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  • PL 56 (Viikinkaari 5)

    00014

    Finland

20062022
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Publications 2006 2019

2019

Cell-Nanoparticle Interactions at (Sub)-Nanometer Resolution Analyzed by Electron Microscopy and Correlative Coherent Anti-Stokes Raman Scattering

Saarinen, J. K. S., Gütter, F., Lindman, M. M., Agopov, M., Fraser-Miller, S. J., Scherließ, R., Jokitalo, E., Almeida Santos, H., Peltonen, L., Isomäki, A. & Strachan, C. J., Apr 2019, In : Biotechnology Journal. 14, 4, 10 p., 1800413.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Chemical analysis using 3D printed glass microfluidics

Gal-Or, E., Gershoni, Y., Scotti, G., Nilsson, S. M. E., Saarinen, J. K. S., Jokinen, V. P., Strachan, C. J., Boije af Gennäs, P. G., Yli-Kauhaluoma, J. T. & Kotiaho, A. A. T., 7 Apr 2019, In : Analytical Methods. 11, 13, p. 1802-1810 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Image-Based Investigation: Biorelevant Solubility of α and γ Indomethacin

Štukelj, J., Svanbäck, S., Kristl, J., Strachan, C. J. & Yliruusi, J., 19 Mar 2019, In : Analytical Chemistry. 91, 6, p. 3997-4003 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Tissue-specific study across the stem reveals the chemistry and transcriptome dynamics of birch bark.

Alonso Serra, J. A., Safronov, O., Lim, K-J., Fraser-Miller, S., Blokhina, O. B., Campilho, A., Chong, S-L., Fagerstedt, K. V., Haavikko, R. H., Helariutta, Y., Immanen, J. J. M., Kangasjärvi, J. S., Kauppila, T. J., Lehtonen, M., Ragni, L., Rajaraman, S., Räsänen, R-M., Safdari, P., Tenkanen, T. M., Yli-Kauhaluoma, J. T. & 4 othersTeeri, T. H., Strachan, C. J., Nieminen, K. & Salojärvi, J. T., Jun 2019, In : New Phytologist. 222, 4, p. 1816-1831 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Crystallization Kinetics of an Amorphous Pharmaceutical Compound Using Fluorescence-Lifetime-Imaging Microscopy

Rautaniemi, K., Vuorimaa-Laukkanen, E., Strachan, C. J. & Laaksonen, T., May 2018, In : Molecular Pharmaceutics. 15, 5, p. 1964-1971 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Direct comparison of low- and mid-frequency Raman spectroscopy for quantitative solid-state pharmaceutical analysis

Lipiäinen, T., Fraser-Miller, S. J., Gordon, K. C. & Strachan, C. J., 5 Feb 2018, In : Journal of Pharmaceutical and Biomedical Analysis. 149, p. 343-350 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Interdependence of particle properties and bulk powder behavior of indomethacin in quench-cooled molten two-phase solid dispersions

Semjonov, K., Salm, M., Lipiäinen, T., Kogermann, K., Lust, A., Laidmäe, I., Antikainen, O., Strachan, C. J., Ehlers, H., Yliruusi, J. & Heinämäki, J., 2018, In : International Journal of Pharmaceutics. 541, 1-2, p. 188-197 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Isomalt and its diastereomer mixtures as stabilizing excipients with freeze-dried lactate dehydrogenase

Tuderman, A-K., Strachan, C. J. & Juppo, A. M., 1 Mar 2018, In : International Journal of Pharmaceutics. 538, 1-2, p. 287-295 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Time-Gated Raman Spectroscopy for Quantitative Determination of Solid-State Forms of Fluorescent Pharmaceuticals

Lipiäinen, T., Pessi, J., Movahedi, P., Koivistoinen, J., Kurki, L., Tenhunen, M., Yliruusi, J., Juppo, A. M., Heikkonen, J., Pahikkala, T. & Strachan, C. J., 3 Apr 2018, In : Analytical Chemistry. 90, 7, p. 4832-4839 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Understanding Dissolution and Crystallization with Imaging: A Surface Point of View

Novakovic, D., Isomäki, A., Pleunis, B., Fraser-Miller, S. J., Peltonen, L. J., Laaksonen, T. & Strachan, C. J., Nov 2018, In : Molecular Pharmaceutics. 15, 11, p. 5361-5373 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

A minitablet formulation made from electrospun nanofibers

Poller, B., Strachan, C., Broadbent, R. & Walker, G. F., May 2017, In : European Journal of Pharmaceutics and Biopharmaceutics. 114, p. 213-220 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Elucidation of Compression-Induced Surface Crystallization in Amorphous Tablets Using Sum Frequency Generation (SFG) Microscopy

Mah, P. T., Novakovic, D., Saarinen, J., Landeghem, S. V., Peltonen, L., Laaksonen, T., Isomäki, A. & Strachan, C. J., 2017, In : Pharmaceutical Research. 34, 5, p. 957-970 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Insights into Caco-2 cell culture structure using coherent anti-Stokes Raman scattering (CARS) microscopy

Saarinen, J., Sõzeri, E., Fraser-Miller, S., Peltonen, L., A. Santos, H., Isomäki, A. & Strachan, C. J., 15 May 2017, In : International Journal of Pharmaceutics. 523, 1, p. 270–280 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Multimodal Nonlinear Optical Imaging for Sensitive Detection of Multiple Pharmaceutical Solid-State Forms and Surface Transformations

Novakovic, D., Saarinen, J., Rojalin, T., Antikainen, O., Fraser-Miller, S., Laaksonen, T., Peltonen, L., Isomäki, A. & Strachan, C. J., 2017, In : Analytical Chemistry. 89, 21, p. 11460-11467 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Probing Pharmaceutical Mixtures during Milling: The Potency of Low-Frequency Raman Spectroscopy in Identifying Disorder

Walker, G., Römann, P., Poller, B., Löbmann, K., Grohganz, H., Rooney, J. S., Huff, G. S., Smith, G. P. S., Rades, T., Gordon, K. C., Strachan, C. J. & Fraser-Miller, S. J., Dec 2017, In : Molecular Pharmaceutics. 14, 12, p. 4675-4684 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Supersaturating drug delivery systems: The potential of co-amorphous drug formulations

Laitinen, R., Löbmann, K., Grohganz, H., Priemel, P., Strachan, C. J. & Rades, T., 30 Oct 2017, In : International Journal of Pharmaceutics. 532, 1, p. 1-12 12 p.

Research output: Contribution to journalArticleScientificpeer-review

The formation and physical stability of two-phase solid dispersion systems of indomethacin in supercooled molten mixtures with different matrix formers

Semjonov, K., Kogermann, K., Laidmae, I., Antikainen, O., Strachan, C. J., Ehlers, H., Yliruusi, J. & Heinämäki, J., 15 Jan 2017, In : European Journal of Pharmaceutical Sciences. 97, p. 237-246 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Fluorescence-suppressed time-resolved Raman spectroscopy of pharmaceuticals using complementary metal-oxide semiconductor (CMOS) single-photon avalanche diode (SPAD) detector

Rojalin, T., Kurki, L., Laaksonen, T., Viitala, T., Kostamovaara, J., Gordon, K. C., Galvis, L., Wachsmann-Hogiu, S., Strachan, C. J. & Yliperttula, M., 2016, In : Analytical and Bioanalytical Chemistry. 408, 3, p. 761-774 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Physical Stability of Freeze-Dried Isomalt Diastereomer Mixtures

Koskinen, A-K., Fraser-Miller, S. J., Boetker, J. P., Heljo, V. P., Barnsley, J. E., Gordon, K. C., Strachan, C. J. & Juppo, A. M., Jul 2016, In : Pharmaceutical Research. 33, 7, p. 1752-1768 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Production, applications and in vivo fate of drug nanocrystals

Tuomela, A. L., Saarinen, J. K. S., Strachan, C. J., Hirvonen, J. T. & Peltonen, L. J., 2016, In : Journal of Drug Delivery Science and Technology. 34, p. 21-31 11 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

The effect of surfactants on the dissolution behavior of amorphous formulations

Mah, P. T., Peltonen, L., Novakovic, D., Rades, T., Strachan, C. J. & Laaksonen, T., Jun 2016, In : European Journal of Pharmaceutics and Biopharmaceutics. 103, p. 13-22 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Vibrational Spectroscopic Imaging: ( Part V: Imaging Techniques, Chapter17)

Fraser-Miller, S., Saarinen, J. & Strachan, C. J., 2016, Analytical Techniques in the Pharmaceutical Sciences. Müllertz, A., Perrie, Y. & Rades, T. (eds.). New York: Springer, p. 523-589 67 p. (Advances in Delivery Science and Technology).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

2015

Amorphous solid dispersions of piroxicam and Soluplus (R): Qualitative and quantitative analysis of piroxicam recrystallization during storage

Lust, A., Strachan, C. J., Veski, P., Aaltonen, J., Heinämäki, J., Yliruusi, J. & Kogermann, K., 30 May 2015, In : International Journal of Pharmaceutics. 486, 1-2, p. 306-314 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Differential scanning calorimetry predicts the critical quality attributes of amorphous glibenclamide

Mah, P. T., Laaksonen, T., Rades, T., Peltonen, L. & Strachan, C. J., 1 Dec 2015, In : European Journal of Pharmaceutical Sciences. 80, p. 74-81 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Evaluation of vibrational spectroscopic methods to identify and quantify multiple adulterants in herbal medicines

Rooney, J. S., McDowell, A., Strachan, C. J. & Gordon, K. C., 1 Jun 2015, In : Talanta. 138, p. 77-85 9 p.

Research output: Contribution to journalArticleScientificpeer-review

FinPharma Doctoral Program (FPDP) 9th Annual Meeting: The Future of Pharma, August 19–21, 2015

Reenilä, I. T. & Strachan, C. J., 2015, In : Dosis. 2015/31, 4, p. 308-312 5 p.

Research output: Contribution to journalArticleProfessional

Investigation of protein distribution in solid lipid particles and its impact on protein release using coherent anti-Stokes Raman scattering microscopy

Christophersen, P. C., Birch, D., Saarinen, J., Isomaki, A., Nielsen, H. M., Yang, M., Strachan, C. J. & Mu, H., 10 Jan 2015, In : Journal of Controlled Release. 197, p. 111-120 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Multimodal Non-Linear Optical Imaging for the Investigation of Drug Nano-/Microcrystal-Cell Interactions

Darville, N., Saarinen, J., Isomäki, A., Khriachtchev, L., Sterkens, P., van Heerden, M., Annaert, P., Peltonen, L., Almeida Santos, H., Strachan, C. J. & Van den Mooter, G., 2 Oct 2015, In : European Journal of Pharmaceutics and Biopharmaceutics. 96, p. 338–348 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Polymer incorporation method affects the physical stability of amorphous indomethacin in aqueous suspension

Surwase, S. A., Itkonen, L., Aaltonen, J., Saville, D., Rades, T., Peltonen, L. & Strachan, C. J., Oct 2015, In : European Journal of Pharmaceutics and Biopharmaceutics. 96, p. 32-43 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Understanding critical quality attributes for nanocrystals from preparation to delivery

Peltonen, L. & Strachan, C., 2015, In : Molecules. 20, 12, p. 22286-22300

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Use of low-frequency Raman spectroscopy and chemometrics for the quantification of crystallinity in amorphous griseofulvin tablets

Mah, P. T., Fraser, S. J., Reish, M. E., Rades, T., Gordon, K. C. & Strachan, C. J., Mar 2015, In : Vibrational Spectroscopy. 77, p. 10-16 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Amino Acids as Co-amorphous Excipients for Simvastatin and Glibenclamide: Physical Properties and Stability

Laitinen, R., Lobmann, K., Grohganz, H., Strachan, C. & Rades, T., Jul 2014, In : Molecular Pharmaceutics. 11, 7, p. 2381-2389 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution

Fussell, A. L., Kleinebudde, P., Herek, J., Strachan, C. & Offerhaus, H. L., 2014, In : Journal of Visualized Experiments. 89, 6 p., e51847.

Research output: Contribution to journalArticleScientificpeer-review

Coherent Anti-Stokes Raman Scattering Microscopy Driving the Future of Loaded Mesoporous Silica Imaging

L. Fussell, A., Ting Mah, P., Offerhaus, H., Niemi, S-M., Salonen, J., Santos, H. A. & Strachan, C., Jul 2014, In : Acta Biomaterialia. 10, 11, p. 4870-4877 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Distribution of binder in granules produced by means of twin screw granulation

Fonteyne, M., Fussell, A. L., Vercruysse, J., Vervaet, C., Remon, J. P., Strachan, C., Rades, T. & De Beer, T., 28 Feb 2014, In : International Journal of Pharmaceutics. 462, 1-2, p. 8-10 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Influence of postharvest processing and storage conditions on key antioxidants in puha (Sonchus oleraceus L.)

Ou, Z-Q., Schmierer, D. M., Strachan, C. J., Rades, T. & McDowell, A., Jul 2014, In : Journal of Pharmacy and Pharmacology. 66, 7, p. 998-1008 11 p.

Research output: Contribution to journalArticleScientificpeer-review

In situ dissolution analysis of pharmaceutical dosage forms using coherent anti-Stokes Raman scattering (CARS) microscopy

Fussell, A. L., Garbacik, E. T., Löbmann, K., Offerhaus, H. L., Kleinebudde, P. & Strachan, C. J., 28 Feb 2014, Multiphoton Microscopy in the Biomedical Sciences XIV. Periasamy, A., So, PTC. & Konig, K. (eds.). Bellington: SPIE, 9 p. 89482J. (Proceedings of SPIE, the International Society for Optical Engineering; vol. 8948).

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Stabilized Amorphous Solid Dispersions with Small Molecule Excipients

Löbmann, K., Tarp Jensen, K., Laitinen, R., Rades, T., Strachan, C. J. & Grohganz, H., 2014, Amorphous Solid Dispersions: Theory and Practice. Shah, N., Sandhu, H., Choi, D. S., Chokshi, H. & Malick, A. W. (eds.). New York: Springer, p. 613-636 24 p. (Advances in Delivery Science and Technology).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Theoretical Considerations in Developing Amorphous Solid Dispersions

Laitinen, R., Priemel, P. A., Surwase, S., Graeser, K., Strachan, C. J., Grohganz, H. & Rades, T., 2014, Amorphous Solid Dispersions: Theory and Practice. Shah, N., Sandhu, H., Choi, D. S., Chokshi, H. & Malick, A. W. (eds.). New York: Springer, p. 35-90 56 p. (Advances in Delivery Science and Technology).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Unravelling the Relationship between Degree of Disorder and the Dissolution Behavior of Milled Glibenclamide

Mah, P. T., Laaksonen, T., Rades, T., Aaltonen, J., Peltonen, L. & Strachan, C. J., Jan 2014, In : Molecular Pharmaceutics. 11, 1, p. 234-242 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Amino acids as co-amorphous stabilizers for poorly water soluble drugs - Part 1: Preparation, stability and dissolution enhancement

Löbmann, K., Grohganz, H., Laitinen, R., Strachan, C. & Rades, T., 2013, In : European Journal of Pharmaceutics and Biopharmaceutics. 85, 3 PART B, p. 873-881 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Amino acids as co-amorphous stabilizers for poorly water-soluble drugs - Part 2: Molecular interactions

Löbmann, K., Laitinen, R., Strachan, C., Rades, T. & Grohganz, H., 2013, In : European Journal of Pharmaceutics and Biopharmaceutics. 85, 3 PART B, p. 882-888 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Amorphous drugs and dosage forms

Grohganz, H., Loebmann, K., Priemel, P., Jensen, K. T., Graeser, K., Strachan, C. & Rades, T., 2013, In : Journal of Drug Delivery Science and Technology. 23, 4, p. 403-408 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Application of terahertz pulsed imaging to analyse film coating characteristics of sustained-release coated pellets

Haaser, M., Karrout, Y., Velghe, C., Cuppok, Y., Gordon, K. C., Pepper, M., Siepmann, J., Rades, T., Taday, P. F. & Strachan, C. J., 5 Dec 2013, In : International Journal of Pharmaceutics. 457, 2, p. 521-526 6 p.

Research output: Contribution to journalArticleScientificpeer-review

A theoretical and spectroscopic study of co-amorphous naproxen and indomethacin

Löbmann, K., Laitinen, R., Grohganz, H., Strachan, C., Rades, T. & Gordon, K. C., 2013, In : International Journal of Pharmaceutics. 453, 1, p. 80-87 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Characterization of chitosan-magnesium aluminum silicate nanocomposite films for buccal delivery of nicotine

Pongjanyakul, T., Khunawattanakul, W., Strachan, C. J., Gordon, K. C., Puttipipatkhachorn, S. & Rades, T., Apr 2013, In : International Journal of Biological Macromolecules. 55, p. 24-31 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Emerging trends in the stabilization of amorphous drugs

Laitinen, R., Lobmann, K., Strachan, C. J., Grohganz, H. & Rades, T., 30 Aug 2013, In : International Journal of Pharmaceutics. 453, 1, p. 65-79 15 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging

Haaser, M., Naelapää, K., Gordon, K. C., Pepper, M., Rantanen, J., Strachan, C. J., Taday, P. F., Zeitler, J. A. & Rades, T., 2013, In : European Journal of Pharmaceutics and Biopharmaceutics. 85, 3 PART B, p. 1095-1102 8 p.

Research output: Contribution to journalArticleScientificpeer-review