Personal profile
Research interests
The questions we address in my lab stand at the interface between ecology and evolution. On the evolutionary side, we ask how genetic variation maps onto phenotypic variation, and ultimately fitness, a central goal of evolutionary biology. In particular, we ask how the structure of the genotype-phenotype map of quantitative traits affects the evolutionary capacity of a species, for instance investigating the effects of gene pleiotropy (the capacity of a gene to affect multiple traits) on adaptive constraints. To address these questions, we use a mix of computational and analytical modelling, and experimental evolution in the lab with the red flour beetle, Tribolium castaneum.
On the ecological side, we use modeling jointly with empirical data on extant species to understand how eco-evolutionary dynamics affect species’ adaptation to shifting environments under climate change. Our modelling approach aims at identifying the key evolutionary (genetic variation, gene flow, plasticity), life history (age/stage-structure, dispersal, mating system) and ecological characteristics (niche breadth, density, species’ interactions) enabling species to persist in rapidly changing environments. Modeling species’ eco-evolutionary responses to climate change is important when projecting the change of species’ ranges in future climates because it integrates ecological and evolutionary processes affecting species' persistence.
Education/Academic qualification
Evolutionary Biology, PhD, Université de Lausanne
2001 → 2005
Award Date: 12 May 2005
Biological Sciences, BSc, Université de Lausanne
2000 → 2001
Award Date: 1 Mar 2001
Fields of Science
- 1181 Ecology, evolutionary biology
- Computational evolutionary biology
- Evolutionary genetics
- Eco-evolutionary dynamics
Collaborations and top research areas from the last five years
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Pleiotropy or linkage? Their relative contributions to the genetic correlation of quantitative traits and detection by multitrait GWA studies
Chebib, J. & Guillaume, F., Dec 2021, In: Genetics. 219, 4, 14 p., 159.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Evolvability: progress and key questions
Pelabon, C., Agudelo-Cantero, G. A., Araya Ajoy, Y. G., Bolstad, G. H., Cheng, C., Galis, F., Guillaume, F., Haaland, T. R., Hallgrimsson, B., Hansen, T. F., Holstad, A., Houle, D., Hunt, G., Isaksen, A., Milocco, L., Mubalegh, N., Nuno de la Rosa, L., Orzack, S. H., Porto, A. & Reid, J. M. & 6 others, , 9 Sept 2025, In: BioScience. 16 p.Research output: Contribution to journal › Review Article › peer-review
Open AccessFile -
Gene expression evolution is predicted by stronger indirect selection at more pleiotropic genes
Koch, E. L., Rocabert, C., Reddy, C. B. & Guillaume, F., Dec 2025, In: Evolution Letters. 9, 6, p. 719-730 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
popGWAS: Data-efficient trait mapping in natural populations for biodiversity research
Guillaume, F., 24 Mar 2025, (Submitted) (Peer community in evolutionary biology).Research output: Working paper › Preprint
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Dissecting the genetic architecture of quantitative traits using genome-wide identity-by-descent sharing
Fraimout, A., Guillaume, F., Li, Z., Sillanpää, M. J., Rastas, P. & Merilä, J., Mar 2024, In: Molecular Ecology. 33, 6, 15 p., e17299.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile
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Eco-evolutionary dynamics and modes of genetic adaptation to environmental changes
Guillaume, F. (Project manager), Alatalo, A. (Participant), Armeni, N. (Participant), Borge Rouco, L. (Participant), Kemppainen, P. (Participant) & Levo, M. J. (Participant)
01/09/2023 → 31/08/2027
Project: Research Council of Finland: Academy Project
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MSCA SalmonScales
Guillaume, F. (Project manager) & Verta, J.-P. (Participant)
01/09/2023 → 30/03/2024
Project: EU MSCA Global Postdoctoral Fellowships (TMA-MSCA-PF-GF)
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WildAP: Wild Animal Phenotyping Infrastructure
Primmer, C. (Project manager), Cabeza, M. (Participant), Duplouy, A. (Participant), Ecke, F. (Participant), Guillaume, F. (Participant), Hancock, G. R. A. (Participant), Mappes, J. (Participant), Saastamoinen, M. (Participant), Thorogood, R. (Participant), Tuominen, E.-P. (Other) & Loehr, J. (Scientific coordinator)
Suomen Akatemia Projektilaskutus
01/01/2023 → 31/12/2025
Project: Research Council of Finland: Research infrastructure
Activities
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Nemo - Forward-in-time eco-evolutionary individual-based simulation software
Guillaume, F. (Participant)
2021 → …Activity: Other activity types › Types for other activities - Other
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Efficiency in Population Genetics Simulations: A tale of two memory representations in the simulator Nemo
Guillaume, F. (Supervisor) & Ahlberg, L. (Other role (describe in more detail in "Relation description, notes" field))
2025Activity: Examination types › Supervision of other thesis (Master's, Licentiate)
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Pleiotropy or Linkage? Their relative role in the evolution of trait correlation
Guillaume, F. (Speaker)
13 Feb 2025Activity: Talk or presentation types › Invited talk
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Aurélien Tellier
Guillaume, F. (Host)
10 Sept 2025Activity: Hosting a visitor types › Academic visit at UH