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Bhagwan Yadav

20112019
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Publications 2012 2019

2019

Dasatinib and navitoclax act synergistically to target NUP98-NSD1(+)/FLT3-ITD+ acute myeloid leukemia

Kivioja, J. L., Thanasopoulou, A., Kumar, A., Kontro, M., Yadav, B., Majumder, M. M., Javarappa, K. K., Eldfors, S., Schwaller, J., Porkka, K. & Heckman, C. A., Jun 2019, In : Leukemia. 33, 6, p. 1360-1372 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Immunological monitoring of newly diagnosed CML patients treated with bosutinib or imatinib first-line

Kreutzman, A., Yadav, B., Brummendorf, T. H., Gjertsen, B. T., Hee, M. L., Janssen, J., Kasanen, T., Koskenvesa, P., Lotfi, K., Markevärn, B., Olsson-Stromberg, U., Stentoft, J., Stenke, L., Söderlund, S., Udby, L., Richter, J., Hjörth-Hansen, H. & Mustjoki, S., 2 Sep 2019, In : OncoImmunology. 8, 9, 13 p., e1638210.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer

Tang, J., Gautam, P., Gupta, A., He, L., Timonen, S., Akimov, Y., Wang, W., Szwajda, A., Jaiswal, A., Turei, D., Yadav, B., Kankainen, M., Saarela, J., Saez-Rodriguez, J., Wennerberg, K. & Aittokallio, T., 2019, In : npj Systems Biology and Applications. 5, 1

Research output: Contribution to journalArticleScientificpeer-review

Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia

Kuusanmäki, H., Leppä, A-M., Pölönen, P., Kontro, M., Dufva, O., Deb, D., Yadav, B., Bruck, O., Kumar, A., Everaus, H., Gjertsen, B. T., Heinäniemi, M., Porkka, K., Mustjoki, S. & Heckman, C., 11 Jul 2019, In : Haematologica.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL

Schrader, A., Crispatzu, G., Oberbeck, S., Mayer, P., Pützer, S., von Jan, J., Vasyutina, E., Warner, K., Weit, N., Pflug, N., Braun, T., Andersson, E. I., Yadav, B., Riabinska, A., Maurer, B., Ferreira, M. S. V., Beier, F., Altmueller, J., Lanasa, M., Herling, C. D. & 16 othersHaferlach, T., Stilgenbauer, S., Hopfinger, G., Peifer, M., Brümmendorf, T. H., Nürnberg, P., Elenitoba-Johnson, K. S. J., Zha, S., Hallek, M., Moriggl, R., Reinhardt, H. C., Stern, M. -H., Mustjoki, S., Newrzela, S., Frommolt, P. & Herling, M., 15 Feb 2018, In : Nature Communications. 9, 22 p., 697.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target

Dufva, O., Kankainen, M., Kelkka, T., Sekiguchi, N., Awad, S. A., Eldfors, S., Yadav, B., Kuusanmäki, H., Malani, D., Andersson, E. I., Pietarinen, P., Saikko, L., Kovanen, P. E., Ojala, T., Lee, D. A., Loughran, T. P., Nakazawa, H., Suzumiya, J., Suzuki, R., Ko, Y. H. & 7 othersKim, W. S., Chuang, S-S., Aittokallio, T., Chan, W. C., Ohshima, K., Ishida, F. & Mustjoki, S., 19 Apr 2018, In : Nature Communications. 9, 12 p., 1567.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling

Andersson, E. I., Pützer, S., Yadav, B., Dufva, O., Khan, S., He, L., Sellner, L., Schrader, A., Crispatzu, G., Oleś, M., Zhang, H., Adnan-Awad, S., Lagström, S., Bellanger, D., Mpindi, J. P., Eldfors, S., Pemovska, T., Pietarinen, P., Lauhio, A., Tomska, K. & 19 othersCuesta-Mateos, C., Faber, E., Koschmieder, S., Brümmendorf, T. H., Kytölä, S., Savolainen, E-R., Siitonen, T., Ellonen, P., Kallioniemi, O., Wennerberg, K., Ding, W., Stern, M-H., Huber, W., Anders, S., Tang, J., Aittokallio, T., Zenz, T., Herling, M. & Mustjoki, S., Mar 2018, In : Leukemia. 32, 3, p. 774-787 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Drug-Sensitivity Screening and Genomic Characterization of 45 HPV-Negative Head and Neck Carcinoma Cell Lines for Novel Biomarkers of Drug Efficacy

Lepikhova, T., Karhemo, P-R., Louhimo, R., Yadav, B., Murumägi, A., Kulesskiy, E., Kivento, M., Sihto, H., Grenman, R., Syrjänen, S. M., Kallioniemi, O., Aittokallio, T., Wennerberg, K., Joensuu, H. & Monni, O., Sep 2018, In : Molecular Cancer Therapeutics. 17, 9, p. 2060-2071 12 p.

Research output: Contribution to journalArticleScientificpeer-review

PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells

Kauko, O., O'Connor, C. M., Kulesskiy, E., Sangodkar, J., Aakula, A., Izadmehr, S., Yetukuri, L., Yadav, B., Padzik, A., Laajala, T. D., Haapaniemi, P., Momeny, M., Varila, T., Ohlmeyer, M., Aittokallio, T., Wennerberg, K., Narla, G. & Westermarck, J., 18 Jul 2018, In : Science translational medicine. 10, 450, 12 p., 1093.

Research output: Contribution to journalArticleScientificpeer-review

Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling

Kuusanmäki, H., Dufva, O., Parri, E., van Adrichem, A. J., Rajala, H., Majumder, M. M., Yadav, B., Parsons, A., Chan, W. C., Wennerberg, K., Mustjoki, S. & Heckman, C. A., 14 Nov 2017, In : Oncotarget. 8, 57, p. 97516-97527 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Enhanced sensitivity to glucocorticoids in cytarabine-resistant AML

Malani, D., Murumagi, A., Yadav, B., Kontro, M., Eldfors, S., Kumar, A., Karjalainen, R., Majumder, M. M., Ojamies, P., Pemovska, T., Wennerberg, K., Heckman, C., Porkka, K., Wolf, M., Aittokallio, T. & Kallioniemi, O., May 2017, In : Leukemia. 31, 5, p. 1187-1195 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia

Kontro, M., Kumar, A., Majumder, M. M., Eldfors, S., Parsons, A., Pemovska, T., Saarela, J. S., Yadav, B., Malani, D. R., Fløisand, Y., Höglund, M., Remes, K., Gjertsen, B-T., Kallioniemi, O-P., Wennerberg, J. K., Heckman, C. A. & Porkka, K. V. K., 2017, In : Leukemia. 31, 2, p. 301-309 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Identification of precision treatment strategies for relapsed/refractory multiple myeloma by functional drug sensitivity testing

Majumder, M. M., Silvennoinen, R., Anttila, P., Tamborero, D., Eldfors, S., Yadav, B., Karjalainen, R., Kuusanmaki, H., Lievonen, J., Parsons, A., Suvela, M., Jantunen, E., Porkka, K. & Heckman, C. A., 22 Aug 2017, In : Oncotarget. 8, 34, p. 56338-56350 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML

Karjalainen, R., Pemovska, T., Popa, M., Liu, M., Javarappa, K. K., Majumder, M. M., Yadav, B., Tamborero, D., Tang, J., Bychkov, D., Kontro, M., Parsons, A., Suvela, M., Safont, M. M., Porkka, K., Aittokallio, T., Kallioniemi, O., McCormack, E., Gjertsen, B. T., Wennerberg, K. & 2 othersKnowles, J. & Heckman, C. A., 10 Aug 2017, In : Blood. 130, 6, p. 789-802 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Quantitative modeling and analysis of drug screening data for personalized cancer medicine

Yadav, B., 2017, Helsinki: [B. Yadav]. 68 p.

Research output: ThesisDoctoral ThesisCollection of Articles

2016

Consistency in drug response profiling

Mpindi, J. P., Yadav, B., Ostling, P., Gautam, P., Malani, D., Murumagi, A., Hirasawa, A., Kangaspeska, S., Wennerberg, K., Kallioniemi, O. & Aittokallio, T., 1 Dec 2016, In : Nature. 540, 7631, p. E5-E6 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Identification of selective cytotoxic and synthetic lethal drug responses in triple negative breast cancer cells

Gautam, P., Karhinen, L., Szwajda, A., Jha, S. K., Yadav, B., Aittokallio, T. & Wennerberg, K., 10 May 2016, In : Molecular Cancer. 15, 16 p., 34.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Mutational Landscape of Aggressive Natural Killer Cell Leukemia and Drug Sensitivity Profiling Reveal Therapeutic Options in Natural Killer Cell Malignancies

Dufva, O., Kankainen, M., Kelkka, T., Awad, S. A., Sekiguchi, N., Yadav, B., Eldfors, S., Kuusanmaki, H., Andersson, E. I., Malani, D., Pietarinen, P., Saikko, L., Kovanen, P. E., Suzumiya, J., Suzuki, R., Ko, Y. H., Kim, W. S., Chuang, S-S., Loughran, T. P., Chan, W. C. & 4 othersOhshima, K., Aittokallio, T., Ishida, F. & Mustjoki, S., 2 Dec 2016, In : Blood. 128, 22, 4 p., 2921.

Research output: Contribution to journalMeeting AbstractResearch

2015

From drug response profiling to target addiction scoring in cancer cell models

Yadav, B., Gopalacharyulu, P., Pemovska, T., Khan, S. A., Szwajda, A., Tang, J., Wennerberg, K. & Aittokallio, T., Oct 2015, In : Disease Models & Mechanisms. 8, 10, p. 1255-1264 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Novel drug candidates for blast phase chronic myeloid leukemia from high-throughput drug sensitivity and resistance testing

Pietarinen, P. O., Pemovska, T., Kontro, M., Yadav, B., Mpindi, J. P., Andersson, E. I., Majumder, M. M., Kuusanmaki, H., Koskenvesa, P., Kallioniemi, O., Wennerberg, K., Heckman, C. A., Mustjoki, S. & Porkka, K., May 2015, In : Blood cancer journal. 5, 6 p., 309.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Systematic Mapping of Kinase Addiction Combinations in Breast Cancer Cells by Integrating Drug Sensitivity and Selectivity Profiles

Szwajda, A., Gautam, P., Karhinen, L., Jha, S. K., Saarela, J., Shakyawar, S., Turunen, L., Yadav, B., Tang, J., Wennerberg, K. & Aittokallio, T., 20 Aug 2015, In : Chemistry & Biology. 22, 8, p. 1144-1155 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies

Yadav, B., Pemovska, T., Szwajda, A., Kulesskiy, E., Kontro, M., Karjalainen, R., Majumder, M. M., Malani, D., Murumagi, A., Knowles, J., Porkka, K., Heckman, C., Kallioniemi, O., Wennerberg, K. & Aittokallio, T., 5 Jun 2014, In : Scientific Reports. 4, 10 p., 5193.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Suppression of BRCA1 sensitizes cells to proteasome inhibitors

Gu, Y., Bouwman, P., Greco, D., Saarela, J., Yadav, B., Jonkers, J. & Kuznetsov, S., 18 Dec 2014, In : Cell Death and Disease. 5, 12 p., e1580.

Research output: Contribution to journalArticleScientificpeer-review

2013

Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice

Kakkola, L., Denisova, O. V., Tynell, J., Viiliainen, J., Ysenbaert, T., Matos, R. C., Nagaraj, A., Öhman, T., Kuivanen, S., Paavilainen, H., Feng, L., Yadav, B., Julkunen, I., Vapalahti, O., Hukkanen, V., Stenman, J., Aittokallio, T., Verschuren, E. W., Ojala, P. M., Nyman, T. & 3 othersSaelens, X., Dzeyk, K. & Kainov, D. E., Jul 2013, In : Cell Death and Disease. 4, Article Number: e742, 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Individualized Systems Medicine Strategy to Tailor Treatments for Patients with Chemorefractory Acute Myeloid Leukemia

Pemovska, T., Kontro, M., Yadav, B., Edgren, H., Eldfors, S., Szwajda, A., Almusa, H., Bespalov, M. M., Ellonen, P., Elonen, E., Gjertsen, B. T., Karjalainen, R., Kulesskiy, E., Lagström, S., Lehto, A., Lepistö, M., Lundan, T., Majumder, M. M., Marti, J. M. L., Mattila, P. & 16 othersMurumagi, A., Mustjoki, S., Palva, A., Parsons, A., Pirttinen, T., Ramet, M. E., Suvela, M., Turunen, L., Vastrik, I., Wolf, M., Knowles, J., Aittokallio, T., Heckman, C. A., Porkka, K., Kallioniemi, O. & Wennerberg, K., Dec 2013, In : Cancer Discovery. 3, 12, p. 1416-1429 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Stromal cell supported high-throughput screening of primary acute myeloid leukemia cells for assessing sensitivity to cytotoxic drugs

Karjalainen, R. J., Pemovska, T., Yadav, B., Wennerberg, J. K. & Heckman, C. A., Feb 2013, In : Annals of Hematology. 92, Supplement 1, p. S17

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Target Inhibition Networks: Predicting Selective Combinations of Druggable Targets to Block Cancer Survival Pathways

Tang, J., Karhinen, L., Xu, T., Szwajda, A., Yadav, B., Wennerberg, K. & Aittokallio, T., Sep 2013, In : PLoS Computational Biology. 9, 9, p. Article Number: e1003226 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Obatoclax, Saliphenylhalamide, and Gemcitabine Inhibit Influenza A Virus Infection

Denisova, O. V., Kakkola, L., Feng, L., Stenman, J., Nagaraj, A., Lampe, J., Yadav, B., Aittokallio, T., Kaukinen, P., Ahola, T., Kuivanen, S., Vapalahti, O., Kantele, A., Tynell, J., Julkunen, I., Kallio-Kokko, H., Paavilainen, H., Hukkanen, V., Elliott, R. M., De Brabander, J. K. & 2 othersSaelens, X. & Kainov, D. E., 12 Oct 2012, In : Journal of Biological Chemistry. 287, 42, p. 35324-35332 9 p.

Research output: Contribution to journalArticleScientificpeer-review