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Publications 2003 2019

  • 50 Article
  • 5 Review Article
  • 1 Conference article
  • 1 Doctoral Thesis
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2019

Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010-2018

Ianevski, A., Zusinaite, E., Shtaida, N., Kallio-Kokko, H., Valkonen, M., Kantele, A., Telling, K., Lutsar, I., Letjuka, P., Metelitsa, N., Oksenych, V., Dumpis, U., Vitkauskiene, A., Stasaitis, K., Öhrmalm, C., Bondeson, K., Bergqvist, A., Cox, R. J., Tenson, T., Merits, A. & 1 othersKainov, D. E., 1 Mar 2019, In : Viruses. 11, 3, 10 p., 207.

Research output: Contribution to journalArticleScientificpeer-review

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2018

Novel activities of safe-in-human broad-spectrum antiviral agents

Ianevski, A., Zusinaite, E., Kuivanen, S., Strand, M., Lysvand, H., Teppor, M., Kakkola, L., Paavilainen, H., Laajala, M., Kallio-Kokko, H., Valkonen, M., Kantele, A., Telling, K., Lutsar, I., Letjuka, P., Metelitsa, N., Oksenych, V., Bjørås, M., Nordbø, S. A., Dumpis, U. & 14 othersVitkauskiene, A., Öhrmalm, C., Bondeson, K., Bergqvist, A., Aittokallio, T., Cox, R. J., Evander, M., Hukkanen, V., Marjomaki, V., Julkunen, I., Vapalahti, O., Tenson, T., Merits, A. & Kainov, D., Jun 2018, In : Antiviral Research. 154, p. 174-182 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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2017

Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins

Bulanova, D., Ianevski, A., Bugai, A., Akimov, Y., Kuivanen, S., Paavilainen, H., Kakkola, L., Nandania, J., Turunen, L., Ohman, T., Ala-Hongisto, H., Pesonen, H. M., Kuisma, M. S., Honkimaa, A., Walton, E. L., Oksenych, V., Lorey, M. B., Guschin, D., Shim, J., Kim, J. & 23 othersThan, T. T., Chang, S. Y., Hukkanen, V., Kulesskiy, E., Marjomaki, V. S., Julkunen, I., Nyman, T. A., Matikainen, S., Saarela, J. S., Sane, F., Hober, D., Gabriel, G., De Brabander, J. K., Martikainen, M., Windisch, M. P., Min, J-Y., Bruzzone, R., Aittokallio, T., Vaha-Koskela, M., Vapalahti, O., Pulk, A., Velagapudi, V. & Kainov, D. E., Oct 2017, In : Viruses. 9, 10, 15 p., 271.

Research output: Contribution to journalArticleScientificpeer-review

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Regulation of kynurenine biosynthesis during influenza virus infection

Gaelings, L., Söderholm, S. L., Bugai, A., Fu, Y., Nandania, J., Schepens, B., Lorey, M. B., Tynell, J., Marjomäki, V., Matikainen, S., Nyman, T. A., Saelens, X., Julkunen, I., Velagapudi, V. & Kainov, D., Jan 2017, In : The FEBS Journal. 284, 2, p. 222-236 15 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Activation of Tryptophan and Phenylalanine Catabolism in the Remission Phase of Allergic Contact Dermatitis: A Pilot Study

Zinkevitiene, A., Kainov, D., Girkontaite, I., Lastauskiene, E., Kvedariene, V., Fu, Y., Anders, S. & Velagapudi, V., 2016, In : International Archives of Allergy and Immunology. 170, 4, p. 262-268 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine

Soderholm, S., Anastasina, M., Islam, M. M., Tynell, J., Poranen, M. M., Bamford, D. H., Stenman, J., Julkunen, I., Sauliene, I., De Brabander, J. K., Matikainen, S., Nyman, T. A., Saelens, X. & Kainov, D., Feb 2016, In : Antiviral Research. 126, p. 69-80 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes

Anastasina, M., Le May, N., Bugai, A., Fu, Y., Soderholm, S., Gaelings, L., Ohman, T., Tynell, J., Kyttanen, S., Barboric, M., Nyman, T. A., Matikainen, S., Julkunen, I., Butcher, S. J., Egly, J-M. & Kainov, D. E., Nov 2016, In : Biochimica et Biophysica Acta. Gene Regulatory Mechanisms. 1859, 11, p. 1440-1448 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses

Fu, Y., Gaelings, L., Soderholm, S., Belanov, S., Nandania, J., Nyman, T. A., Matikainen, S., Anders, S., Velagapudi, V. & Kainov, D. E., Sep 2016, In : Antiviral Research. 133, p. 23-31 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication

Balistreri, G., Viiliainen, J., Turunen, M., Diaz, R., Lyly, L., Pekkonen, P., Rantala, J., Ojala, K., Sarek, G., Teesalu, M., Denisova, O., Peltonen, K., Julkunen, I., Varjosalo, M., Kainov, D., Kallioniemi, O., Laiho, M., Taipale, J., Hautaniemi, S. & Ojala, P. M., Feb 2016, In : PLoS Pathogens. 12, 2, 26 p., 1005424.

Research output: Contribution to journalArticleScientificpeer-review

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Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages

Soderholm, S., Kainov, D. E., Ohman, T., Denisova, O. V., Schepens, B., Kulesskiy, E., Imanishi, S. Y., Corthals, G., Hintsanen, P., Aittokallio, T., Saelens, X., Matikainen, S. & Nyman, T. A., Oct 2016, In : Molecular & Cellular Proteomics. 15, 10, p. 3203-3219 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Protein profiling of nasopharyngeal aspirates of hospitalized and outpatients revealed cytokines associated with severe influenza A(H1N1)pdm09 virus infections: A pilot study

Fu, Y., Gaelings, L., Jalovaara, P., Kakkola, L., Kinnunen, M. T., Kallio-Kokko, H., Valkonen, M., Kantele, A. & Kainov, D. E., Oct 2016, In : Cytokine. 86, p. 10-14 5 p.

Research output: Contribution to journalArticleScientificpeer-review

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2015
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Complete Genome Sequences of Influenza A/H1N1 Strains Isolated from Patients during the 2013-2014 Epidemic Season in Finland

Jalovaara, P., Mishel, P., Kallio-Kokko, H., Valkonen, M., Kantele, A., Ikonen, N., Julkunen, I., Kakkola, L., Kutsaya, A., Vuorinen, T., Mattila, P., Almusa, H. & Kainov, D., 2015, In : Genome Announcements. 3, 2, 2 p., e01523-14.

Research output: Contribution to journalArticleScientificpeer-review

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Genetic Loci Associated with Allergic Sensitization in Lithuanians

Sauliene, I., Greiciuviene, J., Sukiene, L., Juskeviciute, N., Benner, C., Zinkeviciene, A., Ripatti, S., Donner, K. & Kainov, D., 27 Jul 2015, In : PLoS One. 10, 7, 7 p., 0134188.

Research output: Contribution to journalArticleScientificpeer-review

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Genome-Wide Analysis of Evolutionary Markers of Human Influenza A(H1N1)pdm09 and A(H3N2) Viruses May Guide Selection of Vaccine Strain Candidates

Belanov, S. S., Bychkov, D., Benner, C., Ripatti, S., Ojala, T., Kankainen, M., Lee, H. K., Tang, J. W-T. & Kainov, D. E., Dec 2015, In : Genome Biology and Evolution. 7, 12, p. 3472-3483 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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Serum Biomarkers of Allergic Contact Dermatitis: A Pilot Study

Zinkeviciene, A., Kainov, D., Lastauskiene, E., Kvedariene, V., Bychkov, D., Byrne, M. & Girkontaite, I., 2015, In : International Archives of Allergy and Immunology. 168, 3, p. 161-164 4 p.

Research output: Contribution to journalArticleScientificpeer-review

The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice

Anastasina, M., Schepens, B., Soderholm, S., Nyman, T. A., Matikainen, S., Saksela, K., Saelens, X. & Kainov, D. E., Aug 2015, In : Journal of General Virology. 96, p. 2086-2091 6 p.

Research output: Contribution to journalArticleScientificpeer-review

The impact of pollen load on quality of life: a questionnaire-based study in Lithuania

Šaulienė, I., Šukienė, L., Kainov, D. & Greičiuvienė, J., 2015, In : Aerobiologia. p. 1-14 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Akt Inhibitor MK2206 Prevents Influenza pH1N1 Virus Infection In Vitro

Denisova, O., Soderholm, S., Virtanen, S., von Schantz, C., Bychkov, D., Vashchinkina, E., Desloovere, J., Tynell, J., Ikonen, N., Theisen, L. L., Nyman, T. A., Matikainen, S., Kallioniemi, O., Julkunen, I., Muller, C. P., Saelens, X., Verkhusha, V. V. & Kainov, D. E., Jul 2014, In : Antimicrobial Agents and Chemotherapy. 58, 7, p. 3689-3696 8 p.

Research output: Contribution to journalArticleScientificpeer-review

A technique to increase protein yield in a rabbit reticulocyte lysate translation system

Anastasina, M., Terenin, I., Butcher, S. J. & Kainov, D. E., Jan 2014, In : BioTechniques. 56, 1, p. 36-39 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Full-genome sequences of influenza A(H1N1)pdm09 viruses isolated from Finnish patients during 2009 to 2013

Lakspere, T., Tynell, J., Kaloinen, M., Vanlede, M., Parsons, A., Ikonen, N., Kallio-Kokko, H., Kantele, A., Mattila, P., Almusa, H., Julkunen, I., Kainov, D. & Kakkola, L., Jan 2014, In : Genome Announcements. 2, 1, 2 p., e01004-13.

Research output: Contribution to journalArticleScientificpeer-review

Full-genome sequences of influenza H3N2 virus strains isolated from Finnish patients during 2012-2013 epidemic season

Lakspere, T., Kallio-Kokko, H., Kantele, A., Mattila, P., Almusa, H., Kainov, D. & Kakkola, L., 2014, In : Genome Announcements. 2, 2, 1 p., 00039-14.

Research output: Contribution to journalArticleScientificpeer-review

Genetic Instability of Influenza pH1N1 Viruses

Jalovaara, P., Bychkov, D., Ahtiainen, L., Kallio-Kokko, H., Valkonen, M., Kantele, A., Mattila, P., Almusa, H., Kallioniemi, O. & Kainov, D., 2014, In : Genome Announcements. 2, 5, 1 p., e00841-14.

Research output: Contribution to journalArticleScientificpeer-review

Influenza pH1N1 virus accumulated H275Y mutation neuraminidase during propagation in MDCK cells

Mishel, P., Bychkov, D., Kallio-Kokko, H., Valkonen, M., Kantele, A., Mattila, P. M., Almusa, H., Jalovaara, P. & Kainov, D., 2014, In : Genome Announcements. 2, 6, e01349-14.

Research output: Contribution to journalArticleScientificpeer-review

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2013

Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice

Kakkola, L., Denisova, O. V., Tynell, J., Viiliainen, J., Ysenbaert, T., Matos, R. C., Nagaraj, A., Öhman, T., Kuivanen, S., Paavilainen, H., Feng, L., Yadav, B., Julkunen, I., Vapalahti, O., Hukkanen, V., Stenman, J., Aittokallio, T., Verschuren, E. W., Ojala, P. M., Nyman, T. & 3 othersSaelens, X., Dzeyk, K. & Kainov, D. E., Jul 2013, In : Cell Death and Disease. 4, Article Number: e742, 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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Inhibition of Influenza A Virus Infection in Vitro by Saliphenylhalamide-Loaded Porous Silicon Nanoparticles

Bimbo, L. M., Denisova, O. V., Mäkilä, E., Kaasalainen, M., De Brabander, J. K., Hirvonen, J., Salonen, J., Kakkola, L., Kainov, D. & Santos, H. A., Aug 2013, In : ACS Nano. 7, 8, p. 6884-6893 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Molecular evolution and epidemiology of echovirus 6 in Finland

Smura, T., Kakkola, L., Blomqvist, S., Klemola, P., Parsons, A., Kallio-Kokko, H., Savolainen-Kopra, C., Kainov, D. E. & Roivainen, M., Jun 2013, In : Infection, genetics and evolution. 16, p. 234-247 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Tracking in atomic detail the functional specializations in viral RecA helicases that occur during evolution

El Omar, K., Meier, C., Kainov, D., Sutton, G., Grimes, J., Poranen, M., Bamford, D., Tuma, R., Stuart, D. & Mancini, E., 2013, In : Nucleic Acids Research. 41, 20, p. 9396-9410 15 p.

Research output: Contribution to journalArticleScientificpeer-review

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2012

Obatoclax, Saliphenylhalamide, and Gemcitabine Inhibit Influenza A Virus Infection

Denisova, O. V., Kakkola, L., Feng, L., Stenman, J., Nagaraj, A., Lampe, J., Yadav, B., Aittokallio, T., Kaukinen, P., Ahola, T., Kuivanen, S., Vapalahti, O., Kantele, A., Tynell, J., Julkunen, I., Kallio-Kokko, H., Paavilainen, H., Hukkanen, V., Elliott, R. M., De Brabander, J. K. & 2 othersSaelens, X. & Kainov, D. E., 12 Oct 2012, In : Journal of Biological Chemistry. 287, 42, p. 35324-35332 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Technique for strand-specific gene-expression analysis and monitoring of primer-independent cDNA synthesis in reverse transcription

Feng, L., Lintula, S., Ho, T. H., Anastasina, M., Paju, A., Haglund, C., Stenman, U. H., Hotakainen, K., Orpana, A., Kainov, D. & Stenman, J., 2012, In : BioTechniques. 52, 4, p. 263-270 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Differential Effects of NS1 Proteins of Human Pandemic H1N1/2009, Avian Highly Pathogenic H5N1, and Low Pathogenic H5N2 Influenza A Viruses on Cellular Pre-mRNA Polyadenylation and mRNA Translation

Kainov, D. E., Mueller, K. H., Theisen, L. L., Anastasina, M., Kaloinen, M. & Muller, C. P., 2011, In : Journal of Biological Chemistry. 286, 9, p. 7239-7247 9 p.

Research output: Contribution to journalArticleScientificpeer-review

The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections

Mueller, K., Kainov, D., El Bakkouri, K., Saelens, X., De Brabander, JK., Kittel, C., Samm, E. & Muller, C., Sep 2011, In : British Journal of Pharmacology. 164, 2, p. 344-57 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Interacting partners of the Tfb2 subunit from yeast TFIIH

Kainov, D. E., Selth, L. A., Svejstrup, J. Q., Egly, J-M. & Poterzsman, A., 2010, In : DNA Repair. 9, p. 33-39 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Structure determination of the minimal complex between Tfb5 and Tfb2, two subunits of the yeast transcription/DNA-repair factor TFIIH: a retrospective study

Kainov, D. E., Cura, V., Vitorino, M., Nierengarten, H., Poussin, P., Kieffer, B., Cavarelli, J. & Poterszman, A., 2010, In : Acta Crystallographica. Section D: Biological Crystallography. 66, p. 745-755 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Structural basis for group A trichothiodystrophy

Kainov, D. E., Vitorino, M., Cavarelli, J., Poterszman, A. & Egly, J-M., 2008, In : Nature Structural and Molecular Biology. 15, p. 980-984 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Structural basis of mechanochemical coupling in a hexameric molecular motor

Kainov, D. E., Mancini, E. J., Telenius, J., Lisal, J., Grimes, J. M., Bamford, D. H., Stuart, D. I. & Tuma, R., 2008, In : Journal of Biological Chemistry. 283, 6, p. 3607- 3617 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

Stochastic detection of motor protein-RNA complexes by single-channel current recording

Astier, Y., Kainov, D. E., Bayley, H., Tuma, R. & Howorka, S., 2007, In : ChemPhysChem. 8, p. 2189-2194 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Interaction of packaging motor with the polymerase complex of dsRNA bacteriophage

Lisal, J., Kainov, D. E., Lam, T. T., Emmett, M. R., Wei, H., Gottlieb, P., Marshall, A. G. & Tuma, R., 2006, In : Virology. 351, p. 73-79 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

Functional visualization of viral molecular motor by hydrogen-deuterium exchange reveals transient states

Lisal, J., Lam, T. T., Kainov, D. E., Emmett, M. R., Marshall, A. G. & Tuma, R., 2005, In : Nature Structural and Molecular Biology. 12, p. 460-466 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2004

Atomic snapshots of an RNA packaging motor reveal conformational changes linking ATP hydrolysis to RNA translocation

Mancini, E. J., Kainov, D. E., Grimes, J. M., Tuma, R., Bamford, D. H. & Stuart, D. I., 2004, In : Cell. 118, p. 743-755 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Crystallization and preliminary X-ray diffraction analysis of bacteriophage phi 12 packaging factor P7

Kainov, D. E., Simonov, V., Bamford, D. H., Tuma, R., Gottlieb, P., Wei, H., Walsh, M. A., Belrhali, H. & Merckel, M. C., 2004, In : Acta Crystallographica. Section D: Biological Crystallography. 60, p. 2368-2370 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Enzymatic mechanism of RNA translocation in double-stranded RNA Bacteriophages

Lisal, J., Kainov, D. E., Bamford, D. H., Thomas, G. J. & Tuma, R., 2004, In : Journal of Biological Chemistry. 279, p. 1343-1350 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Packaging motor from double-stranded RNA bacteriophage phi 12 acts as an obligatory passive conduit during transcription

Kainov, D. E., Lisal, J., Bamford, D. H. & Tuma, R., 2004, In : Nucleic Acids Research. 32, p. 3515-3521 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Production, crystallization and preliminary X-ray crystallographic studies of the bacteriophage phi 12 packaging motor

Mancini, E. J., Kainov, D. E., Wei, H., Gottlieb, P., Tuma, R., Bamford, D. H., Stuart, D. I. & Grimes, J. M., 2004, In : Acta Crystallographica. Section D: Biological Crystallography. 60, p. 588-590 3 p.

Research output: Contribution to journalArticleScientificpeer-review

2003

Conserved intermediates on the assembly pathway of double-stranded RNA bacteriophages

Kainov, D. E., Butcher, S. J., Bamford, D. H. & Tuma, R., 2003, In : Journal of Molecular Biology. 328, p. 791-804 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Locating the minor components of double-stranded RNA bacteriophage phi 6 by neutron scattering

Ikonen, T., Kainov, D., Timmins, P., Serimaa, R. & Tuma, R., 2003, In : Journal of Applied Crystallography. 36, p. 525-529 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Order and disorder in crystals of hexameric NTPases from dsRNA bacteriophages

Mancini, E. J., Grimes, J. M., Malby, R., Sutton, G. C., Kainov, D. E., Juuti, J. T., Makeyev, E. V., Tuma, R., Bamford, D. H. & Stuart, D. I., 2003, In : Acta Crystallographica. Section D: Biological Crystallography. 59, p. 2337-2341 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Regulatory C protein of the EcoRV modification-restriction system

Kainov, D., Zheleznaya, L. A., Kainov, D. E., Yunusova, A. K. & Matvienko, N. I., 2003, In : Biochemistry (Moscow). 68, p. 105-110 6 p.

Research output: Contribution to journalArticleScientificpeer-review

RNA packaging device of double-stranded RNA bacteriophages, possibly as simple as hexamer of P4 protein

Kainov, D. E., Pirttimaa, M., Tuma, R., Butcher, S. J., Thomas, G. J., Bamford, D. H. & Makeyev, E. V., 2003, In : Journal of Biological Chemistry. 278, 48, p. 48084-48091 8 p.

Research output: Contribution to journalArticleScientificpeer-review