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Publications 2002 2019

2018

Azulene-based compounds for targeting orexin receptors

Leino, T. O., Turku, A., Yli-Kauhaluoma, J. T., Kukkonen, J. P., Xhaard, H. & Wallén, E. A. A., 5 Sep 2018, In : European Journal of Medicinal Chemistry. 157, p. 88-100 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Pharmacological characterization of the orexin/hypocretin receptor agonist Nag 26

Rinne, M. K., Leino, T. O., Turku, A., Turunen, P. M., Steynen, Y., Xhaard, H., Wallen, E. A. A. & Kukkonen, J. P., 15 Oct 2018, In : European Journal of Pharmacology. 837, p. 137-144 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Stapled truncated orexin peptides as orexin receptor agonists

Karhu, L., Weisell, J., Turunen, P. M., Leino, T. O., Pätsi, H., Xhaard, H., Kukkonen, J. P. & Wallén, E. A. A., Apr 2018, In : Peptides. 102, p. 54-60 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Synthesis of azulene-based compounds for targeting orexin receptors

Leino, T. O., 2018, Helsinki: Helsingin yliopisto. 54 p.

Research output: ThesisDoctoral ThesisCollection of Articles

2016

Chroman-4-one and chromone based somatostatin beta-turn mimetics

Friden-Saxin, M., Seifert, T., Malo, M., Andersson, K. D. S., Pemberton, N., Dyrager, C., Friberg, A., Dahlen, K., Wallén, E. A. A., Grotli, M. & Luthman, K., 23 May 2016, In : European Journal of Medicinal Chemistry. 114, p. 59-64 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Development of molecules stimulating the activity of KLK3-an update

Koistinen, H., Wallen, E., Ylikangas, H., Meinander, K., Lahtela-Kakkonen, M., Narvanen, A. & Stenman, U-H., Dec 2016, In : Biological Chemistry. 397, 12, p. 1229-1235 7 p.

Research output: Contribution to journalConference articleScientificpeer-review

Synthesis of 1,3,6-trisubstituted azulenes Based on the 1-acyloxyazulene scaffold

Leino, T. O., Johansson, N. G., Devisscher, L., Sipari, N., Yli-Kauhaluoma, J. & Wallen, E. A. A., Nov 2016, In : European Journal of Organic Chemistry. 33, p. 5539-5544 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Synthesis of 1,3,6-Trisubstituted Azulenes

Leino, T. O., Baumann, M., Yli-Kauhaluoma, J., Baxendale, I. R. & Wallen, E. A. A., 20 Nov 2015, In : Journal of Organic Chemistry. 80, 22, p. 11513-11520 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Chroman-4-one- and Chromone-Based Sirtuin 2 Inhibitors with Antiproliferative Properties in Cancer Cells

Seifert, T., Malo, M., Kokkola, T., Engen, K., Friden-Saxin, M., Wallen, E. A. A., Lahtela-Kakkonen, M., Jarho, E. M. & Luthman, K., 11 Dec 2014, In : Journal of Medicinal Chemistry. 57, 23, p. 9870-9888 19 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Replacement of the Disulfide Bridge in a KLK3-Stimulating Peptide Using Orthogonally Protected Building Blocks

Meinander, K., Pakkala, M., Weisell, J., Stenman, U. H., Koistinen, H., Narvanen, A. & Wallen, E. A. A., Feb 2014, In : ACS Medicinal Chemistry Letters. 5, 2, p. 162-165 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Synthesis and biological evaluation of novel I-123-labeled 4-(4-iodophenyl)butanoyl-L-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivo

Kallinen, A., Todorov, B., Kallionpää, R., Back, S., Sarparanta, M., Raki, M., Garcia-Horsman, J. A., Bergstrom, K. A., Wallen, E. A. A., Mannisto, P. T. & Airaksinen, A. J., 22 May 2014, In : European Journal of Medicinal Chemistry. 79, p. 436-445 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Farmaseuttisen kemian perusteet

Vuorensola, K., Wallen, E., Rautio, J., Laine, K., Jarho, P., Wikberg, T. & Lindeke, B., Dec 2013, 244 p.

Research output: Book/ReportBookProfessional

Pienmolekyyleistä peptideihin: Kokouksia: Lääkekehitys murroksessa

Wallen, E. & Koistinen, H. K., 2013, In : Kemia - Kemi. 7, p. 56 1 p.

Research output: Contribution to journalArticleGeneral public

Pseudopeptides with a centrally positioned alkene-based disulphide bridge mimetic stimulate kallikrein-related peptidase 3 activity

Meinander, K., Weisell, J., Pakkala, M., Tadd, A. C., Hekim, C., Kallionpää, R. A., Widell, K., Stenman, U. H., Koistinen, H., Narvanen, A., Vepsalainen, J., Luthman, K. & Wallen, E. A. A., Mar 2013, In : MedChemComm. 4, 3, p. 549-553 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2011

Inhibitors and promoters of tubulin polymerization: Synthesis and biological evaluation of chalcones and related dienones as potential anticancer agents

Dyrager, C., Wickström, M., Fridén-Saxin, M., Friberg, A., Dahlén, K., Wallen, E. A. A., Gullbo, J., Grötli, M. & Luthman, K., 2011, In : Bioorganic & Medicinal Chemistry. 19, 8, p. 2659-2665

Research output: Contribution to journalArticleScientificpeer-review

Synthesis of Orthogonally Protected Disulfide Bridge Mimetics

Tadd, A. C., Meinander, K., Luthman, K. & Wallen, E. A. A., 2011, In : Journal of Organic Chemistry. 76, 2, p. 673-675

Research output: Contribution to journalArticleScientificpeer-review

2010

Mimetics of the disulfide bridge between the N- and C-terminal cysteines of the KLK3-stimulating peptide B-2

Pakkala, M., Weisell, J., Hekim, C., Vepsalainen, J., Wallen, E. A. A., Stenman, U. H., Koistinen, H. K. & Narvanen, A., 2010, In : Amino Acids. 39, p. 233-242 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

N-epsilon-Thioacetyl-Lysine-Containing Tri-, Tetra-, and Pentapeptides as SIRT1 and SIRT2 Inhibitors

Kiviranta, P. H., Suuronen, T., Wallen, E. A. A., Leppanen, J., Tervonen, J., Kyrylenko, S., Salminen, A., Poso, A. & Jarho, E. M., 9 Apr 2009, In : Journal of Medicinal Chemistry. 52, 7, p. 2153-2156 4 p.

Research output: Contribution to journalArticleScientificpeer-review

N-thioacetyl-lysine-containing tri-, tetra-, and pentapeptides as SIRT1 and SIRT2 inhibitors

Kiviranta, P., Suuronen, T., Wallen, E. A. A., Leppänen, J., Tervonen, J., Kyrylenko, S., Salminen, A., Poso, A. & Jarho, E., 2009, In : Journal of Medicinal Chemistry. 52, 7, p. 2153-2156 4 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Characterization of the binding properties of SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone

Kiviranta, P. H., Salo, H. S., Leppanen, J., Rinne, V. M., Kyrylenko, S., Kuusisto, E., Suuronen, T., Salminen, A., Poso, A., Lahtela-Kakkonen, M. & Wallen, E. A. A., 2008, In : Bioorganic Chemistry. 16, p. 8054-8062 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors

Huhtiniemi, T., Suuronen, T., Rinne, V. M., Wittekindt, C., Lahtela-Kakkonen, M., Jarho, E., Wallen, E. A. A., Salminen, A., Poso, A. & Leppanen, J., 2008, In : Journal of Medicinal Chemistry. 51, p. 4377-4380 4 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

2(S)-(cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines and 2(S)-(aroyl)-1-(4-phenylbutanoyl) pyrrolidines as prolyl oligopeptidase inhibitors

Jarho, E. M., Venäläinen, J. I., Poutiainen, S., Leskinen, H., Vepsäläinen, J., Christiaans, J. A. M., Forsberg, M. M., Männistö, P. & Wallen, E. A. A., 2007, In : Bioorganic & Medicinal Chemistry. 15, 5, p. 2024-2031 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Beneficial effect of prolyl oligopeptidase inhibition on spatial memory in young but not in old scopolamine-treated rats

Jalkanen, A. J., Puttonen, K. A., Venalainen, J. I., Sinerva, V., Mannila, A., Ruotsalainen, S., Jarho, E. M., Wallen, E. A. A. & Männistö, P. T., 2007, In : Basic & Clinical Pharmacology & Toxicology. 100, p. 132-138 7 p.

Research output: Contribution to journalArticleScientificpeer-review

N-(3-(4-hydroxyphenyl)-propenoyl)-amino acid tryptamides as SIRT2 inhibitors

Kiviranta, P. H., Leppanen, J., Rinne, V. M., Suuronen, T., Kyrylenko, O., Kyrylenko, S., Kuusisto, E., Tervo, A. J., Jarvinen, T., Salminen, A., Poso, A. & Wallen, E. A. A., 2007, In : Bioorganic & Medicinal Chemistry Letters. 17, p. 2448-2451 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Synthesis of 3-aminomethyl-2-aryl-8-bromo-6-chlorochromones

Wallen, E. A. A., Dahlen, K., Grotli, M. & Luthman, K., 2007, In : Organic Letters. 9, p. 389-391 3 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

An introduction of a pyridine group into the structure of prolyl oligopeptidase inhibitors

Jarho, E., Venäläinen, J., Juntunen, J., Yli-kokko, A. L., Vepsäläinen, J., Christiaans, J., Forsberg, M., Järvinen, T., Männistö, P. T. & Wallen, E. A. A., 2006, In : Bioorganic & Medicinal Chemistry Letters. 16, 21, p. 5590-5593 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors

Venäläinen, J., García-Horsman, J. A., Forsberg, M., Jalkanen, A., Wallen, E. A. A., Jarho, E., Christiaans, J., Gynther, J. & Männistö, P. T., 2006, In : Biochemical Pharmacology. 71, 5, p. 683-692

Research output: Contribution to journalArticleScientificpeer-review

N,N '-bisbenzylidenebenzene-1,4-diamines and N,N '-bisbenzylidenenaphthalene-1,4-diamines as sirtuin type 2 (SIRT2) inhibitors

Kiviranta, P. H., Leppanen, J., Kyrylenko, S., Salo, H. S., Lahtela-Kakkonen, M., Tervo, A. J., Wittekindt, C., Suuronen, T., Kuusisto, E., Jarvinen, T., Salminen, A., Poso, A. & Wallen, E. A. A., 2006, In : Journal of Medicinal Chemistry. 49, p. 7907-7911 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Synthesis of 2,3,6,8-tetrasubstituted chromone scaffolds

Dahlen, K., Wallen, E. A. A., Grotli, M. & Luthman, K., 2006, In : Journal of Organic Chemistry. 71, p. 6863-6871 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

Dicarboxylic acid azacycle L-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions

Jarho, E., Wallen, E. A. A., Christiaans, J., Forsberg, M., Venäläinen, J., Männistö, P. T., Gynther, J. & Poso, A., 2005, In : Journal of Medicinal Chemistry. 48, 15, p. 4772-4782 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2004

A cyclopent-2-enecarbonyl group mimics proline at the P2 position of prolyl oligopeptidase inhibitors.

Jarho, E. M., Venäläinen, J. I., Huuskonen, J., Christiaans, J. A., Garcia Horsman, J. A., Forsberg, M., Järvinen, T., Gynther, J., Männistö, P. & Wallen, E., 2004, In : Journal of Medicinal Chemistry. 47, 23, p. 5605-7 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site

Venalainen, J. I., Juvonen, R. O., Garcia-Horsman, J. A., Wallen, E. A. A., Christiaans, J. A. M., Jarho, E. M., Gynther, J. & Mannisto, P. T., 2004, In : Biochemical Journal. 382, p. 1003-1008 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2003

Addition of tert-butylcuprate to (2S)-N-acyl-Delta(5)-dehydroprolinates as a diastereoselective synthetic procedure for obtaining (2S,5S)-5-tert-butylproline

Wallen, E. A. A., Christiaans, J. A. M., Gynther, J. & Vepsalainen, J., 2003, In : Tetrahedron Letters. 44, p. 2081-2082 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Conformationally rigid N-acyl-5-alkyl-L-prolyl-pyrrolidines as prolyl oligopeptidase inhibitors

Wallen, E. A. A., Christiaans, J. A. M., Saarinen, T. J., Jarho, E. M., Forsberg, M. M., Venalainen, J. I., Mannisto, P. T. & Gynther, J., 2003, In : Bioorganic Chemistry. 11, p. 3611-3619 9 p.

Research output: Contribution to journalArticleScientificpeer-review

New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis(L-prolyl-pyrrolidine) amides

Wallen, E. A. A., Christiaans, J. A. M., Jarho, E. M., Forsberg, M. M., Venalainen, J. I., Mannisto, P. T. & Gynther, J., 2003, In : Journal of Medicinal Chemistry. 46, p. 4543-4551 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2002

4-phenylbutanoyl-2(S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2(S)-acylpyrrolidines as prolyl oligopeptidase inhibitors

Wallen, E. A. A., Christiaans, J. A. M., Saario, S. M., Forsberg, M. M., Venalainen, J. I., Paso, H. M., Mannisto, P. T. & Gynther, J., 2002, In : Bioorganic Chemistry. 10, p. 2199-2206 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Dicarboxylic acid bis(L-prolyl-pyrrolidine) amides as prolyl oligopeptidase inhibitors

Wallen, E. A. A., Christiaans, J. A. M., Forsberg, M. M., Venalainen, J. I., Mannisto, P. T. & Gynther, J., 2002, In : Journal of Medicinal Chemistry. 45, p. 4581-4584 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819

Venalainen, J. I., Juvonen, R. O., Forsberg, M. M., Garcia-Horsman, A., Poso, A., Wallen, E. A. A., Gynther, J. & Mannisto, P. T., 2002, In : Biochemical Pharmacology. 64, p. 463-471 9 p.

Research output: Contribution to journalArticleScientificpeer-review