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Publications 1975 2018

2018

Floral scent chemistry within the genus Linnaea (Caprifoliaceae)

Bergstrom, L. G. W., Bergquist, S., Stenhagen, G., Gahmberg, C. G., Maia, A. C. D. & Nordenstam, B., Mar 2018, In : Nordic Journal of Botany. 36, 3, 9 p., 01732.

Research output: Contribution to journalArticleScientificpeer-review

Phosphorylation of the α-chain in the integrin LFA-1 enables β2-chain phosphorylation and α-actinin binding required for cell adhesion

Jahan, F., Madhavan, S., Rolova, T., Viazmina, L., Grönholm, M. & Gahmberg, C. G., 10 Aug 2018, In : Journal of Biological Chemistry. 293, 32, p. 12318-12330 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

Neuronal ICAM-5 Inhibits Microglia Adhesion and Phagocytosis and Promotes an Anti-inflammatory Response in LPS Stimulated Microglia

Paetau, S., Rolova, T., Ning, L. & Gahmberg, C. G., 22 Dec 2017, In : Frontiers in Molecular Neuroscience. 10, 12 p., 431.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Karolinska Institutet och Macchiarini-ärendet: En extern granskning

Gahmberg, C. G., Heckscher, S. & Carlberg, I., 5 Sep 2016, Stockholm: Karolinska Institutet University Press. 195 p.

Research output: Book/ReportCommissioned reportProfessional

Open Access

LFA-1 integrin antibodies inhibit leukocyte alpha(4)beta(1)-mediated adhesion by intracellular signaling

Grönholm, M., Jahan, F., Bryushkova, E. A., Madhavan, S., Aglialoro, F., Hinojosa, L. S., Uotila, L. M. & Gahmberg, C. G., 1 Sep 2016, In : Blood. 128, 9, p. 1270-1281 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

ICAM-5 affects spine maturation by regulation of NMDA receptor binding to alpha-actinin

Ning, L., Paetau, S., Nyman-Huttunen, H., Tian, L. & Gahmberg, C. G., 15 Feb 2015, In : Biology open. 4, 2, p. 125-136 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Mitochondrial toxicity of triclosan on mammalian cells

Ajao, C., Andersson, M., Teplova, V. V., Nagy, S., Gahmberg, C. G., Andersson, L. C., Hautaniemi, M., Kakasi, B., Roivainen, M. & Salkinoja-Salonen, M. S., 7 Apr 2015, In : Toxicology reports . 2, p. 624-637 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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RIFINs are adhesins implicated in severe Plasmodium falciparum malaria

Goel, S., Palmkvist, M., Moll, K., Joannin, N., Lara, P., Akhouri, R. R., Moradi, N., Ojemalm, K., Westman, M., Angeletti, D., Kjellin, H., Lehtio, J., Blixt, O., Idestrom, L., Gahmberg, C. G., Storry, J. R., Hult, A. K., Olsson, M. L., von Heijne, G., Nilsson, I. & 1 othersWahlgren, M., Apr 2015, In : Nature Medicine. 21, 4, p. 314-+ 8 p.

Research output: Contribution to journalArticleScientificpeer-review

The Peptide Toxin Amylosin of Bacillus amyloliquefaciens from Moisture-Damaged Buildings Is Immunotoxic, Induces Potassium Efflux from Mammalian Cells, and Has Antimicrobial Activity

Rasimus-Sahari, S., Teplova, V. V., Andersson, M. A., Mikkola, R., Kankkunen, P., Matikainen, S., Gahmberg, C. G., Andersson, L. C. & Salkinoja-Salonen, M. S., 13 Feb 2015, In : Applied and Environmental Microbiology. 81, 8, p. 2939-2949 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Crystal structures of an ICAM-5 ectodomain fragment show electrostatic-based hemophilic adhesions

Recacha, R., Jiménez, D., Tian, L., Barredo, R., Gahmberg, C. G. & Casasnovas, J., 2014, In : Acta Crystallographica. Section D: Biological Crystallography. 70, 7, p. 1934-1943 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Developmental endothelial locus-1 attenuates complement-dependent phagocytosis through inhibition of Mac-1-integrin

Mitroulis, I., Kang, Y-Y., Gahmberg, C. G., Siegert, G., Hajishengallis, G., Chavakis, T. & Choi, E-Y., May 2014, In : Thrombosis and Haemostasis. 111, 5, p. 1004-1006 3 p.

Research output: Contribution to journalArticleScientificpeer-review

ICAM-5 - a neuronal dendritic adhesion molecule involved in immune and neuronal functions

Gahmberg, C. G., Ning, L. & Paetau, S. F., 2014, Cell adhesion molecules: Implications in neurological diseases. Berezin, L. & Walmod, PS. (eds.). Springer, Vol. 8. p. 117-132 16 p. (Advances in Neurobiology; vol. 8).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Interactions between intercellular adhesion molecule-5 positive elements and their surroundings in the rodent visual cortex.

Kelly, E. A., Tremblay, M-E., Gahmberg, C. G., Tian, L. & Majewska, A. K., 2014, In : Communicative & integrative biology . 6, 6, 4 p., e27315.

Research output: Contribution to journalArticleScientificpeer-review

In Vivo Targeting of Activated Leukocytes by a beta(2)-Integrin Binding Peptide

Ranta, T-M., Suojanen, J., Penate-Medina, O., Will, O., Tower, R. J., Glueer, C., Kairemo, K., Gahmberg, C. G., Koivunen, E., Sorsa, T., Saris, P. E. J. & Reunanen, J., 2014, In : Molecular diagnosis & therapy. 18, 1, p. 39-44 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Regulation of integrin activity by phosphorylation.

Gahmberg, C. G., Grönholm, M. & Uotila, L., 2014, I domain integrins. Gullberg, D. (ed.). Springer, p. 85-96 12 p. (Advances in experimental medicine and biology; vol. 819).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Specific Phosphorylations Transmit Signals from Leukocyte beta(2) to beta(1) Integrins and Regulate Adhesion

Uotila, L. M., Jahan, F., Hinojosa, L. S., Melandri, E., Grönholm, M. & Gahmberg, C. G., 2014, In : Journal of Biological Chemistry. 289, 46, p. 32230-32242 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Subcellular Localization of Intercellular Adhesion Molecule-5 (Telencephalin) in the Visual Cortex Is Not Developmentally Regulated in the Absence of Matrix Metalloproteinase-9

Kelly, E. A., Tremblay, M-E., Gahmberg, C. G., Tian, L. & Majewska, A. K., 2014, In : Journal of Comparative Neurology. 522, 3, p. 676-688 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Integrin CD11c/CD18 alpha-Chain Phosphorylation Is Functionally Important

Uotila, L. M., Aatonen, M. & Gahmberg, C. G., 2013, In : Journal of Biological Chemistry. 288, 46, p. 33494-33499 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Interactions between Intercellular Adhesion Molecule-5 (ICAM-5) and β1 integrins regulate neuronal synapse formation.

Ning, L., Tian, L., Smirnov, S., Vihinen, H., Llano Sanchez, O., Vick, K., Davis, R. L., Rivera Baeza, C. & Gahmberg, C. G., 2013, In : Journal of Cell Science. 126, 1, p. 77-89 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Pilus Adhesin RrgA Interacts with Complement Receptor 3, Thereby Affecting Macrophage Function and Systemic Pneumococcal Disease

Orrskog, S., Rounioja, S., Spadafina, T., Gallotta, M., Norman, M., Hentrich, K., Fälker, S., Ygberg-Eriksson, S., Hasenberg, M., Johansson, B., Uotila, L. M., Gahmberg, C. G., Barocchi, M., Gunzer, M., Normark, S. & Henriques-Normark, B., 2013, In : mBio. 4, 1, 12 p., e00535.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Potato Crop as a Source of Emetic Bacillus cereus and Cereulide-Induced Mammalian Cell Toxicity

Hoornstra, D., Andersson, M. A., Teplova, V. V., Mikkola, R., Uotila, L. M., Andersson, L. C., Roivainen, M., Gahmberg, C. G. & Salkinoja-Salonen, M. S., 2013, In : Applied and Environmental Microbiology. 79, 12, p. 3534-3543 10 p.

Research output: Contribution to journalArticleScientificpeer-review

SHARPIN regulates uropod detachment in migrating lymphocytes

Pouwels, J., Nicole, F. D., Rantakari, P., Auvinen, K., Karikoski, M., Mattila, E., Potter, C., Sundberg, J. P., Hogg, N., Gahmberg, C. G. & Salmi, M., 2013, In : Cell Reports. 5, 3, p. 619-628 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2012

Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots

Shulman, Z., Cohen, S. J., Roediger, B., Kalchenko, V., Jain, R., Grabovsky, V., Klein, E., Shinder, V., Stoler-Barak, L., Feigelson, S. W., Meshel, T., Nurmi, S. M., Goldstein, I., Hartley, O., Gahmberg, C. G., Etzioni, A., Weninger, W., Ben-Baruch, A. & Alon, R., Jan 2012, In : Nature immunology.. 13, 1, p. 67-76 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

TCR-Induced Activation of LFA-1 Involves Signaling through Tiam1

Grönholm, M., Jahan, F., Marchesan, S., Karvonen, U., Aatonen, M., Narumanchi, S. & Gahmberg, C. G., 2011, In : Journal of Immunology. 187, 7, p. 3613-3619 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Ulla Hamberg (1918-1985)

Pyykkö, P. & Gahmberg, C. G., 2011, European Women in Chemistry. Apotheker, J. & Sardaki, L. S. (eds.). Weinheim: Wiley-VCH, p. 199-201 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapterGeneral public

2010

Hydrophobic Interaction between the SH2 Domain and the Kinase Domain Is Required for the Activation of Csk

Mikkola, E. T. & Gahmberg, C. G., 2010, In : Journal of Molecular Biology. 399, 4, p. 618-627 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Neuronal regulation of immune responses in the central nervous system

Tian, L., Rauvala, H. & Gahmberg, C. G., 2009, In : Trends in Immunology. 30, 2, p. 91-99 9 p.

Research output: Contribution to journalArticleScientificpeer-review

PKCε regulation of an α5 integrin-ZO-1 complex controls Lamellae formation in migrating cancer cells

Tuomi, S., Mai, A., Nevo, J., Laine, J. O., Vilkki, V., Öhman, T. J., Gahmberg, C. G., Parker, P. J. & Ivaska, J., 2009, In : Science signaling. 2, 77, p. ra32 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Regulation of integrin activity and signalling

Gahmberg, C. G., Fagerholm, S. C., Nurmi, S. M., Chavakis, T., Marchesan, S. & Grönholm, M., 2009, In : Biochimica et Biophysica Acta. General Subjects. 1790, 6, p. 431-444 14 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Role of leukemia cell invadosome in extramedullary infiltration

Stefanidakis, M., Karjalainen, K., Jaalouk, D. E., Gahmberg, C. G., O'Brien, S., Pasqualini, R., Arap, W. & Koivunen, E., 2009, In : Blood. 114, 14, p. 3008-3017 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

An Unusual Allosteric Mobility of the C-Terminal Helix of a High-Affinity L Integrin I Domain Variant Bound to ICAM-5

Zhang, H., Casasnovas, J. M., Jin, M., Liu, J., Gahmberg, C. G., Springer, T. A. & Wang, J., 2008, In : Molecular Cell. 31, 3, p. 432-437 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment

Choi, E. Y., Chavakis, E., Czabanka, M. A., Langer, H. F., Fraemohs, L., Economopoulou, M., Kundu, R. K., Orlandi, A., Zheng, Y. Y., Prieto, D. A., Ballantyne, C. M., Constant, S. L., Aird, W. C., Papayannopoulou, T., Gahmberg, C. G., Udey, M. C., Vajkoczy, P., Quertermous, T., Dimmeler, S., Weber, C. & 2 othersChavakis, T. & Gahmberg, C., 2008, In : Science. 322, 5904, p. 1101-1104 4 p.

Research output: Contribution to journalArticleScientificpeer-review

ICAM-5 - A novel two-facetted adhesion molecule in the mammalian brain

Gahmberg, C. G., Tian, L., Ning, L. & Nyman-Huttunen, H., 2008, In : Immunology Letters. 117, 2, p. 131-135 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Importance of molecular studies on major blood groups - intercellular adhesion molecule-4, a blood group antigen involved in multiple cellular interactions

Toivanen, A., Ihanus, E., Mattila, M., Lutz, H. U. & Gahmberg, C. G., 2008, In : Biochimica et Biophysica Acta. General Subjects. 1780, p. 456-466 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Introduction to the special issue on glycobiology and sphingobiology

Gahmberg, C. G. & Laine, R. A., 2008, In : Biochimica et Biophysica Acta. General Subjects. 1780, 3, p. 323-324 2 p.

Research output: Contribution to journalArticleScientific

Regulation of LFA-1-dependent inflammatory cell recruitment by Cb1-b and 14-3-3 proteins

Choi, E. Y., Orlova, V. V., Fagerholm, S. C., Nurmi, S. M., Zhang, L., Ballantyne, C. M., Gahmberg, C. G. & Chavakis, T., 1 Apr 2008, In : Blood. 111, 7, p. 3607-3614 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins

Choi, E. Y., Orlova, V. V., Fagerholm, S. C., Nurmi, S. M., Zhang, L., Ballantyne, C. M., Gahmberg, C. G. & Chavakis, T., 2008, In : Blood. 111, 7, p. 3607-3614 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Shedded neuronal ICAM-5 suppresses T-cell activation

Tian, L., Lappalainen, J., Autero, M., Hänninen, S., Rauvala, H. & Gahmberg, C. G., 2008, In : Blood. 111, 7, p. 3615-3625 11 p.

Research output: Contribution to journalArticleScientificpeer-review

β2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding

Takala, H., Nurminen, E., Nurmi, S. M., Aatonen, M., Strandin, T., Takatalo, M., Kiema, T., Gahmberg, C. G., Ylänne, J. & Fagerholm, S. C., 1 Sep 2008, In : Blood. 112, 5, p. 1853-1862 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage

Tian, L., Stefanidakis, M., Ning, L., Van Lint, P., Nyman-Huttunen, H., Libert, C., Itohara, S., Mishina, M., Rauvala, H. & Gahmberg, C. G., 2007, In : Journal of Cell Biology. 178, 4, p. 687-700 14 p.

Research output: Contribution to journalArticleScientificpeer-review

A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin

Orlova, V. V., Choi, E. Y., Xie, C., Chavakis, E., Bierhaus, A., Ihanus, E., Ballantyne, C. M., Gahmberg, C. G., Bianchi, M. E., Nawroth, P. P. & Chavakis, T., 2007, In : EMBO Journal. 26, p. 1129-1139 11 p.

Research output: Contribution to journalArticleScientificpeer-review

DC-SIGN binds ICAM-3 isolated from peripheral human leukocytes through Lewis x residues

Bogoevska, V., Nollau, P., Lucka, L., Grunow, D., Klampe, B., Uotila, L. M., Samsen, A., Gahmberg, C. G. & Wagener, C., 2007, In : Glycobiology. 17, 3, p. 324-333 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Red-cell ICAM-4 is a ligand for the monocyte/macrophage integrin CD11c/CD18: characterization of the binding sites on ICAM-4

Ihanus, E., Uotila, L. M., Toivanen, A., Varis, M. & Gahmberg, C. G., 2007, In : Blood. 109, 2, p. 802-810 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

14-3-3 proteins bind both filamin and alpha(L)beta(2) integrin in activated T cells

Nurmi, S. M., Gahmberg, C. G. & Fagerholm, S. C., 2006, SIGNAL TRANSDUCTION PATHWAYS, PT A: APOPTOTIC AND EXTRACELLULAR SIGNALING. p. 318-325 8 p. ( ANNALS OF THE NEW YORK ACADEMY OF SCIENCES; vol. 1090).

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

14-3-3 proteins bind both filamin and Lß2 integrin in activated T cells

Nurmi, S. M., Gahmberg, C. G. & Fagerholm, S. C., 2006, In : Annals of the New York Academy of Sciences. 1090, p. 318-325 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Interfering with leukocyte integrin activation: a novel concept in the development of anti-inflammatory drugs

Hilden, T. J., Nurmi, S. M., Fagerholm, S. C. & Gahmberg, C. G., 2006, In : Annals of Medicine. 38, p. 503-511 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Lipoprotein(a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1 integrin

Sotiriou, S. N., Orlova, V. V., Al-Fakhri, N., Ihanus, E., Economopoulou, M., Isermann, B., Bdeir, K., Nawroth, P. P., Preissner, K. T., Gahmberg, C. G., Koschinsky, M. L. & Chavakis, T., 2006, In : FASEB Journal. 20, p. 559-561 3 p.

Research output: Contribution to journalArticleScientificpeer-review

P-selectin glycoprotein ligand 1 and beta 2-integrins cooperate in the adhesion of leukocytes to von Willebrand factor

Pendu, R., Terraube, V., Christophe, O. D., Gahmberg, C. G., de Groot, P. G., Lenting, P. J. & Denis, C. V., 1 Dec 2006, In : Blood. 108, 12, p. 3746-3752 7 p.

Research output: Contribution to journalArticleScientificpeer-review