Photo of Harri Sihto
  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

20042019
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Publications 2004 2019

  • 55 Article
  • 1 Conference article
  • 1 Doctoral Thesis
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Article
2019

Anagrelide for Gastrointestinal Stromal Tumor

Pulkka, O-P., Gebreyohannes, Y. K., Wozniak, A., Mpindi, J-P., Tynninen, O., Icay, K., Cervera, A., Keskitalo, S., Murumägi, A., Kulesskiy, E., Laaksonen, M., Wennerberg, K., Varjosalo, M., Laakkonen, P., Lehtonen, R., Hautaniemi, S., Kallioniemi, O., Schöffski, P., Sihto, H. & Joensuu, H., 1 Mar 2019, In : Clinical Cancer Research. 25, 5, p. 1676-1687 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

Haikala, H. M., Anttila, J. M., Marques, E., Raatikainen, T., Ilander, M., Hakanen, H., Ala-Hongisto, H., Savelius, M., Balboa, D., Von Eyss, B., Eskelinen, V., Munne, P., Nieminen, A. I., Otonkoski, T., Schüler, J., Laajala, T. D., Aittokallio, T., Sihto, H., Mattson, J., Heikkilä, P. & 7 others, Leidenius, M., Joensuu, H., Mustjoki, S., Kovanen, P., Eilers, M., Leverson, J. D. & Klefström, J., 6 Feb 2019, In : Nature Communications. 10, 17 p., 620.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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SORLA regulates endosomal trafficking and oncogenic fitness of HER2

Pietilä, M., Sahgal, P., Peuhu, E., Jäntti, N. Z., Paatero, I., Närvä, E., Al-Akhrass, H., Lilja, J., Georgiadou, M., Andersen, O. M., Padzik, A., Sihto, H., Joensuu, H., Blomqvist, M., Saarinen, I., Boström, P. J., Taimen, P. & Ivaska, J., 28 May 2019, In : Nature Communications. 10, 16 p., 2340.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization

Le Joncour, V., Filppu, P., Hyvönen, M., Holopainen, M., Turunen, S. P., Sihto, H., Burghardt, I., Joensuu, H., Tynninen, O., Jääskeläinen, J., Weller, M., Lehti, K., Käkelä, R. & Laakkonen, P., Jun 2019, In : EMBO molecular medicine. 11, 6, 21 p., 9034.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Clinical relevance of integrin alpha 4 in gastrointestinal stromal tumours

Pulkka, O-P., Mpindi, J-P., Tynninen, O., Nilsson, B., Kallioniemi, O., Sihto, H. & Joensuu, H., Apr 2018, In : Journal of Cellular and Molecular Medicine. 22, 4, p. 2220-2230 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Drug-Sensitivity Screening and Genomic Characterization of 45 HPV-Negative Head and Neck Carcinoma Cell Lines for Novel Biomarkers of Drug Efficacy

Lepikhova, T., Karhemo, P-R., Louhimo, R., Yadav, B., Murumägi, A., Kulesskiy, E., Kivento, M., Sihto, H., Grenman, R., Syrjänen, S. M., Kallioniemi, O., Aittokallio, T., Wennerberg, K., Joensuu, H. & Monni, O., Sep 2018, In : Molecular Cancer Therapeutics. 17, 9, p. 2060-2071 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Expression of cell cycle regulators and frequency of TP53 mutations in high risk gastrointestinal stromal tumors prior to adjuvant imatinib treatment

Ihle, M. A., Huss, S., Jeske, W., Hartmann, W., Merkelbach-Bruse, S., Schildhaus, H-U., Büttner, R., Sihto, H., Hall, K. S., Eriksson, M., Reichardt, P., Joensuu, H. & Wardelmann, E., 16 Feb 2018, In : PLoS One. 13, 2, 17 p., 0193048.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

Effect of KIT and PDGFRA Mutations on Survival in Patients With Gastrointestinal Stromal Tumors Treated With Adjuvant Imatinib An Exploratory Analysis of a Randomized Clinical Trial

Joensuu, H., Wardelmann, E., Sihto, H., Eriksson, M., Hall, K. S., Reichardt, A., Hartmann, J. T., Pink, D., Cameron, S., Hohenberger, P., Al-Batran, S-E., Schlemmer, M., Bauer, S., Nilsson, B., Kallio, R., Junnila, J., Vehtari, A. & Reichardt, P., May 2017, In : JAMA Oncology. 3, 5, p. 602-609 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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History of chronic inflammatory disorders increases the risk of Merkel cell carcinoma, but does not correlate with Merkel cell polyomavirus infection

Sahi, H., Sihto, H., Artama, M., Koljonen, V., Bohling, T. & Pukkala, E., 17 Jan 2017, In : British Journal of Cancer. 116, 2, p. 260-264 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Motility of glioblastoma cells is driven by netrin-1 induced gain of stemness

Ylivinkka, I., Sihto, H., Tynninen, O., Hu, Y., Laakso, A., Kivisaari, R., Laakkonen, P., Keski-Oja, J. & Hyytiäinen, M., 9 Jan 2017, In : Journal of Experimental and Clinical Cancer Research (Online). 36, 18 p., 9.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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SLUG transcription factor: a pro-survival and prognostic factor in gastrointestinal stromal tumour

Pulkka, O-P., Nilsson, B., Sarlomo-Rikala, M., Reichardt, P., Eriksson, M., Hall, K. S., Wardelmann, E., Vehtari, A., Joensuu, H. & Sihto, H., Apr 2017, In : British Journal of Cancer. 116, 9, p. 1195-1202 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Adjuvant Imatinib for High-Risk GI Stromal Tumor: Analysis of a Randomized Trial

Joensuu, H., Eriksson, M., Hall, K. S., Reichardt, A., Hartmann, J. T., Pink, D., Ramadori, G., Hohenberger, P., Al-Batran, S-E., Schlemmer, M., Bauer, S., Wardelmann, E., Nilsson, B., Sihto, H., Bono, P., Kallio, R., Junnila, J., Alvegard, T. & Reichardt, P., 20 Jan 2016, In : Journal of Clinical Oncology. 34, 3, p. 244-U99 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Biological subtyping of early breast cancer: a study comparing RT-qPCR with immunohistochemistry

Wirtz, R. M., Sihto, H., Isola, J., Heikkila, P., Kellokumpu-Lehtinen, P-L., Auvinen, P., Turpeenniemi-Hujanen, T., Jyrkkio, S., Lakis, S., Schlombs, K., Laible, M., Weber, S., Eidt, S., Sahin, U. & Joensuu, H., Jun 2016, In : Breast Cancer Research and Treatment. 157, 3, p. 437-446 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion

Tervonen, T. A., Belitskin, D., Pant, S. M., Englund, J. I., Marques, E., Ala-Hongisto, H., Nevalaita, L., Sihto, H., Heikkila, P., Leidenius, M., Hewitson, K., Ramachandra, M., Moilanen, A., Joensuu, H., Kovanen, P. E., Poso, A. & Klefstrom, J., 7 Apr 2016, In : Oncogene. 35, 14, p. 1832-1846 15 p.

Research output: Contribution to journalArticleScientificpeer-review

L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling

Jacquemet, G., Baghirov, H., Georgiadou, M., Sihto, H., Peuhu, E., Cettour-Janet, P., He, T., Perala, M., Kronqvist, P., Joensuu, H. & Ivaska, J., 2 Dec 2016, In : Nature Communications. 7, 17 p., 13297.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription

Kaukonen, R., Mai, A., Georgiadou, M., Saari, M., De Franceschi, N., Betz, T., Sihto, H., Ventela, S., Elo, L., Jokitalo, E., Westermarck, J., Kellokumpu-Lehtinen, P-L., Joensuu, H., Grenman, R. & Ivaska, J., Aug 2016, In : Nature Communications. 7, 15 p., 12237.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2014

Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis

Arjonen, A., Kaukonen, R., Mattila, E., Rouhi, P., Hognas, G., Sihto, H., Miller, B. W., Morton, J. P., Bucher, E., Taimen, P., Virtakoivu, R., Cao, Y., Sansom, O. J., Joensuu, H. & Ivaska, J., Mar 2014, In : Journal of Clinical Investigation. 124, 3, p. 1069-1082 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Novel Target for Peptide-Based Imaging and Treatment of Brain Tumors

Hyvönen, M., Enback, J., Huhtala, T., Lammi, J., Sihto, H., Weisell, J., Joensuu, H., Rosenthal-Aizman, K., El-Andaloussi, S., Langel, U., Narvanen, A., Bergers, G. & Laakkonen, P., Apr 2014, In : Molecular Cancer Therapeutics. 13, 4, p. 996-1007 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Prokineticins and Merkel cell polyomavirus infection in Merkel cell carcinoma

Lauttia, S., Sihto, H., Kavola, H., Koljonen, V., Bohling, T. & Joensuu, H., 18 Mar 2014, In : British Journal of Cancer. 110, 6, p. 1446-1455 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Risk Factors for Gastrointestinal Stromal Tumor Recurrence in Patients Treated With Adjuvant Imatinib

Joensuu, H., Eriksson, M., Hall, K. S., Hartmann, J. T., Pink, D., Schuette, J., Ramadori, G., Hohenberger, P., Duyster, J., Al-Batran, S-E., Schlemmer, M., Bauer, S., Wardelmann, E., Sarlomo-Rikala, M., Nilsson, B., Sihto, H., Ballman, K. V., Leinonen, M., DeMatteo, R. P. & Reichardt, P., 1 Aug 2014, In : Cancer. 120, 15, p. 2325-2333 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2013

Lateral distribution of Merkel cell carcinoma in a nationwide cohort

Koljonen, V., Kluger, N., Sihto, H. & Böhling, T., 2013, In : Journal of the European Academy of Dermatology and Venereology. 27, 7, p. 884-888 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Senescence Sensitivity of Breast Cancer Cells Is Defined by Positive Feedback Loop between CIP2A and E2F1

Laine, A., Sihto, H., Come, C., Rosenfeldt, M. T., Zwolinska, A., Niemela, M., Khanna, A., Chan, E. K., Kahari, V-M., Kellokumpu-Lehtinen, P-L., Sansom, O. J., Evan, G. I., Junttila, M. R., Ryan, K. M., Marine, J-C., Joensuu, H. & Westermarck, J., Feb 2013, In : Cancer Discovery. 3, 2, p. 182-197 16 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

CIP2A signature reveals the MYC dependency of CIP2A-regulated phenotypes and its clinical association with breast cancer subtypes

Niemela, M., Kauko, O., Sihto, H., Mpindi, J-P., Nicorici, D., Pernila, P., Kallioniemi, O-P., Joensuu, H., Hautaniemi, S. & Westermarck, J., 1 Sep 2012, In : Oncogene. 31, 39, p. 4266-4278 13 p.

Research output: Contribution to journalArticleScientificpeer-review

One vs Three Years of Adjuvant Imatinib for Operable Gastrointestinal Stromal Tumor A Randomized Trial

Joensuu, H., Eriksson, M., Hall, K. S., Hartmann, J. T., Pink, D., Schuette, J., Ramadori, G., Hohenberger, P., Duyster, J., Al-Batran, S-E., Schlemmer, M., Bauer, S., Wardelmann, E., Sarlomo-Rikala, M., Nilsson, B., Sihto, H., Monge, O. R., Bono, P., Kallio, R., Vehtari, A. & 3 others, Leinonen, M., Alvegard, T. & Reichardt, P., 2012, In : JAMA : The Journal of the American Medical Association. 307, 12, p. 1265-1272 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Tumor Infiltrating Immune Cells and Outcome of Merkel Cell Carcinoma: A Population-Based Study

Sihto, H., Bohling, T., Kavola, H., Koljonen, V., Salmi, M., Jalkanen, S. & Joensuu, H., 2012, In : Clinical Cancer Research. 18, 10, p. 2872-2881 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer

Sihto, H. & Joensuu, H., 2012, In : OncoImmunology. 1, 8, p. 1420-1421 2 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

An extensive tumor array analysis supports tumor suppressive role for nucleophosmin in breast cancer

Karhemo, P-R., Rivinoja, A., Lundin, J. E., Hyvönen, M., Chernenko, A., Lammi, J., Sihto, H., Lundin, M. E., Heikkilä, P., Joensuu, H., Bono, P. & Laakkonen, P. M., 2011, In : The American Journal of Pathology. 179, 2, p. 1004-1014 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Association of Merkel cell polyomavirus infection with tumor p53, KIT, stem cell factor, PDGFR-alpha and survival in Merkel cell carcinoma

Waltari, M., Sihto, H., Kukko, H., Koljonen, V., Sankila, R., Böhling, T. & Joensuu, H., 2011, In : International Journal of Cancer. 129, 3, p. 619-628 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study

Sihto, H., Lundin, J., Lundin, M., Lehtimaki, T., Ristimaki, A., Holli, K., Sailas, L., Kataja, V., Turpeenniemi-Hujanen, T., Isola, J., Heikkila, P. & Joensuu, H., 2011, In : Breast Cancer Research. 13, p. R87 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Development and evaluation of a virtual microscopy application for automated assessment of Ki-67 expression in breast cancer

Konsti, J. P., Lundin, M. E., Joensuu, H., Lehtimäki, T. E., Sihto, H., Holli, K., Turpeenniemi-Hujanen, T., Kataja, V., Sailas, L., Isola, J. & Lundin, J. E., 25 Jan 2011, In : BMC Clinical Pathology. 11, p. art. no. 3

Research output: Contribution to journalArticleScientificpeer-review

Long-term prognosis of breast cancer detected by mammography screening or other methods

Lehtimaki, T., Lundin, M., Linder, N., Sihto, H., Holli, K., Turpeenniemi-Hujanen, T., Kataja, V., Isola, J., Joensuu, H. & Lundin, J., 2011, In : Breast Cancer Research. 13, 6, 11 p., 134.

Research output: Contribution to journalArticleScientificpeer-review

Merkel Cell Polyomavirus Infection, Large T Antigen, Retinoblastoma Protein and Outcome in Merkel Cell Carcinoma

Sihto, H., Kukko, H., Koljonen, V., Sankila, R., Bohling, T. & Joensuu, H., 2011, In : Clinical Cancer Research. 17, 14, p. 4806-4813 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Expression of KIT Receptor Tyrosine Kinase in Endothelial Cells of Juvenile Brain Tumors

Puputti, M., Tynninen, O., Pernila, P., Salmi, M., Jalkanen, S., Paetau, A., Sihto, H. & Joensuu, H., 2010, In : Brain Pathology. 20, p. 763-770 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Clinical factors associated with Merkel cell polyomavirus infection in Merkel cell carcinoma

Sihto, H., Kukko, H., Koljonen, V., Sankila, R., Böhling, T. & Joensuu, H., 2009, In : Journal of the National Cancer Institute. 101, 13, p. 938-945 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Incidence of Merkel cell carcinoma in renal transplant recipients

Koljonen, V., Kukko, H., Tukiainen, E., Böhling, T., Sankila, R., Pukkala, E., Sihto, H., Joensuu, H., Kyllönen, L. & Mäkisalo, H., 2009, In : Nephrology, Dialysis, Transplantation. 24, 10, p. 3231-3235 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Tumour microvessel endothelial cell KIT and stem cell factor expression in human solid tumours

Sihto, H., Tynninen, O., Halonen, M., Puputti, M., Karjalainen-Lindsberg, M-L., Kukko, H. & Joensuu, H., 2009, In : Histopathology. 55, 5, p. 544-553 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Molecular subtypes of breast cancers detected in mammography screening and outside of screening

Sihto, H., Lundin, J. E., Lehtimäki, T. E., Sarlomo-Rikala, M. T. H., Butzow, R., Holli, K., Sailas, L., Kataja, V., Lundin, M. E., Turpeenniemi-Hujanen, T., Isola, J., Heikkilä, P. & Joensuu, H., 2008, In : Clinical Cancer Research. 2008 / 14, 13, p. 4103-4110 8 p.

Research output: Contribution to journalArticleScientificpeer-review

VEGFR-3 expression is restricted to blood and lymphatic vessels in solid tumors: [correspondence]

Petrova, T., Bono, P., Holnthoner, W., Chesnes, J., Pytowski, B., Sihto, H., Laakkonen, P., Heikkilä, P., Joensuu, H. & Alitalo, K., 2008, In : Cancer Cell. 13, 6, p. 554-556 3 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

Endothelial cell KIT expression in human tumours

Sihto, H., Tynninen, O., Butzow, R., Saarialho-Kere, U. & Joensuu, H., 2007, In : Journal of Pathology. 211, 4, p. 481-488 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Allelic imbalance of HER2 variant in sporadic breast and ovarian cancer

Puputti, M., Sihto, H., Isola, J., Butzow, R., Joensuu, H. & Nupponen, N., 2006, In : Cancer Genetics and Cytogenetics. 16, 1, p. 32-38 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Amplification of KIT, PDGFRA, VEGFR2, and EGFR in gliomas

Puputti, M., Tynninen, O., Sihto, H., Blom, T., Mäenpää, H., Isola, J., Paetau, A., Joensuu, H., Nupponen, N. & Mäenpää, H., 2006, In : Molecular Cancer Research. 4, 12, p. 927-934 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Gastrointestinal stromal tumors with KIT exon 11 deletions are associated with poor prognosis

Andersson, J., Bumming, P., Meis-Kindblom, J. M., Sihto, H., Nupponen, N., Joensuu, H., Oden, A., Gustavsson, B., Kindblom, L-G. & Nilsson, B., 2006, In : Gastroenterology. 130, 6, p. 1573-1581 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Gene amplification, mutation, and protein expression of EGFR and mutations of ERBB2 in serous ovarian carcinoma

Lassus, H., Sihto, H., Leminen, A., Joensuu, H., Isola, J., Nupponen, N. N. & Butzow, R., 2006, In : Journal of Molecular Medicine. 84, 8, p. 671-681 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Platelet-derived growth factor receptor family mutations in gastrointestinal stromal tumours

Sihto, H., Franssila, K., Tanner, M., Vasama-Nolvi, C., Sarlomo-Rikala, M., Nupponen, N., Joensuu, H. & Isola, J., 2006, In : Scandinavian Journal of Gastroenterology. 41, 7, p. 805-811 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

Amplification of genes encoding KIT, PDGFRalpha and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme

Joensuu, H., Puputti, M., Sihto, H., Tynninen, O. & Nupponen, N., 2005, In : Journal of Pathology. 207, 2, p. 224-231 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Epidermal growth factor receptor domain II, IV, and kinase domain mutations in human solid tumors

Sihto, H., Puputti, M., Pulli, L., Tynninen, O., Koskinen, W., Aaltonen, L-M., Tanner, M., Böhling, T., Visakorpi, T., Butzow, R., Knuuttila, A., Nupponen, N. & Joensuu, H., 2005, In : Journal of Molecular Medicine. 83, p. 976-983 8 p.

Research output: Contribution to journalArticleScientificpeer-review