Photo of Ayman Khattab
  • PL 21 (Haartmaninkatu 3)

    00014

    Finland

19962019
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Personal profile

Curriculum vitae

In July 2007, I received a visiting scientist grant from the SIGRID JUSELIUS FOUNDATION, Finland and joined the Haartman Institute to set up a malaria lab. The lab now maintains the malaria parasite Plasmodium falciparum cultures and two species of the Anopheles mosquitoes as tools for malaria and other vector-borne disease research. Currently, my research is funded by a Three Years Research grant from the University of Helsinki and a TEKES grant (subcontractor)   

My research is focusing on 1) the malaria parasite Plasmodium falciparum surface antigens as virulence factors 2) complement escape of the Plasmodium falciparum parasite 3) the immune interaction between mosquitoes and the human host and 4) malaria control

My previous research activity started immediately after obtaining my B.Sc. in microbiology (1991) from the faculty of Science, Alexandria University, Egypt. In 1992, I joined a research group working on developing genetically modified Bacillus subtilus strains to produce industrially important enzymes. I got my Master degree in 1995 based on this work and two peer-reviewed articles were the outcome of my Master thesis. In 1996, I received a two years research fellowship from the Italian ministry of foreign affairs to pursue a research on the role of cyclophilins and calcineurins in the killing mechanism of action of Cyclosporin A (CsA) and CsA analogues on Schistosoma mansoni. The research was conducted at the Cell Biology Institute, the National Research Council of Italy. My work on this project resulted in three peer reviewed articles and a book chapter. In 1998, I returned back to my home country and I was appointed an assistant researcher position at Mubarak City for Research. In 1999, I received a PhD fellowship supported by grants from ƒortüne-Programme of the Medical Faculty of the University of Tübingen, Germany and the European consortium PAMVAC to study the molecular basis of the pathogenesis of pregnancy associated malaria. The research work was conducted at the Institute for Tropical Medicine, University of Tübingen and the Albert Schweitzer Hospital, Lambaréné, Gabon. As a result of my work a conserved domain of the Plasmodium falciparum membrane protein 1 was identified as the major ligand for the chondroitin sulfate A expressed on the surface of the syncytiotrophoblastic cells that line the placenta. In 2003, I was awarded my PhD degree based on five peer reviewed articles on that project. In 2003, I started my post-doctoral work at Bernhard Nocht Institute for Tropical Medicine in Hamburg supported by the European PAMVAC and EUROMALVAC consortia. I continued my research on the pregnancy associated malaria and the PfEMP1 protein coded by the multicopy var gene family. The work was extended to other P. falciparum variant antigens such as RIFINs and STEVORs, their expression in various stages of the parasites, function and role in the acquired immunity in individuals from malaria endemic areas. In 2005, I was granted a post-doctoral researcher position form Bernhard Nocht Institute. Eight peer reviewed articles were the outcome of my postdoctoral work.

Keywords

  • 3111 Biomedicine
  • Innate immunity, insect immunity, mosquito
  • Parasitology, Plasmodium, malaria

International and National Collaboration Publications and projects within past five years.

Publications 1996 2019

3D mosquito screens to create window double screen traps for mosquito control

Khattab, A., Jylha, K., Hakala, T., Aalto, M., Malima, R., Kisinza, W., Honkala, M., Nousiainen, P. & Meri, S., 29 Aug 2017, In : Parasites & vectors. 10, 12 p., 400.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Anopheles Midgut Epithelium Evades Human Complement Activity by Capturing Factor H from the Blood Meal

Khattab, A., Barroso, M., Miettinen, T. & Meri, S., Feb 2015, In : PLoS Neglected Tropical Diseases. 9, 2, 23 p., 0003513.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Complement activation in primiparous women from a malaria endemic area is associated with reduced birthweight

Khattab, A., Kremsner, P. G. & Meri, S., Feb 2013, In : Placenta. 34, 2, p. 162-167 6 p.

Research output: Contribution to journalArticleScientificpeer-review

A switch in infected erythrocyte deformability at the maturation and blood circulation of Plasmodium falciparum transmission stages

Tiburcio, M., Niang, M., Deplaine, G., Perrot, S., Bischoff, E., Ndour, P. A., Silvestrini, F., Khattab, A., Milon, G., David, P. H., Hardeman, M., Vernick, K. D., Sauerwein, R. W., Preiser, P. R., Mercereau-Puijalon, O., Buffet, P., Alano, P. & Lavazec, C., 2012, In : Blood. 119, 24, p. E172-E180 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Activities 2005 2017

  • 12 Organisation and participation in conferences, workshops, courses, seminars
  • 4 Peer review of manuscripts
  • 3 Academic visit to other institution
  • 1 Types for other activities - External teaching and subject coordination

Placenta (Journal)

Ayman Khattab (Reviewer)
14 Mar 2017

Activity: Publication peer-review and editorial work typesPeer review of manuscripts

The National Institute for Medical Research, Muheza

Ayman Khattab (Visiting researcher)
29 Mar 20162 Apr 2016

Activity: Visiting an external institution typesAcademic visit to other institution

XXV International Congress of Entomology

Ayman Khattab (Speaker: Presenter)
25 Sep 201630 Sep 2016

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Amani Research Centre

Ayman Khattab (Visiting researcher)
4 Dec 20149 Dec 2014

Activity: Visiting an external institution typesAcademic visit to other institution

European Science Foundation (ESF) - Project evaluator

Ayman Khattab (Participant)
31 Mar 2014

Activity: Other activity typesTypes for other activities - External teaching and subject coordination