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Publications 1995 2019

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2019

Dasatinib and navitoclax act synergistically to target NUP98-NSD1(+)/FLT3-ITD+ acute myeloid leukemia

Kivioja, J. L., Thanasopoulou, A., Kumar, A., Kontro, M., Yadav, B., Majumder, M. M., Javarappa, K. K., Eldfors, S., Schwaller, J., Porkka, K. & Heckman, C. A., Jun 2019, In : Leukemia. 33, 6, p. 1360-1372 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Drug combination sensitivity scoring facilitates the discovery of synergistic and efficacious drug combinations in cancer

Malyutina, A., Majumder, M. M., Wang, W., Pessia, A., Heckman, C. A. & Tang, J., 20 May 2019, In : PLoS Computational Biology. 15, 5, p. e1006752 19 p., 1006752.

Research output: Contribution to journalArticleScientificpeer-review

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Hemap: An Interactive Online Resource for Characterizing Molecular Phenotypes across Hematologic Malignancies

Pölönen, P., Mehtonen, J., Lin, J., Liuksiala, T., Häyrynen, S., Teppo, S., Mäkinen, A., Kumar, A., Malani, D., Pohjolainen, V., Porkka, K., Heckman, C. A., May, P., Hautamäki, V., Granberg, K. J., Lohi, O., Nykter, M. & Heinäniemi, M., 15 May 2019, In : Cancer Research. 79, 10, p. 2466-2479 14 p.

Research output: Contribution to journalArticleScientificpeer-review

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Wnt5a and ROR1 activate non-canonical Wnt signaling via RhoA in TCF3-PBX1 acute lymphoblastic leukemia and highlight new treatment strategies via Bcl-2 co-targeting

Karvonen, H., Perttila, R., Niininen, W., Hautanen, V., Barker, H., Murumagi, A., Heckman, C. A. & Ungureanu, D., 25 Apr 2019, In : Oncogene. 38, 17, p. 3288-3300 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2018

A Multiplexed Screening Assay to Evaluate Chemotherapy-Induced Myelosuppression Using Healthy Peripheral Blood and Bone Marrow

Javarappa, K. K., Tsallos, D. & Heckman, C. A., Aug 2018, In : SLAS discovery . 23, 7, p. 687-696 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Chimeric NUP98-NSD1 transcripts from the cryptic t(5;11)(q35.2;p15.4) in adult de novo acute myeloid leukemia

Kivioja, J., Lopez Marti, J. M., Kumar, A., Kontro, M., Edgren, H., Parsons, A., Lundan, T., Wolf, M., Porkka, K. & Heckman, C., 2018, In : Leukemia & lymphoma. 59, 3, p. 725-732 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Germline alterations in a consecutive series of acute myeloid leukemia

Wartiovaara-Kautto, U., Hirvonen, E. A. M., Pitkänen, E., Heckman, C., Saarela, J., Kettunen, K., Porkka, K. & Kilpivaara, O., Oct 2018, In : Leukemia. 32, 10, p. 2282-2285 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Improving genomics-based predictions for precision medicine through active elicitation of expert knowledge

Sundin, I., Peltola, T., Micallef, L., Afrabandpey, H., Soare, M., Majumder, M. M., Daee, P., He, C., Serim, B., Havulinna, A., Heckman, C., Jacucci, G., Marttinen, P. & Kaski, S., 1 Jul 2018, In : Bioinformatics. 34, 13, p. 395-403 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Crosstalk between ROR1 and BCR pathways defines novel treatment strategies in mantle cell lymphoma

Karvonen, H., Chiron, D., Niininen, W., Ek, S., Jerkeman, M., Moradi, E., Nykter, M., Heckman, C. A., Kallioniemi, O., Murumägi, A. & Ungureanu, D., 14 Nov 2017, In : Blood advances. 1, 24, p. 2257-2268 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors

Pietarinen, P. O., Eide, C. A., Ayuda-Duran, P., Potdar, S., Kuusanmaki, H., Andersson, E. I., Mpindi, J. P., Pemovska, T., Kontro, M., Heckman, C. A., Kallioniemi, O., Wennerberg, K., Hjorth-Hansen, H., Druker, B. J., Enserink, J. M., Tyner, J. W., Mustjoki, S. & Porkka, K., 4 Apr 2017, In : Oncotarget. 8, 14, p. 22606-22615 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling

Kuusanmäki, H., Dufva, O., Parri, E., van Adrichem, A. J., Rajala, H., Majumder, M. M., Yadav, B., Parsons, A., Chan, W. C., Wennerberg, K., Mustjoki, S. & Heckman, C. A., 14 Nov 2017, In : Oncotarget. 8, 57, p. 97516-97527 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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Enhanced sensitivity to glucocorticoids in cytarabine-resistant AML

Malani, D., Murumagi, A., Yadav, B., Kontro, M., Eldfors, S., Kumar, A., Karjalainen, R., Majumder, M. M., Ojamies, P., Pemovska, T., Wennerberg, K., Heckman, C., Porkka, K., Wolf, M., Aittokallio, T. & Kallioniemi, O., May 2017, In : Leukemia. 31, 5, p. 1187-1195 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia

Kontro, M., Kumar, A., Majumder, M. M., Eldfors, S., Parsons, A., Pemovska, T., Saarela, J. S., Yadav, B., Malani, D. R., Fløisand, Y., Höglund, M., Remes, K., Gjertsen, B-T., Kallioniemi, O-P., Wennerberg, J. K., Heckman, C. A. & Porkka, K. V. K., 2017, In : Leukemia. 31, 2, p. 301-309 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia

Eldfors, S., Kuusanmäki, H., Kontro, M., Majumder, M. M., Parsons, A., Edgren, H., Pemovska, T., Kallioniemi, O., Wennerberg, K., Gökbuget, N., Burmeister, T., Porkka, K. & Heckman, C. A., 2017, In : Leukemia. 31, 1, p. 51-57 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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Identification of precision treatment strategies for relapsed/refractory multiple myeloma by functional drug sensitivity testing

Majumder, M. M., Silvennoinen, R., Anttila, P., Tamborero, D., Eldfors, S., Yadav, B., Karjalainen, R., Kuusanmaki, H., Lievonen, J., Parsons, A., Suvela, M., Jantunen, E., Porkka, K. & Heckman, C. A., 22 Aug 2017, In : Oncotarget. 8, 34, p. 56338-56350 13 p.

Research output: Contribution to journalArticleScientificpeer-review

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In silico and preclinical drug screening identifies dasatinib as a targeted therapy for T-ALL

Laukkanen, S., Gronroos, T., Polonen, P., Kuusanmaki, H., Mehtonen, J., Cloos, J., Ossenkoppele, G., Gjertsen, B., Oystein, B., Heckman, C., Heinaniemi, M., Kontro, M. & Lohi, O., 8 Sep 2017, In : Blood cancer journal. 7, 4 p., 604.

Research output: Contribution to journalArticleScientificpeer-review

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JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML

Karjalainen, R., Pemovska, T., Popa, M., Liu, M., Javarappa, K. K., Majumder, M. M., Yadav, B., Tamborero, D., Tang, J., Bychkov, D., Kontro, M., Parsons, A., Suvela, M., Safont, M. M., Porkka, K., Aittokallio, T., Kallioniemi, O., McCormack, E., Gjertsen, B. T., Wennerberg, K. & 2 othersKnowles, J. & Heckman, C. A., 10 Aug 2017, In : Blood. 130, 6, p. 789-802 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Monitoring therapy responses at the leukemic subclone level by ultra-deep amplicon resequencing in acute myeloid leukemia

Ojamies, P., Kontro, M., Edgren, H., Ellonen, P., Lagström, S., Almusa, H., Miettinen, T., Eldfors, S., Tamborero, D., Wennerberg, K., Heckman, C., Porkka, K., Wolf, M. & Kallioniemi, O., 2017, In : Leukemia. 31, 5, p. 1048-1058 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry

Heikkinen, T., Kämpjärvi, K., Keskitalo, S., von Nandelstadh, P., Liu, X., Rantanen, V., Pitkänen, E., Kinnunen, M., Kuusanmäki, H., Kontro, M., Turunen, M., Mäkinen, N., Taipale, J., Heckman, C., Lehti, K., Mustjoki, S., Varjosalo, M. & Vahteristo, P., Mar 2017, In : Human Mutation. 38, 3, p. 269-274 6 p.

Research output: Contribution to journalArticleScientificpeer-review

The impact of RNA sequence library construction protocols on transcriptomic profiling of leukemia

Kumar, A., Kankainen, M., Parsons, A., Kallioniemi, O., Mattila, P. & Heckman, C. A., 17 Aug 2017, In : BMC Genomics. 18, 13 p., 629.

Research output: Contribution to journalArticleScientificpeer-review

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The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomains

Alzrigat, M., Párraga, A. A., Majumder, M. M., Ma, A., Jin, J., Österborg, A., Nahi, H., Nilsson, K., Heckman, C. A., Öberg, F., Kalushkova, A. & Jernberg-Wiklund, H., 2017, In : Oncotarget. 8, 61, p. 103731-103743 13 p.

Research output: Contribution to journalArticleScientificpeer-review

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2015

Individualised systems medicine: Next-generation precision cancer medicine and drug positioning

Pemovska, T., Östling, P., Heckman, C., Kallioniemi, O. & Wennerberg, K., 2015, In : DDW. Drug discovery world. 16, 3, p. 47-53 7 p.

Research output: Contribution to journalArticleScientific

Novel drug candidates for blast phase chronic myeloid leukemia from high-throughput drug sensitivity and resistance testing

Pietarinen, P. O., Pemovska, T., Kontro, M., Yadav, B., Mpindi, J. P., Andersson, E. I., Majumder, M. M., Kuusanmaki, H., Koskenvesa, P., Kallioniemi, O., Wennerberg, K., Heckman, C. A., Mustjoki, S. & Porkka, K., May 2015, In : Blood cancer journal. 5, 6 p., 309.

Research output: Contribution to journalArticleScientificpeer-review

2014

Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia

Kontro, M., Kuusanmaki, H., Eldfors, S., Burmeister, T., Andersson, E. I., Bruserud, O., Bruemmendorf, T. H., Edgren, H., Gjertsen, B. T., Itala-Remes, M., Lagström, S., Lohi, O., Lundan, T., Marti, J. M. L., Majumder, M. M., Parsons, A., Pemovska, T., Rajala, H., Vettenranta, K., Kallioniemi, O. & 3 othersMustjoki, S., Porkka, K. & Heckman, C. A., Aug 2014, In : Leukemia. 28, 8, p. 1738-1742 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies

Yadav, B., Pemovska, T., Szwajda, A., Kulesskiy, E., Kontro, M., Karjalainen, R., Majumder, M. M., Malani, D., Murumagi, A., Knowles, J., Porkka, K., Heckman, C., Kallioniemi, O., Wennerberg, K. & Aittokallio, T., 5 Jun 2014, In : Scientific Reports. 4, 10 p., 5193.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Statistical detection of quantitative protein biomarkers provides insights into signaling networks deregulated in acute myeloid leukemia

Elo, L. L., Karjalainen, R., Ohman, T., Hintsanen, P., Nyman, T. A., Heckman, C. A. & Aittokallio, T., Nov 2014, In : Proteomics (Weinheim). 14, 21-22, p. 2443-2453 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

Koskela, H. L. M., Eldfors, S., Kuusanmäki, H., van Adrichem, A. J. . A., Olson, T., Lagström, S., Andersson, E. I., Jerez, A., Clemente, M. J., Yan, Y., Zhang, D., Awwad, A., Ellonen, P., Kallioniemi, O., Wennerberg, K., Porkka, K., Maciejewski, J. P., Loughran, T. P., Heckman, C. & Mustjoki, S., 30 May 2013, In : Blood. 121, 22, p. 4541-4550 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Individualized Systems Medicine Strategy to Tailor Treatments for Patients with Chemorefractory Acute Myeloid Leukemia

Pemovska, T., Kontro, M., Yadav, B., Edgren, H., Eldfors, S., Szwajda, A., Almusa, H., Bespalov, M. M., Ellonen, P., Elonen, E., Gjertsen, B. T., Karjalainen, R., Kulesskiy, E., Lagström, S., Lehto, A., Lepistö, M., Lundan, T., Majumder, M. M., Marti, J. M. L., Mattila, P. & 16 othersMurumagi, A., Mustjoki, S., Palva, A., Parsons, A., Pirttinen, T., Ramet, M. E., Suvela, M., Turunen, L., Vastrik, I., Wolf, M., Knowles, J., Aittokallio, T., Heckman, C. A., Porkka, K., Kallioniemi, O. & Wennerberg, K., Dec 2013, In : Cancer Discovery. 3, 12, p. 1416-1429 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation

Andersson, E. I., Koskela, H. L. M., Eldfors, S., Ellonen, P., Olson, T., Jerez, A., Clemente, M. J., Kallioniemi, O., Porkka, K., Heckman, C., Loughran, T. P., Maciejewski, J. P. & Mustjoki, S., Dec 2013, In : Blood cancer journal. 3, 9 p., 168.

Research output: Contribution to journalArticleScientificpeer-review

2012

Lamstatin - a novel inhibitor of lymphangiogenesis derived from collagen IV

Weckmann, M., Moir, L. M., Heckman, C. A., Oliver, B. G. & Burgess, J. K., Dec 2012, In : Journal of Cellular and Molecular Medicine. 16, 12, p. 3062-3073 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Phosphoprotein profiling predicts response to tyrosine kinase inhibitor therapy in chronic myeloid leukemia patients

Jalkanen, S. E., Lahesmaa-Korpinen, A-M. K., Heckman, C., Rantanen, V., Porkka, K., Hautaniemi, S. & Mustjoki, S., 2012, In : Experimental Hematology. 40, 9, p. 704-714 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia

Koskela, H. L. M., Eldfors, S., Ellonen, P., van Adrichem, A. J., Kuusanmäki, H., Andersson, E. I., Lagström, S., Clemente, M. J., Olson, T., Jalkanen, S. E., Majumder, M. M., Almusa, H., Edgren, H., Lepistö, M., Mattila, P., Guinta, K., Koistinen, P., Kuittinen, T., Penttinen, K., Parsons, A. & 9 othersKnowles, J., Saarela, J., Wennerberg, K., Kallioniemi, O., Porkka, K., Loughran, T. P., Heckman, C. A., Maciejewski, J. P. & Mustjoki, S., 2012, In : New England Journal of Medicine. 366, 20, p. 1905-1913 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Comparison of solution-based exome capture methods for next generation sequencing

Sulonen, A-M., Ellonen, P., Almusa, H., Lepistö, M., Eldfors, S., Hannula, S., Tyynismaa, H., Miettinen, T., Salo, P., Heckman, C., Joensuu, H., Raivio, T., Suomalainen, A. & Saarela, J., 2011, In : Genome Biology. 12, 9, p. Article Number: R9 17 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Use of Cancer-Specific Genomic Rearrangements to Quantify Disease Burden in Plasma from Patients with Solid Tumors

McBride, D. J., Orpana, A., Sotiriou, C., Joensuu, H., Stephens, P. J., Mudie, L. J., Hämäläinen, E., Stebbings, L. A., Andersson, L. C., Flanagan, A. M., Durbecq, V., Ignatiadis, M., Kallioniemi, O., Heckman, C. A., Alitalo, K., Edgren, S. H. T., Futreal, P. A., Stratton, M. R. & Campbell, P. J., 2010, In : Genes, Chromosomes & Cancer. 49, 11, p. 1062-1069 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Functional Analysis of FLT4 Mutations Associated with Nonne-Milroy Lymphedema

Verstraeten, V. L. R. M., Holnthoner, W., van Steensel, M. A. M., Veraart, J. C. J. M., Bladergroen, R. S., Heckman, C. A., Keskitalo, S., Frank, J., Alitalo, K., van Geel, M. & Steijlen, P. M., 2009, In : Journal of Investigative Dermatology. 129, p. 509-512 4 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis

Heckman, C. A., Holopainen, T., Wirzenius, M., Keskitalo, S., Jeltsch, M., Ylä-Herttuala, S., Wedge, S. R., Jurgensmeier, J. M. & Alitalo, K., 2008, In : Cancer Research. 68, 12, p. 4754-4762 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

The immunoglobulin heavy-chain gene 3’ enhancers deregulate bcl-2 promoter usage in t(14;18) lymphoma cells.

Duan, H., Heckman, C. A. & Boxer, L. M., 2007, In : Oncogene. 26, p. 2635-2641

Research output: Contribution to journalArticleScientificpeer-review

2006

Functional interaction of VEGF-C and VEGF-D with neuropilin receptors

Kärpänen, T., Heckman, C. A., Keskitalo, S., Jeltsch, M., Ollila, H., Neufeld, G., Tamagnone, L. & Alitalo, K., 2006, In : FASEB Journal. 20, 9, p. 1462.1472 1 p.

Research output: Contribution to journalArticleScientificpeer-review

Oct transcription factors mediate t(14;18) lymphoma cell survival by directly regulating bcl-2 expression.

Heckman, C. A., Duan, H., Garcia, P. B. & Boxer, L. M., 2006, In : Oncogene. 25, p. 888-898

Research output: Contribution to journalArticleScientificpeer-review

2005

CCAAT/enhancer binding protein alpha (C/EBPalpha) and C/EBPalpha myeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-kappaB p50.

Paz-Priel, I., Cai, D. H., Wang, D., Kowlaski, J., Blackford, A., Liu, H., Heckman, C. A., Gombart, A. F., Koeffler, H. P., Boxer, L. M. & Friedman, A. D., 2005, In : Molecular Cancer Research. 3, p. 585-596

Research output: Contribution to journalArticleScientificpeer-review

HDAC-inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphoma cells.

Heckman, C. A., Duan, H. & Boxer, L. M., 2005, In : Molecular and Cellular Biology. 25, p. 1608-1619

Research output: Contribution to journalArticleScientificpeer-review

2003

Critical elements of the immunoglobulin heavy chain gene enhancers for deregulated expression of Bcl-2.

Heckman, C. A., Cao, T., Somsouk, L., Duan, H., Mehew, J. W., Zhang, C. Y. & Boxer, L. M., 2003, In : Cancer Research. 63, p. 6666-6673

Research output: Contribution to journalArticleScientificpeer-review

Regulation of Bcl-2 expression by C/EBP in t(14;18) lymphomas.

Heckman, C. A., Wheeler, M. A. & Boxer, L. M., 2003, In : Oncogene. 22, p. 7891-7899

Research output: Contribution to journalArticleScientificpeer-review

2002

Allele-specific analysis of transcription factors binding to promoter regions.

Heckman, C. A. & Boxer, L. M., 2002, In : Methods. 26, p. 19-26

Research output: Contribution to journalArticleScientificpeer-review

NF-kB activates Bcl-2 expression in t(14;18) lymphomas.

Heckman, C. A., Mehew, J. W. & Boxer, L. M., 2002, In : Oncogene. 21, p. 3898-3908

Research output: Contribution to journalArticleScientificpeer-review

2001

Molecular mechanisms of transcriptional control of bcl-2 and c-myc in follicular and transformed lymphoma. Cancer Research, 61: 5202-6, 2001.

Arcinas, M., Heckman, C. A., Mehew, J. W. & Boxer, L. M., 2001, In : Cancer Research. 61, p. 5202-5206

Research output: Contribution to journalArticleScientificpeer-review

Negative regulation of bcl-2 expression by p53 in hematopoietic cells.

Wu, Y. L., Mehew, J. W., Heckman, C. A. & Boxer, L. M., 2001, In : Oncogene. 20, p. 240-251

Research output: Contribution to journalArticleScientificpeer-review

2000

A-Myb up-regulates Bcl-2 through a Cdx binding site in t(14;18) lymphoma cells.

Heckman, C. A., Mehew, J. W., Ying, G. G., Introna, M., Golay, J. & Boxer, L. M., 2000, In : Journal of Biological Chemistry. 275, p. 6499-6508

Research output: Contribution to journalArticleScientificpeer-review

1997

The WT1 protein is a negative regulator of the normal bcl-2 allele in t(14;18) lymphomas.

Heckman, C., Mochon, E., Arcinas, M. & Boxer, L. M., 1997, In : Journal of Biological Chemistry. 272, p. 19609-19614

Research output: Contribution to journalArticleScientificpeer-review