• PL 63 (Haartmaninkatu 8), 4023

    HELSINGIN YLIOPISTO

    Finland

  • PL 66 (Agnes Sjöbergin katu 2)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

  • PL 63 (Haartmaninkatu 8), 4021

    HELSINGIN YLIOPISTO

    Finland

  • Finland

19992019
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Personal profile

Description of research and teaching

Our research is focused on the development of canine models of human complex diseases. We take advantage of an experiment initiated by man ~15,000 years ago, taming of the wolf and, more recently, generating 400 strictly inbred pure dog breeds.  Canine purebreeding has resulted in highly uniform genomes within each breed, in which the “noise” of background genetic variation is reduced making it easier to detect genetic “signals” that contribute to disease.  That alone would not be very helpful without the fact that several of the essential components of most disease phenotypes can be found and measured in dogs. Dog is a large animal and clinically and physiologically close to human than typical laboratory rodent models. Dogs develop biologically analogous, if not homologous, conditions to human genetic disorders. Canine disorders usually respond to human medications and also other clinical and phenomenological studies suggest that these traits may share biological mechanisms across species. We aim to utilize this unique genetic system to identify new genes for morphology, behavior and various disorders.  Towards our aims, we have established one of the largest Dog DNA biobanks in the world with >80 000 samples from 330 different breeds. 
Although we work with many genetic traits in dogs, our research focuses on neurological, neurodegenerative and neurobehavioral conditions such as common epilepsy, ataxia and anxiety.  We have already mapped several new loci and genes in these disorders and believe that the natural canine models provide clinically and physiologically relevant models to corresponding human diseases. Comparison of the identified loci, genes and pathways across species will establish dogs as novel therapeutic models to understand the molecular pathogenesis of these complex traits. Meanwhile, breeders will benefit from the new DNA markers developed to identify the carriers for improved breeding plans. Our research has also led to novel successful commercial diagnostic innovations such as the first advanced gene panel test for dogs, MyDogDNA (www.mydogdna.com), and a NMR-based serum metabolomics test, PetMETA, available from PetBiomics (www.petbiomics.com). These high-resolution tests are transforming the diagnostics in veterinary medicine and breeding programs globally.

More on our research:

www.koirangeenit.fi

www.kissangeenit.fi

External positions

Adjunct Professor, University of Guelph

May 2013 → …

Keywords

  • 3111 Biomedicine
  • 1184 Genetics, developmental biology, physiology
  • 413 Veterinary science
  • 3112 Neurosciences

International and National Collaboration Publications and projects within past five years.

Publications 1999 2019

Assembly and Analysis of Unmapped Genome Sequence Reads Reveal Novel Sequence and Variation in Dogs

Holden, L. A., Arumilli, M., Hytonen, M. K., Hundi, S., Salojärvi, J., Brown, K. H. & Lohi, H., 18 Jul 2018, In : Scientific Reports. 8, 11 p., 10862.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
Open Access
File

Myotonia congenita in a Labrador Retriever with truncated CLCN1

Quitt, P. R., Hytönen, M. K., Matiasek, K., Rosati, M., Fischer, A. & Lohi, H., Jul 2018, In : Neuromuscular Disorders. 28, 7, p. 597-605 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Maternal Inheritance of a Recessive RBP4 Defect in Canine Congenital Eye Disease

Kaukonen, M., Woods, S., Ahonen, S., Lemberg, S., Hellman, M., Hytönen, M. K., Permi, P., Glaser, T. & Lohi, H., 29 May 2018, In : Cell Reports. 23, 9, p. 2643-2652 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Frequency and distribution of 152 genetic disease variants in over 100,000 mixed breed and purebred dogs

Donner, J., Anderson, H., Davison, S., Hughes, A. M., Bouirmane, J., Lindqvist, J., Lytle, K. M., Ganesan, B., Ottka, C., Ruotanen, P., Kaukonen, M., Forman, O. P., Fretwell, N., Cole, C. A. & Lohi, H., Apr 2018, In : PLoS Genetics. 14, 4, 20 p., 1007361.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Projects 2013 2017

Datasets

Feline biobank

Lohi, H. (Creator), University of Helsinki, 2017

Dataset

Canine biobank

Lohi, H. (Creator), University of Helsinki, 2017

Dataset

Prizes

Helsingin kaupungin tiedepalkinto 2013

Hannes Lohi (Recipient), 6 Jun 2013

Prize: Prizes and awards

Activities 2008 2018

Opponent of doctoral dissertation

Hannes Lohi (Supervisor)
24 Aug 2018

Activity: Examination typesOpponent of doctoral dissertation

Chair: Session 3: Neurology

Hannes Tapani Lohi (Speaker)
20 May 201724 May 2017

Activity: Talk or presentation typesInvited talk

Terveydeksi: Koira tieteen palveluksessa

Hannes Lohi (Speaker)
27 Oct 2017

Activity: Talk or presentation typesInvited talk

ECVN 2016

Hannes Lohi (Attendee)
16 Sep 201618 Sep 2016

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

PAG Conference 2016

Hannes Lohi (Attendee)
7 Jan 201612 Jan 2016

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Press / Media

Uhkaako geenimuuntelu terveyttä?

Hannes Lohi

24/10/2018

1 media contribution

Press/Media: Press / Media

Kaikkein paras kaveri

Hannes Lohi

08/07/2017

1 media contribution

Press/Media: Press / Media

Kissojen terveyskartoitus

Hannes Lohi

21/09/2016

1 media contribution

Press/Media: Press / Media

Koirien perinnölliset sairaudet ovat luultua yleisempiä

Hannes Lohi

18/08/2016

1 media contribution

Press/Media: Press / Media

Koirien veritesti

Hannes Lohi

16/08/2016

1 media contribution

Press/Media: Press / Media