Photo of Gustav Boije af Gennäs

Gustav Boije af Gennäs

Principal Investigator, PhD (Pharmaceutical Chemistry), University Researcher

20042020

Research output per year

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Publications

2020

Discovery of Membrane-Bound Pyrophosphatase Inhibitors Derived from an Isoxazole Fragment

Johansson, N. G., Turku, A., Vidilaseris, K., Dreano, L., Khattab, A., Ayuso Perez, D., Wilkinson, A., Zhang, Y., Tamminen, M., Grazhdankin, E., Kiriazis, A., Fishwick, C. W. G., Meri, S., Yli-Kauhaluoma, J., Goldman, A., Boije af Gennäs, G. & Xhaard, H., 9 Apr 2020, In : ACS Medicinal Chemistry Letters. 11, 4, p. 605-610 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Chemical analysis using 3D printed glass microfluidics

Gal-Or, E., Gershoni, Y., Scotti, G., Nilsson, S. M. E., Saarinen, J. K. S., Jokinen, V. P., Strachan, C. J., Boije af Gennäs, P. G., Yli-Kauhaluoma, J. T. & Kotiaho, A. A. T., 7 Apr 2019, In : Analytical Methods. 11, 13, p. 1802-1810 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Mechanism of the Oxidation of Heptafulvenes to Tropones Studied by Online Mass Spectrometry and Density Functional Theory Calculations

Nilsson, S., Henschel, H., Scotti, G., Haapala, M., Kiriazis, A., Boije af Gennäs, G., Kotiaho, T. & Yli-Kauhaluoma, J., 1 Nov 2019, In : Journal of Organic Chemistry. 84, 21, p. 13975-13982 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Simple 3D printed stainless steel microreactors for online mass spectrometric analysis

Scotti, G., Nilsson, S. M. E., Matilainen, V-P., Haapala, M., Boije af Gennäs, G., Yli-Kauhaluoma, J., Salminen, A. & Kotiaho, T., 2 Jul 2019, In : Heliyon. 5, 7, 7 p., 02002.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Adenosine analogs bearing phosphate isosteres as human MDO1 ligands

Zhang, Y., Jumppanen, A. M., Maksimainen, M. M., Auno, A. S., Awol, Z., Ghemtio, L., Venkannagari, H., Lehtiö, L., Yli-Kauhaluoma, J., Xhaard, H. & Boije af Gennäs, G., 1 May 2018, In : Bioorganic & Medicinal Chemistry. 26, 8, p. 1588-1597 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Isoxazole-amides for treating cardiac diseases

Kinnunen, S. M., Tölli, M., Välimäki, M. J., Jumppanen, A. M., Boije af Gennäs, P. G., Yli-Kauhaluoma, J. T. & Ruskoaho, H. J., 29 Mar 2018, IPC No. C07D 261/18 (2006.01), C07D 413/12 (2006.01), C07D 417/12 (2006.01), C07D 413/04 (2006.01), C07D 413/14 (2006.01), A61K 31/42 (2006.01), A61P 9/00 (2006.01), World Intellectual Property Organization (WIPO), Patent No. WO 2018/055235 A1, 20 Sep 2017, Priority date 21 Sep 2016, Priority No. 20165712

Research output: Patent

Open Access
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2017

A miniaturised 3D printed polypropylene reactor for online reaction analysis by mass spectrometry

Scotti, G., Nilsson, S. M. E., Haapala, M., Pöhö, P., Boije af Gennäs, G., Yli-Kauhaluoma, J. & Kotiaho, T., 1 Jun 2017, In : Reaction Chemistry & Engineering. 2, 3, p. 299-303 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Open Access
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Structural Isosteres of Phosphate Groups in the Protein Data Bank

Zhang, Y., Borrel, A., Ghemtio, L., Regad, L., Boije af Gennäs, G., Camproux, A-C., Yli-Kauhaluoma, J. & Xhaard, H., Mar 2017, In : Journal of Chemical Information and Modeling. 57, 3, p. 499-516 18 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Koreassa kumarretaan vanhemmalle kemistille

Boije af Gennäs, P. G., Feb 2016, In : Kemia - Kemi. 43, 1, p. 54-55 2 p.

Research output: Contribution to journalArticleGeneral public

Microfluidics With On-Line Mass Spectrometric Methods For Investigation Of Reaction Mechanisms

Nilsson, S. M. E., Aumuller, I., Kiriazis, A., Boije af Gennäs, P. G., Haapala, M. J., Scotti, G., Franssila, S., Yli-Kauhaluoma, J. T. & Kotiaho, A. A. T., 2016, Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015). San Diego: Chemical and Biological Microsystems Society, p. 2116-2117 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

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Pyrofosfaatti lääketieteessä

Translated title of the contribution: Pyrophosphate in MedicineGoldman, A., Boije af Gennäs, P. G., Xhaard, H. G. M., Meri, S. K. & Yli-Kauhaluoma, J. T., 2016, In : Duodecim. 132, 12, p. 1111-1117 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Beyond the affinity for protein kinase C: exploring 2-phenyl-3-hydroxypropyl pivalate analogues as C1 domain-targeting ligands

Rossi, D., Talman, V., Boije af Gennäs, G., Marra, A., Picconi, P., Nasti, R., Serra, M., Ann, J., Amadio, M., Pascale, A., Tuominen, R. K., Yli-Kauhaluoma, J., Lee, J. & Collina, S., 2015, In : MedChemComm. 6, 4, p. 547-554 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Interaction between Retinoid Acid Receptor-Related Orphan Receptor Alpha (RORA) and Neuropeptide S Receptor 1 (NPSR1) in Asthma

Acevedo, N., Sääf, A., Söderhäll, C., Melén, E., Mandelin, J., Orsmark Pietras, C., Ezer, S., Karisola, P., Vendelin, J., Boije af Gennäs, G., Yli-Kauhaluoma, J., Alenius, H., von Mutius, E., Doekes, G., Braun-Fahrländer, C., Riedler, J., van Hage, M., D'Amato, M., Scheynius, A., Pershagen, G. & 2 others, Kere, J. & Pulkkinen, V., 2013, In : PLoS One. 8, 4, p. e60111 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Separation of steroid isomers by ion mobility mass spectrometry

Ahonen, L., Fasciotti, M., Boije af Gennäs, G., Kotiaho, T., Daroda, R. J., Eberlin, M. & Kostiainen, R., 20 Aug 2013, In : Journal of Chromatography. A. 1310, p. 133-137 5 p.

Research output: Contribution to journalArticleScientificpeer-review

The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells

Talman, V., Amadio, M., Osera, C., Sorvari, S., Boije af Gennäs, G., Yli-Kauhaluoma, J., Rossi, D., Govoni, S., Collina, S., Ekokoski, E., Tuominen, R. K. & Pascale, A., 2013, In : Pharmacological Research. 73, p. 44-54 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Total Synthesis of Bistramide A and Its 36(Z) Isomers: Differential Effect on Cell Division, Differentiation, and Apoptosis

Tomas, L., Boije af Gennäs, G., Hiebel, M. A., Hampson, P., Gueyrard, D., Pelotier, B., Yli-Kauhaluoma, J., Piva, O., Lord, J. M. & Goekjian, P. G., 2012, In : Chemistry: A European Journal. 18, 24, p. 7452-7466

Research output: Contribution to journalArticleScientificpeer-review

2011

C1 Domain-Targeted Isophthalate Derivatives Induce Cell Elongation and Cell Cycle Arrest in HeLa Cells

Talman, V., Tuominen, R. K., Boije af Gennäs, G., Yli-Kauhaluoma, J. & Ekokoski, E., 2011, In : PLoS One. 6, 5, p. e20053 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Current Status and Future Prospects of C1 Domain Ligands as Drug Candidates

Boije af Gennäs, G., Talman, V., Yli-Kauhaluoma, J., Tuominen, R. K. & Ekokoski, E., 2011, In : Current Topics in Medicinal Chemistry. 11, 11, p. 1370-1392 23 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Design, Synthesis, and Biological Activity of Urea Derivatives as Anaplastic Lymphoma Kinase Inhibitors

Boije af Gennäs, G., Mologni, L., Ahmed, S., Rajaratnam, M., Marin, O., Lindholm, N., Viltadi, M., Gambacorti-Passerini, C., Scapozza, L. & Yli-Kauhaluoma, J., 2011, In : ChemMedChem : chemistry enabling drug discovery.. 6, 9, p. 1680-1692

Research output: Contribution to journalArticleScientificpeer-review

Protein Kinase C and Anaplastic Lymphoma Kinase Targeted Compounds

Boije af Gennäs, G., 2011, Helsinki: University of Helsinki. 109 p.

Research output: ThesisDoctoral ThesisCollection of Articles

Stereoselective synthesis of (3-aminodecahydro-1,4-methanonaphthalen-2-yl) methanols targeted to the C1 domain of protein kinase C

Kiriazis, A., Boije af Gennäs, G., Talman, V., Ekokoski, E., Ruotsalainen, T., Kylänlahti, I., Rüffer, T., Wissel, G., Xhaard, H., Lang, H., Tuominen, R. K. & Yli-Kauhaluoma, J., 11 Nov 2011, In : Tetrahedron. 67, 45, p. 8665-8670 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L.

Dastmalchi, K., Ollilainen, V., Lackman, P., af Gennas, G. B., Dorman, H. J. D., Jarvinen, P. P., Yli-Kauhaluoma, J. & Hiltunen, R., 2009, In : Bioorganic & Medicinal Chemistry. 17, 2, p. 867-871 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C

Boije af Gennäs, G., Talman, V., Aitio, O., Ekokoski, E., Finel, M., Tuominen, R. K. & Yli-Kauhaluoma, J., 2009, In : Journal of Medicinal Chemistry. 52, 13, p. 3969-3981 13 p.

Research output: Contribution to journalArticleScientificpeer-review

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2008

Hydrophobic derivatives of 5-(hydroxymethyl)isophthalic acid that selectively induce apoptosis in leukemia cells but not in fibroblasts

Galkin, A., Surakka, A., Boije af Gennäs, G., Ruotsalainen, T., Kreander, K., Tammela, P., Sivonen, K., Yli-Kauhaluoma, J. & Vuorela, P., 2008, In : Drug Development Research. 69, 4, p. 185-195 11 p.

Research output: Contribution to journalArticleScientificpeer-review