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Publications 2014 2019

2019

Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions

Forsström, S., Jackson, C. B., Carroll, C. J., Kuronen, M., Pirinen, E., Pradhan, S., Marmyleva, A., Auranen, M., Kleine, I-M., Khan, N. A., Roivainen, A., Marjamäki, P., Liljenbäck, H., Wang, L., Battersby, B. J., Richter, U., Velagapudi, V., Nikkanen, J., Euro, L. & Suomalainen, A., 3 Dec 2019, In : Cell Metabolism. 30, 6, p. 1040-+ 22 p.

Research output: Contribution to journalArticleScientificpeer-review

Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolaemic mice

Ruotsalainen, A-K., Lappalainen, J. P., Heiskanen, E., Merentie, M., Sihvola, V., Näpänkangas, J., Lottonen-Raikaslehto, L., Kansanen, E., Adinolfi, S., Kaarniranta, K., Ylä-Herttuala, S., Jauhiainen, M., Pirinen, E. & Levonen, A-L., 1 Jan 2019, In : Cardiovascular Research. 115, 1, p. 243-254 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

Vannini, N., Campos, V., Girotra, M., Trachsel, V., Rojas-Sutterlin, S., Tratwal, J., Ragusa, S., Stefanidis, E., Ryu, D., Rainer, P. Y., Nikitin, G., Giger, S., Li, T. Y., Semilietof, A., Oggier, A., Yersin, Y., Tauzin, L., Pirinen, E., Cheng, W-C., Ratajczak, J. & 16 others, Canto, C., Ehrbar, M., Sizzano, F., Petrova, T. V., Vanhecke, D., Zhang, L., Romero, P., Nahimana, A., Cherix, S., Duchosal, M. A., Ho, P-C., Deplancke, B., Coukos, G., Auwerx, J., Lutolf, M. P. & Naveiras, O., 7 Mar 2019, In : Cell Stem Cell. 24, 3, p. 405-+ 21 p.

Research output: Contribution to journalArticleScientificpeer-review

2018

Adipose tissue mitochondrial capacity associates with long-term weight loss success

Jokinen, R., Rinnankoski-Tuikka, R., Kaye, S., Saarinen, L., Heinonen, S., Myöhänen, M., Rappou, E., Jukarainen, S., Rissanen, A., Pessia, A., Velagapudi, V., Virtanen, K. A., Pirinen, E. & Pietiläinen, K. H., Apr 2018, In : International Journal of Obesity. 42, 4, p. 817-825 9 p.

Research output: Contribution to journalArticleScientificpeer-review

NAD(+) repletion produces no therapeutic effect in mice with respiratory chain complex III deficiency and chronic energy deprivation

Purhonen, J., Rajendran, J., Tegelberg, S., Smolander, O-P., Pirinen, E., Kallijärvi, J. & Fellman, V., Nov 2018, In : FASEB Journal. 32, 11, p. 5913-5926 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2017

Adipose tissue NAD(+)-homeostasis, sirtuins and poly(ADP-ribose) polymerases - important players in mitochondrial metabolism and metabolic health

Jokinen, R., Pirnes-Karhu, S., Pietilainen, K. H. & Pirinen, E., Aug 2017, In : Redox biology. 12, p. 246-263 18 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function

Item, F., Wueest, S., Lemos, V., Stein, S., Lucchini, F. C., Denzler, R., Fisser, M. C., Challa, T. D., Pirinen, E., Kim, Y., Hemmi, S., Gulbins, E., Gross, A., O'Reilly, L. A., Stoffel, M., Auwerx, J. & Konrad, D., 7 Sep 2017, In : Nature Communications. 8, 10 p., 480.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Obesity Is Associated With Low NAD(+)/SIRT Pathway Expression in Adipose Tissue of BMI-Discordant Monozygotic Twins

Jukarainen, S., Heinonen, S., Ramo, J. T., Rinnankoski-Tuikka, R., Rappou, E., Tummers, M., Muniandy, M., Hakkarainen, A., Lundbom, J., Lundbom, N., Kaprio, J., Rissanen, A., Pirinen, E. & Pietilainen, K. H., Jan 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 1, p. 275-283 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Weight Loss Is Associated With Increased NAD(+)/SIRT1 Expression But Reduced PARP Activity in White Adipose Tissue

Rappou, E., Jukarainen, S., Rinnankoski-Tuikka, R., Kaye, S. M., Heinonen, S., Hakkarainen, A., Lundbom, J., Lundbom, N., Saunavaara, V., Rissanen, A., Virtanen, K. A., Pirinen, E. & Pietilainen, K. H., Mar 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 3, p. 1263-1273 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2015

ARTD1-induced poly-ADP-ribose formation enhances PPAR gamma ligand binding and co-factor exchange

Lehmann, M., Pirinen, E., Mirsaidi, A., Kunze, F. A., Richards, P. J., Auwerx, J. & Hottiger, M. O., Jan 2015, In : Nucleic Acids Research. 43, 1, p. 129-142 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Evidence for a Direct Effect of the NAD(+) Precursor Acipimox on Muscle Mitochondrial Function in Humans

van de Weijer, T., Phielix, E., Bilet, L., Williams, E. G., Ropelle, E. R., Bierwagen, A., Livingstone, R., Nowotny, P., Sparks, L. M., Paglialunga, S., Szendroedi, J., Havekes, B., Moullan, N., Pirinen, E., Hwang, J-H., Schrauwen-Hinderling, V. B., Hesselink, M. K. C., Auwerx, J., Roden, M. & Schrauwen, P., Apr 2015, In : Diabetes. 64, 4, p. 1193-1201 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

Khan, N. A., Auranen, M., Paetau, I., Pirinen, E., Euro, L., Forsström, S., Pasila, L., Velagapudi, V., Carroll, C. J., Auwerx, J. & Suomalainen, A., Jun 2014, In : EMBO molecular medicine. 6, 6, p. 721-731 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Lack of cardiac and high-fat diet induced metabolic phenotypes in two independent strains of Vegf-b knockout mice

Dijkstra, M. H., Pirinen, E., Huusko, J., Kivelä, R., Schenkwein, D., Alitalo, K. & Yla-Herttuala, S., 29 Aug 2014, In : Scientific Reports. 4, 7 p., 6238.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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NAD+-dependent SIRT1 activation of the mitochondriogenic program corrects the phenotype in a mouse model of COX deficiency

Cerutti, R., Pirinen, E. R. T., Lamperti, C., Marchet, S., Sauve, A. A., Li, W., Leoni, V., Schon, E. A., Dantzer, F., Auwerx, J., Viscomi, C. & Zeviani, M., 2014, In : Cell Metabolism. 19, 6, p. 1042-1049 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

Kraus, D., Yang, Q., Kong, D., Banks, A. S., Zhang, L., Rodgers, J. T., Pirinen, E., Pulinilkunnil, T. C., Gong, F., Wang, Y., Cen, Y., Sauve, A. A., Asara, J. M., Peroni, O. D., Monia, B. P., Bhanot, S., Alhonen, L., Puigserver, P. & Kahn, B. B., 10 Apr 2014, In : Nature. 508, 7495, p. 258-+ 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle

Pirinen, E., Canto, C., Jo, Y. S., Morato, L., Zhang, H., Menzies, K. J., Williams, E. G., Mouchiroud, L., Moullan, N., Hagberg, C., Li, W., Timmers, S., Imhof, R., Verbeek, J., Pujol, A., van Loon, B., Viscomi, C., Zeviani, M., Schrauwen, P., Sauve, A. A. & 2 others, Schoonjans, K. & Auwerx, J., 3 Jun 2014, In : Cell Metabolism. 19, 6, p. 1034-1041 8 p.

Research output: Contribution to journalArticleScientificpeer-review