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Esa Hämäläinen, MD, PhD, prof

19982019
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Publications 1998 2019

2019

Applying mass spectrometric methods to study androgen biosynthesis and metabolism in prostate cancer

Knuuttila, M., Hämäläinen, E. & Poutanen, M., May 2019, In : Journal of Molecular Endocrinology. 62, 4, p. R255-R267 13 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Impact of obesity on angiogenic and inflammatory markers in the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) cohort

the FINNPEC, May 2019, In : International Journal of Obesity. 43, 5, p. 1070-1081 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Psychiat Genomics Consortium, Czamara, D., Eraslan, G., Page, C. M., Lahti, J., Lahti-Pulkkinen, M., Hämäläinen, E., Kajantie, E., Laivuori, H., Villa, P. M., Reynolds, R. M., Nystad, W., Håberg, S. E., London, S. J., O'Donnell, K. J., Garg, E., Meaney, M. J., Entringer, S., Wadhwa, P. D. & Buss, C., 11 Jun 2019, In : Nature Communications. 10, 18 p., 2548.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Laboratoriotutkimusten viitearvojen määrittäminen ja merkitys kliinisessä päätöksenteossa

Uotila, L., Hämäläinen, E. & Kouri, T., 2019, In : Duodecim. 135, 4, p. 367-375 9 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Letrozole versus testosterone for promotion of endogenous puberty in boys with constitutional delay of growth and puberty: a randomised controlled phase 3 trial

Varimo, T., Huopio, H., Kariola, L., Tenhola, S., Voutilainen, R., Toppari, J., Toiviainen-Salo, S., Hämäläinen, E., Pulkkinen, M-A., Lääperi, M., Tarkkanen, A., Vaaralahti, K., Miettinen, P. J., Hero, M. & Raivio, T., Feb 2019, In : Lancet child & adolescent health. 3, 2, p. 109-120 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Kupers, L. K., Monnereau, C., Sharp, G. C., Yousefi, P., Salas, L. A., Ghantous, A., Page, C. M., Reese, S. E., Wilcox, A. J., Czamara, D., Starling, A. P., Novoloaca, A., Lent, S., Roy, R., Hoyo, C., Breton, C., Allard, C., Just, A. C., Bakulski, K. M., Holloway, J. W. & 107 othersEverson, T. M., Xu, C-J., Huang, R-C., van der Plaat, D. A., Wielscher, M., Merid, S. K., Ullemar, V., Rezwan, F., Lahti, J., van Dongen, J., Langie, S. A. S., Richardson, T. G., Magnus, M. C., Nohr, E. A., Xu, Z., Duijts, L., Zhao, S., Zhang, W., Plusquin, M., DeMeo, D. L., Solomon, O., Heimovaara, J. H., Jima, D. D., Gao, L., Bustamante, M., Perron, P., Wright, R. O., Hertz-Picciotto, I., Zhang, H., Karagas, M. R., Gehring, U., Marsit, C. J., Beilin, L. J., Vonk, J. M., Jarvelin, M-R., Bergstrom, A., Ortqvist, A. K., Ewart, S., Villa, P. M., Moore, S. E., Willemsen, G., Standaert, A. R. L., Haberg, S. E., Sorensen, T. I. A., Taylor, J. A., Räikkönen, K., Yang, I., Kechris, K., Nawrot, T. S., Silver, M. J., Gong, Y. Y., Richiardi, L., Kogevinas, M., Litonjua, A. A., Eskenazi, B., Huen, K., Mbarek, H., Maguire, R. L., Dwyer, T., Vrijheid, M., Bouchard, L., Baccarelli, A. A., Croen, L. A., Karmaus, W., Anderson, D., de Vries, M., Sebert, S., Kere, J., Karlsson, R., Arshad, S. H., Hämäläinen, E., Routledge, M. N., Boomsma, D., Feinberg, A. P., Newschaffer, C. J., Govarts, E., Moisse, M., Fallin, M. D., Melen, E., Prentice, A. M., Kajantie, E., Almqvist, C., Oken, E., Dabelea, D., Boezen, H. M., Melton, P. E., Wright, R. J., Koppelman, G. H., Trevisi, L., Hivert, M-F., Sunyer, J., Munthe-Kaas, M. C., Murphy, S. K., Corpeleijn, E., Wiemels, J., Holland, N., Herceg, Z., Binder, E. B., Smith, G. D., Jaddoe, V. W. V., Lie, R. T., Nystad, W., London, S. J., Lawlor, D. A., Relton, C. L., Snieder, H. & Felix, J. F., 23 Apr 2019, In : Nature Communications. 10, 11 p., 1893.

Research output: Contribution to journalArticleScientificpeer-review

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Plasma Heme Scavengers Alpha-l-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies

Kalapotharakos, G., Murtoniemi, K., Åkerström, B., Hämäläinen, E., Kajantie, E., Räikkönen, K., Villa, P., Laivuori, H. & Hansson, S. R., 4 Apr 2019, In : Frontiers in Physiology. 10, 7 p., 300.

Research output: Contribution to journalArticleScientificpeer-review

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2018

Angiogenic Profile in the Finnish Genetics of Pre-Eclampsia Consortium (Finnpec) Cohort

Jääskeläinen, T., Heinonen, S., Hämäläinen, E., Pulkki, K., Romppanen, J. & Laivuori, H., Oct 2018, In : Pregnancy Hypertension : an international journal of women's cardiovascular health. 14, p. 252-259 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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An immunocapture-LC-MS-based assay for serum SPINK1 allows simultaneous quantification and detection of SPINK1 variants

Ravela, S., Valmu, L., Domanskyy, M., Koistinen, H., Kylänpää, L., Lindström, O., Stenman, J., Hämäläinen, E., Stenman, U-H. & Itkonen, O., Feb 2018, In : Analytical and Bioanalytical Chemistry. 410, 6, p. 1679-1688 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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Comparison of serum serotonin and serum 5-HIAA LC-MS/MS assays in the diagnosis of serotonin producing neuroendocrine neoplasms: A pilot study

Lindström, M., Tohmola, N., Renkonen, R., Hämäläinen, E., Schalin-Jäntti, C. & Itkonen, O., Jul 2018, In : Clinica Chimica Acta. 482, p. 78-83 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Increased body fat mass and androgen metabolism - A twin study in healthy young women

Vihma, V., Heinonen, S., Naukkarinen, J., Kaprio, J., Rissanen, A., Turpeinen, U., Hämäläinen, E., Hakkarainen, A., Lundbom, J., Lundbom, N., Mikkola, T. S., Tikkanen, M. J. & Pietiläinen, K. H., Dec 2018, In : Steroids. 140, p. 24-31 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Maternal early pregnancy obesity and depressive symptoms during and after pregnancy.

Kumpulainen, S. M., Girchenko, P., Lahti-Pulkkinen, M., Reynolds, R. M., Tuovinen, S., Pesonen, A-K., Heinonen, K., Kajantie, E., Villa, P. M., Hämäläinen, E., Laivuori, H. & Räikkönen, K., Oct 2018, In : Psychological Medicine. 48, 14, p. 2353-2363 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Placental Morphology Is Associated with Maternal Depressive Symptoms during Pregnancy and Toddler Psychiatric Problems.

Lahti-Pulkkinen, M., Cudmore, M., Haeussner, E., Schmitz, C., Pesonen, A-K., Hämäläinen, E., Villa, P. M., Mehtälä, S., Kajantie, E., Laivuori, H., Reynolds, R. M., Frank, H-G. & Räikkönen, K., 15 Jan 2018, In : Scientific Reports. 8, 1, 12 p., 791.

Research output: Contribution to journalArticleScientificpeer-review

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Prediction of pre-eclampsia and its subtypes in high-risk cohort: hyperglycosylated human chorionic gonadotropin in multivariate models

Murtoniemi, K., Villa, P. M., Matomäki, J., Keikkala, E., Vuorela, P., Hämäläinen, E., Kajantie, E., Pesonen, A-K., Räikkönen, K., Taipale, P., Stenman, U-H. & Laivuori, H., 3 Jul 2018, In : BMC Pregnancy and Childbirth. 18, 10 p., 279.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The relationship between diurnal cortisol secretion and climacteric-related symptoms

Katainen, R., Kalleinen, N., Teperi, S., Vahlberg, T., Turpeinen, U., Hämäläinen, E., Nelimarkka, L. & Polo-Kantola, P., Sep 2018, In : Maturitas. 115, p. 37-44 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2017

Angiogenic profile and smoking in the Finnish Genetics of Pre-Eclampsia Consortium (FINNPEC) cohort

FINNPEC, 2017, In : Annals of Medicine. 49, 7, p. 593–602 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth

Girchenko, P., Lahti, J., Czamara, D., Knight, A. K., Jones, M. J., Suarez Figueiredo, A., Hämäläinen, E., Kajantie, E., Laivuori, H., Villa, P. M., Reynolds, R. M., Kobor, M. S., Smith, A. K., Binder, E. B. & Räikkönen, K., 8 May 2017, In : Clinical epigenetics. 9, 14 p., 49.

Research output: Contribution to journalArticleScientificpeer-review

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Cluster analysis to estimate the risk of preeclampsia in the high-risk Prediction and Prevention of Preeclampsia and Intrauterine Growth Restriction (PREDO) study

Villa, P. M., Marttinen, P., Gillberg, J., Lokki, A. I., Majander, K., Ordén, M-R., Taipale, P., Pesonen, A., Räikkönen, K., Hämäläinen, E., Kajantie, E. & Laivuori, H., 28 Mar 2017, In : PLoS One. 12, 3, 14 p., 0174399.

Research output: Contribution to journalArticleScientificpeer-review

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Cohort Profile: Prediction and prevention of preeclampsia and intrauterine growth restriction (PREDO) study

Girchenko, P., Lahti, M., Tuovinen, S., Savolainen, K., Lahti, J., Binder, E. B., Reynolds, R. M., Entringer, S., Buss, C., Wadhwa, P. D., Hamalainen, E., Kajantie, E., Pesonen, A-K., Villa, P. M., Laivuori, H. & Raikkonen, K., Oct 2017, In : International Journal of Epidemiology. 46, 5, p. 1380-+ 9 p.

Research output: Contribution to journalEditorialScientificpeer-review

Open Access

Epigenetic clock at birth and psychiatric problems during early childhood

Suarez, A., Lahti, J., Czamara, D., Lahti, M., Knight, A. K., Girchenko, P., Hämäläinen, E., Kajantie, E., Laivuori, H., Villa, P. M., Reynolds, R. M., Smith, A. K., Binder, E. B. & Räikkönen, K., Sep 2017, In : Psychoneuroendocrinology. 83S, p. 52-52 1 p.

Research output: Contribution to journalMeeting AbstractResearch

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Gender has to be taken into account in diagnosing adult growth hormone deficiency by the GHRH plus arginine test

Markkanen, H. M., Pekkarinen, T., Hamalainen, E., Valimaki, M. J., Alfthan, H. V. & Stenman, U-H., Aug 2017, In : Growth Hormone & IGF Research. 35, p. 52-56 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Metabolism of sex steroids is influenced by acquired adiposity-A study of young adult male monozygotic twin pairs

Vihma, V., Naukkarinen, J., Turpeinen, U., Hämäläinen, E., Kaprio, J., Rissanen, A., Heinonen, S., Hakkarainen, A., Lundbom, J., Lundbom, N., Mikkola, T. S., Tikkanen, M. J. & Pietiläinen, K. H., Sep 2017, In : Journal of Steroid Biochemistry and Molecular Biology. 172, p. 98-105 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

An epigenetic clock for gestational age at birth based on blood methylation data

Knight, A. K., Craig, J. M., Theda, C., Baekvad-Hansen, M., Bybjerg-Grauholm, J., Hansen, C. S., Hollegaard, M. V., Hougaard, D. M., Mortensen, P. B., Weinsheimer, S. M., Werge, T. M., Brennan, P. A., Cubells, J. F., Newport, D. J., Stowe, Z. N., Cheong, J. L. Y., Dalach, P., Doyle, L. W., Loke, Y. J., Baccarelli, A. A. & 26 othersJust, A. C., Wright, R. O., Tellez-Rojo, M. M., Svensson, K., Trevisi, L., Kennedy, E. M., Binder, E. B., Iurato, S., Räikkönen, K., Lahti, J. M. T., Pesonen, A-K., Kajantie, E., Villa, P. M., Laivuori, H., Hämäläinen, E., Park, H. J., Bailey, L. B., Parets, S. E., Kilaru, V., Menon, R., Horvath, S., Bush, N. R., LeWinn, K. Z., Tylavsky, F. A., Conneely, K. N. & Smith, A. K., 7 Oct 2016, In : Genome Biology. 17, 11 p., 206.

Research output: Contribution to journalArticleScientificpeer-review

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Hepsidiinin nykyrooli anemiaselvittelyissä

Itkonen, O. & Hämäläinen, E., 2016, In : Kliin lab : kliinisen laboratorioalan julkaisu : SKKY:n jäsenlehti.. 33, 2, p. 24-28 5 p.

Research output: Contribution to journalArticleProfessional

Maternal depression during pregnancy and epigenetic age in their newborns: The PREDO study

Suarez Figueiredo, A., Lahti, J. M. T., Girchenko, P., Lahti, M., Hämäläinen, E., Laivuori, H. M., Kajantie, E. O., Pesonen, A-K., Villa, P. M., Reynolds, R., Czamara, D., Smith, A. K., Binder, E. B. & Räikkönen, K., Sep 2016, In : Psychoneuroendocrinology. 71S, 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

Maternal Prenatal Positive Affect, Depressive and Anxiety Symptoms and Birth Outcomes: The PREDO Study

Pesonen, A-K., Lahti, M., Kuusinen, T., Tuovinen, S., Villa, P., Hämäläinen, E., Laivuori, H., Kajantie, E. & Räikkönen, K., 26 Feb 2016, In : PLoS One. 11, 2, 13 p., 0150058.

Research output: Contribution to journalArticleScientificpeer-review

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Response to the comments by Per E. Lonning

Vihma, V., Tikkanen, M. J. & Hämäläinen, E., May 2016, In : Journal of Steroid Biochemistry and Molecular Biology. 159, p. 70-71 2 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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The risk of adverse pregnancy outcome among pregnancies with extremely low maternal PAPP-A

Kaijomaa, M., Ulander, V-M., Hämäläinen, E., Alfthan, H., Markkanen, H. M., Heinonen, S. & Stefanovic, V., 2016, In : Prenatal Diagnosis. 36, 12, p. 1115-1120 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Maternal depressive symptoms during pregnancy, placental expression of genes regulating glucocorticoid and serotonin function and infant regulatory behaviors

Raikkonen, K., Pesonen, A. -K., O'Reilly, J. R., Tuovinen, S., Lahti, M., Kajantie, E., Villa, P., Laivuori, H., Hamalainen, E., Seckl, J. R. & Reynolds, R. M., Nov 2015, In : Psychological Medicine. 45, 15, p. 3217-3226 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Maternal depressive symptoms throughout pregnancy are associated with increased placental glucocorticoid sensitivity

Reynolds, R. M., Pesonen, A. -K., O'Reilly, J. R., Tuovinen, S., Lahti, M., Kajantie, E., Villa, P. M., Laivuori, H., Hämäläinen, E., Seckl, J. R. & Raikkonen, K., Jul 2015, In : Psychological Medicine. 45, 10, p. 2023-2030 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Miehen matala testosteronitaso : miten diagnosoin ja hoidan?

Vehkavaara, S. & Hämäläinen, E., 2015, In : Suomen lääkärilehti. 70, 11, p. 723-727 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Multiple sclerosis and vitamin D during pregnancy and lactation

Jalkanen, A., Kauko, T., Turpeinen, U., Hamalainen, E. & Airas, L., Jan 2015, In : Acta Neurologica Scandinavica. 131, 1, p. 64-67 4 p.

Research output: Contribution to journalArticleScientific

Seerumin hCGbeta-, PAPP-A- ja AFP-pitoisuuksien vertailu kahden näytteenottoputken (vakuumiputki ja geeliputki) välillä

Alfthan, H., Syysjoki, E., Latva, H., Koskinen, P., Markkanen, H. & Hämäläinen, E., 2015, In : Kliin lab : kliinisen laboratorioalan julkaisu : SKKY:n jäsenlehti.. 32, 6, p. 114-115 2 p.

Research output: Contribution to journalArticleProfessional