Liljenbäck, H., Hakovirta, H., Gardberg, M., Airaksinen, A. J., Knuuti, J., Saraste, A. & Roivainen, A., Feb 2016, In : Molecular Imaging and Biology. 18, 1, p. 99-108 10 p.

Research output: Contribution to journalArticleScientificpeer-review

In Vitro and In Vivo Assessment of Heart-Homing Porous Silicon Nanoparticles

Almeida Ferreira, M. P., Ranjan, S., Correia, A., Mäkilä, E., Kinnunen, S. M., Zhang, H., Shahbazi, M-A., Vingadas Almeida, P., Salonen, J., Ruskoaho, H. J., Airaksinen, A., Hirvonen, J. T. & Almeida Santos, H., Jul 2016, In : Biomaterials. 94, p. 93–104 12 p.

Research output: Contribution to journalArticleScientificpeer-review

MICROLOCALIZED TRANSPORT OF AGENTS INTO ARTICULAR CARTILAGE USING HIGH INTENSITY ULTRASOUND

Nieminen, H. J., Lampsijarvi, E., Salmi, A., Airaksinen, A., Saarakkala, S., Pritzker, K. P. & Haeggstrom, E., Apr 2016, p. S522-S523. 2 p.

Research output: Conference materialsAbstractResearchpeer-review

2015

Adenovirus Improves the Efficacy of Adoptive T-cell Therapy by Recruiting Immune Cells to and Promoting Their Activity at the Tumor

Tähtinen, S., Gronberg-Vähä-Koskela, S., Lumen, D., Merisalo-Soikkeli, M., Siurala, M., Airaksinen, A. J., Vähä-Koskela, M. & Hemminki, A., Aug 2015, In : Cancer immunology research. 3, 8, p. 915-925 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Multifunctional porous silicon nanoparticles for cancer theranostics

Wang, C-F., Sarparanta, M. P., Mäkilä, E. M., Hyvönen, M. L. K., Laakkonen, P. M., Salonen, J. J., Hirvonen, J. T., Airaksinen, A. J. & Santos, H. A., Apr 2015, In : Biomaterials. 48, p. 108-118 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Oxidative Stress Protection by Exogenous Delivery of rhHsp70 Chaperone to the Retinal Pigment Epithelium (RPE), a Possible Therapeutic Strategy Against RPE Degeneration

Subrizi, A., Toropainen, E., Ramsay, E., Airaksinen, A. J., Kaarniranta, K. & Urtti, A., Jan 2015, In : Pharmaceutical Research. 32, 1, p. 211-221 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists

Yrjölä, S., Sarparanta, M., Airaksinen, A. J., Hytti, M., Kauppinen, A., Pasonen-Seppanen, S., Adinolfi, B., Nieri, P., Manera, C., Keinanen, O., Poso, A., Nevalainen, T. J. & Parkkari, T., 25 Jan 2015, In : European Journal of Pharmaceutical Sciences. 67, p. 85-96 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Copper-free azide-alkyne cycloaddition of targeting peptides to porous silicon nanoparticles for intracellular drug uptake

Wang, C-F., Mäkilä, E. M., Kaasalainen, M. H., Liu, D., Sarparanta, M. P., Airaksinen, A. J., Salonen, J. J., Hirvonen, J. T. & Santos, H. A., Jan 2014, In : Biomaterials. 35, 4, p. 1257-1266 10 p.

Research output: Contribution to journalArticleScientificpeer-review

In Vivo Evaluation of Porous Silicon and Porous Silicon Solid Lipid Nanocomposites for Passive Targeting and Imaging

Kallinen, A. M., Sarparanta, M. P., Liu, D., Makila, E. M., Salonen, J. J., Hirvonen, J. T., Santos, H. A. & Airaksinen, A. J., Aug 2014, In : Molecular Pharmaceutics. 11, 8, p. 2876-2886 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Porous silicon nanoparticles for nanomedicine: preparation and biomedical applications

Santos, H. A., Mäkilä, E., Airaksinen, A., Bimbo, L. M. & Hirvonen, J., 2014, In : Nanomedicine. 9, 4, p. 535-554 20 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Radiolabeled porous silicon for bioimaging applications

Airaksinen, A., 2014, Porous silicon for biomedical applications. Santos, H. (ed.). Woodhead Publishing Limited, p. 253-269 17 p. (Woodhead Publishing Series in Biomaterials; no. 68).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Synthesis and biological evaluation of novel I-123-labeled 4-(4-iodophenyl)butanoyl-L-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivo

Kallinen, A., Todorov, B., Kallionpää, R., Back, S., Sarparanta, M., Raki, M., Garcia-Horsman, J. A., Bergstrom, K. A., Wallen, E. A. A., Mannisto, P. T. & Airaksinen, A. J., 22 May 2014, In : European Journal of Medicinal Chemistry. 79, p. 436-445 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Using 5-deoxy-5-[F-18] fluororibose to glycosylate peptides for positron emission tomography

Li, X-G., Helariutta, K., Roivainen, A., Jalkanen, S., Knuuti, J. & Airaksinen, A. J., Jan 2014, In : Nature Protocols. 9, 1, p. 138-145 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Evaluation of the Physicochemical and Biopharmaceutical properties of Fluoro-Indomethacin

Mori, M. M., Airaksinen, A. J., Hirvonen, J. T., A. Santos, H. & Caramella, C. M., 2013, In : Current Drug Metabolism. 14, 1, p. 80-89 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Radiosynthesis and evaluation of new alpha(1)-adrenoceptor antagonists as PET radioligands for brain imaging

Airaksinen, A. J., Finnema, S. J., Balle, T., Varnäs, K., Bang-Andersen, B., Gulyas, B., Farde, L. & Halldin, C., Aug 2013, In : Nuclear Medicine and Biology. 40, 6, p. 747-754 8 p.

Research output: Contribution to journalArticleScientificpeer-review

SPECT/CT imaging of radiolabeled cubosomes and hexosomes for potential theranostic applications

Nilsson, C., Barrios-Lopez, B., Kallinen, A., Laurinmäki, P., Butcher, S. J., Raki, M., Weisell, J., Bergström, K., Larsen, S. W., Ostergaard, J., Larsen, C., Urtti, A., Airaksinen, A. J. & Yaghmur, A., Nov 2013, In : Biomaterials. 34, 33, p. 8491-8503 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Translating the concept of peptide labeling with 5-deoxy-5-[F-18] fluororibose into preclinical practice: F-18-labeling of Siglec-9 peptide for PET imaging of inflammation

Li, X-G., Autio, A., Ahtinen, H., Helariutta, K., Liljenbäck, H., Jalkanen, S., Roivainen, A. & Airaksinen, A. J., 2013, In : Chemical Communications. 49, 35, p. 3682-3684 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2012

Amine-modification of thermally carbonized porous silicon with silane coupling chemistry

Mäkilä, E., Bimbo, L. M., Kaasalainen, M., Herranz, B., Airaksinen, A. J., Heinonen, M., Kukk, E., Hirvonen, J., A. Santos, H. & Salonen, J., 2 Oct 2012, In : Langmuir. 28, 39, p. 14045–14054 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Cellular interactions of surface modified nanoporous silicon particles

Bimbo, L. M., Sarparanta, M., Mäkilä, E., Laaksonen, T., Laaksonen, P., Salonen, J., Linder, M. B., Hirvonen, J., Airaksinen, A. J. & Santos, H. A., 12 Mar 2012, In : Nanoscale. 4, 10, p. 3184-3192 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Evolution of microglial activation in ischaemic core and peri-infarct regions after stroke: A PET study with the TSPO molecular imaging biomarker [11C]vinpocetine

Gulyás, B., Tóth, M., Schain, M., Airaksinen, A., Vas, Á., Kostulas, K., Lindström, P., Hillert, J. & Halldin, C., 15 Sep 2012, In : Journal of the Neurological Sciences. 320, 1–2, p. 110-117 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Intravenous Delivery of Hydrophobin-Functionalized Porous Silicon Nanoparticles: Stability, Plasma Protein Adsorption and Biodistribution

Sarparanta, M., Bimbo, L. M., Rytkönen, J., Mäkilä, E., Laaksonen, T. J., Laaksonen, P., Nyman, M., Salonen, J., Linder, M. B., Hirvonen, J., Santos, H. A. & Airaksinen, A. J., 25 Jan 2012, In : Molecular Pharmaceutics. 9, 3, p. 654-663 10 p.

Research output: Contribution to journalArticleScientificpeer-review

SPECT/CT Imaging of hNIS - Expression after Intravenous Delivery of an Oncolytic Adenovirus and I-131

Rajecki, M., Sarparanta, M., Hakkarainen, T., Tenhunen, M., Diaconu, I., Kuhmonen, V., Kairemo, K., Kanerva, A-M., Airaksinen, A. J. & Hemminki, A., 2012, In : PLoS One. 7, 3, p. e32871 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The mucoadhesive and gastroretentive properties of hydrophobin-coated porous silicon nanoparticle oral drug delivery systems

Sarparanta, M. P., Bimbo, L. M., Mäkilä, E. M., Salonen, J. J., Laaksonen, P. H., Helariutta, A. M. K., Linder, M. B., Hirvonen, J. T., Laaksonen, T. J., Santos, H. A. & Airaksinen, A. J., 28 Jan 2012, In : Biomaterials. 33, 11, p. 3353-3362 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

18F-Labeled Modified Porous Silicon Particles for Investigation of Drug Delivery Carrier Distribution In Vivo with Positron Emission Tomography

Sarparanta, M., Mäkilä, E., Heikkilä, T., Juhani Salonen, J., Kukk, E., Lehto, V-P., Santos, H. A., Hirvonen, J. & Airaksinen, A., 2011, In : Molecular Pharmaceutics. 8, 5, p. 1799-1806

Research output: Contribution to journalArticleScientificpeer-review

A Comparative study on the effect of solvent on nucleophilic fluorination with [18F]fluoride: protic solvents as co-solvents in SN2 and SNAr reactions

Koivula, T., Simecek, J., Jalomäki, J., Helariutta, K. & Airaksinen, A. J., May 2011, In : Radiochimica Acta. 99, 5, p. 293-300 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Fluorine-18 radiolabeling as a tool to evaluate novel porous silicon based nano- and microcarriers for drug delivery

Sarparanta, M., Bimbo, L. M., Mäkilä, E., Salonen, J., Santos, H. A., Laaksonen, T., Hirvonen, J., Lehto, V-P., Laaksonen, P., Linder, M. B. & Airaksinen, A., 2011, In : Journal of Labelled Compounds & Radiopharmaceuticals. 54, S1, p. S538 1 p.

Research output: Contribution to journalConference articleScientific

Mesoporous silicon particles as biocompatible drug delivery agents

Bimbo, L. M., Sarparanta, M., Mäkilä, E., Laaksonen, T., Peltonen, L., Lehto, V-P., Airaksinen, A., Salonen, J., Hirvonen, J. & Santos, H. A., 2011, In : European Journal of Pharmaceutical Sciences. 44, S1, p. S129-S130 2 p.

Research output: Contribution to journalConference articleScientificpeer-review

Multifunctional Porous Silicon for Therapeutic Drug Delivery and Imaging

Santos, H. A., Bimbo, L. M., Lehto, V-P., Airaksinen, A., Salonen, J. & Hirvonen, J., Sep 2011, In : Current Drug Discovery Technologies. 8, 3, p. 228-249 22 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Quantification of the neurokinin 1 receptor ligand [11C]R116301

Wolfensberger, S. P., Maruyama, K., van Berckel, B. N., Lubberink, M., Airaksinen, A., Boellaard, R., Luurtsema, G., Reddingius, W., Janssens, F. E., Veltman, D. J., Wondhorst, A. D., Leysen, J. E. & Lammertsma, A. A., 2011, In : Nuclear Medicine Communications. 32, p. 896-902

Research output: Contribution to journalArticleScientificpeer-review

2010

Biocompatibility of Thermally Hydrocarbonized Porous Silicon Nanoparticles and their Biodistribution in Rats

Bimbo, L. M., Sarparanta, M., Santos, H. A., Airaksinen, A. J., Makila, E., Laaksonen, T., Peltonen, L., Lehto, V-P., Hirvonen, J. & Salonen, J., 28 May 2010, In : ACS Nano. 4, 6, p. 3023-3032 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

[¹F]Flumazenil binding to central benzodiazepine receptor studies by PET - Quantitative analysis and comparisons with [¹¹C]flumazenil

Odano, I., Halldin, C., Karlsson, P., Varrone, A., Airaksinen, A. J., Krasikova, R. N. & Farde, L., 2009, In : NeuroImage. 45, p. 891-902 12 p.

Research output: Contribution to journalArticleScientificpeer-review

First Evaluation of [C-11]R116301 as an In Vivo Tracer of NK1 Receptors in Man

Wolfensberger, S. P. A., van Berckel, B. N. M., Airaksinen, A. J., Maruyama, K., Lubberink, M., Boellaard, R., Carey, W. D. H., Reddingius, W., Veltman, D. J., Windhorst, A. D., Leysen, J. E. & Lammertsma, A. A., 2009, In : Molecular Imaging and Biology. 11, 4, p. 241-245 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Targeted Radiotherapy for Prostate Cancer with an Oncolytic Adenovirus Coding for Human Sodium Iodide Symporter

Hakkarainen, T., Rajecki, M., Sarparanta, M., Tenhunen, M., Airaksinen, A. J., Desmond, R. A., Kairemo, K. & Hemminki, A., 2009, In : Clinical Cancer Research. 15, 17, p. 5396-5403 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

[¹¹C]Cyclopropyl-FLB 457: A PET radioligand for low densities of dopamine D receptors

Airaksinen, A. J., Nag, S., Finnema, S. J., Mukherjee, J., Chattopadhyay, S., Gulyas, B., Farde, L. & Halldin, C., 2008, In : Bioorganic & Medicinal Chemistry. 16, p. 6467-6473 7 p.

Research output: Contribution to journalArticleScientificpeer-review