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Publications 1983 2019

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2019

Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors

Diniz, C. R. A. F., Biojone, C., Joca, S. R. L., Rantamäki, T., Castren, E., Guimaraes, F. S. & Casarotto, P. C., 21 Feb 2019, In : PeerJ. 7, 21 p., 6493.

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Neurotrophin receptor Ntrk2b function in the maintenance of dopamine and serotonin neurons in zebrafish

Sahu, M. P., Pazos-Boubeta, Y., Pajanoja, C., Rozov, S., Panula, P. & Castren, E., 14 Feb 2019, In : Scientific Reports. 9, 13 p., 2036.

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TrkB-ICD Fragment, Originating From BDNF Receptor Cleavage, Is Translocated to Cell Nucleus and Phosphorylates Nuclear and Axonal Proteins

Fonseca-Gomes, J., Jerónimo-Santos, A., Lesnikova, A., Casarotto, P., Castrén, E., Sebastião, A. M. & Diógenes, M. J., 1 Feb 2019, In : Frontiers in Molecular Neuroscience. 12

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2018

Antidepressant-like effect of losartan involves TRKB transactivation from angiotensin receptor type 2 (AGTR2) and recruitment of FYN

Diniz, C. R. A. F., Casarotto, P. C., Fred, S. M., Biojone, C., Castrén, E. & Joca, S. R. L., Jun 2018, In : Neuropharmacology. 135, p. 163-171 9 p.

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Automated analysis of images for molecular quantification in immunohistochemistry

Guirado, R., Carceller, H., Castillo-Gomez, E., Castren, E. & Nacher, J., Jun 2018, In : Heliyon. 4, 6, 16 p., 00669.

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Culturing primary neurons from rat hippocampus and cortex

Sahu, M. P., Nikkilä, O., Lågas, S. A., Kolehmainen, S. & Castrén, E., 13 Dec 2018, (Submitted) In : BioRxiv beta : the preprint server for biology.

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Effects of the Antidepressant Fluoxetine on the Somatostatin Interneurons in the Basolateral Amygdala

Carceller, H., Perez-Rando, M., Castren, E., Nacher, J. & Guirado, R., 21 Aug 2018, In : Neuroscience. 386, p. 205-213 9 p.

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Elastase-2 Knockout Mice Display Anxiogenic- and Antidepressant-Like Phenotype: Putative Role for BDNF Metabolism in Prefrontal Cortex

Diniz, C. R. A. F., Becari, C., Lesnikova, A., Biojone, C., Salgado, M. C. O., Salgado, H. C., Resstel, L. B. M., Guimaraes, F. S., Castren, E., Casarotto, P. C. & Joca, S. R. L., Aug 2018, In : Molecular Neurobiology. 55, 8, p. 7062-7071 10 p.

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Fluoxetine does not enhance the effect of perceptual learning on visual function in adults with amblyopia

Huttunen, H. J., Palva, J. M., Lindberg, L., Palva, S., Saarela, V., Karvonen, E., Latvala, M-L., Liinamaa, J., Booms, S., Castren, E. & Uusitalo, H., 27 Aug 2018, In : Scientific Reports. 8, 12 p., 12830.

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Inducible nitric oxide synthase (NOS2) knockout mice as a model of trichotillomania

Casarotto, P. C., Biojone, C., Montezuma, K., Cunha, F. Q., Joca, S. R. L., Castren, E. & Guimaraes, F. S., 17 Apr 2018, In : PeerJ. 6, p. e4635 13 p., 4635.

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Longitudinal two-photon imaging in somatosensory cortex of behaving mice reveals dendritic spine formation enhancement by subchronic administration of low-dose ketamine

Pryazhnikov, E., Mugantseva, E., Casarotto, P., Kolikova, J., Fred, S. M., Toptunov, D., Afzalov, R., Hotulainen, P., Voikar, V., Terry-Lorenzo, R., Engel, S., Kirov, S., Castren, E. & Khiroug, L., 24 Apr 2018, In : Scientific Reports. 8, 12 p., 6464.

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Social Learning Requires Plasticity Enhanced by Fluoxetine Through Prefrontal Bdnf-TrkB Signaling to Limit Aggression Induced by Post-Weaning Social Isolation

Mikics, E., Guirado, R., Umemori, J., Toth, M., Biro, L., Miskolczi, C., Balazsfi, D., Zelena, D., Castrén, E., Haller, J. & Karpova, N., Jan 2018, In : Neuropsychopharmacology. 43, 2, p. 235-245 11 p.

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2017

Chronic fluoxetine administration enhances synaptic plasticity and increases functional dynamics in hippocampal CA3-CA1 synapses

Popova, D., Castren, E. & Taira, T., Nov 2017, In : Neuropharmacology. 126, p. 250-256 7 p.

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Chronic imaging through "transparent skull" in mice

Steinzeig, A., Molotkov, D. & Castren, E., 16 Aug 2017, In : PLoS One. 12, 8, 16 p., 0181788.

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Depolarizing γ-aminobutyric acid contributes to glutamatergic network rewiring in epilepsy

Kourdougli, N., Pellegrino, C., Renko, J-M., Khirug, S., Chazal, G., Kukko-Lukjanov, T-K., Lauri, S. E., Gaiarsa, J-L., Zhou, L., Peret, A., Castrén, E., Tuominen, R. K., Crepel, V. & Rivera Baeza, C., Feb 2017, In : Annals of Neurology. 81, 2, p. 251-265 15 p.

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Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

Antila, H., Ryazantseva, M., Popova, D., Sipilä, P., Guirado, R., Kohtala, S., Yalcin, I., Lindholm, J., Vesa, L., Sato, V., Cordeira, J., Autio, H., Kislin, M., Rios, M., Joca, S., Casarotto, P., Khiroug, L., Lauri, S., Taira, T., Castren, E. & 1 othersRantamäki, T., 10 Aug 2017, In : Scientific Reports. 7, 12 p., 7811.

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Ovatko aivosairaudet tartuntatauteja?

Castrén, E., 2017, In : Duodecim. 133, 16, p. 1514 1 p.

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2016

Actin Tyrosine-53-Phosphorylation in Neuronal Maturation and Synaptic Plasticity

Bertling, E., Englund, J., Minkeviciene, R., Koskinen, M., Segerstrale, M., Castrén, E., Taira, T. & Hotulainen, P., 11 May 2016, In : Journal of Neuroscience. 36, 19, p. 5299-5313 15 p.

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Ciliary dyslexia candidate genes DYX1C1 and DCDC2 are regulated by Regulatory Factor X (RFX) transcription factors through X-box promoter motifs

Tammimies, K., Bieder, A., Lauter, G., Sugiaman-Trapman, D., Torchet, R., Hokkanen, M-E., Burghoorn, J., Castrén, E., Kere, J., Tapia-Paez, I. & Swoboda, P., Oct 2016, In : FASEB Journal. 30, 10, p. 3578-3587 10 p.

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Effects of PSA Removal from NCAM on the Critical Period Plasticity Triggered by the Antidepressant Fluoxetine in the Visual Cortex

Guirado, R., La Terra, D., Bourguignon, M., Carceller, H., Umemori, J., Sipilä, P., Nacher, J. & Castren, E., 5 Feb 2016, In : Frontiers in Cellular Neuroscience. 10, 9 p., 22.

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Evidence for competition for target innervation in the medial prefrontal cortex

Guirado, R., Umemori, J., Sipilä, P. & Castrén, E., 2016, In : Cerebral Cortex. 26, 3, p. 1287-1294 8 p.

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Neurochemical Phenotype of Reelin Immunoreactive Cells in the Piriform Cortex Layer II

Carceller, H., Rovira-Esteban, L., Nacher, J., Castrén, E. & Guirado, R., 10 Mar 2016, In : Frontiers in Cellular Neuroscience. 10, 11 p., 65.

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Dysregulation of TrkB Receptors and BDNF Function by Amyloid-beta Peptide is Mediated by Calpain

Jeronimo-Santos, A., Vaz, S. H., Parreira, S., Rapaz-Lerias, S., Caetano, A. P., Buee-Scherrer, V., Castren, E., Valente, C. A., Blum, D., Sebastiao, A. M. & Diogenes, M. J., Sep 2015, In : Cerebral Cortex. 25, 9, p. 3107-3121 15 p.

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GDNF is not required for catecholaminergic neuron survival in vivo

Kopra, J., Vilenius, C., Grealish, S., Härma, M-A., Varendi, K., Lindholm, J., Castrén, E., Voikar, V., Björklund, A., Piepponen, T. P., Saarma, M. & Andressoo, J-O., Mar 2015, In : Nature Neuroscience. 18, 3, p. 319-322 4 p.

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Interplay Between Nitric Oxide and Brain-Derived Neurotrophic Factor in Neuronal Plasticity

Biojone, C., Casarotto, P. C., Joca, S. R. & Castren, E., 2015, In : C N S & Neurological Disorders. 14, 8, p. 979-987 9 p.

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NCAM-deficient mice show prominent abnormalities in serotonergic and BDNF systems in brain - Restoration by chronic amitriptyline

Aonurm-Helm, A., Anier, K., Zharkovsky, T., Castren, E., Rantamäki, T., Stepanov, V., Jaerv, J. & Zharkovsky, A., Dec 2015, In : European Neuropsychopharmacology. 25, 12, p. 2394-2403 10 p.

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Slitrk5 Mediates BDNF-Dependent TrkB Receptor Trafficking and Signaling

Song, M., Giza, J., Proenca, C. C., Jing, D., Elliott, M., Dincheva, I., Shmelkov, S. V., Kim, J., Schreiner, R., Huang, S-H., Castren, E., Prekeris, R., Hempstead, B. L., Chao, M. V., Dictenberg, J. B., Rafii, S., Chen, Z-Y., Rodriguez-Boulan, E. & Lee, F. S., 22 Jun 2015, In : Developmental Cell. 33, 6, p. 690-702 13 p.

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The Impact of Aerobic Exercise on Brain-Derived Neurotrophic Factor and Neurocognition in Individuals With Schizophrenia: A Single-Blind, Randomized Clinical Trial

Kimhy, D., Vakhrusheva, J., Bartels, M. N., Armstrong, H. F., Ballon, J. S., Khan, S., Chang, R. W., Hansen, M. C., Ayanruoh, L., Lister, A., Castren, E., Smith, E. E. & Sloan, R. P., Jul 2015, In : Schizophrenia bulletin. 41, 4, p. 859-868 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Chronic fluoxetine treatment alters the structure, connectivity and plasticity of cortical interneurons

Guirado, R., Perez-Rando, M., Sanchez-Matarredona, D., Castren, E. & Nacher, J., 2014, In : International Journal of Neuropsychopharmacology. 17, 10, p. 1635-1646 12 p.

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Combination of fluoxetine and extinction treatments forms a unique synaptic protein profile that correlates with long-term fear reduction in adult mice

Popova, D., Agustsdottir, A., Lindholm, J., Mazulis, W., Akamine, Y., Castren, E. & Karpova, N. N., Jul 2014, In : European Neuropsychopharmacology. 24, 7, p. 1162-1174 13 p.

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Neurotrophins and psychiatric disorders

Castrén, E., 2014, In : Handbook of Experimental Pharmacology. 220, p. 461-79 19 p.

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TrkB overexpression in mice buffers against memory deficits and depression-like behavior but not all anxiety- and stress-related symptoms induced by developmental exposure to methylmercury

Karpova, N. N., Lindholm, J. S. O., Kulesskaya, N., Onishchenko, N., Vahter, M., Popova, D., Ceccatelli, S. & Castren, E., 12 Sep 2014, In : Frontiers in Behavioral Neuroscience. 8, 12 p., 315.

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Utilization of in situ ELISA method for examining Trk receptor phosphorylation in cultured cells

Antila, H., Autio, H., Turunen, L., Harju, K., Tammela, P., Wennerberg, K., Yli-Kauhaluoma, J., Huttunen, H. J., Castren, E. & Rantamaki, T., 30 Jan 2014, In : Journal of Neuroscience Methods. 222, p. 142-146 5 p.

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2013

Gene Expression Patterns Underlying the Reinstatement of Plasticity in the Adult Visual System

Tiraboschi, E., Guirado, R., Greco, D., Auvinen, P., Fernando Maya-Vetencourt, J., Maffei, L. & Castren, E., 2013, In : Neural Plasticity. 2013, 8 p., 605079.

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Lahkus närvikasvufaktori avastaja Rita Levi-Montalcini

Saarma, M. & Castrén, E., 2013, In : Sirp : Eesti kultuurleht.

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Rita levi-Montalcini 1909-2012. Hermostotutkimus toi Nobelin palkinnon

Castrén, E. & Saarma, M., 2013, In : Helsingin Sanomat.

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The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer's Disease

Rantamäki, T., Kemppainen, S., Autio, H., Staven, S., Koivisto, H., Kojima, M., Antila, H., Miettinen, P. O., Kärkkäinen, E., Karpova, N., Vesa, L., Lindemann, L., Hoener, M. C., Tanila, H. & Castren, E., 3 Jul 2013, In : PLoS One. 8, 7, 14 p., e68722.

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2012

Brain-derived neurotrophic factor expression after acute administration of ethanol

Raivio, N., Tiraboschi, E., Saarikoski, S. T., Castrén, E. & Kiianmaa, K., 2012, In : European Journal of Pharmacology. 687, 1-3, p. 9-13 5 p.

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Experience-dependent expression of NPAS4 regulates plasticity in adult visual cortex

Maya-Vetencourt, J. F., Tiraboschi, E., Greco, D., Restani, L., Cerri, C., Auvinen, P., Maffei, L. & Castrén, E., Oct 2012, In : Journal of Physiology. 590, 19, p. 4777-4787 11 p.

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IGF-1 Restores Visual Cortex Plasticity in Adult Life by Reducing Local GABA Levels

Maya-Vetencourt, J. F., Baroncelli, L., Viegi, A., Tiraboschi, E., Castren, E., Cattaneo, A. & Maffei, L., 2012, In : Neural Plasticity. p. Article Number: 250421 10 p.

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Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice

Kemppainen, S., Rantamäki, T., Jeronimo-Santos, A., Lavasseur, G., Autio, H., Karpova, N., Kärkkäinen, E., Staven, S., Miranda, H. V., Outeiro, T. F., Diogenes, M. J., Laroche, S., Davis, S., Sebastiao, A. M., Castrén, E. & Tanila, H., Jun 2012, In : Neurobiology of Aging. 33, 6, p. 1122.e23–1122.e39 17 p.

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Loop-diureetti voi edistää vaurioituneiden hermosolujen selviytymistä

Shulga, A., Magalhaes, A. C., Autio, H., Plantman, S., Di Lieto, A., Nykjaer, A., Carlstedt, T., Risling, M., Arumäe, U., Castrén, E. & Rivera Baeza, C., 2012, In : Duodecim. 128, 6, p. 602 1 p.

Research output: Contribution to journalArticleProfessional

Mapping of the Interaction Site between Sortilin and the p75 Neurotrophin Receptor Reveals a Regulatory Role for the Sortilin Intracellular Domain in p75 Neurotrophin Receptor Shedding and Apoptosis

Skeldal, S., Sykes, A. M., Glerup, S., Matusica, D., Palstra, N., Autio, H., Boskovic, Z., Madsen, P., Castren, E., Nykjaer, A. & Coulson, E. J., 2012, In : Journal of Biological Chemistry. 287, 52, p. 43798-43809 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Mielipide: Parantuuko masennus vain lääkehoidolla?

Rantamäki, T. & Castrén, E., 15 Apr 2012, In : Helsingin Sanomat.

Research output: Contribution to journalArticleGeneral public

Neuroscience Center of the University of Helsinki

Rauvala, H. & Castrén, E., 2012, In : FENS Trimestrial Newsletter .

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Reduction of BDNF expression in Fmr1 knockout mice worsens cognitive deficits but improves hyperactivity and sensorimotor deficits

Uutela, M., Lindholm, J., Louhivuori, V., Wei, H., Louhivuori, L. M., Pertovaara, A., Åkerman, K., Castrén, E. & Castrén, M., 2012, In : Genes, Brain and Behavior. 11, 5, p. 513-523 11 p.

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Sleep homeostasis and depression: Studies with the rat clomipramine model of depression

Savelyev, S. A., Rantamäki, T., Rytkönen, K-M., Castren, E. & Porkka-Heiskanen, T., 2012, In : Neuroscience. 212, p. 149-158 10 p.

Research output: Contribution to journalArticleScientificpeer-review

The antidepressant-like effects of glutamatergic drugs ketamine and AMPA receptor potentiator LY 451646 are preserved in bdnf(+/-) heterozygous null mice.

Lindholm, J., Autio, H., Vesa, L. K., Antila, H., Lindemann, L., Hoener, M., Skolnick, P., Rantamäki, T. & Castrén, E., 2012, In : Neuropharmacology. 62, 1, p. 391-397 7 p.

Research output: Contribution to journalArticleScientificpeer-review