Photo of Emmy Verschuren
  • PL 20 (Tukholmankatu 8)

    00014

    Finland

19972019
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Personal profile

Description of research and teaching

Background

Lung cancer remains the leading cause of cancer-related mortality worldwide. Curing late stage disseminated lung cancer is challenging, as cell populations are highly heterogeneous both molecularly and histologically, and often genomically unstable. Despite promising progress in treatment strategies that harness anti-tumour immunity, therapeutic resistance limits clinical efficacy. A shift to early cancer detection and prevention is therefore necessary, and this requires an improved understanding of the biological basis of cancer initiation in its physiological niche.

 

Research Overview

We take a comprehensive approach to tackle challenges in the field of lung cancer research, progressing from mouse model systems of cancer to human disease cohorts. First, tumour-initiating events are identified in murine lung cancer cohorts, comprised of validated and putative driver combinations expressed in tissue progenitor cells. Second, we apply pathology-specific functional and immune profiling studies to identify drivers of malignancy. Third, we implement a mouse-to-patient comparative personalised medicine study, establishing the ability of cultured cells and tissue explants to reliably predict or validate in vivo drug sensitivities.

 

Research Directions

Foreseeing rapid technological advances in personalised cancer diagnostics, we aim to implement our gained insights in the rational design of cancer treatment and intervention strategies. To achieve these goals, our research increasingly interfaces with biobanking and translational infrastructures available at FIMM, associated Life Science Biocentres, and the Helsinki University Hospital. We collaborate with pulmonary surgeons, clinicians and pathologists to implement personalised disease profiling on patient tumour samples. These efforts will permit us to evaluate whether the functional diagnostic elucidation of patient tumour-selective therapeutic vulnerabilities has the potential to benefit the health of locally-treated cancer patients.

Fields of Science

  • 3111 Biomedicine
  • 3122 Cancers

Fields of Science

  • 3111 Biomedicine
  • Cancer biology
  • Lung cancer
  • Cell biology
  • Precision medicine
  • Diagnostics
  • Tumour heterogeneity
  • 3122 Cancers
  • NSCLC

International and National Collaboration Publications and projects within past five years.

Publications 1997 2019

Open Access
File

Establishment and Analysis of Tumor Slice Explants As a Prerequisite for Diagnostic Testing

Nagaraj, A. S., Bao, J., Hemmes, A., Machado, M., Närhi, K. & Verschuren, E. W., 29 Nov 2018, In : Journal of Visualized Experiments. 141, 9 p., e58569.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

More than a Tumor Suppressor: E-Cadherin Loss Drives Lung Cancer Metastasis

Devlin, J. R. & Verschuren, E. W., Aug 2018, In : American Journal of Respiratory Cell and Molecular Biology. 59, 2, p. 141-142 2 p.

Research output: Contribution to journalEditorialScientific

Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras-driven lung tumours

Närhi, K., Nagaraj, A. S., Parri, E., Turkki, R., van Duijn, P. W., Hemmes, A., Lahtela, J., Uotinen, V., Mäyränpää, M. I., Salmenkivi, K., Räsänen, J., Linder, N., Trapman, J., Rannikko, A., Kallioniemi, O., Af Hällström, T. M., Lundin, J., Sommergruber, W., Anders, S. & Verschuren, E. W., May 2018, In : Journal of Pathology. 245, 1, p. 101-113 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1

Nagaraj, A. S., Lahtela, J., Hemmes, A., Pellinen, T., Blom, S., Devlin, J. R., Salmenkivi, K., Kallioniemi, O., Mäyränpää, M., Narhi, K. & Verschuren, E. W., 17 Jan 2017, In : Cell Reports. 18, 3, p. 673-684 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Projects 2011 2016

PREDECT

Verschuren, E., Kallioniemi, O., Klefström, J., Monni, O. & Kovanen, P.

01/02/201131/01/2016

Project: Research project

Activities 2009 2009

  • 1 Supervision of other thesis (Master's, Licentiate)

BS. thesis supervisor of summer trainee Katariina Lassila

Emmy Verschuren (Supervisor)
20092010

Activity: Examination typesSupervision of other thesis (Master's, Licentiate)

Press / Media

Press Release IMI-PREDECT consortium

Emmy Verschuren

12/05/2011

1 media contribution

Press/Media: Press / Media

LabTimes Interview: 'Doing research in the land of a thousand lakes'

Emmy Verschuren

01/02/2011

1 media contribution

Press/Media: Press / Media