Clare Strachan

Publications

Research output per year 2006 2007 2009 2013 2014 2015 2024

• 101 Article
• 7 Review Article
• 4 Conference article
• 3 Chapter
• 1 More
  • 1 Conference contribution

Research output per year

Research output per year

Search results

• 2024

  Amorphous solid dispersions of amphiphilic polymer excipients and indomethacin prepared by hot melt extrusion

  Kessler, L. M., Mishra, R., Hietala, S., Lammens, M., Peltonen, L., Rades, T., van Veen, B., Juppo, A., Laaksonen, T., Strachan, C. & Luxenhofer, R., 8 Nov 2024, In: European Journal of Pharmaceutical Sciences. 204

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Multimodal nonlinear optical microscope for material and life sciences

  Tomberg, T., Isomäki, A., Vainio, M., Metsälä, M., Saarinen, J. & Strachan, C., 15 Oct 2024, In: Optics Continuum. 3, 10, p. 1918-1937 20 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Thermodynamic solubility measurement without chemical analysis

  Hokkala, E., Strachan, C. J., Agopov, M., Järvinen, E., Semjonov, K., Heinämäki, J., Yliruusi, J. & Svanbäck, S., 25 Mar 2024, In: International Journal of Pharmaceutics. 653, 14 p., 123890.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Use of dairy industry side-stream lactose for tablet manufacturing - proof of concept study

  Karttunen, A.-P., Junnila, A., Myöhänen, E., Harju, E., Xuan, C., Okuyucu, I. N., Heininen, J., Kivimäki, S., Harju, V., Julkunen, M., Vähäjärvi, P., Mikkonen, K. S., Tomberg, T., Moilanen, U., Strachan, C. J., Teppo, J., Tossavainen, M. & Peltonen, L., 20 Jul 2024, In: International Journal of Pharmaceutics. 660, 12 p., 124354.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• 2023

  Nonclassical Crystallization and Core–Shell Structure Formation of Ibuprofen from Binary Solvent Solutions

  Mani, R., Peltonen, L., Strachan, C., Karppinen, M. & Louhi-Kultanen, M., 2023, In: Crystal Growth & Design. 23, 1, p. 236–245 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Solid-state analysis for pharmaceuticals: Pathways to feasible and meaningful analysis

  Rantanen, J., Rades, T. & Strachan, C., 30 Nov 2023, In: Journal of Pharmaceutical and Biomedical Analysis. 236, 7 p., 115649.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• 2022

  Fast imaging-based single particle analysis method for solubility determination

  Hokkala, E., Strachan, C. J., Agopov, M., Semjonov, K., Heinämäki, J., Yliruusi, J. & Svanback, S., 25 Aug 2022, In: International Journal of Pharmaceutics. 624, 8 p., 121976.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Low- versus Mid-frequency Raman Spectroscopy for in Situ Analysis of Crystallization in Slurries

  Koskela, J., Sutton, J. J., Lipiäinen, T., Gordon, K. C., Strachan, C. J. & Fraser-Miller, S. J., 3 May 2022, In: Molecular Pharmaceutics. 19, 7, p. 2316-2326 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Nonresonant CARS Imaging of Porous and Solid Silicon Nanoparticles in Human Cells

  Gongalsky, M. B., Muftieva, D. A., Saarinen, J. K. S., Isomaki, A., Pervushin, N. V., Kopeina, G. S., Peltonen, L. J., Strachan, C. J., Zhivotovsky, B., Santos, H. A. & Osminkina, L. A., 2022, In: ACS Biomaterials Science and Engineering. 8, 10, p. 4185–4195 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2021

  Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin

  Toropainen, E., Fraser-Miller, S. J., Novakovic, D., Del Amo, E. M., Vellonen, K.-S., Ruponen, M., Viitala, T., Korhonen, O., Auriola, S., Hellinen, L., Reinisalo, M., Tengvall, U., Choi, S., Absar, M., Strachan, C. & Urtti, A., Apr 2021, In: Pharmaceutics. 13, 4, 13 p., 452.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Combined Effect of the Preparation Method and Compression on the Physical Stability and Dissolution Behavior of Melt-Quenched Amorphous Celecoxib

  Berzins, K., Fraser-Miller, S. J., Di, R., Liu, J., Peltonen, L., Strachan, C. J., Rades, T. & Gordon, K. C., 1 Mar 2021, In: Molecular Pharmaceutics. 18, 3, p. 1408-1418 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2020

  Degrees of order: A comparison of nanocrystal and amorphous solids for poorly soluble drugs

  Peltonen, L. & Strachan, C. J., 30 Aug 2020, In: International Journal of Pharmaceutics. 586, 11 p., 119492.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Effect of trehalose and melibiose on crystallization of amorphous paracetamol

  Palomäki, E. A. K., Lipiäinen, T., Strachan, C. J. & Yliruusi, J. K., 30 Nov 2020, In: International Journal of Pharmaceutics. 590, 8 p., 119878.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Image-based dissolution analysis for tracking the surface stability of amorphous powders

  Stukelj, J., Agopov, M., Yliruusi, J., Strachan, C. J. & Svanbäck, S., 2020, In: ADMET & DMPK. 8, 4, p. 401-409 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Machine-Vision-Enabled Salt Dissolution Analysis

  Stukelj, J., Agopov, M., Yliruusi, J., Strachan, C. J. & Svanbäck, S., 21 Jul 2020, In: Analytical Chemistry. 92, 14, p. 9730−9738 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• ORBIS (Open Research Biopharmaceutical Internships Support) – Building Bridges Between Academia and Pharmaceutical Industry to Improve Drug Development

  Jakubowska, E., Davin, S., Dumicic, A., Garbacz, G., Juppo, A., Michniak-Kohn, B., Rudzki, P., Smulek, W., Strachan, C., Svyarkevych, O., Tajber, L. & Lulek, J., 2020, In: Journal of Medical Science. 89, 1, 8 p., e419.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Surface stabilization and dissolution rate improvement of amorphous compacts with thin polymer coatings: can we have it all?

  Novakovic, D., Peltonen, L., Isomäki, A. O., Fraser-Miller, S. J., Hagner Nielsen, L., Laaksonen, T. & Strachan, C., 6 Apr 2020, In: Molecular Pharmaceutics. 17, 4, p. 1248-1260 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2019

  Cell-Nanoparticle Interactions at (Sub)-Nanometer Resolution Analyzed by Electron Microscopy and Correlative Coherent Anti-Stokes Raman Scattering

  Saarinen, J. K. S., Gütter, F., Lindman, M. M., Agopov, M., Fraser-Miller, S. J., Scherließ, R., Jokitalo, E., Almeida Santos, H., Peltonen, L., Isomäki, A. & Strachan, C. J., Apr 2019, In: Biotechnology Journal. 14, 4, 10 p., 1800413.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Chemical analysis using 3D printed glass microfluidics

  Gal-Or, E., Gershoni, Y., Scotti, G., Nilsson, S. M. E., Saarinen, J. K. S., Jokinen, V. P., Strachan, C. J., Boije af Gennäs, P. G., Yli-Kauhaluoma, J. T. & Kotiaho, A. A. T., 7 Apr 2019, In: Analytical Methods. 11, 13, p. 1802-1810 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Direct Measurement of Amorphous Solubility

  Stukelj, J., Svanback, S., Agopov, M., Lobmann, K., Strachan, C. J., Rades, T. & Yliruusi, J., 4 Jun 2019, In: Analytical Chemistry. 91, 11, p. 7411-7417 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Image-Based Investigation: Biorelevant Solubility of α and γ Indomethacin

  Štukelj, J., Svanbäck, S., Kristl, J., Strachan, C. J. & Yliruusi, J., 19 Mar 2019, In: Analytical Chemistry. 91, 6, p. 3997-4003 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Tissue-specific study across the stem reveals the chemistry and transcriptome dynamics of birch bark.

  Alonso Serra, J. A., Safronov, O., Lim, K.-J., Fraser-Miller, S., Blokhina, O. B., Campilho, A., Chong, S.-L., Fagerstedt, K. V., Haavikko, R. H., Helariutta, Y., Immanen, J. J. M., Kangasjärvi, J. S., Kauppila, T. J., Lehtonen, M., Ragni, L., Rajaraman, S., Räsänen, R.-M., Safdari, P., Tenkanen, T. M. & Yli-Kauhaluoma, J. T. & 4 others, Teeri, T. H., Strachan, C. J., Nieminen, K. & Salojärvi, J. T., Jun 2019, In: New Phytologist. 222, 4, p. 1816-1831 16 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• 2018

  Crystallization Kinetics of an Amorphous Pharmaceutical Compound Using Fluorescence-Lifetime-Imaging Microscopy

  Rautaniemi, K., Vuorimaa-Laukkanen, E., Strachan, C. J. & Laaksonen, T., May 2018, In: Molecular Pharmaceutics. 15, 5, p. 1964-1971 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Direct comparison of low- and mid-frequency Raman spectroscopy for quantitative solid-state pharmaceutical analysis

  Lipiäinen, T., Fraser-Miller, S. J., Gordon, K. C. & Strachan, C. J., 5 Feb 2018, In: Journal of Pharmaceutical and Biomedical Analysis. 149, p. 343-350 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Interdependence of particle properties and bulk powder behavior of indomethacin in quench-cooled molten two-phase solid dispersions

  Semjonov, K., Salm, M., Lipiäinen, T., Kogermann, K., Lust, A., Laidmäe, I., Antikainen, O., Strachan, C. J., Ehlers, H., Yliruusi, J. & Heinämäki, J., 25 Apr 2018, In: International Journal of Pharmaceutics. 541, 1-2, p. 188-197 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Isomalt and its diastereomer mixtures as stabilizing excipients with freeze-dried lactate dehydrogenase

  Tuderman, A.-K., Strachan, C. J. & Juppo, A. M., 1 Mar 2018, In: International Journal of Pharmaceutics. 538, 1-2, p. 287-295 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Preparation and characterization of multi-component tablets containing co-amorphous salts: Combining multimodal non-linear optical imaging with established analytical methods

  Ojarinta, R., Saarinen, J., Strachan, C. J., Korhonen, O. & Laitinen, R., Nov 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 132, p. 112-126 15 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Time-Gated Raman Spectroscopy for Quantitative Determination of Solid-State Forms of Fluorescent Pharmaceuticals

  Lipiäinen, T., Pessi, J., Movahedi, P., Koivistoinen, J., Kurki, L., Tenhunen, M., Yliruusi, J., Juppo, A. M., Heikkonen, J., Pahikkala, T. & Strachan, C. J., 3 Apr 2018, In: Analytical Chemistry. 90, 7, p. 4832-4839 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Understanding Dissolution and Crystallization with Imaging: A Surface Point of View

  Novakovic, D., Isomäki, A., Pleunis, B., Fraser-Miller, S. J., Peltonen, L. J., Laaksonen, T. & Strachan, C. J., Nov 2018, In: Molecular Pharmaceutics. 15, 11, p. 5361-5373 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2017

  A minitablet formulation made from electrospun nanofibers

  Poller, B., Strachan, C., Broadbent, R. & Walker, G. F., May 2017, In: European Journal of Pharmaceutics and Biopharmaceutics. 114, p. 213-220 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Elucidation of Compression-Induced Surface Crystallization in Amorphous Tablets Using Sum Frequency Generation (SFG) Microscopy

  Mah, P. T., Novakovic, D., Saarinen, J., Landeghem, S. V., Peltonen, L., Laaksonen, T., Isomäki, A. & Strachan, C. J., 2017, In: Pharmaceutical Research. 34, 5, p. 957-970 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Insights into Caco-2 cell culture structure using coherent anti-Stokes Raman scattering (CARS) microscopy

  Saarinen, J., Sõzeri, E., Fraser-Miller, S., Peltonen, L., A. Santos, H., Isomäki, A. & Strachan, C. J., 15 May 2017, In: International Journal of Pharmaceutics. 523, 1, p. 270–280 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Multimodal Nonlinear Optical Imaging for Sensitive Detection of Multiple Pharmaceutical Solid-State Forms and Surface Transformations

  Novakovic, D., Saarinen, J., Rojalin, T., Antikainen, O., Fraser-Miller, S., Laaksonen, T., Peltonen, L., Isomäki, A. & Strachan, C. J., 2017, In: Analytical Chemistry. 89, 21, p. 11460-11467 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Probing Pharmaceutical Mixtures during Milling: The Potency of Low-Frequency Raman Spectroscopy in Identifying Disorder

  Walker, G., Römann, P., Poller, B., Löbmann, K., Grohganz, H., Rooney, J. S., Huff, G. S., Smith, G. P. S., Rades, T., Gordon, K. C., Strachan, C. J. & Fraser-Miller, S. J., Dec 2017, In: Molecular Pharmaceutics. 14, 12, p. 4675-4684 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Supersaturating drug delivery systems: The potential of co-amorphous drug formulations

  Laitinen, R., Löbmann, K., Grohganz, H., Priemel, P., Strachan, C. J. & Rades, T., 30 Oct 2017, In: International Journal of Pharmaceutics. 532, 1, p. 1-12 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• The formation and physical stability of two-phase solid dispersion systems of indomethacin in supercooled molten mixtures with different matrix formers

  Semjonov, K., Kogermann, K., Laidmae, I., Antikainen, O., Strachan, C. J., Ehlers, H., Yliruusi, J. & Heinämäki, J., 15 Jan 2017, In: European Journal of Pharmaceutical Sciences. 97, p. 237-246 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2016

  Fluorescence-suppressed time-resolved Raman spectroscopy of pharmaceuticals using complementary metal-oxide semiconductor (CMOS) single-photon avalanche diode (SPAD) detector

  Rojalin, T., Kurki, L., Laaksonen, T., Viitala, T., Kostamovaara, J., Gordon, K. C., Galvis, L., Wachsmann-Hogiu, S., Strachan, C. J. & Yliperttula, M., 2016, In: Analytical and Bioanalytical Chemistry. 408, 3, p. 761-774 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Physical Stability of Freeze-Dried Isomalt Diastereomer Mixtures

  Koskinen, A.-K., Fraser-Miller, S. J., Boetker, J. P., Heljo, V. P., Barnsley, J. E., Gordon, K. C., Strachan, C. J. & Juppo, A. M., Jul 2016, In: Pharmaceutical Research. 33, 7, p. 1752-1768 17 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• The effect of surfactants on the dissolution behavior of amorphous formulations

  Mah, P. T., Peltonen, L., Novakovic, D., Rades, T., Strachan, C. J. & Laaksonen, T., Jun 2016, In: European Journal of Pharmaceutics and Biopharmaceutics. 103, p. 13-22 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2015

  Amorphous solid dispersions of piroxicam and Soluplus (R): Qualitative and quantitative analysis of piroxicam recrystallization during storage

  Lust, A., Strachan, C. J., Veski, P., Aaltonen, J., Heinämäki, J., Yliruusi, J. & Kogermann, K., 30 May 2015, In: International Journal of Pharmaceutics. 486, 1-2, p. 306-314 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Differential scanning calorimetry predicts the critical quality attributes of amorphous glibenclamide

  Mah, P. T., Laaksonen, T., Rades, T., Peltonen, L. & Strachan, C. J., 1 Dec 2015, In: European Journal of Pharmaceutical Sciences. 80, p. 74-81 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Evaluation of vibrational spectroscopic methods to identify and quantify multiple adulterants in herbal medicines

  Rooney, J. S., McDowell, A., Strachan, C. J. & Gordon, K. C., 1 Jun 2015, In: Talanta. 138, p. 77-85 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• FinPharma Doctoral Program (FPDP) 9th Annual Meeting: The Future of Pharma, August 19–21, 2015

  Reenilä, I. T. & Strachan, C. J., 2015, In: Dosis : farmaseuttinen aikakauskirja. 2015/31, 4, p. 308-312 5 p.

  Research output: Contribution to journal › Article › Professional

• Investigation of protein distribution in solid lipid particles and its impact on protein release using coherent anti-Stokes Raman scattering microscopy

  Christophersen, P. C., Birch, D., Saarinen, J., Isomaki, A., Nielsen, H. M., Yang, M., Strachan, C. J. & Mu, H., 10 Jan 2015, In: Journal of Controlled Release. 197, p. 111-120 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Multimodal Non-Linear Optical Imaging for the Investigation of Drug Nano-/Microcrystal-Cell Interactions

  Darville, N., Saarinen, J., Isomäki, A., Khriachtchev, L., Sterkens, P., van Heerden, M., Annaert, P., Peltonen, L., Almeida Santos, H., Strachan, C. J. & Van den Mooter, G., 2 Oct 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 96, p. 338–348 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Polymer incorporation method affects the physical stability of amorphous indomethacin in aqueous suspension

  Surwase, S. A., Itkonen, L., Aaltonen, J., Saville, D., Rades, T., Peltonen, L. & Strachan, C. J., Oct 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 96, p. 32-43 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Suomen lääketutkimuksen tohtoriohjelman (FinPharma Doctoral Program, FPDP) 9. vuositapaaminen: The Future of Pharma, 19.–21.8.2015

  Reenilä, I. & Strachan, C., 2015, In: Dosis : farmaseuttinen aikakauskirja. 31, 4, p. 306-308 3 p.

  Research output: Contribution to journal › Article › Professional

• Use of low-frequency Raman spectroscopy and chemometrics for the quantification of crystallinity in amorphous griseofulvin tablets

  Mah, P. T., Fraser, S. J., Reish, M. E., Rades, T., Gordon, K. C. & Strachan, C. J., Mar 2015, In: Vibrational Spectroscopy. 77, p. 10-16 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2014

  Amino Acids as Co-amorphous Excipients for Simvastatin and Glibenclamide: Physical Properties and Stability

  Laitinen, R., Lobmann, K., Grohganz, H., Strachan, C. & Rades, T., Jul 2014, In: Molecular Pharmaceutics. 11, 7, p. 2381-2389 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution

  Fussell, A. L., Kleinebudde, P., Herek, J., Strachan, C. & Offerhaus, H. L., 2014, In: Journal of Visualized Experiments. 89, 6 p., e51847.

  Research output: Contribution to journal › Article › Scientific › peer-review