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Publications 2013 2019

2019

Concise Review: Human Pluripotent Stem Cells for the Modeling of Pancreatic beta-Cell Pathology

Balboa, D., Saarimaki-Vire, J. & Otonkoski, T., Jan 2019, In : Stem Cells. 37, 1, p. 33-41 9 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

Haikala, H. M., Anttila, J. M., Marques, E., Raatikainen, T., Ilander, M., Hakanen, H., Ala-Hongisto, H., Savelius, M., Balboa, D., Von Eyss, B., Eskelinen, V., Munne, P., Nieminen, A. I., Otonkoski, T., Schüler, J., Laajala, T. D., Aittokallio, T., Sihto, H., Mattson, J., Heikkilä, P. & 7 othersLeidenius, M., Joensuu, H., Mustjoki, S., Kovanen, P., Eilers, M., Leverson, J. D. & Klefström, J., 6 Feb 2019, In : Nature Communications. 10, 17 p., 620.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

A complex genomic locus drives mtDNA replicase POLG expression to its disease-related nervous system regions

Nikkanen, J., Landoni, J. C., Balboa, D., Haugas, M., Partanen, J., Paetau, A., Isohanni, P., Brilhante, V. & Suomalainen, A., Jan 2018, In : EMBO molecular medicine. 10, 1, p. 13-21 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Human pluripotent reprogramming with CRISPR activators

Weltner, J., Balboa, D., Katayama, S., Bespalov, M., Krjutskov, K., Jouhilahti, E-M., Trokovic, R., Kere, J. & Otonkoski, T., 6 Jul 2018, In : Nature Communications. 9, 12 p., 2643.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Human pluripotent stem cells and CRISPR-Cas9 genome editing to model diabetes

Balboa Alonso, D., 2018, Helsinki: Helsingin yliopisto. 164 p.

Research output: ThesisDoctoral ThesisCollection of Articles

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

Balboa, D., Saarimäki-Vire, J., Borshagovski, D., Survila, M., Lindholm, P., Galli, E., Eurola, S., Ustinov, J., Grym, H., Huopio, H., Partanen, J., Wartiovaara, K. & Otonkoski, T., 9 Nov 2018, In : eLife. 7, 35 p., 38519.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Pancreatic beta-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

Cosentino, C., Toivonen, S., Villamil, E. D., Atta, M., Ravanat, J-L., Demine, S., Schiavo, A. A., Pachera, N., Deglasse, J-P., Jonas, J-C., Balboa, D., Otonkoski, T., Pearson, E. R., Marchetti, P., Eizirik, D. L., Cnop, M. & Igoillo-Esteve, M., 2 Nov 2018, In : Nucleic Acids Research. 46, 19, p. 10302-10318 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Redox regulation of GRPEL2 nucleotide exchange factor for mitochondrial HSP70 chaperone

Konovalova, S., Liu, X., Manjunath, P., Baral, S., Neupane, N., Hilander, T., Yang, Y., Balboa, D., Terzioglu, M., Euro, L., Varjosalo, M. & Tyynismaa, H., Oct 2018, In : Redox biology. 19, p. 37-45 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Transcription Factor PROX1 Suppresses Notch Pathway Activation via the Nucleosome Remodeling and Deacetylase Complex in Colorectal Cancer Stem-like Cells

Högström, J., Heino, S., Kallio, P., Lähde, M., Leppänen, V-M., Balboa, D., Wiener, Z. & Alitalo, K., 15 Oct 2018, In : Cancer Research. 78, 20, p. 5820-5832 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2017

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation

Saarimaki-Vire, J., Balboa, D., Russell, M. A., Saarikettu, J., Kinnunen, M., Keskitalo, S., Malhi, A., Valensisi, C., Andrus, C., Eurola, S., Grym, H., Ustinov, J., Wartiovaara, K., Hawkins, R. D., Silvennoinen, O., Varjosalo, M., Morgan, N. G. & Otonkoski, T., 11 Apr 2017, In : Cell Reports. 19, 2, p. 281-294 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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A Strong Contractile Actin Fence and Large Adhesions Direct Human Pluripotent Colony Morphology and Adhesion

Narva, E., Stubb, A., Guzman, C., Blomqvist, M., Balboa, D., Lerche, M., Saari, M., Otonkoski, T. & Ivaska, J., 11 Jul 2017, In : Stem cell reports. 9, 1, p. 67-76 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Generation of an OCT4 reporter human induced pluripotent stem cell line using CRISPR/SpCas9

Balboa, D., Weltner, J., Novik, Y., Eurola, S., Wartiovaara, K. & Otonkoski, T., Aug 2017, In : Stem Cell Research. 23, p. 105-108 4 p.

Research output: Contribution to journalArticleScientific

Open Access
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Generation of a SOX2 reporter human induced pluripotent stem cell line using CRISPR/SaCas9

Balboa, D., Weltner, J., Novik, Y., Eurola, S., Wartiovaara, K. & Otonkoski, T., Jul 2017, In : Stem Cell Research. 22, p. 16-19 4 p.

Research output: Contribution to journalArticleScientific

Open Access
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p73 is required for appropriate BMP-induced mesenchymal-to-epithelial transition during somatic cell reprogramming

Martin-Lopez, M., Maeso-Alonso, L., Fuertes-Alvarez, S., Balboa, D., Rodriguez-Cortez, V., Weltner, J., Diez-Prieto, I., Davis, A., Wu, Y., Otonkoski, T., Flores, E. R., Menendez, P., Marques, M. M. & Marin, M. C., Sep 2017, In : Cell Death and Disease. 8, 13 p., 3034.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Activating STAT3 mutation leads to pancreatic hypoplasia through premature differentiation

Saarimaki-Vire, J., Balboa, D., Russell, M., Morgan, N., Eurola, S., Grym, H., Ustinov, J., Valensisi, C., Andrus, C., Saarikettu, J., Silvennoinen, O., Hawkins, D., Varjosalo, M. & Otonkoski, T., Nov 2016, In : Human Gene Therapy. 27, 11, p. A142-A142 1 p.

Research output: Contribution to journalArticleScientificpeer-review

CRISPR/Cas9-mediated transcriptional activation for maturation of human stem cell derived beta cells

Balboa, D., Saarimaki-Vire, J., Eurola, S., Weltner, J., Grym, H., Ustinov, J. & Otonkoski, T., Nov 2016, In : Human Gene Therapy. 27, 11, p. A142-A142 1 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation

Balboa, D., Weltner, J., Eurola, S., Trokovic, R., Wartiovaara, K. & Otonkoski, T., 8 Sep 2015, In : Stem cell reports. 5, 3, p. 448-459 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Human pluripotent stem cell based islet models for diabetes research

Balboa, D. & Otonkoski, T. P. J., 2015, In : Best Practice & Research. Clinical Endocrinology & Metabolism. 29, 6, p. 899-909 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Intestinal Commitment and Maturation of Human Pluripotent Stem Cells Is Independent of Exogenous FGF4 and R-spondin1

Tamminen, K., Balboa Alonso, D., Toivonen, S., Pakarinen, M. P., Wiener, Z., Alitalo, K. & Otonkoski, T., 31 Jul 2015, In : PLoS One. 10, 7, 19 p., 0134551.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Selective MicroRNA-Offset RNA Expression in Human Embryonic Stem Cells

Asikainen, S., Heikkinen, L., Juhila, J. J., Holm, F., Weltner, J., Trokovic, R., Mikkola, M., Toivonen, S., Balboa, D., Lampela, R., Icay, K., Tuuri, T., Otonkoski, T., Wong, G. & Hovatta, O., 30 Mar 2015, In : PLoS One. 10, 3, 25 p., 0116668.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2013

Activin A and Wnt-dependent specification of human definitive endoderm cells

Toivonen, S., Lundin, K., Balboa, D., Ustinov, J., Tamminen, K., Palgi, J., Trokovic, R., Tuuri, T. & Otonkoski, T., 15 Oct 2013, In : Experimental Cell Research. 319, 17, p. 2535-2544 10 p.

Research output: Contribution to journalArticleScientificpeer-review