Research output per year
Research output per year
Personal profile
Curriculum vitae
Denis Kainov received his PhD in Genetics from the University of Helsinki, Institute of Biotechnology in 2005. He performed his postdoctoral training in IGBMC, France and in CRP-Sante, Luxembourg during 2005-2009. He then returned to Finland, and started his independent career as a FIMM-EMBL group leader in 2010.
Fields of Science
- 312 Clinical medicine
- Influenza virus, respiratory infections
- 118 Biological sciences
- Virus, Drugs, Immunity, Health
International and National Collaboration
Publications and projects within past five years.
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Seeking innovative concepts in development of antiviral drug combinations
Kainov, D. E., Ravlo, E. & Ianevski, A., Feb 2025, In: Antiviral Research. 234, 4 p., 106079.Research output: Contribution to journal › Review Article › peer-review
Open AccessFile -
Synergistic combination of orally available safe-in-man pleconaril, AG7404, and mindeudesivir inhibits enterovirus infections in human cell and organoid cultures
Ravlo, E., Ianevski, A., Schjolberg, J.-O., Solvang, V., Dumaru, R., Lysvand, H., Hankinson, J., Vaha-Koskela, M., Vainionpaa, S., Varhe, A., Seppänen, H., Smura, T., Wang, X., Wang, Y., Li, P., Pan, Q., Dahl-Jorgensen, K., Krogvold, L., Kamyshnyi, O. & Nilsen, H.-J. S. & 11 others, , Jan 2025, In: Cellular and Molecular Life Sciences. 82, 1, 13 p., 57.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
The combination of pleconaril, rupintrivir, and remdesivir efficiently inhibits enterovirus infections in vitro, delaying the development of drug-resistant virus variants
Ianevski, A., Frøysa, I. T., Lysvand, H., Calitz, C., Smura, T., Schjelderup Nilsen, H. J., Høyer, E., Afset, J. E., Sridhar, A., Wolthers, K. C., Zusinaite, E., Tenson, T., Kurg, R., Oksenych, V., Galabov, A. S., Stoyanova, A., Bjørås, M. & Kainov, D. E., Apr 2024, In: Antiviral Research. 224, 8 p., 105842.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
A pan-SARS-CoV-2-specific soluble angiotensin-converting enzyme 2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery
Benjakul, S., Anthi, A. K., Kolderup, A., Vaysburd, M., Lode, H. E., Mallery, D., Fossum, E., Vikse, E. L., Albecka, A., Ianevski, A., Kainov, D., Karlsen, K. F., Sakya, S. A., Nyquist-Andersen, M., Gjolberg, T. T., Moe, M. C., Bjoras, M., Sandlie, I., James, L. C. & Andersen, J. T., 1 Dec 2023, In: PNAS nexus. 2, 12, 15 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Boosted production of antibodies that neutralized different SARS-CoV-2 variants in a COVID-19 convalescent following messenger RNA vaccination - a case study
Ravlo, E., Ianevski, A., Starheim, E., Wang, W., Ji, P., Lysvand, H., Smura, T., Kivi, G., Voolaid, M.-L., Plaan, K., Ustav, M., Ustav Jr, M., Zusinaite, E., Tenson, T., Kurg, R., Oksenych, V., Walstad, K., Nordba, S. A., Kaarba, M. & Ernits, K. & 3 others, , Dec 2023, In: International Journal of Infectious Diseases. 137, p. 75-78 4 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile
Projects
- 2 Finished
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Flu diagnostics: Three-year Research Projects (a UH funding type)
Kainov, D. (Project manager), Mishel, P. (Participant) & Belanov, S. (Participant)
01/01/2015 → 31/12/2017
Project: Research project
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Center of Excellence in Virus Research (CoE_VIRRES)
Bamford, D. H. (Principal Investigator), Bamford, J. (Participant), Butcher, S. (Principal Investigator), Oksanen, H. M. (Principal Investigator), Poranen, M. (Principal Investigator), Roine, E. (Principal Investigator), Kainov, D. (Principal Investigator), Tuma, R. (Participant), Ravantti, J. (Participant), Huiskonen, J. (Participant), Jäälinoja, H. (Participant), Ora, A. (Participant), Hattula, K. (Participant), Ziedaite, G. (Participant), Romanovskaya, A. (Participant), Lisal, J. (Participant), Buivydas, A. (Participant), Redder, P. (Participant), Domanska, A. (Participant), Vilen, S. (Participant), Manole, V. (Participant), Happonen, L. (Participant), Seitsonen, J. (Participant), Liljeroos, L. (Participant), Suchanova, B. (Participant), Falck, S. (Participant), Daugelavicius, R. (Participant), Golubtsov, A. (Participant), Yuan, P. (Participant), Anastasina, M. (Participant), Karhu, N. J. (Participant), Koivunen, M. (Participant), Laurinavicius, S. (Participant), Wallin, A. (Participant), Aalto, A. P. (Participant), Sarin, P. (Participant), Atanasova, N. (Participant), Sun, X. (Participant), Pietilä, M. (Participant), Krupovic, M. (Participant), Cvirkaite-Krupovic, V. (Participant), Kukkaro, P. (Participant) & Pirttimaa, M. (Participant)
25/02/2011 → 31/12/2016
Project: Research Evaluation 2011
Prizes
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Docentship in infectious diseases: Emerging cellular targets for potential influenza antivirals
Kainov, D. (Recipient), 22 Dec 2011
Prize: Prizes and awards
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First Prize for the Best Doctoral Thesis, University of Helsinki
Kainov, D. (Recipient), 2006
Prize: Prizes and awards
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Activities
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Influenza A virus-host interactions and their control by viral non-structural protein NS1
Kainov, D. (Supervisor)
17 Apr 2015Activity: Examination types › Supervisor or co-supervisor of doctoral thesis
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Influenza virus-host interactions and their modulation by small molecules
Kainov, D. (Supervisor)
9 May 2014Activity: Examination types › Supervisor or co-supervisor of doctoral thesis
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Nordic Molecular Medicine Network Meeting
Kainov, D. (Speaker: Presenter)
17 Sept 2013 → 19 Sept 2013Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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member of thesis committee
Kainov, D. (Member of thesis committee / follow-up group)
2013 → 2014Activity: Examination types › Member of doctoral thesis committee / follow-up group
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supervision of master's thesis
Kainov, D. (Co-supervisor)
1 Jan 2013 → 31 Dec 2013Activity: Examination types › Supervision of other thesis (Master's, Licentiate)