Harri Sihto &ndash; Publications

2019

Anagrelide for Gastrointestinal Stromal Tumor

Pulkka, O-P., Gebreyohannes, Y. K., Wozniak, A., Mpindi, J-P., Tynninen, O., Icay, K., Cervera, A., Keskitalo, S., Murumägi, A., Kulesskiy, E., Laaksonen, M., Wennerberg, K., Varjosalo, M., Laakkonen, P., Lehtonen, R., Hautaniemi, S., Kallioniemi, O., Schöffski, P., Sihto, H. & Joensuu, H., 1 Mar 2019, In : Clinical Cancer Research. 25, 5, p. 1676-1687 12 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

Haikala, H. M., Anttila, J. M., Marques, E., Raatikainen, T., Ilander, M., Hakanen, H., Ala-Hongisto, H., Savelius, M., Balboa, D., Von Eyss, B., Eskelinen, V., Munne, P., Nieminen, A. I., Otonkoski, T., Schüler, J., Laajala, T. D., Aittokallio, T., Sihto, H., Mattson, J., Heikkilä, P. & 7 others, Leidenius, M., Joensuu, H., Mustjoki, S., Kovanen, P., Eilers, M., Leverson, J. D. & Klefström, J., 6 Feb 2019, In : Nature Communications. 10, 17 p., 620.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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SORLA regulates endosomal trafficking and oncogenic fitness of HER2

Pietilä, M., Sahgal, P., Peuhu, E., Jäntti, N. Z., Paatero, I., Närvä, E., Al-Akhrass, H., Lilja, J., Georgiadou, M., Andersen, O. M., Padzik, A., Sihto, H., Joensuu, H., Blomqvist, M., Saarinen, I., Boström, P. J., Taimen, P. & Ivaska, J., 28 May 2019, In : Nature Communications. 10, 16 p., 2340.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization

Le Joncour, V., Filppu, P., Hyvönen, M., Holopainen, M., Turunen, S. P., Sihto, H., Burghardt, I., Joensuu, H., Tynninen, O., Jääskeläinen, J., Weller, M., Lehti, K., Käkelä, R. & Laakkonen, P., Jun 2019, In : EMBO molecular medicine. 11, 6, 21 p., 9034.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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2018

Clinical relevance of integrin alpha 4 in gastrointestinal stromal tumours

Pulkka, O-P., Mpindi, J-P., Tynninen, O., Nilsson, B., Kallioniemi, O., Sihto, H. & Joensuu, H., Apr 2018, In : Journal of Cellular and Molecular Medicine. 22, 4, p. 2220-2230 11 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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Drug-Sensitivity Screening and Genomic Characterization of 45 HPV-Negative Head and Neck Carcinoma Cell Lines for Novel Biomarkers of Drug Efficacy

Lepikhova, T., Karhemo, P-R., Louhimo, R., Yadav, B., Murumägi, A., Kulesskiy, E., Kivento, M., Sihto, H., Grenman, R., Syrjänen, S. M., Kallioniemi, O., Aittokallio, T., Wennerberg, K., Joensuu, H. & Monni, O., Sep 2018, In : Molecular Cancer Therapeutics. 17, 9, p. 2060-2071 12 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Expression of cell cycle regulators and frequency of TP53 mutations in high risk gastrointestinal stromal tumors prior to adjuvant imatinib treatment

Ihle, M. A., Huss, S., Jeske, W., Hartmann, W., Merkelbach-Bruse, S., Schildhaus, H-U., Büttner, R., Sihto, H., Hall, K. S., Eriksson, M., Reichardt, P., Joensuu, H. & Wardelmann, E., 16 Feb 2018, In : PLoS One. 13, 2, 17 p., 0193048.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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2017

Effect of KIT and PDGFRA Mutations on Survival in Patients With Gastrointestinal Stromal Tumors Treated With Adjuvant Imatinib An Exploratory Analysis of a Randomized Clinical Trial

Joensuu, H., Wardelmann, E., Sihto, H., Eriksson, M., Hall, K. S., Reichardt, A., Hartmann, J. T., Pink, D., Cameron, S., Hohenberger, P., Al-Batran, S-E., Schlemmer, M., Bauer, S., Nilsson, B., Kallio, R., Junnila, J., Vehtari, A. & Reichardt, P., May 2017, In : JAMA Oncology. 3, 5, p. 602-609 8 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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History of chronic inflammatory disorders increases the risk of Merkel cell carcinoma, but does not correlate with Merkel cell polyomavirus infection

Sahi, H., Sihto, H., Artama, M., Koljonen, V., Bohling, T. & Pukkala, E., 17 Jan 2017, In : British Journal of Cancer. 116, 2, p. 260-264 5 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

Motility of glioblastoma cells is driven by netrin-1 induced gain of stemness

Ylivinkka, I., Sihto, H., Tynninen, O., Hu, Y., Laakso, A., Kivisaari, R., Laakkonen, P., Keski-Oja, J. & Hyytiäinen, M., 9 Jan 2017, In : Journal of Experimental and Clinical Cancer Research (Online). 36, 18 p., 9.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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SLUG transcription factor: a pro-survival and prognostic factor in gastrointestinal stromal tumour

Pulkka, O-P., Nilsson, B., Sarlomo-Rikala, M., Reichardt, P., Eriksson, M., Hall, K. S., Wardelmann, E., Vehtari, A., Joensuu, H. & Sihto, H., Apr 2017, In : British Journal of Cancer. 116, 9, p. 1195-1202 8 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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2016

Adjuvant Imatinib for High-Risk GI Stromal Tumor: Analysis of a Randomized Trial

Joensuu, H., Eriksson, M., Hall, K. S., Reichardt, A., Hartmann, J. T., Pink, D., Ramadori, G., Hohenberger, P., Al-Batran, S-E., Schlemmer, M., Bauer, S., Wardelmann, E., Nilsson, B., Sihto, H., Bono, P., Kallio, R., Junnila, J., Alvegard, T. & Reichardt, P., 20 Jan 2016, In : Journal of Clinical Oncology. 34, 3, p. 244-U99 10 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Biological subtyping of early breast cancer: a study comparing RT-qPCR with immunohistochemistry

Wirtz, R. M., Sihto, H., Isola, J., Heikkila, P., Kellokumpu-Lehtinen, P-L., Auvinen, P., Turpeenniemi-Hujanen, T., Jyrkkio, S., Lakis, S., Schlombs, K., Laible, M., Weber, S., Eidt, S., Sahin, U. & Joensuu, H., Jun 2016, In : Breast Cancer Research and Treatment. 157, 3, p. 437-446 10 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion

Tervonen, T. A., Belitskin, D., Pant, S. M., Englund, J. I., Marques, E., Ala-Hongisto, H., Nevalaita, L., Sihto, H., Heikkila, P., Leidenius, M., Hewitson, K., Ramachandra, M., Moilanen, A., Joensuu, H., Kovanen, P. E., Poso, A. & Klefstrom, J., 7 Apr 2016, In : Oncogene. 35, 14, p. 1832-1846 15 p.

Research output: Contribution to journal › Article › Scientific › peer-review

L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling

Jacquemet, G., Baghirov, H., Georgiadou, M., Sihto, H., Peuhu, E., Cettour-Janet, P., He, T., Perala, M., Kronqvist, P., Joensuu, H. & Ivaska, J., 2 Dec 2016, In : Nature Communications. 7, 17 p., 13297.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription

Kaukonen, R., Mai, A., Georgiadou, M., Saari, M., De Franceschi, N., Betz, T., Sihto, H., Ventela, S., Elo, L., Jokitalo, E., Westermarck, J., Kellokumpu-Lehtinen, P-L., Joensuu, H., Grenman, R. & Ivaska, J., Aug 2016, In : Nature Communications. 7, 15 p., 12237.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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2015

Elevated Levels of StAR-Related Lipid Transfer Protein 3 Alter Cholesterol Balance and Adhesiveness of Breast Cancer Cells Potential Mechanisms Contributing to Progression of HER2-Positive Breast Cancers

Vassilev, B., Sihto, H., Li, S., Holtta-Vuori, M., Ilola, J., Lundin, J., Isola, J., Kellokumpu-Lehtinen, P-L., Joensuu, H. & Ikonen, E., Apr 2015, In : The American Journal of Pathology. 185, 4, p. 987-1000 14 p.

Research output: Contribution to journal › Article › Scientific › peer-review

2014

Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis

Arjonen, A., Kaukonen, R., Mattila, E., Rouhi, P., Hognas, G., Sihto, H., Miller, B. W., Morton, J. P., Bucher, E., Taimen, P., Virtakoivu, R., Cao, Y., Sansom, O. J., Joensuu, H. & Ivaska, J., Mar 2014, In : Journal of Clinical Investigation. 124, 3, p. 1069-1082 14 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Novel Target for Peptide-Based Imaging and Treatment of Brain Tumors

Hyvönen, M., Enback, J., Huhtala, T., Lammi, J., Sihto, H., Weisell, J., Joensuu, H., Rosenthal-Aizman, K., El-Andaloussi, S., Langel, U., Narvanen, A., Bergers, G. & Laakkonen, P., Apr 2014, In : Molecular Cancer Therapeutics. 13, 4, p. 996-1007 12 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Prokineticins and Merkel cell polyomavirus infection in Merkel cell carcinoma

Lauttia, S., Sihto, H., Kavola, H., Koljonen, V., Bohling, T. & Joensuu, H., 18 Mar 2014, In : British Journal of Cancer. 110, 6, p. 1446-1455 10 p.

Research output: Contribution to journal › Article › Scientific › peer-review

RB1 gene in Merkel cell carcinoma: hypermethylation in all tumors and concurrent heterozygous deletions in the polyomavirus-negative subgroup

Sahi, H., Savola, S., Sihto, H., Koljonen, V., Bohling, T. & Knuutila, S., Dec 2014, In : APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. 122, 12, p. 1157-1166 10 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Risk Factors for Gastrointestinal Stromal Tumor Recurrence in Patients Treated With Adjuvant Imatinib

Joensuu, H., Eriksson, M., Hall, K. S., Hartmann, J. T., Pink, D., Schuette, J., Ramadori, G., Hohenberger, P., Duyster, J., Al-Batran, S-E., Schlemmer, M., Bauer, S., Wardelmann, E., Sarlomo-Rikala, M., Nilsson, B., Sihto, H., Ballman, K. V., Leinonen, M., DeMatteo, R. P. & Reichardt, P., 1 Aug 2014, In : Cancer. 120, 15, p. 2325-2333 9 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access

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2013

Lateral distribution of Merkel cell carcinoma in a nationwide cohort

Koljonen, V., Kluger, N., Sihto, H. & Böhling, T., 2013, In : Journal of the European Academy of Dermatology and Venereology. 27, 7, p. 884-888 5 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Senescence Sensitivity of Breast Cancer Cells Is Defined by Positive Feedback Loop between CIP2A and E2F1

Laine, A., Sihto, H., Come, C., Rosenfeldt, M. T., Zwolinska, A., Niemela, M., Khanna, A., Chan, E. K., Kahari, V-M., Kellokumpu-Lehtinen, P-L., Sansom, O. J., Evan, G. I., Junttila, M. R., Ryan, K. M., Marine, J-C., Joensuu, H. & Westermarck, J., Feb 2013, In : Cancer Discovery. 3, 2, p. 182-197 16 p.

Research output: Contribution to journal › Article › Scientific › peer-review

2012

Bcl-2 expression indicates better prognosis of Merkel cell carcinoma regardless of the presence of Merkel cell polyomavirus

Sahi, H., Koljonen, V., Kavola, H., Haglund, C., Tukiainen, E., Sihto, H. & Böhling, T., Nov 2012, In : Virchows Archiv. 461, 5, p. 553-559 7 p.

Research output: Contribution to journal › Article › Scientific › peer-review

CIP2A signature reveals the MYC dependency of CIP2A-regulated phenotypes and its clinical association with breast cancer subtypes

Niemela, M., Kauko, O., Sihto, H., Mpindi, J-P., Nicorici, D., Pernila, P., Kallioniemi, O-P., Joensuu, H., Hautaniemi, S. & Westermarck, J., 1 Sep 2012, In : Oncogene. 31, 39, p. 4266-4278 13 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Merkel cell polyomavirus infection and host defence in patients with Merkel cell carcinoma

Sihto, H., 2012, Helsinki: [H. Sihto]. 80 p.

Research output: Thesis › Doctoral Thesis

One vs Three Years of Adjuvant Imatinib for Operable Gastrointestinal Stromal Tumor A Randomized Trial

Joensuu, H., Eriksson, M., Hall, K. S., Hartmann, J. T., Pink, D., Schuette, J., Ramadori, G., Hohenberger, P., Duyster, J., Al-Batran, S-E., Schlemmer, M., Bauer, S., Wardelmann, E., Sarlomo-Rikala, M., Nilsson, B., Sihto, H., Monge, O. R., Bono, P., Kallio, R., Vehtari, A. & 3 others, Leinonen, M., Alvegard, T. & Reichardt, P., 2012, In : JAMA : The Journal of the American Medical Association. 307, 12, p. 1265-1272 8 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Tumor Infiltrating Immune Cells and Outcome of Merkel Cell Carcinoma: A Population-Based Study

Sihto, H., Bohling, T., Kavola, H., Koljonen, V., Salmi, M., Jalkanen, S. & Joensuu, H., 2012, In : Clinical Cancer Research. 18, 10, p. 2872-2881 10 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer

Sihto, H. & Joensuu, H., 2012, In : OncoImmunology. 1, 8, p. 1420-1421 2 p.

Research output: Contribution to journal › Article › Scientific › peer-review

2011

An extensive tumor array analysis supports tumor suppressive role for nucleophosmin in breast cancer

Karhemo, P-R., Rivinoja, A., Lundin, J. E., Hyvönen, M., Chernenko, A., Lammi, J., Sihto, H., Lundin, M. E., Heikkilä, P., Joensuu, H., Bono, P. & Laakkonen, P. M., 2011, In : The American Journal of Pathology. 179, 2, p. 1004-1014 14 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Association of Merkel cell polyomavirus infection with tumor p53, KIT, stem cell factor, PDGFR-alpha and survival in Merkel cell carcinoma

Waltari, M., Sihto, H., Kukko, H., Koljonen, V., Sankila, R., Böhling, T. & Joensuu, H., 2011, In : International Journal of Cancer. 129, 3, p. 619-628 10 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study

Sihto, H., Lundin, J., Lundin, M., Lehtimaki, T., Ristimaki, A., Holli, K., Sailas, L., Kataja, V., Turpeenniemi-Hujanen, T., Isola, J., Heikkila, P. & Joensuu, H., 2011, In : Breast Cancer Research. 13, p. R87 11 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Development and evaluation of a virtual microscopy application for automated assessment of Ki-67 expression in breast cancer

Konsti, J. P., Lundin, M. E., Joensuu, H., Lehtimäki, T. E., Sihto, H., Holli, K., Turpeenniemi-Hujanen, T., Kataja, V., Sailas, L., Isola, J. & Lundin, J. E., 25 Jan 2011, In : BMC Clinical Pathology. 11, p. art. no. 3

Research output: Contribution to journal › Article › Scientific › peer-review

Long-term prognosis of breast cancer detected by mammography screening or other methods

Lehtimaki, T., Lundin, M., Linder, N., Sihto, H., Holli, K., Turpeenniemi-Hujanen, T., Kataja, V., Isola, J., Joensuu, H. & Lundin, J., 2011, In : Breast Cancer Research. 13, 6, 11 p., 134.

Research output: Contribution to journal › Article › Scientific › peer-review

Merkel Cell Polyomavirus Infection, Large T Antigen, Retinoblastoma Protein and Outcome in Merkel Cell Carcinoma

Sihto, H., Kukko, H., Koljonen, V., Sankila, R., Bohling, T. & Joensuu, H., 2011, In : Clinical Cancer Research. 17, 14, p. 4806-4813 8 p.

Research output: Contribution to journal › Article › Scientific › peer-review

2010

Expression of KIT Receptor Tyrosine Kinase in Endothelial Cells of Juvenile Brain Tumors

Puputti, M., Tynninen, O., Pernila, P., Salmi, M., Jalkanen, S., Paetau, A., Sihto, H. & Joensuu, H., 2010, In : Brain Pathology. 20, p. 763-770 8 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Unusually young Merkel cell carcinoma patients are Merkel cell polyomavirus positive and frequently immunocompromised

Sahi, H., Kukko, H., Böhling, T., Tukiainen, E. J., Sihto, H., Joensuu, H. & Koljonen, V., 2010, In : European Journal of Plastic Surgery. 33, 6, p. 349-353 5 p.

Research output: Contribution to journal › Article › Scientific › peer-review

2009

2008

Molecular subtypes of breast cancers detected in mammography screening and outside of screening

Sihto, H., Lundin, J. E., Lehtimäki, T. E., Sarlomo-Rikala, M. T. H., Butzow, R., Holli, K., Sailas, L., Kataja, V., Lundin, M. E., Turpeenniemi-Hujanen, T., Isola, J., Heikkilä, P. & Joensuu, H., 2008, In : Clinical Cancer Research. 2008 / 14, 13, p. 4103-4110 8 p.

Research output: Contribution to journal › Article › Scientific › peer-review

VEGFR-3 expression is restricted to blood and lymphatic vessels in solid tumors: [correspondence]

Petrova, T., Bono, P., Holnthoner, W., Chesnes, J., Pytowski, B., Sihto, H., Laakkonen, P., Heikkilä, P., Joensuu, H. & Alitalo, K., 2008, In : Cancer Cell. 13, 6, p. 554-556 3 p.

Research output: Contribution to journal › Article › Scientific › peer-review

2007

Breast cancer detection in mammography screening has independent influence on survival when cancer size and biological subtype are accounted for

Sihto, H., Puputti, M., Heikkila, R., Lehtimaki, T., Holli, K., Kataja, V., Turpeenniemi-Hujanen, T., Isola, J., Lundin, J. & Joensuu, H., 2007, In : EJC supplements. 5, p. 97-97 1 p.

Research output: Contribution to journal › Conference article › Scientific › peer-review

Endothelial cell KIT expression in human tumours

Sihto, H., Tynninen, O., Butzow, R., Saarialho-Kere, U. & Joensuu, H., 2007, In : Journal of Pathology. 211, 4, p. 481-488 8 p.

Research output: Contribution to journal › Article › Scientific › peer-review

2006