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Heikki Kuusanmäki

20122019
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Publications 2012 2019

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2019

Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia

Kuusanmäki, H., Leppä, A-M., Pölönen, P., Kontro, M., Dufva, O., Deb, D., Yadav, B., Bruck, O., Kumar, A., Everaus, H., Gjertsen, B. T., Heinäniemi, M., Porkka, K., Mustjoki, S. & Heckman, C., 11 Jul 2019, In : Haematologica.

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2018

Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target

Dufva, O., Kankainen, M., Kelkka, T., Sekiguchi, N., Awad, S. A., Eldfors, S., Yadav, B., Kuusanmäki, H., Malani, D., Andersson, E. I., Pietarinen, P., Saikko, L., Kovanen, P. E., Ojala, T., Lee, D. A., Loughran, T. P., Nakazawa, H., Suzumiya, J., Suzuki, R., Ko, Y. H. & 7 othersKim, W. S., Chuang, S-S., Aittokallio, T., Chan, W. C., Ohshima, K., Ishida, F. & Mustjoki, S., 19 Apr 2018, In : Nature Communications. 9, 12 p., 1567.

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2017

Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors

Pietarinen, P. O., Eide, C. A., Ayuda-Duran, P., Potdar, S., Kuusanmaki, H., Andersson, E. I., Mpindi, J. P., Pemovska, T., Kontro, M., Heckman, C. A., Kallioniemi, O., Wennerberg, K., Hjorth-Hansen, H., Druker, B. J., Enserink, J. M., Tyner, J. W., Mustjoki, S. & Porkka, K., 4 Apr 2017, In : Oncotarget. 8, 14, p. 22606-22615 10 p.

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Open Access

Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling

Kuusanmäki, H., Dufva, O., Parri, E., van Adrichem, A. J., Rajala, H., Majumder, M. M., Yadav, B., Parsons, A., Chan, W. C., Wennerberg, K., Mustjoki, S. & Heckman, C. A., 14 Nov 2017, In : Oncotarget. 8, 57, p. 97516-97527 12 p.

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Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia

Eldfors, S., Kuusanmäki, H., Kontro, M., Majumder, M. M., Parsons, A., Edgren, H., Pemovska, T., Kallioniemi, O., Wennerberg, K., Gökbuget, N., Burmeister, T., Porkka, K. & Heckman, C. A., 2017, In : Leukemia. 31, 1, p. 51-57 7 p.

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Identification of precision treatment strategies for relapsed/refractory multiple myeloma by functional drug sensitivity testing

Majumder, M. M., Silvennoinen, R., Anttila, P., Tamborero, D., Eldfors, S., Yadav, B., Karjalainen, R., Kuusanmaki, H., Lievonen, J., Parsons, A., Suvela, M., Jantunen, E., Porkka, K. & Heckman, C. A., 22 Aug 2017, In : Oncotarget. 8, 34, p. 56338-56350 13 p.

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In silico and preclinical drug screening identifies dasatinib as a targeted therapy for T-ALL

Laukkanen, S., Gronroos, T., Polonen, P., Kuusanmaki, H., Mehtonen, J., Cloos, J., Ossenkoppele, G., Gjertsen, B., Oystein, B., Heckman, C., Heinaniemi, M., Kontro, M. & Lohi, O., 8 Sep 2017, In : Blood cancer journal. 7, 4 p., 604.

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Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry

Heikkinen, T., Kämpjärvi, K., Keskitalo, S., von Nandelstadh, P., Liu, X., Rantanen, V., Pitkänen, E., Kinnunen, M., Kuusanmäki, H., Kontro, M., Turunen, M., Mäkinen, N., Taipale, J., Heckman, C., Lehti, K., Mustjoki, S., Varjosalo, M. & Vahteristo, P., Mar 2017, In : Human Mutation. 38, 3, p. 269-274 6 p.

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2015

Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3

Haapaniemi, E. M., Kaustio, M., Rajala, H. L. M., van Adrichem, A. J., Kainulainen, L., Glumoff, V., Doffinger, R., Kuusanmaki, H., Heiskanen-Kosma, T., Trotta, L., Chiang, S., Kulmala, P., Eldfors, S., Katainen, R., Siitonen, S., Karjalainen-Lindsberg, M-L., Kovanen, P. E., Otonkoski, T., Porkka, K., Heiskanen, K. & 7 othersHanninen, A., Bryceson, Y. T., Uusitalo-Seppala, R., Saarela, J., Seppanen, M., Mustjoki, S. & Kere, J., 22 Jan 2015, In : Blood. 125, 4, p. 639-648 10 p.

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Novel drug candidates for blast phase chronic myeloid leukemia from high-throughput drug sensitivity and resistance testing

Pietarinen, P. O., Pemovska, T., Kontro, M., Yadav, B., Mpindi, J. P., Andersson, E. I., Majumder, M. M., Kuusanmaki, H., Koskenvesa, P., Kallioniemi, O., Wennerberg, K., Heckman, C. A., Mustjoki, S. & Porkka, K., May 2015, In : Blood cancer journal. 5, 6 p., 309.

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2014

Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia

Kontro, M., Kuusanmaki, H., Eldfors, S., Burmeister, T., Andersson, E. I., Bruserud, O., Bruemmendorf, T. H., Edgren, H., Gjertsen, B. T., Itala-Remes, M., Lagström, S., Lohi, O., Lundan, T., Marti, J. M. L., Majumder, M. M., Parsons, A., Pemovska, T., Rajala, H., Vettenranta, K., Kallioniemi, O. & 3 othersMustjoki, S., Porkka, K. & Heckman, C. A., Aug 2014, In : Leukemia. 28, 8, p. 1738-1742 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

Koskela, H. L. M., Eldfors, S., Kuusanmäki, H., van Adrichem, A. J. . A., Olson, T., Lagström, S., Andersson, E. I., Jerez, A., Clemente, M. J., Yan, Y., Zhang, D., Awwad, A., Ellonen, P., Kallioniemi, O., Wennerberg, K., Porkka, K., Maciejewski, J. P., Loughran, T. P., Heckman, C. & Mustjoki, S., 30 May 2013, In : Blood. 121, 22, p. 4541-4550 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia

Koskela, H. L. M., Eldfors, S., Ellonen, P., van Adrichem, A. J., Kuusanmäki, H., Andersson, E. I., Lagström, S., Clemente, M. J., Olson, T., Jalkanen, S. E., Majumder, M. M., Almusa, H., Edgren, H., Lepistö, M., Mattila, P., Guinta, K., Koistinen, P., Kuittinen, T., Penttinen, K., Parsons, A. & 9 othersKnowles, J., Saarela, J., Wennerberg, K., Kallioniemi, O., Porkka, K., Loughran, T. P., Heckman, C. A., Maciejewski, J. P. & Mustjoki, S., 2012, In : New England Journal of Medicine. 366, 20, p. 1905-1913 9 p.

Research output: Contribution to journalArticleScientificpeer-review