Photo of Elina Ikonen
  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

  • PL 63 (Haartmaninkatu 8), B112B

    HELSINGIN YLIOPISTO

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

1991 …2019
If you made any changes in Pure these will be visible here soon.

Publications 1991 2019

2019

HSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo

Gungör, B., Vanharanta, L., Hölttä-Vuori, M., Pirhonen, J., Petersen, N. H. T., Gramolelli, S., Ojala, P. M., Kirkegaard, T. & Ikonen, E., 6 Jul 2019, In : Molecular metabolism.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases

Yambire, K. F., Fernandez-Mosquera, L., Steinfeld, R., Muehle, C., Ikonen, E., Milosevic, I. & Raimundo, N., 18 Feb 2019, In : eLife. 8, 29 p., 39598.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Moving out but keeping in touch: contacts between endoplasmic reticulum and lipid droplets

Salo, V. T. & Ikonen, E., Apr 2019, In : Current Opinion in Cell Biology. 57, p. 64-70 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File

ORP2 interacts with phosphoinositides and controls the subcellular distribution of cholesterol

Koponen, A., Arora, A., Takahashi, K., Kentala, H., Kivela, A. M., Jaaskelainen, E., Peranen, J., Somerharju, P., Ikonen, E., Viitala, T. & Olkkonen, V. M., Mar 2019, In : Biochimie. 158, p. 90-101 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2018

A Ceramide-Regulated Element in the Late Endosomal Protein LAPTM4B Controls Amino Acid Transporter Interaction

Zhou, K., Dichlberger, A., Martinez-Seara, H., Nyholm, T. K. M., Li, S., Kim, Y. A., Vattulainen, I., Ikonen, E. & Blom, T., 23 May 2018, In : ACS central science. 4, 5, p. 548-558 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Association of tamoxifen resistance and lipid reprogramming in breast cancer

Hultsch, S., Kankainen, M., Paavolainen, L., Kovanen, R-M., Ikonen, E., Kangaspeska, S., Pietiäinen, V. & Kallioniemi, O., 24 Aug 2018, In : BMC Cancer. 18, 14 p., 850.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells

Sandhu, J., Li, S., Fairall, L., Pfisterer, S. G., Gurnett, J. E., Xiao, X., Weston, T. A., Vashi, D., Ferrari, A., Orozco, J. L., Hartman, C. L., Strugatsky, D., Lee, S. D., He, C., Hong, C., Jiang, H., Bentolila, L. A., Gatta, A. T., Levine, T. P., Ferng, A. & 6 othersLee, R., Ford, D. A., Young, S. G., Ikonen, E., Schwabe, J. W. R. & Tontonoz, P., 4 Oct 2018, In : Cell. 175, 2, p. 514-+ 36 p.

Research output: Contribution to journalArticleScientificpeer-review

Mechanisms of cellular cholesterol compartmentalization: recent insights

Ikonen, E., Aug 2018, In : Current Opinion in Cell Biology. 53, p. 77-83 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File

OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism

Kentala, H., Koponen, A., Vihinen, H., Pirhonen, J., Liebisch, G., Pataj, Z., Kivelä, A., Li, S., Karhinen, L., Jääskeläinen, E., Andrews, R., Meriläinen, L., Matysik, S., Ikonen, E., Zhou, Y., Jokitalo, E. & Olkkonen, V. M., Nov 2018, In : Cellular and Molecular Life Sciences. 75, 21, p. 4041-4057 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2017

Concerted regulation of NPC2 binding to endosomal/lysosomal membranes by bis(monoacylglycero)phosphate and sphingomyelin

Enkavi, G., Mikkolainen, H., Gungor, B., Ikonen, E. & Vattulainen, I., Oct 2017, In : PLoS Computational Biology. 13, 10, 21 p., 1005831.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

How does membrane composition modulate cholesterol carrier protein NPC2?

Enkavi, G., Mikkolainen, H., Güngör, B., Ikonen, E. M. & Vattulainen, I. T., 16 Jul 2017.

Research output: Conference materialsPosterResearch

Introducing inducible fluorescent split cholesterol oxidase to mammalian cells

Chernov, K. G., Neuvonen, M., Brock, I., Ikonen, E. & Verkhusha, V. V., 26 May 2017, In : Journal of Biological Chemistry. 292, 21, p. 8811-8822 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Plant sterols, cholesterol precursors and oxysterols: Minute concentrations-Major physiological effects

Olkkonen, V., Gylling, H. & Ikonen, E., May 2017, In : Journal of Steroid Biochemistry and Molecular Biology. 169, p. 4-9 6 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File
Open Access
File

Severe neurodegenerative disease in brothers with homozygous mutation in POLR1A

Kara, B., Koroglu, C., Peltonen, K., Steinberg, R. C., Genc, H. M., Holtta-Vuori, M., Guven, A., Kanerva, K., Kotil, T., Solakoglu, S., Zhou, Y., Olkkonen, V. M., Ikonen, E., Laiho, M. & Tolun, A., Feb 2017, In : European Journal of Human Genetics. 25, 3, p. 315-323 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Sphingolipid metabolic flow controls phosphoinositide turnover at the trans-Golgi network

Capasso, S., Sticco, L., Rizzo, R., Pirozzi, M., Russo, D., Dathan, N. A., Campelo, F., van Galen, J., Hölttä-Vuori, M., Turacchio, G., Hausser, A., Malhotra, V., Riezman, I., Riezman, H., Ikonen, E., Luberto, C., Parashuraman, S., Luini, A. & D'Angelo, G., 14 Jun 2017, In : EMBO Journal. 36, 12, p. 1736-1754 19 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Studies on Proteins Influencing Cancer Progression and Regulating Endocytic Lipid Trafficking

Vassilev, B., 2017, Helsinki: University of Helsinki. 40 p.

Research output: ThesisDoctoral ThesisCollection of Articles

Open Access

The endocytic pathways of a secretory granule membrane protein in HEK293 cells: PAM and EGF traverse a dynamic multivesicular body network together

Back, N., Kanerva, K., Kurutihallib, V., Yanik, A., Ikonen, E., Mains, R. E. & Eipper, B. A., Aug 2017, In : European Journal of Cell Biology. 96, 5, p. 407-417 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2016

A loss-of-function variant in OSBPL1A predisposes to low plasma HDL cholesterol levels and impaired cholesterol efflux capacity

Motazacker, M. M., Pirhonen, J., van Capelleveen, J. C., Weber-Boyvat, M., Kuivenhoven, J. A., Shah, S., Hovingh, G. K., Metso, J., Li, S., Ikonen, E., Jauhiainen, M., Dallinga-Thie, G. M. & Olkkonen, V. M., Jun 2016, In : Atherosclerosis. 249, p. 140-147 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Continuous Grading of Early Fibrosis in NAFLD Using Label-Free Imaging: A Proof-of-Concept Study

Pirhonen, J., Arola, J., Sädevirta, S., Luukkonen, P., Karppinen, S-M., Pihlajaniemi, T., Isomäki, A., Hukkanen, M., Yki-Jarvinen, H. & Ikonen, E., 25 Jan 2016, In : PLoS One. 11, 1, 14 p., 0147804.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

D38-cholesterol as a Raman active probe for imaging intracellular cholesterol storage

Alfonso-Garcia, A., Pfisterer, S. G., Riezman, H., Ikonen, E. & Potma, E. O., Jun 2016, In : Journal of Biomedical Optics. 21, 6, 8 p., 061003.

Research output: Contribution to journalArticleScientificpeer-review

Language-Agnostic Reproducible Data Analysis Using Literate Programming

Vassilev, B., Louhimo, R., Ikonen, E. & Hautaniemi, S., 6 Oct 2016, In : PLoS One. 11, 10, 14 p., 0164023.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

LDL-cholesterol transport to the endoplasmic reticulum: current concepts

Pfisterer, S. G., Peranen, J. & Ikonen, E., Jun 2016, In : Current Opinion in Lipidology. 27, 3, p. 282-287 6 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File

Seipin regulates ER-lipid droplet contacts and cargo delivery

Salo, V. T., Belevich, I., Li, S., Karhinen, L., Vihinen, H., Vigouroux, C., Magre, J., Thiele, C., Hölttä-Vuori, M., Jokitalo, E. & Ikonen, E., 2016, In : EMBO Journal. 35, 24, p. 2699-2716 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism

Kettunen, K. M., Karikoski, R., Hamalainen, R. H., Toivonen, T. T., Antonenkov, V. D., Kulesskaya, N., Voikar, V., Holtta-Vuori, M., Ikonen, E., Sainio, K., Jalanko, A., Karlberg, S., Karlberg, N., Lipsanen-Nyman, M., Toppari, J., Jauhiainen, M., Hiltunen, J. K., Jalanko, H. & Lehesjoki, A-E., 15 May 2016, In : Biology open. 5, 5, p. 584-595 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Use of BODIPY-Cholesterol (TF-Chol) for Visualizing Lysosomal Cholesterol Accumulation

Holtta-Vuori, M., Sezgin, E., Eggeling, C. & Ikonen, E., Sep 2016, In : Traffic. 17, 9, p. 1054-1057 4 p.

Research output: Contribution to journalArticleScientific

Open Access
File
2015

Deuterated Cholesterol Uptake Revealed With Stimulated Raman Microscopy

IEEE, 2015, 2015 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO). New York: IEEE, 2 p. (Conference on Lasers and Electro-Optics).

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Kasvisterolit, kolesterolin esiasteet ja oksisterolit : pienet määrät, suuret vaikutukset

Olkkonen, V. M., Gylling, H. & Ikonen, E., 2015, In : Duodecim. 131, 3, p. 235-241 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

LAPTM4B facilitates late endosomal ceramide export to control cell death pathways

Blom, T., Li, S., Dichlberger, A., Back, N., Kim, Y. A., Loizides-Mangold, U., Riezman, H., Bittman, R. & Ikonen, E., Oct 2015, In : Nature Chemical Biology. 11, 10, p. 799-+ 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Lipidienkuljettajaproteiinin metsästys johti syövän lääkeresistenssin jäljille

Blom, T., Li, S., Dichlberger, A., Back, N., Kim, Y. A., Loizides-Mangold, U., Riezman, H., Bittman, R. & Ikonen, E., 2015, In : Duodecim. 131, 20, p. 1900 1 p.

Research output: Contribution to journalArticleScientific

Lipid transport takes the 'omics' highway

Pfisterer, S. G. & Ikonen, E., Aug 2015, In : Current Opinion in Lipidology. 26, 4, p. 348-349 2 p.

Research output: Contribution to journalArticleScientific

The impact of low-frequency and rare variants on lipid levels

Surakka, I., Horikoshi, M., Magi, R., Sarin, A-P., Mahajan, A., Lagou, V., Marullo, L., Ferreira, T., Miraglio, B., Timonen, S., Kettunen, J., Pirinen, M., Karjalainen, J., Thorleifsson, G., Hagg, S., Hottenga, J-J., Isaacs, A., Ladenvall, C., Beekman, M., Esko, T. & 31 othersRied, J. S., Nelson, C. P., Willenborg, C., Gustafsson, S., Westra, H-J., Blades, M., de Craen, A. J. M., de Geus, E. J., Deelen, J., Grallert, H., Hamsten, A., Havulinna, A. S., Hengstenberg, C., Houwing-Duistermaat, J. J., Hypponen, E., Karssen, L. C., Lehtimaki, T., Lyssenko, V., Magnusson, P. K. E., Mihailov, E., Mpindi, J-P., Perola, M., Kaprio, J., Groop, L., Eriksson, J. G., Ikonen, E., Kallioniemi, O., Pietiainen, V., Palotie, A., Ripatti, S. & ENGAGE Consortium, Jun 2015, In : Nature Genetics. 47, 6, p. 589-597 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Amyloid precursor protein alpha- and beta-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2

Wang, W., Mutka, A-L., Zmrzljak, U. P., Rozman, D., Tanila, H., Gylling, H., Remes, A. M., Huttunen, H. J. & Ikonen, E., Feb 2014, In : FASEB Journal. 28, 2, p. 849-860 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Cholesterol precursors: more than mere markers of biosynthesis

Brown, A. J., Ikonen, E. & Olkkonen, V. M., Apr 2014, In : Current Opinion in Lipidology. 25, 2, p. 133-139 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Enzymatic Oxidation of Cholesterol: Properties and Functional Effects of Cholestenone in Cell Membranes

Neuvonen, M., Manna, M., Mokkila, S., Javanainen, M., Rog, T., Liu, Z., Bittman, R., Vattulainen, I. & Ikonen, E., 26 Aug 2014, In : PLoS One. 9, 8, 13 p., 103743.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

PNPLA3 mediates hepatocyte triacylglycerol remodeling

Ruhanen, H., Perttila, J., Holtta-Vuori, M., Zhou, Y., Yki-Jarvinen, H., Ikonen, E., Kakela, R. & Olkkonen, V. M., Apr 2014, In : Journal of Lipid Research. 55, 4, p. 739-746 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Polarized THG Microscopy Identifies Compositionally Different Lipid Droplets in Mammalian Cells

Bautista, G., Pfisterer, S. G., Huttunen, M. J., Ranjan, S., Kanerva, K., Ikonen, E. & Kauranen, M., 18 Nov 2014, In : Biophysical Journal. 107, 10, p. 2230-2336 107 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2013

Alleviation of seipinopathy-related ER stress by triglyceride storage

Hölttä-Vuori, M., Salo, V. T., Ohsaki, Y., Suster, M. L. & Ikonen, E., 15 Mar 2013, In : Human Molecular Genetics. 22, 6, p. 1157-1166 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Cholesterol Dependence of Collagen and Echovirus 1 Trafficking along the Novel alpha 2 beta 1 Integrin Internalization Pathway

Siljamaki, E., Rintanen, N., Kirsi, M., Upla, P., Wang, W., Karjalainen, M., Ikonen, E. & Marjomaki, V., 5 Feb 2013, In : PLoS One. 8, 2, p. Article Number: e55465 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Desmosterol and DHCR24: Unexpected new directions for a terminal step in cholesterol synthesis

Zerenturk, E. J., Sharpe, L. J., Ikonen, E. & Brown, A. J., Oct 2013, In : Progress in Lipid Research. 52, 4, p. 666-680 15 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

LDL Cholesterol Recycles to the Plasma Membrane via a Rab8a-Myosin5b-Actin-Dependent Membrane Transport Route

Kanerva, K., Uronen, R-L., Blom, T., Li, S., Bittman, R., Lappalainen, P., Peränen, J., Raposo, G. & Ikonen, E., 11 Nov 2013, In : Developmental Cell. 27, 3, p. 249-262 14 p.

Research output: Contribution to journalArticleScientificpeer-review

NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation

Pietiäinen, V., Vassilev, B., Blom, J. T., Wang, W., Nelson, J., Bittman, R., Bäck, N., Zelcer, N. & Ikonen, E., 1 Sep 2013, In : Journal of Cell Science. 126, 17, p. 3961-3971 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Nobelin palkinto solunsisäisen kalvoliikenteen tutkijoille

Ikonen, E. & Olkkonen, V., 2013, In : Duodecim. 129, 22, p. 2397-2398 2 p.

Research output: Contribution to journalArticleProfessional

What dictates the accumulation of desmosterol in the developing brain?

Jansen, M., Wang, W., Greco, D., Bellenchi, G. C., di Porzio, U., Brown, A. J. & Ikonen, E., Mar 2013, In : FASEB Journal. 27, 3, p. 865-870 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Cln5-deficiency in mice leads to microglial activation, defective myelination and changes in lipid metabolism

Schmiedt, M-L., Blom, T. S., Blom, J. T., Kopra, O., Andrew, W., von Schantz-Fant, C., Ikonen, E. M., Kuronen, M., Jauhiainen, M., Cooper, J. D. & Jalanko, A., 2012, In : Neurobiology of Disease. 46, 1, p. 19-29 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Endosomal Actin Remodeling by Coronin-1A Controls Lipoprotein Uptake and Degradation in Macrophages

Hölttä-Vuori, M., Vainio, S., Kauppi, M., Van Eck, M., Jokitalo, E. & Ikonen, E., 2012, In : Circulation Research. 110, 3, p. 450-455 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Lipid-protein interactions: finding the perfect match

Blom, J. T. & Ikonen, E., 1 Dec 2012, In : Current Opinion in Lipidology. 23, 6, p. 581-583 3 p.

Research output: Contribution to journalArticleScientific