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Arja Pasternack

20022019
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Publications 2002 2019

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2019

Activin Receptor Ligand Blocking and Cancer Have Distinct Effects on Protein and Redox Homeostasis in Skeletal Muscle and Liver

Hentila, J., Nissinen, T. A., Korkmaz, A., Lensu, S., Silvennoinen, M., Pasternack, A., Ritvos, O., Atalay, M. & Hulmi, J. J., 18 Jan 2019, In : Frontiers in Physiology. 9, 16 p., 1917.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury

Magga, J., Vainio, L., Kilpio, T., Hulmi, J. J., Taponen, S., Lin, R., Räsänen, M., Szabo, Z., Gao, E., Rahtu-Korpela, L., Alakoski, T., Ulvila, J., Laitinen, M., Pasternack, A., Koch, W. J., Alitalo, K., Kivela, R., Ritvos, O. & Kerkelä, R., 6 Mar 2019, In : Molecular therapy. 27, 3, p. 600-610 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

Activin inhibition limits early innate immune response in rat kidney allografts-a pilot study

Palin, N. K., Savikko, J., Pasternack, A., Rintala, J. M., Kalra, B., Mistry, S., Kumar, A., Roth, M-P., Helin, H. & Ritvos, O., Jan 2017, In : Transplant International. 30, 1, p. 96-107 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Transglutaminase 2-specific coeliac disease autoantibodies induce morphological changes and signs of inflammation in the small-bowel mucosa of mice

Kalliokoski, S., Piqueras, V. O., Frias, R., Sulic, A-M., Määttä, J. A. E., Kähkönen, N., Viiri, K., Huhtala, H., Pasternack, A., Laurila, K., Sblattero, D., Korponay-Szabo, I. R., Mäki, M., Caja, S., Kaukinen, K. & Lindfors, K., Mar 2017, In : Amino Acids. 49, 3, p. 529-540 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Treatment with soluble activin type IIB-receptor improves bone mass and strength in a mouse model of Duchenne muscular dystrophy

Puolakkainen, T., Ma, H., Kainulainen, H., Pasternack, A., Rantalainen, T., Ritvos, O., Heikinheimo, K., Hulmi, J. & Kiviranta, R., 19 Jan 2017, In : BMC Musculoskeletal Disorders. 18, 11 p., 20.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres

Omairi, S., Matsakas, A., Degens, H., Kretz, O., Hansson, K-A., Solbra, A. V., Bruusgaard, J. C., Joch, B., Sartori, R., Giallourou, N., Mitchell, R., Collins-Hooper, H., Foster, K., Pasternack, A., Ritvos, O., Sandri, M., Narkar, V., Swann, J. R., Huber, T. B. & Patel, K., 5 Aug 2016, In : eLife. 5, 25 p., 16940.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Inhibition of Activin Signaling Slows Progression of Polycystic Kidney Disease

Leonhard, W. N., Kunnen, S. J., Plugge, A. J., Pasternack, A., Jianu, S. B. T., Veraar, K., el Bouazzaoui, F., Hoogaars, W. M. H., ten Dijke, P., Breuning, M. H., De Heer, E., Ritvos, O. & Peters, D. J. M., Dec 2016, In : Journal of the American Society of Nephrology. 27, 12, p. 3589-3599 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Systemic blockade of ACVR2B ligands prevents chemotherapy-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative capacity or atrogenes

Nissinen, T. A., Degerman, J., Räsänen, M., Poikonen, A. R., Koskinen, S., Mervaala, E., Pasternack, A., Ritvos, O., Kivela, R. & Hulmi, J. J., 26 Sep 2016, In : Scientific Reports. 6, 16 p., 32695.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2015

Activin A contributes to the development of hyperoxia-induced lung injury in neonatal mice

Lim, R., Muljadi, R., Koulaeva, E., Vosdoganes, P., Chan, S. T., Acharya, R., Gurusinghe, S., Ritvos, O., Pasternack, A. & Wallace, E. M., Jun 2015, In : Pediatric Research. 77, 6, p. 749-756 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice

Kainulainen, H., Papaioannou, K. G., Silvennoinen, M., Autio, R., Saarela, J., Oliveira, B. M., Nyqvist, M., Pasternack, A., 't Hoen, P. A. C., Kujala, U. M., Ritvos, O. & Hulmi, J. J., 5 Jan 2015, In : Molecular and Cellular Endocrinology. 399, C, p. 131-142 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Overexpression of activin-A and -B in malignant mesothelioma - Attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth

Tamminen, J. A., Yin, M., Ronty, M., Sutinen, E., Pasternack, A., Ritvos, O., Myllarniemi, M. & Koli, K., 1 Mar 2015, In : Experimental Cell Research. 332, 1, p. 102-115 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin

Haridas, P. A. N., Soronen, J., Sädevirta, S., Mysore, R., Quagliarini, F., Pasternack, A., Metso, J., Perttila, J., Leivonen, M., Smas, C. M., Fischer-Posovszky, P., Wabitsch, M., Ehnholm, C., Ritvos, O., Jauhiainen, M., Olkkonen, V. M. & Yki-Jarvinen, H., Oct 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 10, p. E1299-E1307 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2014

Upregulation of activin-B and follistatin in pulmonary fibrosis - a translational study using human biopsies and a specific inhibitor in mouse fibrosis models

Myllärniemi, M., Tikkanen, J., Hulmi, J. J., Pasternack, A., Sutinen, E., Ronty, M., Lepparanta, O., Ma, H., Ritvos, O. & Koli, K., 1 Nov 2014, In : BMC Pulmonary Medicine. 14, 14 p., 170.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2013

Exercise restores decreased physical activity levels and increases markers of autophagy and oxidative capacity in myostatin/activin-blocked mdx mice

Hulmi, J. J., Oliveira, B. M., Silvennoinen, M., Hoogaars, W. M. H., Pasternack, A., Kainulainen, H. & Ritvos, O., Jul 2013, In : American Journal of Physiology: Endocrinology and Metabolism. 305, 2, p. E171-E182 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Muscle protein synthesis, mTORC1/MAPK/Hippo signaling, and capillary density are altered by blocking of myostatin and activins

Hulmi, J. J., Oliveira, B. M., Silvennoinen, M., Hoogaars, W. M. H., Ma, H., Pierre, P., Pasternack, A., Kainulainen, H. & Ritvos, O., Jan 2013, In : American Journal of Physiology: Endocrinology and Metabolism. 304, 1, p. E41-E50 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

A Covalently Dimerized Recombinant Human Bone Morphogenetic Protein-15 Variant Identifies Bone Morphogenetic Protein Receptor Type 1B as a Key Cell Surface Receptor on Ovarian Granulosa Cells

Pulkki, M. M., Mottershead, D. G., Pasternack, A. H., Muggalla, P., Ludlow, H., van Dinther, M., Myllymaa, S., Koli, K., ten Dijke, P., Laitinen, M. & Ritvos, O., 2012, In : Endocrinology. 153, 3, p. 1509-1518 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Activin-A Overexpression in the Murine Lung Causes Pathology That Simulates Acute Respiratory Distress Syndrome

Apostolou, E., Stavropoulos, A., Sountoulidis, A., Xirakia, C., Giaglis, S., Protopapadakis, E., Ritis, K., Mentzelopoulos, S., Pasternack, A., Foster, M., Ritvos, O., Tzelepis, G. E., Andreakos, E. & Sideras, P., 2012, In : American Journal of Respiratory and Critical Care Medicine. 185, 4, p. 382-391 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Combined Effect of AAV-U7-Induced Dystrophin Exon Skipping and Soluble Activin Type IIB Receptor in mdx Mice

Hoogaars, W. M. H., Mouisel, E., Pasternack, A., Hulmi, J. J., Relizani, K., Schuelke, M., Schirwis, E., Garcia, L., Ritvos, O., Ferry, A., 't Hoen, P. A. & Amthor, H., Dec 2012, In : Human Gene Therapy. 23, 12, p. 1269-1279 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

The bioactivity of human bone morphogenetic protein-15 is sensitive to C-terminal modification: Characterization of the purified untagged processed mature region

Pulkki, M. M., Myllymaa, S. J. P., Pasternack, A. H., Lun, S., Ludlow, H., Al-Qahtani, A., Korchynskyi, O., Groome, N., Juengel, J. L., Kalkkinen, N., Laitinen, M., Ritvos, O. & Mottershead, D. G., 2011, In : Molecular and Cellular Endocrinology. 332, 1-2, p. 106-115 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Inhibition of oocyte growth factors in vivo modulates ovarian folliculogenesis in neonatal and immature mice

Myllymaa, S., Pasternack, A., Mottershead, D. G., Poutanen, M., Pulkki, M. M., Pelliniemi, L. J., Ritvos, O. & Laitinen, M. P. E., 2010, In : Reproduction. 139, 3, p. 587-598 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Characterization of recombinant human growth differentiation factor-9 signaling in ovarian granulosa cells

Mottershead, D. G., Pulkki, M. M., Muggalla, P., Pasternack, A., Tolonen, M., Myllymaa, S., Korchynskyi, O., Nishi, Y., Yanase, T., Lun, S., Juengel, J. L., Laitinen, M. & Ritvos, O., 2008, In : Molecular and Cellular Endocrinology. 283, 1-2, p. 58-67 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

Functional characterization of rat rho(2) subunits expressed in HEK 293 cells

Alakuijala, A., TalviOja, K., Pasternack, A. & Pasternack, M., Feb 2005, In : European Journal of Neuroscience. 21, 3, p. 692-700 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2003

Characterization of the functional role of the N-glycans in the AMPA receptor ligand-binding domain

Pasternack, A., Coleman, S. K., Fethiere, J., Madden, D. R., LeCaer, J. P., Rossier, J., Pasternack, M. & Keinanen, K., 2003, In : Journal of Neurochemistry. 84, p. 1184-1192 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2002

alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor channels lacking the N-terminal domain

Pasternack, A., Coleman, S. K., Jouppila, A., Mottershead, D. G., Lindfors, M., Pasternack, M. & Keinänen, K., 2002, In : Journal of Biological Chemistry. 277, 51, p. 49662-49667 6 p.

Research output: Contribution to journalArticleScientificpeer-review