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Publications 1995 2019

2019

Dasatinib and navitoclax act synergistically to target NUP98-NSD1(+)/FLT3-ITD+ acute myeloid leukemia

Kivioja, J. L., Thanasopoulou, A., Kumar, A., Kontro, M., Yadav, B., Majumder, M. M., Javarappa, K. K., Eldfors, S., Schwaller, J., Porkka, K. & Heckman, C. A., Jun 2019, In : Leukemia. 33, 6, p. 1360-1372 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Drug combination sensitivity scoring facilitates the discovery of synergistic and efficacious drug combinations in cancer

Malyutina, A., Majumder, M. M., Wang, W., Pessia, A., Heckman, C. A. & Tang, J., 20 May 2019, In : PLoS Computational Biology. 15, 5, p. e1006752 19 p., 1006752.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Elevated expression of S100A8 and S100A9 correlates with resistance to the BCL-2 inhibitor venetoclax in AML

Karjalainen, R., Liu, M., Kumar, A., Malani, D., Parsons, A. O., Kontro, M., Kallioniemi, O., Porkka, K. & Heckman, C., 2019, In : Leukemia.

Research output: Contribution to journalLetterScientificpeer-review

Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies

Pölönen, P., Mehtonen, J., Lin, J., Liuksiala, T., Häyrynen, S., Teppo, S., Mäkinen, A., Kumar, A., Malani, D., Pohjolainen, V., Porkka, K., Heckman, C. A., May, P., Hautamäki, V., Granberg, K. J., Lohi, O., Nykter, M. & Heinäniemi, M., 15 May 2019, In : Cancer Research. 79, 10, p. 2466-2479 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Making Sense of the Epigenome Using Data Integration Approaches

Cazaly, E., Saad, J., Wang, W., Heckman, C., Ollikainen, M. & Tang, J., 19 Feb 2019, In : Frontiers in Pharmacology. 10, 15 p., 126.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Wnt5a and ROR1 activate non-canonical Wnt signaling via RhoA in TCF3-PBX1 acute lymphoblastic leukemia and highlight new treatment strategies via Bcl-2 co-targeting

Karvonen, H., Perttila, R., Niininen, W., Hautanen, V., Barker, H., Murumagi, A., Heckman, C. A. & Ungureanu, D., 25 Apr 2019, In : Oncogene. 38, 17, p. 3288-3300 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2018

A Multiplexed Screening Assay to Evaluate Chemotherapy-Induced Myelosuppression Using Healthy Peripheral Blood and Bone Marrow

Javarappa, K. K., Tsallos, D. & Heckman, C. A., Aug 2018, In : SLAS discovery . 23, 7, p. 687-696 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Case studies investigating genetic heterogeneity between anatomically distinct bone marrow compartments in acute myeloid leukemia

Ojamies, P. N., Kontro, M., Edgren, H., Ellonen, P., Heckman, C., Porkka, K., Wolf, M. & Kallioniemi, O., 2 Dec 2018, In : Leukemia & lymphoma. 59, 12, p. 3002-3005 4 p.

Research output: Contribution to journalLetterScientificpeer-review

Chimeric NUP98-NSD1 transcripts from the cryptic t(5;11)(q35.2;p15.4) in adult de novo acute myeloid leukemia

Kivioja, J., Lopez Marti, J. M., Kumar, A., Kontro, M., Edgren, H., Parsons, A., Lundan, T., Wolf, M., Porkka, K. & Heckman, C., 2018, In : Leukemia & lymphoma. 59, 3, p. 725-732 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Combined Targeting of BET Family Proteins and BCL2 Is Synergistic in Acute Myeloid Leukemia Cells Overexpressing S100A8 and S100A9

Karjalainen, R., Liu, M., Kumar, A., Parsons, A., He, L., Malani, D. R., Kontro, M., Porkka, K. & Heckman, C. A., 2018, In : Blood. 132

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Open Access

Eltrombopag Promotes Megakaryocyte Survival and Signaling in the Presence of Specific Cytotoxic Agents

Javarappa, K. K., Tsallos, D., Zagidullin, B., Saad, J., Tang, J., Ramos, P. M., Pallaud, C. & Heckman, C. A., 2018, In : Blood. 132

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Germline alterations in a consecutive series of acute myeloid leukemia

Wartiovaara-Kautto, U., Hirvonen, E. A. M., Pitkänen, E., Heckman, C., Saarela, J., Kettunen, K., Porkka, K. & Kilpivaara, O., Oct 2018, In : Leukemia. 32, 10, p. 2282-2285 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Improving genomics-based predictions for precision medicine through active elicitation of expert knowledge

Sundin, I., Peltola, T., Micallef, L., Afrabandpey, H., Soare, M., Majumder, M. M., Daee, P., He, C., Serim, B., Havulinna, A., Heckman, C., Jacucci, G., Marttinen, P. & Kaski, S., 1 Jul 2018, In : Bioinformatics. 34, 13, p. 395-403 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Multi-Parametric Single Cell Profiling Defines Distinct Drug Responses in Healthy Hematological Cell Lineages That Are Retained in Corresponding Malignant Cell Types

Majumder, MM., Leppä, A-M., Hellesøy, M., Dowling, P., Malyutina, A., Bazou, D., Andersson, E. I., Parsons, A., Tang, J., Kallioniemi, O-P., Mustjoki, S. M., O'Gorman, P., Wennerberg, J. K., Porkka, K. V. K., Gjertsen, B-T. & Heckman, C. A., 2018, In : Blood. 132

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Open Access

Precision Treatment of Acute Myeloid Leukemia: Predictive Response Biomarkers for BET inhibitor JQ1

Saad, J., 27 Sep 2018, 63 p.

Research output: ThesisMaster's thesisTheses

Open Access

Crosstalk between ROR1 and BCR pathways defines novel treatment strategies in mantle cell lymphoma

Karvonen, H., Chiron, D., Niininen, W., Ek, S., Jerkeman, M., Moradi, E., Nykter, M., Heckman, C. A., Kallioniemi, O., Murumägi, A. & Ungureanu, D., 14 Nov 2017, In : Blood advances. 1, 24, p. 2257-2268 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors

Pietarinen, P. O., Eide, C. A., Ayuda-Duran, P., Potdar, S., Kuusanmaki, H., Andersson, E. I., Mpindi, J. P., Pemovska, T., Kontro, M., Heckman, C. A., Kallioniemi, O., Wennerberg, K., Hjorth-Hansen, H., Druker, B. J., Enserink, J. M., Tyner, J. W., Mustjoki, S. & Porkka, K., 4 Apr 2017, In : Oncotarget. 8, 14, p. 22606-22615 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling

Kuusanmäki, H., Dufva, O., Parri, E., van Adrichem, A. J., Rajala, H., Majumder, M. M., Yadav, B., Parsons, A., Chan, W. C., Wennerberg, K., Mustjoki, S. & Heckman, C. A., 14 Nov 2017, In : Oncotarget. 8, 57, p. 97516-97527 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Enhanced sensitivity to glucocorticoids in cytarabine-resistant AML

Malani, D., Murumagi, A., Yadav, B., Kontro, M., Eldfors, S., Kumar, A., Karjalainen, R., Majumder, M. M., Ojamies, P., Pemovska, T., Wennerberg, K., Heckman, C., Porkka, K., Wolf, M., Aittokallio, T. & Kallioniemi, O., May 2017, In : Leukemia. 31, 5, p. 1187-1195 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia

Kontro, M., Kumar, A., Majumder, M. M., Eldfors, S., Parsons, A., Pemovska, T., Saarela, J. S., Yadav, B., Malani, D. R., Fløisand, Y., Höglund, M., Remes, K., Gjertsen, B-T., Kallioniemi, O-P., Wennerberg, J. K., Heckman, C. A. & Porkka, K. V. K., 2017, In : Leukemia. 31, 2, p. 301-309 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia

Eldfors, S., Kuusanmäki, H., Kontro, M., Majumder, M. M., Parsons, A., Edgren, H., Pemovska, T., Kallioniemi, O., Wennerberg, K., Gökbuget, N., Burmeister, T., Porkka, K. & Heckman, C. A., 2017, In : Leukemia. 31, 1, p. 51-57 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Identification of precision treatment strategies for relapsed/refractory multiple myeloma by functional drug sensitivity testing

Majumder, M. M., Silvennoinen, R., Anttila, P., Tamborero, D., Eldfors, S., Yadav, B., Karjalainen, R., Kuusanmaki, H., Lievonen, J., Parsons, A., Suvela, M., Jantunen, E., Porkka, K. & Heckman, C. A., 22 Aug 2017, In : Oncotarget. 8, 34, p. 56338-56350 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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In silico and preclinical drug screening identifies dasatinib as a targeted therapy for T-ALL

Laukkanen, S., Gronroos, T., Polonen, P., Kuusanmaki, H., Mehtonen, J., Cloos, J., Ossenkoppele, G., Gjertsen, B., Oystein, B., Heckman, C., Heinaniemi, M., Kontro, M. & Lohi, O., 8 Sep 2017, In : Blood cancer journal. 7, 4 p., 604.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML

Karjalainen, R., Pemovska, T., Popa, M., Liu, M., Javarappa, K. K., Majumder, M. M., Yadav, B., Tamborero, D., Tang, J., Bychkov, D., Kontro, M., Parsons, A., Suvela, M., Safont, M. M., Porkka, K., Aittokallio, T., Kallioniemi, O., McCormack, E., Gjertsen, B. T., Wennerberg, K. & 2 othersKnowles, J. & Heckman, C. A., 10 Aug 2017, In : Blood. 130, 6, p. 789-802 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Monitoring therapy responses at the leukemic subclone level by ultra-deep amplicon resequencing in acute myeloid leukemia

Ojamies, P., Kontro, M., Edgren, H., Ellonen, P., Lagström, S., Almusa, H., Miettinen, T., Eldfors, S., Tamborero, D., Wennerberg, K., Heckman, C., Porkka, K., Wolf, M. & Kallioniemi, O., 2017, In : Leukemia. 31, 5, p. 1048-1058 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry

Heikkinen, T., Kämpjärvi, K., Keskitalo, S., von Nandelstadh, P., Liu, X., Rantanen, V., Pitkänen, E., Kinnunen, M., Kuusanmäki, H., Kontro, M., Turunen, M., Mäkinen, N., Taipale, J., Heckman, C., Lehti, K., Mustjoki, S., Varjosalo, M. & Vahteristo, P., Mar 2017, In : Human Mutation. 38, 3, p. 269-274 6 p.

Research output: Contribution to journalArticleScientificpeer-review

The impact of RNA sequence library construction protocols on transcriptomic profiling of leukemia

Kumar, A., Kankainen, M., Parsons, A., Kallioniemi, O., Mattila, P. & Heckman, C. A., 17 Aug 2017, In : BMC Genomics. 18, 13 p., 629.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomains

Alzrigat, M., Párraga, A. A., Majumder, M. M., Ma, A., Jin, J., Österborg, A., Nahi, H., Nilsson, K., Heckman, C. A., Öberg, F., Kalushkova, A. & Jernberg-Wiklund, H., 2017, In : Oncotarget. 8, 61, p. 103731-103743 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia

Andersson, E., Kuusanmaki, H., Bortoluzzi, S., Lagström, S., Parsons, A., Rajala, H., van Adrichem, A., Eldfors, S., Olson, T., Clemente, M. J., Laasonen, A., Ellonen, P., Heckman, C., Loughran, T. P., Maciejewski, J. P. & Mustjoki, S., May 2016, In : Leukemia. 30, 5, p. 1204-1208 5 p.

Research output: Contribution to journalLetterScientificpeer-review

Novel Mutations in Patients with Blast Crisis or Accelerated Phase Chronic Myeloid Leukemia

Awad, S. A., Kankainen, M., Eldfors, S., Kytola, S., Ellonen, P., Kamel, M., Heckman, C. A., Porkka, K. & Mustjoki, S., 2 Dec 2016, In : Blood. 128, 22, 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Somatic MED12 mutations in hematological malignancies

Heikkinen, T., Kampjarvi, K., Leppa, S., Hokland, P., Kuusanmaki, H., Mustjoki, S., Sinisalo, M., Heckman, C., Kontro, M. & Vahteristo, P., Jul 2016, In : Cancer Research. 76, 3 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

2015

Individualised systems medicine: Next-generation precision cancer medicine and drug positioning

Pemovska, T., Östling, P., Heckman, C., Kallioniemi, O. & Wennerberg, K., 2015, In : DDW. Drug discovery world. 16, 3, p. 47-53 7 p.

Research output: Contribution to journalArticleScientific

Novel drug candidates for blast phase chronic myeloid leukemia from high-throughput drug sensitivity and resistance testing

Pietarinen, P. O., Pemovska, T., Kontro, M., Yadav, B., Mpindi, J. P., Andersson, E. I., Majumder, M. M., Kuusanmaki, H., Koskenvesa, P., Kallioniemi, O., Wennerberg, K., Heckman, C. A., Mustjoki, S. & Porkka, K., May 2015, In : Blood cancer journal. 5, 6 p., 309.

Research output: Contribution to journalArticleScientificpeer-review

2014

Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia

Kontro, M., Kuusanmaki, H., Eldfors, S., Burmeister, T., Andersson, E. I., Bruserud, O., Bruemmendorf, T. H., Edgren, H., Gjertsen, B. T., Itala-Remes, M., Lagström, S., Lohi, O., Lundan, T., Marti, J. M. L., Majumder, M. M., Parsons, A., Pemovska, T., Rajala, H., Vettenranta, K., Kallioniemi, O. & 3 othersMustjoki, S., Porkka, K. & Heckman, C. A., Aug 2014, In : Leukemia. 28, 8, p. 1738-1742 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies

Yadav, B., Pemovska, T., Szwajda, A., Kulesskiy, E., Kontro, M., Karjalainen, R., Majumder, M. M., Malani, D., Murumagi, A., Knowles, J., Porkka, K., Heckman, C., Kallioniemi, O., Wennerberg, K. & Aittokallio, T., 5 Jun 2014, In : Scientific Reports. 4, 10 p., 5193.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Statistical detection of quantitative protein biomarkers provides insights into signaling networks deregulated in acute myeloid leukemia

Elo, L. L., Karjalainen, R., Ohman, T., Hintsanen, P., Nyman, T. A., Heckman, C. A. & Aittokallio, T., Nov 2014, In : Proteomics (Weinheim). 14, 21-22, p. 2443-2453 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

Koskela, H. L. M., Eldfors, S., Kuusanmäki, H., van Adrichem, A. J. . A., Olson, T., Lagström, S., Andersson, E. I., Jerez, A., Clemente, M. J., Yan, Y., Zhang, D., Awwad, A., Ellonen, P., Kallioniemi, O., Wennerberg, K., Porkka, K., Maciejewski, J. P., Loughran, T. P., Heckman, C. & Mustjoki, S., 30 May 2013, In : Blood. 121, 22, p. 4541-4550 10 p.

Research output: Contribution to journalArticleScientificpeer-review

High-throughput drug screening and molecular profiling for therapeutic targeting of NUP98-NSD1-positive AML

Kontro, M. P., Pemovska, T., Heckman, C. A., Kallioniemi, O-P., Wennerberg, J. K. & Porkka, K. V. K., Feb 2013, In : Annals of Hematology. 92, Supplement 1, p. S18

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Individualized Systems Medicine Strategy to Tailor Treatments for Patients with Chemorefractory Acute Myeloid Leukemia

Pemovska, T., Kontro, M., Yadav, B., Edgren, H., Eldfors, S., Szwajda, A., Almusa, H., Bespalov, M. M., Ellonen, P., Elonen, E., Gjertsen, B. T., Karjalainen, R., Kulesskiy, E., Lagström, S., Lehto, A., Lepistö, M., Lundan, T., Majumder, M. M., Marti, J. M. L., Mattila, P. & 16 othersMurumagi, A., Mustjoki, S., Palva, A., Parsons, A., Pirttinen, T., Ramet, M. E., Suvela, M., Turunen, L., Vastrik, I., Wolf, M., Knowles, J., Aittokallio, T., Heckman, C. A., Porkka, K., Kallioniemi, O. & Wennerberg, K., Dec 2013, In : Cancer Discovery. 3, 12, p. 1416-1429 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation

Andersson, E. I., Koskela, H. L. M., Eldfors, S., Ellonen, P., Olson, T., Jerez, A., Clemente, M. J., Kallioniemi, O., Porkka, K., Heckman, C., Loughran, T. P., Maciejewski, J. P. & Mustjoki, S., Dec 2013, In : Blood cancer journal. 3, 9 p., 168.

Research output: Contribution to journalArticleScientificpeer-review

Stromal cell supported high-throughput screening of primary acute myeloid leukemia cells for assessing sensitivity to cytotoxic drugs

Karjalainen, R. J., Pemovska, T., Yadav, B., Wennerberg, J. K. & Heckman, C. A., Feb 2013, In : Annals of Hematology. 92, Supplement 1, p. S17

Research output: Contribution to journalMeeting AbstractResearchpeer-review

2012

Discovery of STAT5b Mutations and Small Subclones of STAT3 Mutations in Large Granular Lymphocytic (LGL) Leukemia

Rajala, H. L. M., Eldfors, S., Kuusanmaki, H., Andersson, E. I., van Adrichem, A. J., Lagstrom, S., Olson, T., Jerez, A., Clemente, M. J., Zhang, D., Awwad, A., Pihlman, M., Ellonen, P., Kallioniemi, O., Wennerberg, K., Porkka, K., Maciejewski, J. P., Loughran, T. P., Heckman, C. A. & Mustjoki, S., 16 Nov 2012, In : Blood. 120, 21, 2 p., Meeting Abstract: 871.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Lamstatin - a novel inhibitor of lymphangiogenesis derived from collagen IV

Weckmann, M., Moir, L. M., Heckman, C. A., Oliver, B. G. & Burgess, J. K., Dec 2012, In : Journal of Cellular and Molecular Medicine. 16, 12, p. 3062-3073 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Phosphoprotein profiling predicts response to tyrosine kinase inhibitor therapy in chronic myeloid leukemia patients

Jalkanen, S. E., Lahesmaa-Korpinen, A-M. K., Heckman, C., Rantanen, V., Porkka, K., Hautaniemi, S. & Mustjoki, S., 2012, In : Experimental Hematology. 40, 9, p. 704-714 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Somatic PTPRT and ANGPT2 Mutations in Large Granulocyte Leukemia

Andersson, E. I., Eldfors, S., Koskela, H. L. M., Ellonen, P., Olson, T., Jerez, A., Clemente, M. J., Kallioniemi, O., Porkka, K., Loughran, T. P., Maciejewski, J. P., Heckman, C. & Mustjoki, S., 16 Nov 2012, In : Blood. 120, 21, 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review