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Dan Bj Lindholm

  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

1991 …2020

Research output per year

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Publications

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Article
2020

Dynamic Interaction of USP14 with the Chaperone HSC70 Mediates Crosstalk between the Proteasome, ER Signaling, and Autophagy

Srinivasan, V., Bruelle, C., Scifo, E., Pham, D. D., Soliymani, R., Lalowski, M. & Lindholm, D. B., 24 Jan 2020, In : iScience. 23, 1, 33 p., 100790.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2019

Caspase-2 and p75 neurotrophin receptor (p75NTR) are involved in the regulation of SREBP and lipid genes in hepatocyte cells

Pham, D. D., Bruelle, C., Do, H. T., Pajanoja, C., Jin, C., Olkkonen, V. M., Eriksson-Rosenberg, O., Jauhiainen, M., Lalowski, M. & Lindholm, D., 11 Jul 2019, In : Cell Death and Disease. 10, 15 p., 537.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Prolyl oligopeptidase inhibition reduces PolyQ aggregation and improves cell viability in cellular model of Huntington’s disease

Norrbacka, S., Lindholm, D. & Myöhänen, T. T., Dec 2019, In : Journal of Cellular and Molecular Medicine. 23, 12, p. 8511-8515 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration - A Mass Spectrometry Imaging Study of the Perfused Rat Liver

Calza, G., Nyberg, E., Mäkinen, M., Soliymani, R., Cascone, A., Lindholm, D., Barborini, E., Baumann, M., Lalowski, M. & Eriksson, O., 22 Feb 2018, In : Frontiers in Pharmacology. 9, 12 p., 141.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Prostaglandin D2 Receptor DP1 Antibodies Predict Vaccine-induced and Spontaneous Narcolepsy Type 1: Large-scale Study of Antibody Profiling

Sadam, H., Pihlak, A., Kivil, A., Pihelgas, S., Jaago, M., Adler, P., Vilo, J., Vapalahti, O., Neuman, T., Lindholm, D., Partinen, M., Vaheri, A. & Palm, K., Mar 2018, In : EBioMedicine. 29, p. 47-59 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017
Open Access
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Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease

Lindholm, D., Korhonen, L., Eriksson-Rosenberg, O. & Koks, S., 2017, In : Frontiers in Cell and Developmental Biology. 5, 16 p., 48.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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XIAP Interacts with and Regulates the Activity of FAF1

Caballero-López, MJ., Nieto-Díaz, M., Yunta, M., Reigada, D., Muñoz-Galdeano, T., Del Águila, Á., Navarro-Ruíz, R., Pita-Thomas, W., Lindholm, D. & Maza, RM., 2017, In : Biochimica et Biophysica Acta. Molecular Cell Research. 1864, 7, p. 1335-1348 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Eskelinen, E-L., Hulmi, J. J., Korhonen, L., Lindholm, D., Screen, M., Stratoulias, V. & Zughaier, S. M., 21 Jan 2016, In : Autophagy. 12, 1, p. 1-222

Research output: Contribution to journalArticleScientificpeer-review

Nerve growth factor (NGF) and pro-NGF increase low-density lipoprotein (LDL) receptors in neuronal cells partly by different mechanisms: role of LDL in neurite outgrowth.

Do, H. T., Bruelle, C. P. T., Pham, D. D., Jauhiainen, M., Eriksson, O., Korhonen, L. T. & Lindholm, D., 2016, In : Journal of Neurochemistry. 136, 2, p. 306-315 10 p.

Research output: Contribution to journalArticleScientificpeer-review

p75 Neurotrophin Receptor Signaling Activates Sterol Regulatory Element-binding Protein-2 in Hepatocyte Cells via p38 Mitogen-activated Protein Kinase and Caspase-3

Pham, D. D., Do, H. T., Bruelle, C., Kukkonen, J. P., Eriksson, O., Mogollon, I., Korhonen, L., Arumae, U. & Lindholm, D., 13 May 2016, In : Journal of Biological Chemistry. 291, 20, p. 10747-10758 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Parkinson's disease: towards better preclinical models and personalized treatments

Lindholm, D., Mäkelä, J., Di Liberto, V., Mudo, G., Belluardo, N., Eriksson-Rosenberg, O. & Saarma, M., Apr 2016, In : Cellular and Molecular Life Sciences. 73, 7, p. 1383-1385 3 p.

Research output: Contribution to journalArticleScientific

Open Access
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Peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonist is neuroprotective and stimulates PGC-1 alpha expression and CREB phosphorylation in human dopaminergic neurons

Mäkelä, J., Tselykh, T. V., Kukkonen, J. P., Eriksson, O., Korhonen, L. T. & Lindholm, D., 2016, In : Neuropharmacology. 102, p. 266-275 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Peroxisome proliferator-activated receptor-gamma coactivator-1 alpha mediates neuroprotection against excitotoxic brain injury in transgenic mice: role of mitochondria and X-linked inhibitor of apoptosis protein

Mäkelä, J., Mudo, G., Pham, D. D., Di Liberto, V., Eriksson, O., Louhivuori, L., Bruelle, C., Soliymani, R., Baumann, M., Korhonen, L., Lalowski, M., Belluardo, N. & Lindholm, D., Mar 2016, In : European Journal of Neuroscience. 43, 5, p. 626-639 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Diabetes drugs and neurological disorders: new views and therapeutic possibilities

Patrone, C., Eriksson, O. & Lindholm, D., Mar 2014, In : The Lancet diabetes & endocrinology. 2, 3, p. 256-262 7 p.

Research output: Contribution to journalArticleScientific

Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1alpha in human dopaminergic neurons via Sirtuin-1

Mäkelä, J., Tselykh, T., Maiorana, F., Eriksson-Rosenberg, O., Do, H. T., Mudo, G., Korhonen, L., Belluardo, N. & Lindholm, D. B., 2014, In : SpringerPlus. 12 p., 3:2.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Kemiallisesti tuotetut kantasolut: Ikuisen nuoruuden lähde?

Baumann, M., Eriksson-Rosenberg, O. & Lindholm, D. B., 2014, In : Kemia - Kemi. 2, p. 52-54 3 p.

Research output: Contribution to journalArticleGeneral public

Stem cell therapy: how to do it right

Cova, L. & Lindholm, D. B., 2014, In : Frontiers in Cell and Developmental Biology. 2 p., 2:66.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1 alpha

Hyrskyluoto, A., Bruelle, C., Lundh, S. H., Do, H. T., Kivinen, J., Rappou, E., Reijonen, S., Waltimo, T., Petersen, A., Lindholm, D. & Korhonen, L., 15 Nov 2014, In : Human Molecular Genetics. 23, 22, p. 5928-5939 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Hepatocyte Growth Factor Activator Inhibitor-1 Is Induced by Bone Morphogenetic Proteins and Regulates Proliferation and Cell Fate of Neural Progenitor Cells

Koivuniemi, R., Mäkelä, J., Hokkanen, M-E., Bruelle, C., Ho, T. H., Ola, R., Korhonen, L., Schroder, J., Kataoka, H. & Lindholm, D., 7 Feb 2013, In : PLoS One. 8, 2, p. Article Number: e56117 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Reciprocal Regulation of Very Low Density Lipoprotein Receptors (VLDLRs) in Neurons by Brain-derived Neurotrophic Factor (BDNF) and Reelin INVOLVEMENT OF THE E3 LIGASE Mylip/Idol

Do, H. T., Bruelle, C., Tselykh, T., Jalonen, P., Korhonen, L. & Lindholm, D., 11 Oct 2013, In : Journal of Biological Chemistry. 288, 41, p. 29613-29620 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-kappa B pathway

Hyrskyluoto, A., Pulli, I., Tornqvist, K., Ho, T. H., Korhonen, L. & Lindholm, D., May 2013, In : Cell Death and Disease. 4, Article Number: e646 , 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2012

Destabilization of the Outer and Inner Mitochondrial Membranes by Core and Linker Histones

Cascone, A., Bruelle, C., Lindholm, D., Bernardi, P. & Eriksson-Rosenberg, O., 2012, In : PLoS One. 7, 4, p. Article Number: e35357 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Fibroblast Growth Factor-21 (FGF21) Regulates Low-density Lipoprotein Receptor (LDLR) Levels in Cells via the E3-ubiquitin Ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting Saposin-like Protein (Msap)

Do, H. T., Tselykh, T. V., Mäkelä, J., Ho, T. H., Olkkonen, V. M., Bornhauser, B. C., Korhonen, L., Zelcer, N. & Lindholm, D., 2012, In : Journal of Biological Chemistry. 287, 16, p. 12602-12611 10 p.

Research output: Contribution to journalArticleScientificpeer-review

GADD34 mediates cytoprotective autophagy in mutant huntingtin expressing cells via the mTOR pathway

Hyrskyluoto, A., Reijonen, S., Kivinen, J., Lindholm, D. & Korhonen, L., 2012, In : Experimental Cell Research. 318, 1, p. 33-42 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Involvement of estrogen receptors in the resveratrol-mediated increase in dopamine transporter in human dopaminergic neurons and in striatum of female mice

Di Liberto, V., Makela, J., Korhonen, L., Olivieri, M., Tselykh, T., Malkia, A., Thi, H. D., Belluardo, N., Lindholm, D. & Mudo, G., 2012, In : Neuropharmacology. 62, 2, p. 1011-1018 8 p.

Research output: Contribution to journalArticleScientificpeer-review

PGC-1 alpha: a master gene that is hard to master

Lindholm, D., Eriksson-Rosenberg, O., Makela, J., Belluardo, N. & Korhonen, L., 2012, In : Cellular and Molecular Life Sciences. 69, 15, p. 2465-2468 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Transgenic expression and activation of PGC-1 alpha protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease

Mudo, G., Mäkelä, J., Di Liberto, V., Tselykh, T. V., Olivieri, M., Piepponen, T. P., Eriksson-Rosenberg, O., Malkia, A., Bonomo, A., Kairisalo, M., Aguirre, J. A., Korhonen, L., Belluardo, N. & Lindholm, D., 2012, In : Cellular and Molecular Life Sciences. 69, 7, p. 1153-1165 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Tutkija löysi uutta tietoa hermostosta

Saarma, M., Castrén, E. & Lindholm, D. B., 13 Jul 2012, In : Helsingin Sanomat. 1 p.

Research output: Contribution to journalArticleGeneral public

2011

Involvement of cyclin-dependent kinase-5 in the kainic acid-mediated degeneration of glutamatergic synapses in the rat hippocampus

Putkonen, N., Kukkonen, J. P., Mudo, G., Putula, J., Belluardo, N., Lindholm, D. & Korhonen, L., 2011, In : European Journal of Neuroscience. 34, 8, p. 1212-1221

Research output: Contribution to journalArticleScientificpeer-review

Resveratrol reduces oxidative stress and cell death and increases mitochondrial antioxidants and XIAP in PC6.3-cells

Kairisalo, M., Bonomo, A., Hyrskyluoto, A., Mudo, G., Belluardo, N., Korhonen, L. & Lindholm, D., 2011, In : Neuroscience Letters. 488, p. 263-266 4 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Downregulation of NF-kappa B signaling by mutant huntingtin proteins induces oxidative stress and cell death

Reijonen, S., Kukkonen, J. P., Hyrskyluoto, A., Kivinen, J., Kairisalo, M., Takei, N., Lindholm, D. & Korhonen, L., 2010, In : Cellular and Molecular Life Sciences. 67, 11, p. 1929-1941 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Interferon-gamma produced by microglia and the neuropeptide PACAP have opposite effects on the viability of neural progenitor cells

Mäkelä, J., Koivuniemi, R., Korhonen, L. & Lindholm, D., 2010, In : PLoS One. 5, 6, 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Reduced VGLUT2 expression increases motor neuron viability in Sod1(G93A) mice

Wootz, H., Enjin, A., Wallen-Mackenzie, A., Lindholm, D. & Kullander, K., Jan 2010, In : Neurobiology of Disease. 37, 1, p. 58-66 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Regulation of HERG (KCNH2) potassium channel surface expression by diacylglycerol

Ramstrom, C., Chapman, H., Viitanen, T., Afrasiabi, E., Fox, H., Kivela, J., Soini, S., Korhonen, L., Lindholm, D., Pasternack, M. & Tornquist, K., 2010, In : Cellular and Molecular Life Sciences. 67, p. 157-169 13 p.

Research output: Contribution to journalArticleScientificpeer-review

The E3 Ubiquitin Ligase IDOL Induces the Degradation of the Low Density Lipoprotein Receptor Family Members VLDLR and ApoER2

Hong, C., Duit, S., Jalonen, P., Out, R., Scheer, L., Sorrentino, V., Boyadjian, R., Rodenburg, K. W., Foley, E., Korhonen, L., Lindholm, D., Nimpf, J., van Berkel, T. J. C., Tontonoz, P. & Zelcer, N., 2010, In : Journal of Biological Chemistry. 285, p. 19720-19726 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Dexamethasone regulates expression of BRUCE/Apollon and the proliferation of neural progenitor cells

Sippel, M., Koivuniemi, R. J., Korhonen, L. T. T., Bornhauser, B., Sokka, A-L., Naito, M. & Lindholm, D. B. V., 2009, In : FEBS Letters. 583, p. 2213-2217 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Inducerade pluripotenta stamceller – nya löften och möjligheter för forskning och terapi

Trokovic, R. & Lindholm, D., 2009, In : Finska Läkaresällskapets Handlingar. 169, 2, p. 50-55 6 p.

Research output: Contribution to journalArticleScientific

Mylip makes an Idol turn into regulation of LDL receptor

Lindholm, D., Bornhauser, B. C. & Korhonen, L., 2009, In : Cellular and Molecular Life Sciences. 66, p. 3399-3402 4 p.

Research output: Contribution to journalArticleScientificpeer-review

NF-kappa B-dependent regulation of brain-derived neurotrophic factor in hippocampal neurons by X-linked inhibitor of apoptosis protein

Kairisalo, M., Korhonen, L., Sepp, M., Pruunsild, P., Kukkonen, J. P., Kivinen, J., Timmusk, T., Blomgren, K. & Lindholm, D., 2009, In : European Journal of Neuroscience. 30, 6, p. 958-966 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Evolution of a family of metazoan active-site-serine enzymes from penicillin-binding proteins: a novel facet of the bacterial legacy

Peitsaro, N., Polianskyte, Z., Tuimala, J., Porn-Ares, I., Liobikas, J., Speer, O., Lindholm, D., Thompson, J. & Eriksson, O., 2008, In : BMC Evolutionary Biology. 8, 26, p. - 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins

Reijonen, S., Putkonen, N., Norremolle, A., Lindholm, D. & Korhonen, L., 2008, In : Experimental Cell Research. 314, 5, p. 950-960 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain

Sokka, A-L., Putkonen, N. J. E., Mudo, G., Pryazhnikov, E., Reijonen, S., Khirug, L., Belluardo, N., Lindholm, D. & Korhonen, L., 2007, In : Journal of Neuroscience. 27, 4, p. 901-908 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Low-dose arsenic trioxide sensitizes glucocorticoid-resistant acute lymphoblastic leukemia cells to dexamethasone via an Akt-dependent pathway

Bornhauser, B. C., Bonapace, L., LindholM, D., Martinez, R., Cario, G., Schrappe, M., Niggli, F. K., Schaefer, B. W. & Bourquin, J-P., 2007, In : Blood purification. 110, p. 2084-2091 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Neural network and "Ganglion" formations in vitro: A video Microscopy and scanning electron Microscopy study on adult cultured spiral ganglion cells

Bostroem, M., Anderson, M., Lindholm, D., Park, K-H., Schrott-Fischer, A., Pfaller, K., Glueckert, R. & Rask-Andersen, H., 2007, In : Otology & Neurotology. 28, p. 1109-1119 11 p.

Research output: Contribution to journalArticleScientificpeer-review

X chromosome-linked inhibitor of apoptosis protein reduces oxidative stress after cerebral irradiation or hypoxia-ischemia through up-regulation of mitochondrial antioxidants

Zhu, C., Xu, F., Fukuda, A., Wang, X., Fukuda, H., Korhonen, L., Hagberg, H., Lannering, B., Nilsson, M., Eriksson, P. S., Northington, F. J., Bjoerk-Eriksson, T., Lindholm, D. & Blomgren, K., 2007, In : European Journal of Neuroscience. 26, p. 3402-3410 9 p.

Research output: Contribution to journalArticleScientificpeer-review

X-linked inhibitor of apoptosis protein increases mitochondrial antioxidants through NF-kappa B activation

Kairisalo, M., Korhonen, L., Blomgren, K. & Lindholm, D., 2007, In : Biochemical and Biophysical Research Communications. 364, 1, p. 138-144 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Altered distribution and levels of cathepsind and cystatins in amyotrophic lateral sclerosis transgenic mice: Possible roles in motor neuron survival

Wootz, H., Weber, E., Korhonen, L. & Lindholm, D., 2006, In : Neuroscience. 143, 2, p. 419-430 12 p.

Research output: Contribution to journalArticleScientificpeer-review

ER stress and neurodegenerative diseases

Lindholm, D., Wootz, H. & Korhonen, L., 2006, In : Cell Death and Differentiation. 13, p. 385-392 8 p.

Research output: Contribution to journalArticleScientificpeer-review